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355 Health - Alzheimer Resources

Misc. - Numbers

'5-D protein fingerprinting' with nanopores could give insights into Alzheimer's, Parkinson's
In research that could one day lead to advances against neurodegenerative diseases like Alzheimer's and Parkinson's, University of Michigan engineering researchers have demonstrated a technique for precisely measuring the properties of individual protein molecules floating in a liquid.
January 17, 2017
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23andMe is finally allowed to tell you if you have the genes for Parkinson's
The Food and Drug Administration finally gave 23andMe a long sought-after green light today to sell to consumers genetic tests and their accompanying health risk reports for up to 10 diseases, including late-onset Alzheimer's and Parkinson's.
April 6, 2017
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23andMe wins FDA approval to give customers health risk info
The gene testing company can now tell US customers who use its home DNA kit whether they have a genetic risk for any of 10 diseases and conditions.
April 6, 2017
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Misc. - A

A Healthy Diet May Help Ward Off Dementia
New studies suggest that, yes, eating right could boost your brain function
July 17, 2017
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A Healthy Middle-Aged Heart May Protect your Brain
Dementia expert says take up heart-healthy habits sooner rather than later
April 11, 2017
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A new view of twisted proteins could help scientists understand Alzheimer's
A critical molecule in the neurodegenerative disease has finally been mapped.
July 14, 2017
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A star is born: Lesser-known brain cell takes center stage
A new method efficiently grows human astrocytes in a dish, advancing studies of stroke, Alzheimer's and depression.
June 6, 2017
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Action-consequence feature of unitization strategy improves memory in older adults, study shows
The next time you hear about the possibility of rain on the weather forecast, try imagining the umbrella tip being lodged in your home's door lock, blocking you from locking it. This mental exercise could prevent you from leaving home without an umbrella.
August 11, 2017
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ActuRx and Insillico Medicine collaborate to prevent, treat age-related illnesses
Can big data and financial engineering cure Cancer, Alzheimer's, and other age-related illnesses? ActuRx and Insillico Medicine think so. Both companies have developed complementary techniques to filter potential solutions against aging illnesses and now they think they can convert financial masses into health improvements worldwide.
July 4, 2017
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ADDF awards $2.1 million grant for clinical study of cancer drug in Alzheimer's patients
The Alzheimer's Drug Discovery Foundation (ADDF) announces a $2.1 million grant awarded to R. Scott Turner, MD, PhD, of Georgetown University Medical Center to conduct a phase II clinical trial of low-dose nilotinib (marketed as Tasigna® for use as a cancer therapy) in patients with Alzheimer's disease.
September 29, 2016
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Advances made in Alzheimer's research
A major advance has been made in Alzheimer's research, say researchers. they showed how a diseased vertebrate brain can naturally react to Alzheimer's pathology by forming more neurons. Two proteins (Interleukin-4 and STAT6) have been identified to be relevant for this process.
October 20, 2016
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African plant extract could pave way for new drug to treat Alzheimer's disease
A plant extract used for centuries in traditional medicine in Nigeria could form the basis of a new drug to treat Alzheimer's disease, researchers at The University of Nottingham have found.
June 19, 2017
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After natural disasters, elderly survivors show cognitive decline
Loss of home, resulting depression, less contact with neighbors tied to dementia.
October 30, 2016
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Air pollution may lead to dementia in older women
Tiny, dirty airborne particles called PM2.5 invade the brain and wreak havoc, study suggests
January 31, 2017
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Alzheimer's Association
Our vision is a world without Alzheimer's disease
Provides Information
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Alzheimer's advance: Early stage study in mice show new drugs restore memory loss and prolong life
Breakthrough findings demonstrate a possible target and potential drug treatment to restore memory loss and extend life span in mice with neurodegeneration.
December 19, 2016
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Alzheimer's could be diagnosed early with sniff tests
Testing the sense of smell of people at a high risk of Alzheimer's disease might help to provide an early diagnosis, a new study suggests.
August 17, 2017
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Alzheimer's Deaths Jump 55 Percent: CDC
More patients also dying at home, with the caregiving burden falling on loved ones
May 25, 2017
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Alzheimer's Death Toll Nearly Doubles in 15 Years
Price tag hits $259 billion a year, projected to exceed $1 trillion by 2050, report finds
March 7, 2017
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Alzheimer's disease likely not caused by low body mass index
Research clarifies past studies on weight, common cause of dementia
May 9, 2017
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Alzheimer's disease linked to the metabolism of unsaturated fats
A new study has found that the metabolism of omega-3 and omega-6 unsaturated fatty acids in the brain are associated with the progression of Alzheimer's disease.
March 22, 2017
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Alzheimer's disease progression predicted by gene mutation
Research, published today in the journal Neurology, describes how mutations in a specific gene that codes for a neural growth factor appear to predict how quickly memory loss will progress in people with Alzheimer's disease.
May 4, 2017
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Alzheimer's disease proteins could be at fault for leading cause of vision loss among older people
Research provides new insight into possible causes of Age-related Macular Degeneration (AMD), a leading cause of vision loss among people aged 50 and older.
November 21, 2016
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Alzheimer's disease study links brain health, physical activity
People at risk for Alzheimer's disease who do more moderate-intensity physical activity, but not light-intensity physical activity, are more likely to have healthy patterns of glucose metabolism in their brain, according to a new study.
June 22, 2017
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Alzheimer's disease: Family history may explain puzzling link to metabolic gene
For years, scientists have contemplated the link between the risk of developing Alzheimer's disease and a metabolic gene called TOMM40, which affects the function of mitochondria, the components inside cells that provide them with energy. Studies have produced mixed results, giving rise to much frustration. However, a new study now finds that a third factor, family history of Alzheimer's, may be the missing link.
May 23, 2017
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Alzheimer's disease: on the hunt for the biomarker signal for early detection
Around 100,000 Austrians suffer from Alzheimer's disease and 16,000 from Parkinson's. Experts estimate that, in view of the ageing population, these numbers are set to triple over the next 30 years. Both Alzheimer's and Parkinson's diseases are progressive degenerative diseases of the brain, which start up to 30 years before the onset of symptoms. Early diagnosis would be a huge help in combating the disease. However, the early detection tests that are available do not provide any reliable prediction about the further course of the disease and also carry the risk of producing a false positive result.
March 27, 2017
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Alzheimer's disease: Targeting enzyme may reverse memory loss
A new study has suggested that it may be possible to reverse the memory loss that occurs in Alzheimer's disease with drugs that selectively block the ability of the HDAC2 enzyme to interfere with the communication between brain cells.
August 9, 2017
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Alzheimer's linked to unsaturated fatty acids in the brain
While it is not yet clear what causes Alzheimer's disease, researchers are examining a variety of genetic, environmental, and lifestyle causes. new research examines some of the key brain regions involved in the development of Alzheimer's and finds several fatty acids to be associated with this form of dementia.
March 22, 2017
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Alzheimer's may be linked to defective brain cells spreading disease
Study finds toxic proteins doing harm to neighboring neurons
February 10, 2017
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Alzheimer's Protein Plaques May Also Harm Heart
Deposits can cause patients' heart muscle to stiffen, keeping it from pumping properly, study suggests
November 28, 2016
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Alzheimer's: Low serotonin levels may drive development
Could Alzheimer's disease be caused by low levels of serotonin, the brain chemical known to affect mood and sleep? New research investigates.
August 15, 2017
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Alzheimer's: Nicotinic receptors as a new therapeutic target
Studies have indicated that nicotine may be beneficial for memory function. Scientists are set out to shed further light on the properties attributed to nicotine by determining the precise structure of the nicotinic receptors in the hippocampus region of the brain. Using mouse models for Alzheimer's disease, they identified the a subunit of the nicotinic receptor as a target that, if blocked, prevents the memory loss associated with Alzheimer's.
August 29, 2016
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Among antidementia drugs, memantine is associated with the highest risk of pneumonia
Among users of antidementia drugs, persons using memantine have the highest risk of pneumonia, new research shows. the use of rivastigmine patches is associated with an increased risk as well, say researchers.
November 21, 2016
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Anti-seizure drug could have beneficial effect in patients with mild Alzheimer's disease
In the last decade, mounting evidence has linked seizure-like activity in the brain to some of the cognitive decline seen in patients with Alzheimer's disease. Patients with Alzheimer's disease have an increased risk of epilepsy and nearly half may experience subclinical epileptic activity -- disrupted electrical activity in the brain that doesn't result in a seizure but which can be measured by electroencephalogram (EEG) or other brain scan technology.
June 23, 2017
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Anti-epilepsy drug restores normal brain activity in mild Alzheimer's disease
Feasibility study suggests suppressing seizure-like activity may help patients
June 23, 2017
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Antibiotic restores cell communication in brain areas damaged by Alzheimer's-like disease in mice
New research has found a way to partially restore brain cell communication around areas damaged by plaques associated with Alzheimer's disease.
November 15, 2016
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Antidepressant use increases hip fracture risk among elderly
Antidepressant use nearly doubles the risk of hip fracture among community-dwelling persons with Alzheimer's disease, according to a new study. the increased risk was highest at the beginning of antidepressant use and remained elevated even 4 years later.
January 11, 2017
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Antidepressant use increases risk of head injuries among persons with Alzheimer's disease
Antidepressant use is associated with an increased risk of head injuries and traumatic brain injuries among persons with Alzheimer's disease, according to a new study. Antidepressant use has previously been linked with an increased risk of falls and hip fractures, but the risk of head injuries has not been studied before.
August 9, 2017
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Antidepressant use linked to higher risk of head injuries among persons with Alzheimer's disease
Antidepressant use is associated with an increased risk of head injuries and traumatic brain injuries among persons with Alzheimer's disease, according to a new study from the University of Eastern Finland. Antidepressant use has previously been linked with an increased risk of falls and hip fractures, but the risk of head injuries has not been studied before.
August 9, 2017
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Antipsychotic drug use linked to 60% increased risk of mortality among people with Alzheimer's disease
Antipsychotic drug use is associated with a 60 percent increased risk of mortality among persons with Alzheimer's disease, shows a recent study from the University of Eastern Finland. the risk was highest at the beginning of drug use and remained increased in long-term use. Use of two or more antipsychotic drugs concomitantly was associated with almost two times higher risk of mortality than monotherapy.
December 14, 2016
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Antipsychotic medications linked to increased risk of pneumonia in persons with Alzheimer's disease
Antipsychotic medications are associated with an increased risk of pneumonia in persons with Alzheimer's disease, according to new research. the risk of pneumonia was the highest at the beginning of antipsychotic treatment, remaining elevated also in long-term use. No major differences were observed between the most commonly used antipsychotics.
August 30, 2016
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Antipsychotic use linked to higher pneumonia risk in patients with Alzheimer's disease
Antipsychotic medications are associated with an increased risk of pneumonia in persons with Alzheimer's disease (AD), according to new research from the University of Eastern Finland. the risk of pneumonia was the highest at the beginning of antipsychotic treatment, remaining elevated also in long-term use. No major differences were observed between the most commonly used antipsychotics.
August 30, 2016
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Antiulcer drugs do not increase risk of Alzheimer's disease
The use of proton pump inhibitors does not increase the risk of Alzheimer's disease, according to a recent study. Proton pump inhibitors are a type of antiulcer drug that is commonly used among older people.
August 7, 2017
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Autoimmune conditions and dementia: What's the link?
A recent large-scale study concludes that individuals with autoimmune conditions may have an increased risk of developing dementia later in life. Although the effect size is relatively small, if the findings are replicated, they will have important clinical implications.
March 2, 2017
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Misc. - B

Bad sleep increases Alzheimer's-related brain proteins
Researchers from the United States and the Netherlands have shown that bouts of bad sleep can significantly increase the amount of tau and amyloid beta in the brain, which are linked to a higher risk of Alzheimer's disease.
July 11, 2017
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Benefits of cognitive training in dementia patients unclear
Positive effects of cognitive training in healthy elderly people have been reported, but data regarding its effects in patients with dementia is unclear, say investigators.
February 22, 2017
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Benzodiazepines, related drugs increase stroke risk among persons with Alzheimer's disease
The use of benzodiazepines and benzodiazepine-like drugs was associated with a 20 per cent increased risk of stroke among persons with Alzheimer's disease, shows a recent study. Benzodiazepines were associated with a similar risk of stroke as benzodiazepine-like drugs.
January 16, 2017
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Big trash pickup for cells
Cells are garbage pickers, carefully selecting the trash they want to keep or discard
August 1, 2016
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Blood screening tests could predict Alzheimer's disease
Researchers from Missouri reveal that blood test screening may identify markers of Alzheimer's disease before individuals begin to experience memory loss and confusion. This finding is a significant step toward predicting disease risk.
July 19, 2017
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BMI status of older adults influences benefits accrued from memory training, study finds
In the first study to compare the results of cognitive training by body mass index (BMI) category, scientists from the Indiana University Center for Aging Research found that memory training provided only one-third the benefit to older adults with obesity than the benefit it provided to older adults without obesity.
January 10, 2017
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Bone density could be one of early indicators of brain degeneration in Alzheimer's disease
Researchers at NEOMED have just identified a major connection between areas of the brainstem - the ancient area that controls mood, sleep and metabolism - and detrimental changes to bone in a preclinical model of Alzheimer's disease.
December 1, 2016
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'Boot Camp' helps Alzheimer's, dementia caregivers take care of themselves, too
Gary Carmona thought he could do it all. He's run companies and chaired nonprofit boards. But since his wife was diagnosed with dementia, Carmona, 77, has felt overwhelmed.
May 9, 2017
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'Brain training' app found to improve memory in people with mild cognitive impairment
A 'brain training' game could help improve the memory of patients in the very earliest stages of dementia, suggests a new study.
July 3, 2017
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Brain activity higher in women than men, study finds
Some brain disorders are much more common in women than men, but why? A new study may help to shed light on this sex difference, after finding that many brain regions are much more active in women.
August 8, 2017
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Brain training can help in fight against dementia, meta-analysis shows
Engaging in computer-based brain training can improve memory and mood in older adults with mild cognitive impairment, say researchers, but training is no longer effective once a dementia diagnosis has been made, they add.
November 14, 2016
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Brain waves show promise against Alzheimer's protein in mice
Flickering light induces nerve cells to trigger immune response to amyloid-beta
December 6, 2016
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Brain's immune cells linked to Alzheimer's, Parkinson's, schizophrenia
Scientists conducted a vast microglia survey, revealing links to neurodegenerative diseases and psychiatric illnesses.
May 31, 2017
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Brain's power to adapt offers short-term gains, long-term strains
Like air-traffic controllers scrambling to reconnect flights when a major hub goes down, the brain has a remarkable ability to rewire itself after suffering an injury. However, maintaining these new connections between brain regions can strain the brain's resources, which can lead to serious problems later, including Alzheimer's Disease, according to researchers.
April 24, 2017
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Brain-aging gene discovered
Genetic variant accelerates normal brain aging in older people by up to 12 years
March 15, 2017
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Brain-training games 'do not boost cognition'
The past decade has seen a rise in popularity of brain-training games that claim to improve a range of mental skills. However, a recent study that measured brain activity, decision-making, and cognitive ability found that playing commercial brain games offered no benefits above those of playing online video games.
July 12, 2017
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BUSM researchers participate in five-year program to develop biomarkers for small vessel disease
To better predict, study and diagnose small vessel disease in the brain and its role in vascular contributions to cognitive impairment and dementia (VCID), Boston University School of Medicine (BUSM) has been selected to participate in MarkVCID, a consortium designed to accelerate the development of new and existing biomarkers for small vessel VCID.
March 2, 2017
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Misc. - C

Caffeine boosts enzyme that could protect against dementia
New analysis reveals 24 compounds that can help reduce impact of harmful proteins in the brain
March 7, 2017
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Caffeine may be able to block inflammation, new research says
This could help explain why caffeine is correlated with health benefits
January 16, 2017
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Caffeine may ward off dementia by boosting protective enzyme
A new study suggests that there may be more uses for caffeine than simply providing a morning fix. It has the potential to protect against dementia and other neurodegenerative disorders.
March 8, 2017
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Can Air Pollution Heighten Alzheimer's Risk?
Fine particles from power plants and cars may be to blame for about 20 percent of cases, study suggests
February 1, 2017
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Can paint strokes help identify Alzheimer's?
A new study shows that it may be possible to detect neurodegenerative disorders in artists before they are diagnosed.
December 29, 2016
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Chemical that detects plaques in Alzheimer's brains extends lifespan of roundworms
Researchers say compound may prevent damaged proteins from accumulating
March 9, 2017
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Children of patients with C9orf72 mutations are at a greater risk of frontotemporal dementia or ALS at a younger age
The most common genetic cause of the brain diseases frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is a mutation in the C9orf72 gene. Researchers have demonstrated that if an affected parent passes on this mutation, the children will be affected at a younger age (than the parent). There are no indications that the disease progresses more quickly.
February 14, 2017
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Cholesterol-fighting drugs lower risk of Alzheimer's disease
Study of Medicare beneficiaries indicates statins could be an early preventive measure against Alzheimer's
December 13, 2016
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Combating iron in the brain: Researchers find anti-aging micromolecule
The older we get, the more our brain ages. Cognitive abilities decline and the risk of developing neurodegenerative diseases like dementia, Alzheimer's and Parkinson's disease or having a stroke steadily increases. a possible cause is the accumulation of iron molecules within neurons, which seems to be valid for all vertebrates. In a collaborative research project, scientists found that this iron accumulation is linked to a microRNA called miR-29.
February 14, 2017
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Combustion-derived nanoparticles in brain cells concern for Alzheimer's disease development
A new study by researchers at the University of Montana, Universidad del Valle de Mexico, Instituto Nacional de Pediatría, Boise State, and Universidad Nacional Autónoma de Mexico, heightens concerns over the detrimental short- and long-term impact of airborne iron-rich strongly magnetic combustion-derived nanoparticles (CDNPs) present in young urbanites' brains.
June 8, 2017
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Common cause of both neurological diseases such as dementia and motor neuron diseases
Currently, most scientists do not see a link between ALS and Alzheimer's disease, frontotemporal dementia (FTD), or other dementias. new research confirms the relevance of a certain neurotoxic pathway. the article also confirms TDP-43 inhibition as a viable therapeutic option for the treatment of neurologic disorders, including Alzheimer disease.
January 23, 2017
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Common genetic variant may age the brain
Researchers have identified a common genetic variant that disrupts normal brain aging and may increase susceptibility to Alzheimer's disease and other neurodegenerative conditions.
March 15, 2017
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Common sedatives linked to increased risk of pneumonia in people with Alzheimer's disease
Commonly used sedatives called benzodiazepines are associated with an increased risk of pneumonia when used in people with Alzheimer's disease, according to a study.
April 10, 2017
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Common sedatives raise pneumonia risk in Alzheimer's patients
New research suggests that a sedative commonly prescribed to Alzheimer's patients may significantly increase their risk of developing pneumonia.
April 10, 2017
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Computer game may improve symptoms of mild cognitive impairment
Scientists have designed a brain training app that might boost episodic memory in people living with amnestic mild cognitive impairment - a potential precursor to dementia.
July 3, 2017
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Computer-designed antibodies target toxins associated with Alzheimer's disease
The researchers used computer-based methods to develop antibodies -- the star players of the body's natural defence system -- to target the deposits of misfolded proteins which are a hallmark of Alzheimer's disease. Early tests of the antibodies in test tubes and in nematode worms showed an almost complete elimination of these pathogens.
June 23, 2017
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Concern over high US prescribing levels of common drug linked to dementia
A new analysis raises concern over high prescription rates in the USA of a common drug used to treat overactive bladder. the drug, oxybutynin, when taken orally, is consistently linked with cognitive impairment and dementia in the elderly. the analysis shows that oxybutynin, is prescribed in more than a quarter of cases of overactive bladder (27.3%), even though other more suitable drugs are available.
March 27, 2017
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Concern that radiation may contribute to development of Alzheimer's
More humans than ever are exposed to higher levels of ionizing radiation from medical equipment, airplanes, etc. a new study suggests that this kind of radiation may be a confounding factor in the neurodegenerative disease Alzheimer's.
October 27, 2016
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Cognitive tests can detect early Alzheimer's in people without symptoms, study suggests
Long before symptoms of Alzheimer's disease become apparent to patients and their families, biological changes are occurring within the brain. Amyloid plaques, which are clusters of protein fragments, along with tangles of protein known as tau, form in the brain and grow in number, eventually getting in the way of the brain's ability to function.
May 31, 2017
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Contrary to decades of hype, curcumin alone is unlikely to boost health
Curcumin, a compound in turmeric, continues to be hailed as a natural treatment for a wide range of health conditions, including cancer and Alzheimer's disease. But a new review of the scientific literature on curcumin has found it's probably not all it's ground up to be. the report instead cites evidence that, contrary to numerous reports, the compound has limited -- if any -- therapeutic benefit.
January 11, 2017
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Couch potatoes face same chance of dementia as those with genetic risk factors: Research
Sedentary older adults with no genetic risk factors for dementia may be just as likely to develop the disease as those who are genetically predisposed, according to a major study which followed more than 1,600 Canadians over five years.
January 10, 2017
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Could a Chemical Found In Marijuana be a Treatment for Alzheimer'S Disease?
Researchers Have Discovered the Benefits of THC In the Brain
October 4, 2016
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Could an epilepsy drug help to slow Alzheimer's?
A drug currently used for the treatment of epilepsy may help to slow the progression of Alzheimer's disease, suggest the results of a new study.
June 26, 2017
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Could Loneliness be an Early Sign of Alzheimer's?
People with 'biomarkers' for the brain disease were more likely to feel socially detached, study finds
November 2, 2016
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Could olfactory loss point to Alzheimer's disease?
Odor identification tests may help scientists track the evolution of the disease in persons at risk
August 16, 2017
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Could Statins Cut Alzheimer's Risk? It Depends
Type of statin used also made a difference in study, but black men did not see any benefits
December 12, 2016
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Critical protein shows promise for the treatment of Alzheimer's
In new research, researchers examine p62 -- a critical protein associated with tell-tale symptoms of Alzheimer's. the study demonstrates for the first time that p62 may have a role in reversing the effects of damaged plaques in the brain.
August 30, 2016
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Misc. - D

Deep brain stimulation studies in Alzheimer's disease pose ethical challenges
Researchers propose guidelines to better protect patients in DBS clinical trials
January 24, 2017
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Defective brain cells disposing toxic proteins may be linked to neurodegenerative diseases
Rutgers scientists say neurodegenerative diseases like Alzheimer's and Parkinson's may be linked to defective brain cells disposing toxic proteins that make neighboring cells sick.
February 10, 2017
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Delayed anticoagulation treatment for atrial fibrillation patients increases dementia risk, study finds
A new study has found that dementia rates increase when anticoagulation treatment is delayed for patients with atrial fibrillation, the most common heart arrhythmia in the world that affects more than 2.7 million American adults.
May 12, 2017
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Delaying blood thinning treatment may raise dementia risk
Atrial fibrillation is a common form of heart abnormality, and patients who have it are often prescribed anticoagulants, or blood thinners. new research suggests that dementia rates increase in patients with atrial fibrillation whose anticoagulation treatment is delayed.
May 12, 2017
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Dementia not prevented with vitamin E, selenium, study finds
An ample body of research has shown that oxidative stress plays a key role in the development of neurodegenerative disorders such as Alzheimer's and Parkinson's disease. as a result, antioxidant supplements have been proposed as preventive measures against dementia. a new trial, however, tests the effect of vitamin E and selenium on aging men and finds no evidence that they have therapeutic value.
March 19, 2017
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Dementia on the downslide, especially among people with more education, study finds
In a hopeful sign for the health of the nation's brains, the percentage of American seniors with dementia is dropping, a new study finds. the downward trend has emerged despite something else the study shows: a rising tide of three factors that are thought to raise dementia risk by interfering with brain blood flow, namely diabetes, high blood pressure and obesity.
November 21, 2016
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Dementia-related brain changes observed before memory or thinking problems are noticeable
Scientists discover a potential predictor for early dementia that could inform the development of drug and therapeutic interventions to treat or slow down the disease.
May 12, 2017
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Dementia: BACE inhibitor improves brain function
BACE inhibitor successfully tested in Alzheimer's animal model
July 28, 2017
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Dementia: the right to rehabilitation
Rehabilitation is important for people with dementia as it is for people with physical disabilities, according to a leading dementia expert.
March 28, 2017
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Designer compound may untangle damage leading to some dementias
NIH-funded preclinical study suggests a possible treatment for Alzheimer™ disease and other neurodegenerative disorders.
February 8, 2017
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Designer compound may untangle damage leading to some dementias
Preclinical study suggests a possible treatment for Alzheimer's disease and other neurodegenerative disorders
February 8, 2017
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Despite Alzheimer's plaques, some seniors remain mentally sharp
Proteins linked to dementia don't diminish memory in some brains
November 16, 2016
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Developing a sensor for vitamin B12 deficiency
A world-first optical sensor has been developed that can detect vitamin B12 in diluted human blood -- a first step towards a low-cost, portable, broadscale vitamin B12 deficiency test. Vitamin B12 deficiency is associated with an increased risk of dementia and Alzheimer's disease.
October 17, 2016
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Diet rich in saturated fat reduces person's cognitive function making it difficult to control eating habits
A diet high in saturated fat can make your brain struggle to control what you eat, says a new study in Frontiers in Cellular Neuroscience.
July 29, 2016
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Discovery opens door to new Alzheimer's treatments
Researchers have discovered the role of a key protein in the development of Alzheimer's disease, outlines a new report.
November 17, 2016
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Discriminating remembrance may be marker for early stages of memory loss in older adults
People who selectively recalled positive information over neutral and negative information performed worse on memory tests conducted by University of California, Irvine neurobiologists, who said the results suggest that this discriminating remembrance may be a marker for early stages of memory loss in the elderly.
July 20, 2016
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Disrupted fat breakdown in the brain makes mice dumb
A new study opens a new perspective with regard to the development of dementia. The scientists blocked the breakdown of a certain fat molecule in the mouse brain. As a result the animals exhibited learning and memory problems. Also the quantity of Alzheimer-specific proteins in their brains increased significantly. The researchers now have a clue as to why the mice become dumb.
May 19, 2017
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Disrupting protein interaction may slow Alzheimer's progression
Inhibiting an interaction between two specific proteins may be a new way to target dementia. a recent study using a fruit fly model could help to design a way of slowing the progression of Alzheimer's and other neurodegenerative diseases.
March 3, 2017
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DNA vaccine protects against toxic proteins linked to Alzheimer's
A new DNA vaccine, when delivered to the skin, prompts an immune response that produces antibodies to protect against toxic proteins associated with Alzheimer's disease -- without triggering severe brain swelling that earlier antibody treatments caused in some patients.
May 23, 2017
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Dozens of Patients Are Suing a Clinic that Gave Them Fake Alzheimer's Diagnoses
Imagine that a doctor told you that your brain was slowly starting to self-destruct, that soon your once-healthy neurons would stop functioning, that you would lose all connection with reality, with the things and people that you loved. Then imagine that you found out that not only did that doctor make it all up, but he wasn't even actually a doctor. you would be pretty pissed, right?
February 9, 2017
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Dozens of Potential Alzheimer's Meds in the Pipeline
Last new drug for the memory-robbing disease was introduced in the United States in 2003
July 18, 2017
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Drinking tea could help stave off cognitive decline
Thanks to its high levels of antioxidants, tea has been linked to a lower risk of diabetes, heart disease, and cancer. However, its potential health benefits may not end there. Researchers have found that regular tea consumption could more than halve the risk of cognitive decline for older adults, particularly for those with a genetic risk of Alzheimer's disease.
March 28, 2017
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Drug candidate stabilizes essential transport mechanism in nerve cells
NAP blocks formation of 'tangles' that contribute to Alzheimer's disease
January 31, 2017
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Drug compound halts Alzheimer's-related damage in mice
Appears to reverse some neurological harm
January 25, 2017
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Drugs already in medicine cabinets may fight dementia, early data suggests
In mouse and cell studies, drugs shut down damaging stress response, protected brain.
April 25, 2017
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Dysfunctional microglia cells contribute to loss of synapses in Alzheimer's disease
Similar to other neurodegenerative disorders, Alzheimer's is a disease in which the cognitive abilities of afflicted persons continuously worsen. The reason is the increasing loss of synapses, the contact points of the neurons, in the brain. In the case of Alzheimer's, certain protein fragments, the β-amyloid peptides, are suspected of causing the death of neurons. These protein fragments clump together and form the disease's characteristic plaques.
June 30, 2017
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Misc. - E

E-Scape Bio announces extension of funding to develop novel drug for Alzheimer's disease
E-Scape Bio announced an extension of its Series A funding to a total of $63 million. Created as a spin-off from research conducted at the Gladstone Institutes, E-Scape Bio is a biopharmaceutical company with a mission to develop new therapies to treat neurodegenerative disorders such as Alzheimer's disease.
July 12, 2017
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Early life physical activity may prevent cognitive decline
Could early life physical exercise protect against age-related cognitive decline by creating a so-called cognitive reserve? A study in rodents investigates.
August 15, 2017
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Early signs of Alzheimer's detected in cerebrospinal fluid
Immune cells of the brain become active years before the disease becomes apparent
December 14, 2016
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Electrical brain stimulation found to improve working memory
Scientists may have found a way to improve brain connectivity. the findings may boost short-term working memory, and in the future, they may help to repair brain damage in patients with traumatic brain injury, stroke, or epilepsy.
March 15, 2017
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Emory scientists show how same enzyme spurs Alzheimer's and Parkinson's disease
Alzheimer's disease and Parkinson's disease are not the same. They affect different regions of the brain and have distinct genetic and environmental risk factors.
July 4, 2017
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Evidence of Alzheimer's in patients with Lewy body disease tracks with course of dementia
Patients who had a diagnosis of Parkinson's disease with dementia or dementia with Lewy bodies and had higher levels of Alzheimer's disease pathology in their donated post-mortem brains also had more severe symptoms of these Lewy body diseases during their lives, compared to those whose brains had less AD pathology.
January 5, 2017
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Evidence of brain damage found in former soccer players
Evidence of chronic traumatic encephalopathy (CTE), a potential cause of dementia caused by repeated blows to the head, has been found in the brains of former association football (soccer) players.
February 15, 2017
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Exercise may benefit elderly people with memory and thinking problems
The research involved people with vascular cognitive impairment, which is the second most common cause of dementia after Alzheimer's disease. In vascular cognitive impairment, problems with memory and thinking skills result from damage to large and small blood vessels in the brain.
October 19, 2016
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Exercise May Help People with Memory Loss
But effects only lasted as long as activity continued, study found
October 19, 2016
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Expert provides insights into risks of dementia and Alzheimer's disease
While often used interchangeably, dementia and Alzheimer's disease are not the same. Dementia is a general term for a decline in mental ability severe enough to interfere with daily life. Alzheimer's disease is a specific type of dementia that causes memory loss and impairment of other important mental functions. An expert from the Texas Aamp;&M School of Public Health describes how these conditions can impact the lives of both patients and those around them, and provides insights into ways of minimizing risks.
July 4, 2017
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Experts explore ways to improve safety of care for nursing home residents with dementia
By 2050, the number of people 65 and older with dementia in the United States is expected to nearly triple -- from 5 million to more than 13 million -- increasing the numbers in assisted living and nursing homes.
August 16, 2017
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Extra-virgin olive oil preserves memory, protects brain against Alzheimer's
The Mediterranean diet is associated with a variety of health benefits, including a lower incidence of dementia. Now, researchers have identified a specific ingredient that protects against cognitive decline: extra-virgin olive oil. In a new study, the researchers show that consumption of extra-virgin olive oil protects memory and learning ability and reduces the formation of amyloid-beta plaques and neurofibrillary tangles in the brain -- classic markers of Alzheimer's disease.
June 21, 2017
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Extra-virgin olive oil may prevent Alzheimer's
New research suggests that extra-virgin olive oil - a key component of the Mediterranean diet - may protect the brain from Alzheimer's disease symptoms. Mouse experiments revealed changes in both cognitive performance and the appearance of nerve cells.
June 21, 2017
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Misc. - F

Feinstein researcher awarded NIH grant to better understand genetic causes of Alzheimer's disease
Feinstein Institute for Medical Research Assistant Professor Yun Freudenberg-Hua, MD, has been awarded a five-year, $600,000 grant from the National Institutes of Health's (NIH) National Institute on Aging to identify genetic risk factors for Alzheimer's disease. A better understanding of the genetic causes of the disease will help develop possible treatments for the estimated 5.5 million Americans currently suffering from the condition along with intervention programs for those at risk.
August 11, 2017
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Fewer Americans Suffering from Dementia
Rates have dropped over last decade, and better education might be one reason why
November 21, 2016
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First Alzheimer's Patient Treated with Focused Ultrasound to Open Blood-Brain Barrier
The blood-brain barrier prevents almost all potentially therapeutic drugs from passing into the brain. this has been a major roadblock for clinical neurology, but we may have a solution, perhaps a partial one, in the form of focused ultrasound. the first Alzheimer's patient has just been treated using ultrasound to open up the blood-brain barrier in his brain. Though no drugs have been administered, the researchers are evaluating the safety and effectiveness of the technique on such patients. Previously, only chemo agents have been delivered into the brain by opening the blood-brain barrier using ultrasound, but if this study goes well the next step will involve drug delivery.
May 5, 2017
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Five of the best Alzheimer's blogs
Alzheimer's disease is the most common form of dementia and affects more than 5 million people in the United States. After a diagnosis, many people with Alzheimer's and their families turn to the Internet for information on what to expect in the upcoming years. we have searched the web for the most helpful blogs for people affected by Alzheimer's.
April 5, 2017
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Flies the key to studying the causes of dementia
Discovery relating to brain proteins could lead to new effective therapies for dementia and other neurodegenerative diseases
May 19, 2017
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For white middle class, moderate drinking is linked to cognitive health in old age
Older adults who consume alcohol moderately on a regular basis are more likely to live to the age of 85 without dementia or other cognitive impairments than non-drinkers, according to a new study.
August 1, 2017
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Former Teen Heartthrob David Cassidy Has Dementia
David Cassidy, a teen heartthrob from the 1970s, said Monday that he is battling dementia.
February 21, 2017
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From champagne bubbles, dance parties and disease to new nanomaterials
Whether it is clouds or champagne bubbles forming, or the early onset of Alzheimer's disease or Type 2 diabetes, a common mechanism is at work: nucleation processes.
November 22, 2016
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Misc. - G

Gene variant protecting against Alzheimer's disease decreases plasma beta-amyloid levels
The APP gene variant protecting against Alzheimer's disease significantly decreases plasma beta-amyloid levels in a population cohort. This is a very significant discovery, as many on-going drug trials in the field of Alzheimer's disease focus on decreasing beta-amyloid levels in the brain tissue.
June 19, 2017
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Glucose deprivation in the brain triggers onset of cognitive decline, research shows
One of the earliest signs of Alzheimer's disease is a decline in glucose levels in the brain. It appears in the early stages of mild cognitive impairment -- before symptoms of memory problems begin to surface. Whether it is a cause or consequence of neurological dysfunction has been unclear, but new research at the Lewis Katz School of Medicine at Temple University now shows unequivocally that glucose deprivation in the brain triggers the onset of cognitive decline, memory impairment in particular.
January 31, 2017
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Google creates a new virtual reality experience: "A Walk Through Dementia"
The experiences of others can be difficult to understand -- do you see green in the same way as me? But things are even harder -- and more important -- to grasp in the world of medicine. Just what is it like to have dementia, for example? it's much more than just memory loss and confusion.
September 30, 2016
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Gram-negative bacteria may influence Alzheimer's disease pathology
For the first time, researchers have found higher levels of Gram-negative bacteria antigens in brain samples from late-onset Alzheimer's disease patients. Compared to controls, patients with Alzheimer's had much higher levels of lipopolysaccharide (LPS) and E coli K99 pili protein.
November 30, 2016
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Gut bacteria can accelerate development of Alzheimer's disease, research shows
New research from Lund University in Sweden has shown that intestinal bacteria can accelerate the development of Alzheimer's disease. According to the researchers behind the study, the results open up the door to new opportunities for preventing and treating the disease.
February 10, 2017
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Gut bacteria may play a role in Alzheimer's disease
New research has shown that intestinal bacteria can accelerate the development of Alzheimer's disease. According to the researchers behind the study, the results open up the door to new opportunities for preventing and treating the disease.
February 10, 2017
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Misc. - H

'Heart Harm' In Middle Age Can Lead To Dementia
Of greatest importance are diabetes, blood pressure and smoking, researchers say
August 7, 2017
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Heart-healthy middle age tied to lower risk of dementia
The chance of developing dementia is tied to a number of factors, including some that can also influence cardiovascular health, such as diabetes, high blood pressure, and smoking. A new study shows that having these risk factors in middle age might increase the likelihood of having dementia later in life.
August 7, 2017
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Heartburn Meds Don't Raise Alzheimer's Risk: Study
New research debunks other studies suggesting that medications used to treat ulcers, reflux cause mental decline
June 28, 2017
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High blood pressure in middle age could be potential risk factor for Alzheimer's disease
High blood pressure in middle age can lead to impaired cognition and is a potential risk factor for Alzheimer's disease, according to a statement from the American Heart Association co-authored by Loyola Medicine neurologist Jose Biller, MD.
October 26, 2016
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High Blood Pressure May not be all Bad in Elderly
Developing it after 80 might help prevent mental decline, research suggests
January 17, 2017
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High cholesterol intake and eggs do not increase risk of memory disorders
A relatively high intake of dietary cholesterol, or eating one egg every day, are not associated with an elevated risk of dementia or Alzheimer's disease. Furthermore, no association was found in persons carrying the APOE4 gene variant that affects cholesterol metabolism and increases the risk of memory disorders, report researchers at conclusion of a new study.
January 9, 2017
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High-definition eye scan could reveal crucial warning signs of Alzheimer's disease
Cedars-Sinai neuroscience investigators have found that Alzheimer's disease affects the retina -- the back of the eye -- similarly to the way it affects the brain. The study also revealed that an investigational, noninvasive eye scan could detect the key signs of Alzheimer's disease years before patients experience symptoms.
August 17, 2017
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Higher dementia risk associated with birth in high stroke mortality states
Is being born in states with high stroke mortality associated with dementia risk in a group of individuals who eventually all lived outside those states? A new article suggests it might be.
July 31, 2017
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History of traumatic brain injury not related to cognitive decline, study shows
Although much research has examined traumatic brain injury (TBI) as a possible risk factor for later life dementia from neurodegenerative diseases such as Alzheimer's disease (AD), little is known regarding how TBI influences the rate of age-related cognitive change. A new study now shows that history of TBI (with loss of consciousness) does not appear to affect the rate of cognitive change over time for participants with normal cognition or even those with AD dementia.
July 4, 2017
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Hospital patients with dementia and other causes of confusion 'have worse outcomes'
Hospital patients with dementia and other causes of confusion have longer stays and worse treatment outcomes than people without the condition, new research has found.
August 1, 2017
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How can PTSD trigger Alzheimer's disease? Study sheds light
More and more evidence is suggesting that developing post-traumatic stress disorder early in life can raise the risk of dementia in old age. New research finds a molecular link between the two conditions, which paves the way for new therapies.
August 4, 2017
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How One Drug Could Affect Pain, Memory and Nicotine Addiction
Researchers are working to develop drugs to enhance the function of these receptors in the brain, which could have three very different applications: easing pain, slowing the cognitive decline associated with Alzheimer's and making it easier for people to stop smoking.
May 5, 2017
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How One Town Hopes to Cure Alzheimer's
Judy Culbertson gets lost sometimes. She might be on her way home from the grocery store or some other place she's been dozens of times, when she suddenly finds herself on a street she doesn't recognize.
May 19, 2017
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HRT Won't Lower Women's Alzheimer's Risk
There was some hint that long-term hormone therapy might have a benefit, but results weren't definitive
February 16, 2017
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Human enzyme can reduce neurotoxic amyloids in a mouse model of dementia
A naturally occurring human enzyme -called cyclophilin 40 or CyP40- can unravel protein aggregates that contribute to both Alzheimer's disease and Parkinson's disease, according to a study. The finding may point toward a new therapeutic strategy for these diseases.
June 27, 2017
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Human enzyme may be key to unraveling Alzheimer's disease
Protein aggregates are the hallmark of a number of neurodegenerative diseases. New research, published in the journal PLOS Biology, examines a human enzyme that unravels these disruptive plaques.
June 28, 2017
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Misc. - I

In Alzheimer's, excess tau protein damages brain's GPS
Finding may explain why many Alzheimer's disease patients wander
January 19, 2017
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Incidence of dementia in primary care increased in the Netherlands over 23 years
The incidence of registered dementia cases has increased slightly over a 23-year period (1992 to 2014) in the Netherlands, according to a new study.
March 7, 2017
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Interventions to prevent cognitive decline, dementia
Evidence supporting three interventions that might slow cognitive decline and the onset of dementia is encouraging but insufficient to justify a public health campaign focused on their adoption
June 22, 2017
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Is Need for More Sleep a Sign of Pending Dementia?
Study finds an association but doesn't prove cause and effect
February 22, 2017
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Isolating anti-Alzheimer's compounds in plants
Scientists develop new technique to isolate active therapeutic compounds for Alzheimer's disease from plants
June 19, 2017
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Misc. - J

Johns Hopkins researchers identify protein that triggers brain cell death from strokes and injuries
Despite their different triggers, the same molecular chain of events appears to be responsible for brain cell death from strokes, injuries and even such neurodegenerative diseases as Alzheimer's.
October 7, 2016
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Just one night of poor sleep can boost Alzheimer's proteins
Amyloid-beta levels rose in healthy adults with interrupted slow-wave Zs
July 10, 2017
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Misc. - K

Kale nutrient may yield significant cognitive benefits
Researchers have found that lutein, a nutrient and organic pigment found in kale, spinach, avocados, and eggs, may be effective in rejuvenating cognitive functions.
July 28, 2017
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KU research on physical activity could be key to designing interventions for people with early AD
For older adults, physical activity is apt to shield against cognitive decline and forms of dementia such as Alzheimer's disease (AD). Yet, as people age and some experience cognitive impairment, they tend to become less physically active.
November 9, 2016
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Misc. - L

Large-scale production of living brain cells enables entirely new research
Important pieces of the puzzle to understand what drives diseases such as Alzheimer's and Parkinson's are still missing today. One crucial obstacle for researchers is that it is impossible to examine a living brain cell in someone who is affected by the disease. With the help of a new method for cell conversion, researchers have found a way to produce diseased, aging brain cells on a large scale in a cell culture dish.
June 26, 2017
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Large-scale production of living brain cells enables entirely new research
Important pieces of the puzzle to understand what drives diseases such as Alzheimer's and Parkinson's are still missing today. One crucial obstacle for researchers is that it is impossible to examine a living brain cell in someone who is affected by the disease.
June 26, 2017
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Leading dementia expert calls for greater public awareness of dementia risk factors
National Clinical Director for Dementia calls for risk awareness drive
March 8, 2016
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Leaving 'Stroke Belt' Doesn't Lower Dementia Risk
Study found odds for mental decline still higher for those born in certain southeastern U.S. states
July 31, 2017
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Leisure activities lower blood pressure in Alzheimer's caregivers
Going for a walk outside, reading, listening to music -- these and other enjoyable activities can reduce blood pressure for elderly caregivers of spouses with Alzheimer's disease, suggests a study.
June 23, 2017
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Life-extending protein could treat Alzheimer's and Parkinson's
New research has shown that a naturally occurring protein can improve cognition in mice with Alzheimer's and Parkinson's disease-like characteristics. The findings open up a new therapeutic avenue for treating these neurodegenerative illnesses.
August 8, 2017
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Link between vascular disease and Alzheimer's strengthened
The more risk factors for vascular disease one has in middle age, the higher the risk may be of developing Alzheimer's disease in later life.
April 11, 2017
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Long-term use of opioid patches common among persons with Alzheimer's disease
Approximately seven per cent of persons with Alzheimer's disease use strong pain medicines, opioids, for non-cancer pain for a period longer than six months, according to a recent study. One third of people initiating opioid use became long-term users, and long-term use was heavily associated with transdermal opioid patches.
November 14, 2016
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Loving Kids May Help Lower Seniors' Dementia Risk
But negative relationships with children, spouse increased chances, study finds
May 2, 2017
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Lumosity Brain-Training Didn't Boost Thinking Skills: Study
Young adults who took the program performed no better than those who played video games
July 10, 2017
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Misc. - M

Major step towards Alzheimer's blood test
A research team, led by Cardiff University, has made a significant step towards the development of a simple blood test to predict the onset of Alzheimer's disease.
August 31, 2016
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MAO is a possible Alzheimer's disease biomarker
Alzheimer's disease affects more than 35 million people, a number that is expected to increase in the coming years. Currently, Alzheimer's diagnoses rely on clinical neuropathologic assessment of amyloid-beta peptide aggregates (plaques) and neurofibrillary tangles. But now researchers reveal that an enzyme already implicated in a host of neural disorders could someday serve as a biomarker.
December 6, 2016
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May smartphones help to maintain memory in patients with mild Alzheimer's disease?
Small trial succeeds using Goggle calendar application to maintain prospective memory (the ability to remember to do things in the future) in a patient with mild Alzheimer's disease
March 1, 2017
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Mathematical Analysis of Brush Strokes Spots Artists with Dementia
Artists often develop new creative techniques late in life, often at the same time as they begin suffering from dementia. some scientists suspect that it is the dementia itself that fosters ways of expression that haven't been tried by the artists before. at the University of Liverpool a team of researchers wanted to examine this connection further by performing fractal analysis of paintings of famous artists. Specifically, they were looking for evidence of cognitive decline within the brush strokes of art works completed before and after the onset of artists' dementia.
January 3, 2017
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Memocate offers solutions for interaction problems that arise from memory disorders
A startup based on University of Helsinki research offers solutions for the interaction problems that arise from memory disorders.
July 4, 2017
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Midlife cardiovascular risk factors may increase chances of dementia
Study supports link between cognition and vascular health
August 7, 2017
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Midlife cardiovascular risk factors may increase chances of dementia
NIH funded study supports link between cognition and vascular health.
August 7, 2017
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Mild cognitive impairment, Alzheimer's diagnoses trigger lower self-ratings of quality of life
A patient's awareness of a diagnosis of cognitive impairment may diminish their self-assessment of quality of life, suggests new research.
August 3, 2017
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Moderate drinking correlates with cognitive health, longevity
The results of a new study point to a correlation between regular but moderate drinking in older adults, and a reduced risk of cognitive impairments. This research was based on a cohort study of middle-class adults in the United States.
August 3, 2017
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Molecular link between post-traumatic stress disorder and Alzheimer's disease
There is increasing evidence that post-traumatic stress disorder (PTSD) increases the risk of developing dementia later in life. Researchers now shed light on the molecular mechanism that links the two disorders.
August 2, 2017
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More brain activity is not always better when it comes to memory, attention
Potential new ways of understanding the cause of cognitive impairments, such as problems with memory and attention, in brain disorders including schizophrenia and Alzheimer's are under the spotlight in a new research review.
June 15, 2017
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More human-like model of Alzheimer's better mirrors tangles in the brain
A new animal model using tau tangles isolated from the brains of Alzheimer's patients rather than synthetic tau tangles paints a closer picture of the tau pathology in the AD brain, outlines a new report.
November 16, 2016
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More than half of persons with Alzheimer's disease aged 90 years or more use psychotropic drugs
Psychotropic drug use is rather common among persons aged 90 years of more diagnosed with Alzheimer's disease compared with those who were diagnosed at younger age, concludes a study in Finland. Persons aged 90 years or more used antipsychotics 5 times and antidepressants 2.5 times more often than those without the disease in the same age group.
October 3, 2016
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Mouse model points to potential new treatment for Alzheimer's disease
Treatment with an inhibitor of 12/15-lipoxygenase, an enzyme elevated in patients with Alzheimer's disease (AD), reverses cognitive decline and neuropathology in an AD mouse model, reports a new study. the effects were observed after the AD-like phenotype was already established in the mice, which is promising for its potential therapeutic use, as neuropathology tends to develop many years before the appearance of AD symptoms in patients.
January 5, 2017
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Multi-purpose protein may offer clues for successful treatment of Alzheimer's disease
The tidal wave approaches. In the coming decades, Alzheimer's disease is projected to exact a devastating economic and emotional toll on society, with patient numbers in the US alone expected to reach 13.5 million by mid-century at a projected cost of over a trillion dollars.
August 30, 2016
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Misc. - N

'Nanobottles' offer blueprint for enhanced biological imaging
A pan-European team of researchers involving the University of Oxford has developed a new technique to provide cellular 'blueprints' that could help scientists interpret the results of X-ray fluorescence (XRF) mapping.
October 27, 2016
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NAS report: Promising but inconclusive evidence on interventions to prevent cognitive decline, dementia
Suggests NIH, others carefully cue public about potential benefits of cognitive training, blood pressure management, exercise.
June 22, 2017
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Natural compound found in strawberries may help prevent age-related diseases
Salk scientists have found further evidence that a natural compound in strawberries reduces cognitive deficits and inflammation associated with aging in mice. The work, which appeared in the Journals of Gerontology Series A in June 2017, builds on the team's previous research into the antioxidant fisetin, finding it could help treat age-related mental decline and conditions like Alzheimer's or stroke.
July 11, 2017
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Natural tooth repair method, using Alzheimer's drug, could revolutionize dental treatments
A new method of stimulating the renewal of living stem cells in tooth pulp using an Alzheimer's drug has been discovered by a team of researchers.
January 9, 2017
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Navigation and spatial memory: New brain region identified to be involved
Navigation in mammals including humans and rodents depends on specialized neural networks that encode the animal's location and trajectory in the environment, serving essentially as a GPS, findings that led to the 2014 Nobel Prize in Medicine. Failure of these networks to function properly, as seen in Alzheimer's disease and other neurological conditions, results in severe disorientation and memory deficits.
August 16, 2017
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Never before seen images of early stage Alzheimer's disease
Researchers have used the MAX IV synchrotron in Lund -- the strongest of its kind in the world - to produce images that predate the formation of toxic clumps of beta-amyloid, the protein believed to be at the root of Alzheimer's disease. the unique images appear to contradict a previously unchallenged consensus. Instead of attempting to eliminate beta-amyloid, or so-called plaques, the researchers now suggest stabilizing the protein.
March 13, 2017
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New algorithms may revolutionize drug discoveries, and our understanding of life
A new set of machine learning algorithms that can generate 3-D structures of tiny protein molecules may revolutionize the development of drug therapies for a range of diseases, from Alzheimer's to cancer.
February 7, 2017
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New analysis shows correlation between testosterone-lowering therapy for prostate cancer and dementia
A new analysis of patients who have undergone treatment for prostate cancer shows a connection between androgen deprivation therapy (ADT) - a testosterone-lowering therapy and a common treatment for the disease - and dementia, according to researchers from the Perelman School of Medicine at the University of Pennsylvania.
March 30, 2017
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New approach to treating Alzheimer's disease
Researchers have introduced a new approach to treat Alzheimer's disease. Alzheimer's disease is the sixth leading cause of death among in older adults. the exact causes of Alzheimer's disease are still unknown, but several factors are presumed to be causative agents.
February 28, 2017
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New clinical study to test promising Diabetes drug in people with MND
Could a Diabetes drug be used for Motor Neurone Disease?
March 10, 2017
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New data mining strategy spots those at high risk of Alzheimer's
Method could group similar Alzheimer's patients for more precise drug trials
July 28, 2017
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New device uses AI algorithm to monitor sleep with radio waves
More than 50 million Americans suffer from sleep disorders, and diseases including Parkinson's and Alzheimer's can also disrupt sleep. Diagnosing and monitoring these conditions usually requires attaching electrodes and a variety of other sensors to patients, which can further disrupt their sleep.
August 7, 2017
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New function discovered for compound that may help slow aging
Researchers have found that a compound called rapamycin has unusual properties that may help address neurologic damage such as Alzheimer's disease, and reduce the cellular senescence associated with aging.
April 5, 2017
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New genetic variants associated with extreme old age
The search for the genetic determinants of extreme longevity has been challenging, with the prevalence of centenarians (people older than 100) just one per 5,000 population in developed nations. But a recently published study that combines four studies of extreme longevity, has identified new rare variants in chromosomes 4 and 7 associated with extreme survival and with reduced risks for cardiovascular and Alzheimer's disease.
April 25, 2017
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New 'GPS' neuron discovered
A new type of neuron that might play a vital role in humans' ability to navigate their environments, report investigators. The discovery is an important step towards understanding how the brain codes navigation behavior at larger scales and could potentially open up new treatment strategies for people with impaired topographical orientation like Alzheimer's patients.
May 29, 2017
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New imaging technique able to watch molecular dynamics of neurodegenerative diseases
Researchers have developed a fast and practical molecular-scale imaging technique that could let scientists view never-before-seen dynamics of biological processes involved in neurodegenerative diseases such as Alzheimer's disease and multiple sclerosis.
July 13, 2017
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New imaging technique in Alzheimer's disease opens up possibilities for new drug development
Tau PET is a new and promising imaging method for Alzheimer's disease. a case study in Sweden now confirms that tau PET images correspond to a higher degree to actual changes in the brain. According to the researchers behind the study, this increases opportunities for developing effective drugs.
September 28, 2016
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New insight into how Alzheimer's disease begins
A new study offers important insight into how Alzheimer's disease begins within the brain. the researchers found a relationship between inflammation, a toxic protein and the onset of the disease. the study also identified a way that doctors can detect early signs of Alzheimer's by looking at the back of patients' eyes.
November 18, 2016
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New laser activated technique sheds light on memory loss conditions
New method uses near infrared light to shed light on memory loss conditions
February 3, 2017
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New molecular discovery may help identify drug therapies to prevent dementia
Scientists pinpoint protein in brain pathway that enhances memory
January 10, 2017
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New partnership uses artificial intelligence methods to develop solutions for preventing early aging
Center for Healthy Aging at the University of Copenhagen today announced a research collaboration with a company specializing in artificial intelligence (AI) to develop solutions for preventing early aging. The aim of this partnership is to develop medicines to prevent and cure a broad range of diseases associated with aging such as Alzheimer's, Parkinson's and cardiovascular diseases.
August 1, 2017
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New report highlights increasing cost of caring for people with Alzheimer's and dementia
The national cost of caring for those with Alzheimer's and dementia is estimated to be $259 billion this year, according to a new report from the Alzheimer's Association.
March 13, 2017
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New study examines potential Alzheimer's disease prevention strategies
Alzheimer's disease (AD) is a type of dementia that causes problems with memory, thinking, and behavior. It affects more than 5 million Americans. The Alzheimer's Association estimates that some 16 million people will develop the disease by the year 2050 if an effective treatment is not discovered. Symptoms of AD usually develop slowly and worsen over time. They often become severe enough to interfere with daily tasks, and can eventually cause death.
August 9, 2017
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New study of fMRI aims to develop efficient real-time method to detect brain activation in AD patients
Researchers at University Hospitals Case Medical Center are beginning a study of functional magnetic resonance imaging (fMRI) to detect how brain activation in patients in early and middle stages of Alzheimer's disease compares to people without it.
July 20, 2016
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New study of Phase II Alzheimer's drug pipeline reveals more ways to combat disease
A new analysis of the Phase II Alzheimer's drug pipeline, conducted by ResearchersAgainstAlzheimer's (RA2), revealed 57 new Alzheimer's drugs. According to the analysis, nearly twice as many mechanisms of action are being tested in Phase II than in Phase III clinical trials.
October 7, 2016
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New study to learn about risk factors for Alzheimer's disease in older Latino adults
Rush University Medical Center has launched a unique, cohort study called Latino Core to learn about the aging process and risk factors for Alzheimer's disease in older Latino adults.
February 22, 2017
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New substance restores brain function in Alzheimer's animal model
The protein amyloid beta is believed to be the major cause of Alzheimer's disease. Substances that reduce the production of amyloid beta, such as BACE inhibitors, are therefore promising candidates for new drug treatments. A team at the Technical University of Munich (TUM) has recently demonstrated that one such BACE inhibitor reduces the amount of amyloid beta in the brain. By doing so, it can restore the normal function of nerve cells and significantly improve memory performance.
July 28, 2017
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New technology aims to provide peace and positive stimulation to dementia patients
To alleviate boredom and increase engagement, elderly patients in long-term care facilities can engage with the Ambient Activity Technology device any time to view family photos, hear their favorite music, and play games.
June 28, 2017
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New type of cell that clears waste from the brain discovered
Scientists have found a previously unknown type of cell that clears waste away from the brain. they suggest that their findings will increase our understanding of the brain's biology and of diseases such as dementia and stroke.
May 2, 2017
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Newly-discovered mechanism for compound may help prevent neurologic damage
Researchers at Oregon State University have found that a compound called rapamycin has unusual properties that may help address neurologic damage such as Alzheimer's disease.
April 5, 2017
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Noninvasive retinal imaging may improve early detection of Alzheimer's disease
Alzheimer's disease (AD) represents the leading cause of dementia worldwide. Currently, challenges in making an early and definitive diagnosis of AD limit opportunities to intervene with disease-modifying therapies before substantial neurodegeneration occurs.
August 17, 2017
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Novel mechanism identified to protect the brain from many neurodegenerative conditions
Scientists at Case Western Reserve University School of Medicine have identified a novel mechanism that could be used to protect the brain from damage due to stroke and a variety of neurodegenerative conditions, including sporadic Creutzfeldt-Jakob disease, Alzheimer's disease, and Parkinson's disease.
March 8, 2016
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Novel perspectives on anti-amyloid treatment for the prevention of Alzheimer's disease
For decades, researches have been investigating the underlying foundations of Alzheimer's disease to provide clues for the design of a successful therapy. Breakthrough insights reveal the molecular basis of the hereditary form of Alzheimer's disease that strikes early in life.
July 27, 2017
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Novel wearable device can track activities of dementia patients, help in combat training
Researchers at Missouri University of Science and Technology have developed a multi-modal sensing device that can track the fine-grained activities and behavior of people with dementia – and it could help in Army combat training, too.
September 2, 2016
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NYU Langone launches Alzheimer's and Related Dementias Family Support Program for caregivers
Two new grants from the New York State Department of Health (NYSDOH) will enable new Yorkers with Alzheimer's disease and dementia, and their families, to get the most comprehensive care and support services available in the New York City area.
July 20, 2016
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Misc. - O

Occupational therapy holds potential to provide clinical benefits to dementia patients
A French observational study in real life showed that dementia patients benefiting from occupational therapy sessions report relevant clinical benefits over the intervention period, according to a research study published in the Journal of Alzheimer's Disease this month. the research suggested the influence of occupational therapy on reducing behavioral troubles, caregivers' burden and amount of informal care over the intervention period and a stabilization over the 3-months period thereafter.
December 22, 2016
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Occupational therapy may have the potential to slow down functional decline and reduce behavioral troubles
Dementia patients benefiting from occupational therapy sessions report relevant clinical benefits over the intervention period, according to a research study. the research suggested the influence of occupational therapy on reducing behavioral troubles, caregivers' burden and amount of informal care over the intervention period and a stabilization over the 3-months period thereafter.
December 22, 2016
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Omega-3 fatty acids could promote clearance of metabolites in the brain, research shows
New research published online in the FASEB Journal suggests that omega-3 polyunsaturated fatty acids, which are found in fish oil, could improve the function of the glymphatic system, which facilitates the clearance of waste from the brain, and promote the clearance of metabolites including amyloid-ݠpeptides, a primary culprit in Alzheimer's disease.
October 26, 2016
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Misc. - P

Pathologic hallmarks of Alzheimer's found in aged chimpanzee brains
Humans are considered uniquely susceptible to Alzheimer's disease, potentially due to genetic differences, changes in brain structure and function during evolution, and an increased lifespan. However, a new study provides the most extensive evidence of Alzheimer's disease brain pathology in a primate species to date. Researchers found that the brains of aged chimpanzees, our closest living relatives, show pathology similar to the human Alzheimer's disease brain.
August 1, 2017
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People with dementia have right to cognitive rehabilitation, says expert
Rehabilitation is important for people with dementia as it is for people with physical disabilities, according to a leading dementia expert.
March 28, 2017
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Penn researcher searches for common factor linked to smell loss
Studies have shown that loss of the sense of smell can be among the first warning signs of diseases such as Alzheimer's and Parkinson's. now a researcher at the Perelman School of Medicine at the University of Pennsylvania wants to shift the search for clues about this process back even further, to find out if there is a common factor responsible for the loss of smell that may also serve as an early warning signal for a number of neurodegenerative diseases.
May 10, 2017
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PET scans can stage Alzheimer's disease in living people
Alzheimer's is a disease of protein aggregation. Amyloid-beta (Aݩ protein fibrils are terrible little fragments of protein that tangle up in Gordian knots, like earbud cords stuffed hastily in your pocket, and they build up and form creeping, spreading structures in the brain called plaques.
March 8, 2016
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Promising discovery for a non-invasive early detection of Alzheimer's disease
A team of scientists has pioneered new technology that detects in human blood platelets the pathological oligomeric forms of brain tau protein in patients with Alzheimer's disease and other neurodegenerative disorders, leading toward high relevance findings for the research community.
December 22, 2016
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Poor diet may fuel Alzheimer's in people who carry disease-related gene
A diet high in cholesterol, fat and sugar may influence the development of Alzheimer's disease in people who carry the ApoE4 gene, a leading risk factor for the memory-erasing disease, indicates a new USC study.
June 13, 2017
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Poor diet, plus Alzheimer's gene, may fuel disease
Could a healthy diet protect against the onset of Alzheimer's disease?
June 13, 2017
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Postmenopausal hormone therapy exceeding ten years may protect from dementia
Postmenopausal estrogen-based hormone therapy lasting longer than ten years was associated with a decreased risk of Alzheimer's disease in a large study. the study explored the association between postmenopausal hormone replacement therapy, Alzheimer's disease, dementia and cognition in two nation-wide case-control studies and two longitudinal cohort studies. the largest study comprised approximately 230,000 Finnish women and the follow-up time in different studies was up to 20 years.
February 16, 2017
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Pot May Restrict Blood Flow to Brain: Study
It's too early to say if this contributes to mental decline, Alzheimer's expert says
December 30, 2016
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Powerful defenders of the brain discovered, with big implications for disease and injury
A rare and potent type of immune cell has been discovered around the brain, suggesting the cells may play a critical role in battling Alzheimer's, multiple sclerosis and other diseases. by harnessing the cells' power, doctors may be able to develop new treatments for disease, traumatic brain injury and spinal cord injuries -- even migraines.
December 19, 2016
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Precision NanoSystems NanoAssemblr™ Chosen for Horizon 2020 Project to develop Novel RNA Therapeutics
Precision NanoSystems NanoAssemblr™ platform has been selected for the controlled manufacture of nanomedicines as part of the multinational B-SMART (Brain-Specific, Modular and Active RNA Therapeutics) translational research project. this €6 million initiative, funded by the EU Horizon 2020 program, aims to use RNA-based therapeutics to silence the production of disease-causing proteins for a range of neurodegenerative disorders, such as Parkinson's, Alzheimer's and Huntington's.
March 29, 2017
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Prevention of vascular risk factors could reduce incidence of Alzheimer's disease
Currently, no possibility exists to reliably quantify the risk of Alzheimer's disease (AD) onset in the general population and in subjects with mild cognitive impairment. Metabolic and genetic factors involved in increasing the probability of developing dementia have already been identified. Some vascular risk factors, as hypertension, dyslipidaemia, diabetes or smoking can cause a derangement in extra or intracranial vessels architecture, which can be responsible for an early aging of the brain. However, reliable tools for early identification of subjects at greater risk of evolution from mild cognitive impairment to AD are not available.
August 2, 2017
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Proton pump inhibitor use not linked to increased risk of Alzheimer's disease
The use of proton pump inhibitors does not increase the risk of Alzheimer's disease, shows a recent study from the University of Eastern Finland. Proton pump inhibitors are a type of antiulcer drug that is commonly used among older persons.
August 7, 2017
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Proton pump inhibitors do not increase risk for dementia or Alzheimer's disease
Proton pump inhibitors (PPIs) are medications used to treat digestive problems such as ulcers and reflux disease by reducing the body's production of the acid that helps us digest food. Ulcers are sores that develop on the lining of our digestive system; when they develop in the upper part of the small intestine they are called "duodenal ulcers." Reflux disease is a condition in which stomach acid or other fluids in the digestive system irritate our food pipe, also known as the esophagus.
June 22, 2017
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Misc. - R

Rapid blood pressure drops in middle age linked to dementia in old age
Temporary episodes of dizziness or light-headedness when standing could reduce blood flow to the brain with lasting impacts
March 10, 2017
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Regular, moderate drinking may increase chances of remaining cognitively healthy in older age
Older adults who consume alcohol moderately on a regular basis are more likely to live to the age of 85 without dementia or other cognitive impairments than non-drinkers, according to a University of California San Diego School of Medicine-led study.
August 1, 2017
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Research findings may provide highly effective therapeutic strategy for treatment of Alzheimer's, AMD
for the first time, researchers at LSU Health new Orleans have shown that a protein critical to the body's ability to remove waste products from the brain and retina is diminished in age-related macular degeneration (AMD), after first making the discovery in an Alzheimer's disease (AD) brain.
March 8, 2016
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Research hints at underlying cause for Alzheimer's drug trial failures
A certain form of immunotherapy targeted to Alzheimer's patients may be ineffective when that patient also has Vascular Cognitive Impairment and Dementia, report scientists. While these drugs showed promise in animal studies, clinical trials have failed to show similar benefits in human patients.
October 3, 2016
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Researchers develop simple method for capturing proteins implicated in Alzheimer's, other conditions
The new methodology involves easily trapping proteins that bear a specific modification that can provide potential markers for conditions. The specific modification is based on sugar and when attached to a protein affects how the protein functions. Protein modification is a normal, carefully regulated cellular function, but in some instances, this can go wrong.
July 17, 2017
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Researchers discover how tau disrupts functioning of nerve cells even before forming tangles
Tau proteins are best known as the proteins that are stacked to form neuronal "tangles" in Alzheimer's patients' brains, but they also play a role in many other brain disorders such as Parkinson's and Huntington's disease. In healthy circumstances, tau proteins are connected to the cytoskeleton of nerve cells, where they support the cells' structural stability. In the nerve cells of patients, however, tau is dislodged from the cytoskeleton and ultimately tangles together to form protein accumulations that disrupt the nerve cell's functioning.
May 19, 2017
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Researchers discover new natural tooth repair method using Alzheimer's drug
A new method of stimulating the renewal of living stem cells in tooth pulp using an Alzheimer's drug has been discovered by a team of researchers at King's College London.
January 9, 2017
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Researchers find a potential target for anti-Alzheimer treatments
Scientists have identified a gene that may provide a new starting point for developing treatments for Alzheimer's disease (AD). the USP9 gene has an indirect influence on the so-called tau protein, which is believed to play a significant role in the onset of Alzheimer's disease. this discovery may open a new door to developing active ingredients to treat Alzheimer's disease.
January 11, 2017
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Researchers identify genetic switch that may be potential target for Alzheimer's disease
A team at the MRC Clinical Sciences Centre (CSC), based at Imperial College London, has found an important part of the machinery that switches on a gene known to protect against Alzheimer's Disease.
September 20, 2016
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Researchers identify how amyloid beta linked to Alzheimer's disease could trigger Parkinson's
Alzheimer's and Parkinson's diseases are different neurodegenerative conditions that can sometimes affect the same person, which has led scientists to investigate possible links between the two. now one team, reporting in the journal ACS Chemical Neuroscience, has identified how amyloid beta, the protein fragment strongly associated with Alzheimer's disease, can induce cellular changes that might lead to Parkinson's.
October 12, 2016
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Researchers measure spread of tau protein in the brains of Alzheimer's patients
In a new study presented in Molecular Psychiatry, researchers at Karolinska Institutet have measured how deposits of the pathological protein tau spread through the brain over the course of Alzheimer's disease. Their results show that the size of the deposit and the speed of its spread differ from one individual to the next, and that large amounts of tau in the brain can be linked to episodic memory impairment.
May 16, 2017
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Researchers produce images that predate formation of beta-amyloid plaques in Alzheimer's disease
Researchers at Lund University in Sweden have used the MAX IV synchrotron in Lund - the strongest of its kind in the world - to produce images that predate the formation of toxic clumps of beta-amyloid, the protein believed to be at the root of Alzheimer's disease. the unique images appear to contradict a previously unchallenged consensus. Instead of attempting to eliminate beta-amyloid, or so-called plaques, the researchers now suggest stabilizing the protein.
March 13, 2017
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Researchers reveal how neurodegenerative diseases spread through the brain
Synapses, the place where brain cells contact one another, play a pivotal role in the transmission of toxic proteins. this allows neurodegenerative diseases such as Alzheimer's to spread through the brain, scientists conclude. If the spreading of these toxic proteins could be prevented, the progression of neurodegenerative diseases might be slowed down substantially.
November 9, 2016
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Researchers spot two genes that influence person's risk of Alzheimer's disease
The new finding, which builds on the team's previous work of identifying 24 susceptibility genes, enables a better understanding of the mechanisms underlying the disease and offers further hope in developing new treatments.
July 17, 2017
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Researchers study molecular mechanisms responsible for Alzheimer's disease
Members of the Faculty of Fundamental Medicine at the Lomonosov Moscow State University have determined the structure of a peptide complex, formed in the brain at the early stages of Alzheimer's disease progression. The research results will contribute to the rational design of compounds, capable to block disease progress.
July 14, 2017
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Researchers uncover mechanism that may help prevent or treat Alzheimer's disease
Researchers have uncovered a mechanism that helps block the accumulation of proteins involved in Alzheimer's disease. Tapping into this natural process may therefore help prevent or treat the condition.
March 14, 2017
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Researchers unlock specific mechanisms behind Aα-induced cytoxicity in Alzheimer's disease
Alzheimer's disease is a progressive neurodegenerative disorder that leads to dementia via advanced neuronal dysfunction and death. a person with Alzheimer's disease suffers loss of control over thought, memory and language abilities. Additionally, the disease takes an emotional, social and economic toll on family members of individuals living with the disease. Alzheimer's disease is also a burden for health care system in the U.S., with as many as 5 million Americans living with the disease in 2013, according to the U.S. Centers for Disease Control and Prevention, and that number is expected to continue rising.
February 14, 2017
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Researchers working to develop simple blood test to predict onset of Alzheimer's disease
A research team, led by Cardiff University, has made a significant step towards the development of a simple blood test to predict the onset of Alzheimer's disease.
August 31, 2016
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Risks of dementia and Alzheimer's disease develop at high rates in older kidney transplant recipients
Dementia and Alzheimer's disease develop at elevated rates in older kidney transplant recipients and may threaten the health of their transplanted organ as well as their own survival.
December 16, 2016
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Role for lysosome transport in Alzheimer's disease progression revealed
Researchers have discovered that defects in the transport of lysosomes within neurons promote the buildup of protein aggregates in the brains of mice with Alzheimer's disease. The study suggests that developing ways to restore lysosome transport could represent a new therapeutic approach to treating the neurodegenerative disorder.
August 7, 2017
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Roots of Alzheimer's disease can extend as far back as the womb
Vitamin a deficiency could 'program' brain tissue
January 27, 2017
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Rutgers study discovers that chemical used to detect amyloid plaques increases roundworm lifespan
While many anti-aging drugs don't live up to their claim, a tightly replicated study by Rutgers and a group of researchers from around the country discovered that a chemical used to detect amyloid plaques found in the brains of those with Alzheimer's extended the lifespan of thousands of roundworms similar in molecular form, function and genetics to humans.
March 10, 2017
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Misc. - S

Scientists detail structure of molecule implicated in Alzheimer's disease
Scientists at Washington University School of Medicine in St. Louis have detailed the structure of a molecule that has been implicated in Alzheimer's disease. Knowing the shape of the molecule -- and how that shape may be disrupted by certain genetic mutations -- can help in understanding how Alzheimer's and other neurodegenerative diseases develop and how to prevent and treat them.
December 21, 2016
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Scientists discover gene that may open new door to developing treatments for Alzheimer's disease
Scientists at the Luxembourg Centre for Systems Biomedicine of the University of Luxembourg have identified a gene that may provide a new starting point for developing treatments for Alzheimer's disease. the USP9 gene has an indirect influence on the so-called tau protein, which is believed to play a significant role in the onset of Alzheimer's disease.
January 11, 2017
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Scientists discover how misfolded proteins can damage cells' energy-producing powerhouses
Working with yeast and human cells, researchers at Johns Hopkins say they have discovered an unexpected route for cells to eliminate protein clumps that may sometimes be the molecular equivalent of throwing too much or the wrong trash into the garbage disposal. Their finding, they say, could help explain part of what goes awry in the progression of such neurodegenerative diseases as Parkinson's and Alzheimer's.
March 3, 2017
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Scientists discover potential brain imaging predictor for early dementia
University of Toronto and Baycrest Rotman Research Institute (RRI) scientists have discovered a potential brain imaging predictor for dementia, which illustrates that changes to the brain's structure may occur years prior to a diagnosis, even before individuals notice their own memory problems.
May 12, 2017
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Scientists find two new risk genes for Alzheimer's
New research moves us closer to understanding the genetic underpinnings of Alzheimer's disease, as scientists find two new genes that have been found to raise the risk for the condition.
July 18, 2017
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Scientists find way to recover protein structure after chemical denaturation
Scientists from ITMO University in Saint Petersburg and Hebrew University in Jerusalem have found a way to recover a protein structure after its chemical denaturation. The method is based on electrostatic interaction between folded, or denatured, proteins and alumina, which unwrap them. The authors highlight the versatility of the method: it works for both specific molecules and, for the first time ever, multiprotein systems - nobody has been able to recover mixtures of enzymes before.
June 9, 2017
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Scientists identify potential drug treatment in fight against Alzheimer's disease
An international team of scientists has announced a new advance in the fight against Alzheimer's disease by identifying a new drug target for not only improving symptoms of brain degeneration -- but also to extend the life-span of the terminally ill mice.
December 21, 2016
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Scientists provide detailed view of tau protein structures found in Alzheimer's disease
New research by scientists at the MRC Laboratory of Molecular Biology in the United Kingdom and Indiana University School of Medicine gives the most detailed view yet of tau protein structures found in Alzheimer's disease.
July 6, 2017
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Scientists shed new light on how tau protein transitions from liquid state to solid tangles
While much about Alzheimer's disease remains a mystery, scientists do know that part of the disease's progression involves a normal protein called tau, aggregating to form ropelike inclusions within brain cells that eventually strangle the neurons. Yet how this protein transitions from its soluble liquid state to solid fibers has remained unknown -- until now.
July 6, 2017
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Scientists stop formation of protein clumps linked to ALS and frontotemporal dementia
Scientists report in a new study that by imitating a natural process of cells, they prevented the formation of protein clumps associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.
August 8, 2017
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Scientists surprised to discover lymphatic 'scavenger' brain cells
The brain has its own inbuilt processes for mopping up damaging cellular waste -- and these processes may provide protection from stroke and dementia. Scientists discovered a new type of lymphatic brain 'scavenger' cell by studying tropical freshwater zebrafish -- which share many of the same cell types and organs as humans.
May 1, 2017
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Scientists use novel algorithm to group similar Alzheimer's patients for precise drug trials
The push to develop treatments for Alzheimer's disease has been a promising and disappointing endeavor over the past two decades, yielding a greater understanding of the disease yet still failing to generate successful new drugs.
July 28, 2017
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Scientists uncover potential driver of age- and Alzheimer's-related memory loss
Scientists have made an important discovery toward the development of drugs to treat age-related memory loss in diseases like Alzheimer's. they found that reduced levels of a protein called Rheb result in spontaneous symptoms of memory loss in animal models and are linked to increased levels of another protein known to be elevated in the brains of Alzheimer's disease patients.
December 6, 2016
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Security issues with health apps for dementia patients uncovered by researchers
Many health apps designed to assist dementia patients and their caregivers have inadequate security policies or lack security policies altogether, new research concludes.
August 21, 2017
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Sedentary older adults likely to develop dementia as those with genetic risk factors, research finds
Sedentary older adults with no genetic risk factors for dementia may be just as likely to develop the disease as those who are genetically predisposed, according to a major study which followed more than 1,600 Canadians over five years.
January 10, 2017
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Sedatives May Raise Pneumonia Risk in Alzheimer's
Researchers suspect people may breathe saliva or food into their lungs due to fatigue from the drugs
April 10, 2017
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Short and long sleep, and sleep disturbances associated with increased risk of dementia and lung cancer
Difficulties in initiating or maintaining sleep at middle-age are associated with an increased risk of dementia, according to a new study. The 20-year follow-up study was conducted among 2,682 men participating the Kuopio Ischaemic Heart Disease Study.
May 24, 2017
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Silent seizures recorded in the hippocampus of two patients with Alzheimer's disease
Seizure-like activity in key memory structure may contribute to cognitive symptoms, offering new therapeutic target
May 1, 2017
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'Silent' Seizures Tied to Alzheimer's Symptoms
Researchers suggest they're a potential target for treating the disease
May 2, 2017
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Simple odor identification tests may help track progression of Alzheimer's disease
Odor identification tests may help scientists track the evolution of the disease in persons at risk
August 16, 2017
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Simulation shows the high cost of dementia, especially for families
A new simulation of the dementia epidemic estimates the economic impact the disease has on households and public insurance programs and provides a tool for projecting the impact that different interventions could have.
August 17, 2017
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Sleep disorders may predict Alzheimer's disease
Sleeplessness may cause a variety of health problems, some of which include cognitive dysfunction and diabetes. New research suggests that Alzheimer's disease is yet another condition that may be caused by sleep disorders.
July 6, 2017
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Sleep Disturbances Linked to Alzheimer's Risk
Here's another reason to get a good night's sleep: Interrupting a deep phase of sleep appears to cause more of the proteins associated with Alzheimer's disease to collect in your brain, a new study from researchers at Washington University concludes.
July 10, 2017
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Smartphone calendars may alleviate memory compromise in patients with mild Alzheimer's disease
The patient is a retired teacher who had reported memory difficulties 12 months prior to the study. These difficulties referred to trouble remembering names and groceries she wanted to purchase, as well as frequently losing her papers and keys. According to the patient and her husband, the main difficulties that she encountered were related to prospective memory (e.g., forgetting medical appointments or to take her medication).
March 1, 2017
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'Sniff test' may be useful in diagnosing early Alzheimer's disease
Adds to evidence that decline in sense of smell occurs alongside cognitive decline
December 20, 2016
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Some with Alzheimer's Brain Plaques Stay Sharp
Study finding raises question of whether something protected their brains
November 14, 2016
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Spread of tau protein measured in brains of Alzheimer's patients
Researchers have measured how deposits of the pathological protein tau spread through the brain over the course of Alzheimer's disease. Their results show that the size of the deposit and the speed of its spread differ from one individual to the next, and that large amounts of tau in the brain can be linked to episodic memory impairment.
May 16, 2017
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Strawberry compound may prevent Alzheimer's
A natural compound found in strawberries and other fruits and vegetables could help to prevent Alzheimer's disease and other age-related neurodegenerative diseases, new research suggests.
July 11, 2017
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Stroke prevention may also reduce dementia
Ontario's stroke prevention strategy is also reducing incidence of dementia among people 80+
May 1, 2017
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Studies do not provide clear information on benefits of cognitive training in dementia patients
"The effects of cognitive training in dementia patients have been studied actively during recent decades but the quality and reliability of the studies varies," says licenced neuropsychologist Eeva-Liisa Kallio. She reviewed 31 randomized controlled trials on cognitive training in dementia patients.
February 22, 2017
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Study details molecular roots of Alzheimer's
Cellular 'housekeeping' molecule's structure linked to neurodegeneration
December 20, 2016
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Study finds brains of women to be more active than men
In the largest functional brain imaging study to date, the Amen Clinics (Newport Beach, CA) compared 46,034 brain SPECT (single photon emission computed tomography) imaging studies provided by nine clinics, quantifying differences between the brains of men and women. The study is published in the Journal of Alzheimer's Disease.
August 7, 2017
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Study finds evidence on preventive interventions for cognitive decline and dementia
A new report published by the National Academies of Sciences, Engineering, and Medicine shows evidence supporting three interventions for cognitive decline and dementia--cognitive training, blood pressure management for people with hypertension, and increased physical activity, which might slow down cognitive decline and the onset of dementia.
June 26, 2017
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Study finds link between tooth loss and elevated risk of dementia
In a study of 1566 community-dwelling Japanese elderly who were followed for 5 years, the risk of developing dementia was elevated in individuals with fewer remaining teeth.
March 8, 2017
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Study highlights rate of misdiagnosis in Alzheimer's disease patients with psychosis
People with Alzheimer's disease who experience psychosis--including delusions and hallucinations--are five times more likely to be misdiagnosed with dementia with Lewy bodies compared to patients who do not, new research suggests.
June 30, 2017
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Study identifies potential biomarker for Alzheimer's disease
In one of the largest studies to date to use metabolomics, the study of compounds that are created through various chemical reactions in the body, researchers have been able to identify new circulating compounds associated with the risk of developing dementia and Alzheimer's disease (AD). The findings point to new biological pathways that may be implicated in AD and could serve as biomarkers for risk of the disease.
June 12, 2017
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Study looks at how relationship to dementia patient can affect caregiver's depression
Too often overlooked is the risk of depression in caregivers of patients with dementia, and a new study focuses on how depressive symptoms may differ depending on the familial relationship between caregiver and patient.
October 13, 2016
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Study of classical Chinese medical literature finds references similar to Alzheimer's disease
A new study of classical Chinese medical texts identifies references to age-related memory impairment similar to modern-day Alzheimer's disease, and to several plant-based ingredients used centuries ago -- and still in use today -- to treat memory impairment.
September 20, 2016
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Study offers new insights into brain mechanisms for spatial navigation
An international research team led by UvA researchers Jeroen Bos, Martin Vinck and Cyriel Pennartz has identified a new type of neuron which might play a vital role in humans' ability to navigate their environments. The discovery is an important step towards understanding how the brain codes navigation behaviour at larger scales and could potentially open up new treatment strategies for people with impaired topographical orientation like Alzheimer's patients. The team's results are published in the latest edition of Nature Communications.
May 29, 2017
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Study predicts dementia in over 1.2 million people in England and Wales by 2040
A study by an international team of researchers from University College London and the University of Liverpool published in The BMJ predicts that dementia will affect more than 1.2 million people in England and Wales by 2040.
July 6, 2017
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Study provides new insight into cells that rejuvenate the brain
Alzheimer's disease is a neurodegenerative disease manifested by various neuronal pathological processes and a significant decline in brain function. Aggregates of beta-amyloid protein ("plaques") accumulate within and between brain cells. Due to both structural changes and the weakening of chemical communication pathways, the junctions of neuronal networks (synapses) are lost. In addition, the cytoskeletal proteins of the axons lose their normal structure, impairing their function and causing massive neuronal death.
June 9, 2017
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Study sheds new light on role of Tau proteins in certain brain diseases
In a study published in the journal PNAS scientists of the German Center for Neurodegenerative Diseases (DZNE) present new findings on the role of the protein Tau in certain brain diseases. Their report which is based on laboratory studies suggests that the drug "Rolofylline" could possibly alleviate learning and memory problems associated with aggregating Tau proteins.
October 7, 2016
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Study shows feasibility of noninvasive retinal imaging for screening people at risk of AD
Alzheimer's disease (AD) represents the leading cause of dementia worldwide. Currently, challenges in making an early and definitive diagnosis of AD limit opportunities to intervene with disease-modifying therapies before substantial neurodegeneration occurs.
August 17, 2017
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Study shows possibility to reduce antipsychotic use among nursing home residents with dementia
The use of antipsychotic medication in nearly 100 Massachusetts nursing homes was significantly reduced when staff was trained to recognize challenging behaviors of cognitively impaired residents as communication of their unmet needs, according to a new study led by Jennifer Tjia, MD, MSCE, associate professor of quantitative health sciences.
April 17, 2017
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Study suggests new strategy for treating Alzheimer's disease
Alzheimer's disease (AD) is one of the most common form of dementia. In search for new drugs for AD, the research team, led by Professor Mi Hee Lim of Natural Science at UNIST has developed a metal-based substance that works like a pair of genetic scissors to cut out amyloid-α (Aα), the hallmark protein of AD.
February 28, 2017
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Study to examine how improvisational dance can help people with dementia
Depending on what generation you belong to, the term "improvisational dance" may conjure up images of beatniks grooving to the beat of bongos in a darkened coffeehouse or the black-clad Dieter gyrating to techno pop in a Sprockets sketch on "Saturday Night Live".
July 14, 2017
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Study using Cubresa SPECT scanner finds potential non-invasive diagnosis for Alzheimer's
Cubresa Inc., a medical imaging company that develops and markets molecular imaging systems, today announced that their compact SPECT (Single-Photon Emission Computed Tomography) scanner was used in a study by Dalhousie University and Mount Saint Vincent University researchers in Halifax, Nova Scotia to help evaluate the diagnostic potential of a new molecular label that could lead to the early detection of Alzheimer's disease in living patients.
November 28, 2016
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Study: Abnormal proteins in Alzheimer's, Parkinson's, and Huntington's diseases share similar feature
A Loyola University Chicago study has found that abnormal proteins found in Alzheimer's disease, Parkinson's disease, and Huntington's disease all share a similar ability to cause damage when they invade brain cells.
May 23, 2017
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Study: Lumosity boosts brain function as much as normal video games--by 0%
But taking cognitive tests repeatedly makes you better at taking cognitive tests
July 10, 2017
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Study: People with confusion caused by dementia or delirium have worse treatment outcomes
Hospital patients with dementia and other causes of confusion have longer stays and worse treatment outcomes than people without the condition, research led by the University of Stirling has found.
August 1, 2017
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Study: Unsaturated fatty acid metabolism associated with progression of Alzheimer's disease
A new study published in PLOS Medicine's Special Issue on Dementia has found that the metabolism of omega-3 and omega-6 unsaturated fatty acids in the brain are associated with the progression of Alzheimer's disease.
March 22, 2017
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Substance present in ayahuasca brew stimulates generation of human neural cells
Harmine increases the number of neural progenitors, cells that give rise to neurons, study suggests
December 6, 2016
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Sudden BP Drops Tied to Higher Dementia Odds
Dizziness, faintness on standing could be sign of danger to brain, but study couldn't prove cause and effect
October 11, 2016
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Syngene's G:BOX Chemi XX6 used to help identify biomarkers in Alzheimer's disease
Syngene, a world-leading manufacturer of image analysis solutions, is pleased to announce its G:BOX Chemi XX6 multi-application imager is being utilised by scientists at the University of Brescia for analysing nitrated proteins. this is providing the researchers with accurate information on changes in proteins and may help to identify biomarkers related to Alzheimer's disease.
March 17, 2017
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Misc. - T

Taking out the cellular 'trash' at the right place and the right time
New possibilities for the regulation of molecular processes
October 20, 2016
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Tau PET imaging in Alzheimer's disease increases opportunities for developing effective drugs
Tau PET is a new and promising imaging method for Alzheimer's disease. a case study from Lund University in Sweden now confirms that tau PET images correspond to a higher degree to actual changes in the brain. According to the researchers behind the study, this increases opportunities for developing effective drugs.
September 28, 2016
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Tau prevents synaptic transmission at early stage of neurodegeneration
Tau proteins are involved in more than twenty neurodegenerative diseases, including various forms of dementia. These proteins clump together in patients' brains to form neuronal tangles: protein aggregation that eventually coincides with the death of brain cells. A research team has now discovered how tau disrupts the functioning of nerve cells, even before it starts forming tangles. They immediately suggest a way to intervene in this process.
May 19, 2017
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TBI and dementia: Link or no link?
Whether or not traumatic brain injury predisposes individuals to dementia has long been under investigation, and the results of different studies are often conflicting. But evidence is mounting that traumatic brain injury can cause long-term damage to the brain.
July 14, 2017
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TBI in middle age may raise dementia risk
Middle-aged adults who experience a moderate to severe traumatic brain injury may be at significantly greater risk of developing dementia in later life, a new study suggests.
July 6, 2017
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The first-in-human clinical trial targeting Alzheimer's tau protein
For the first time, targeting the other feature of Alzheimer's disease, tau, has given fruitful results. In an unprecedented study, active vaccination in humans has resulted in a favorable immune response in 29 out of the 30 patients with only minor side effects.
December 12, 2016
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The lasting effects of ministrokes may contribute to dementia
Investigators report preclinical research showing that microinfarcts induce prolonged dysfunction in brain areas estimated to be 12-times larger than the visible injury site. Data from c-Fos assays and in vivo hemodynamic imaging reveal how individually miniscule microinfarcts might collectively contribute to broader brain dysfunction in patients with vascular cognitive impairment and dementia.
January 16, 2017
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Therapies that target dementia in early stages critical to success
Targeting dementia in the earlier stages of the condition could be critical for the success of future therapies, say researchers who have found that the very earliest symptoms of dementia might be due to abnormal stability in brain cell connections rather than the death of brain tissue, which comes after.
March 28, 2017
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Thin People not More Prone to Alzheimer's
Gene-based research suggests that, instead, early stage disease might cause weight loss
May 9, 2017
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This Prostate Cancer Therapy May Up Dementia Risk
Study found chances doubled, but did not prove androgen deprivation caused damage to brain
October 13, 2016
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Training And Meds May Help Advanced Alzheimer's
Skills lost, such as dressing or bathing, can potentially be relearned, small study suggests
July 18, 2017
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Treatment approach used in cancer holds promise for Alzheimer's disease
New Alzheimer's treatment could be delivered as nasal spray, say scientists. Researchers have developed a novel treatment that could block the development of Alzheimer's disease using microscopic droplets of fat to carry drugs into the brain.
October 20, 2016
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Treatments for Alzheimer's Proving Elusive
Finding a treatment to reverse or stop Alzheimer's disease is proving elusive.
December 13, 2016
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Two existing drugs halt neurodegeneration in mice
Researchers have made a major leap forward in the treatment of Alzheimer's and Parkinson's, after identifying two existing drugs that prevented brain cell death in mouse models of neurodegenerative disease.
April 20, 2017
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Misc. - U

UAlberta scientists finding ways to inhibit 'rogue' protein believed to be key player in Alzheimer's
Every day tens of thousands of Canadians unwillingly find themselves becoming shadows of their former selves. they grasp onto moments of clarity--fleeting windows of time--before slipping away again into confusion; robbed of memories, talents and their very personalities.
February 16, 2017
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UCLA study shows how the brain initiates repair by generating replacement cells after stroke
UCLA researchers have shown that the brain can be repaired – and brain function can be recovered – after a stroke in animals. the discovery could have important implications for treating a mind-robbing condition known as a white matter stroke, a major cause of dementia.
December 21, 2016
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Understanding psychological dimensions of dementia can improve care, says new report
To help people live well with dementia we need a better understanding of its psychological impact, according to a new report.
November 14, 2016
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Unique visual stimulation may be new treatment for Alzheimer's
Noninvasive technique reduces beta amyloid plaques in mouse models of Alzheimer's disease
December 6, 2016
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Unraveling how a brain works, block by high-tech block
Researchers modernizing cognitive skills testing to detect deficits, problem-solving strategies and more
November 17, 2016
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Untangling a cause of memory loss in neurodegenerative diseases
NIH-funded mouse study identifies a possible therapeutic target for a family of disorders.
October 12, 2016
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Using herpes drugs to slow down Alzheimer's disease could become reality
The first clinical study to investigate if herpes virus drugs can have an effect on fundamental Alzheimer's disease processes has been launched. the research group has previously demonstrated a correlation between herpes virus infection and an increased risk of Alzheimer's disease.
December 13, 2016
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Using magnets to improve memory
The ability to remember sounds, and manipulate them in our minds, is incredibly important to our daily lives -- without it we would not be able to understand a sentence, or do simple arithmetic. new research is shedding light on how sound memory works in the brain, and is even demonstrating a means to improve it.
March 27, 2017
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Using tau imaging as diagnostic marker for Alzheimer disease
The accumulation of ?-Amyloid and tau proteins in the brain is hallmark pathology for Alzheimer disease. Recently developed positron emission tomography (PET) tracers, including [18F]-AV-1451, bind to tau in neurofibrillary tangles in the brain. So, could tau imaging become a diagnostic marker for Alzheimer disease and provide insights into the pathophysiology of the neurodegenerative disorder that destroys brain cells?
July 25, 2016
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Misc. - V

Vascular risk factors and Alzheimer's disease: A new therapeutic opportunity?
Currently, no possibility exists to reliably quantify the risk of Alzheimer's disease (AD) onset in the general population and in subjects with mild cognitive impairment. Metabolic and genetic factors involved in increasing the probability of developing dementia have already been identified. Some vascular risk factors, as hypertension, dyslipidaemia, diabetes or smoking can cause a derangement in extra or intracranial vessels architecture, which can be responsible for an early aging of the brain.
August 2, 2017
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Viral vectors for gene transfer can travel to distant areas in the brain, study shows
Gene transfer is seen as a hopeful therapy for Alzheimer's and Parkinson's patients. The approach involves using harmless laboratory-produced viruses to introduce important genes into the brain cells. In a study on mice, a team of researchers from Vetmeduni Vienna for the first time investigated how far these viruses spread in the brain and which cells they infect.
June 16, 2017
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Viral vectors for gene transfer travel longer distances in the brain than thought
Gene transfer as a treatment of neurodegenerative diseases
June 16, 2017
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Virtual reality may be new way to prevent cognitive decline in elderly people
Ping Jiang and her Helsinki Challenge semifinalist team Senior Cognitive Booster want to increase the cognitive abilities of elderly people with the help of virtual reality.
April 5, 2017
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Vitamins a and C help erase cell memory
Discovery important in development of cells for regenerative medicine
October 12, 2016
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Misc. - W

Western diet increases Alzheimer's pathology in genetically predisposed mice
Obese mice with a particular version of a gene strongly associated with Alzheimer's disease in humans show increased Alzheimer's pathology, according to new research.
June 12, 2017
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What is survival among patients with Parkinson, Dementia with lewy bodies?
A new article compares survival rates among patients with synucleinopathies, including Parkinson disease, dementia with Lewy bodies, Parkinson disease dementia and multiple system atrophy with parkinsonism, with individuals in the general population.
May 15, 2017
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What's the 'SuperAgers' Mental Secret?
Some folks stay sharp into their 80s, 90s, and brain scans may show why
April 4, 2017
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When is It Worth Worrying About Dementia?
If you didn't know better, you'd think Alzheimer's disease is the plot of a bad horror movie: a creeping silent killer steals your memories, distorts your experiences of the present, and transforms your family's love into dutiful pity.
April 28, 2017
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Why are African Americans more likely to develop Alzheimer's?
Researchers know that African Americans are at a much higher risk of developing Alzheimer's disease than white Americans. But a new series of studies explores the reasons behind this, analyzing socioeconomic and psychological factors that may play a role.
July 17, 2017
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Women may have better verbal memory skills than men during early stages of Alzheimer's disease
Women may have better verbal memory skills than men even when their brains show the same level of problems metabolizing glucose, which occurs in people with Alzheimer's disease, according to research published in the October 5, 2016, online issue of Neurology®, the medical journal of the American Academy of Neurology.
October 5, 2016
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Misc. - X

Xanax, Valium May Boost Pneumonia Risk in Alzheimer's Patients
Researchers suspect people may breathe saliva or food into their lungs due to fatigue from the drugs
April 10, 2017
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Misc. - Y

Year in review: Alzheimer's drug may clarify disease's origins
Treatment shows early promise in sweeping away amyloid brain plaques
December 14, 2016
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