Health — Cancer — February 18th, 2025

Aston University collaborates on injectable paste for bone cancer treatment
Aston University is collaborating in research to develop an injectable paste which could treat bone cancer.
February 18, 2025 — Source

Disruption of immune cells in blood is linked to cancer outcomes, new tool reveals
The immune systems of cancer patients are highly disrupted, with those who have a higher number of immune cells in their blood having a better survival rate, finds a new study that uses a pioneering technique developed by researchers at UCL and the Francis Crick Institute.
February 18, 2025 — Source

Gold nanodots can help boost cancer cell response to ultrasound treatment
Cells have surface receptors called integrins that bind to repetitive domains present on the extracellular matrix (ECM) surrounding the cells, allowing them to grow and spread. A new study from the Department of Bioengineering (BE), Indian Institute of Science (IISc) and collaborators shows that tweaking the spacing between these binding domains on the ECM can boost the efficiency of ultrasound treatment applied to kill cancer cells.
February 18, 2025 — Source

Having dense breasts is linked to cancer, but advice about breast density can depend on where you live
Having dense breasts is a clear risk factor for breast cancer. It can also make cancers hard to spot on mammograms.
February 18, 2025 — Source

ImmuneLENS method provides new insights into cancer prognosis
The immune systems of cancer patients are highly disrupted, with those who have a higher number of immune cells in their blood having a better survival rate, finds a new study that uses a pioneering technique developed by researchers at UCL and the Francis Crick Institute.
February 18, 2025 — Source

Mobile prostate cancer screening clinic can ID the disease in disadvantaged men
Masood Moghul, M.B.B.S., from the Institute of Cancer Research in London and colleagues moved a bespoke nurse-led mobile clinical unit to community-based locations in areas of high deprivation indices in London with targeted invitations to high-risk men. Participants were offered prostate-specific antigen tests and a general health check.
February 18, 2025 — Source

New biomarker panel shows promise for early detection of pancreatic cancer
The discovery of a 'biomarker panel' could have a profound impact on the ability to identify patients at risk of developing PC at an earlier stage.
February 18, 2025 — Source

New gold nanoparticle-based therapy shows promise in colorectal cancer treatment
Researchers have designed and constructed a new type of two-photon photodynamic therapy photosensitizer based on cell membrane targeting of luminescent gold nanoparticles.
February 18, 2025 — Source or Source

New tool reveals disruption of immune cells in blood is linked to cancer outcomes
The immune systems of cancer patients are highly disrupted, with those who have a higher number of immune cells in their blood having a better survival rate, finds a new study that uses a pioneering technique.
February 18, 2025 — Source

Self-protecting nanoparticles can enhance colorectal cancer drug delivery
Colorectal cancer (CRC) is one of the most prevalent types of cancer and has a high mortality rate globally. Oral administration of anticancer drugs that pass through the gastrointestinal (GI) tract into the colorectum is a common strategy to deliver drugs in CRC treatment. However, this approach presents distinct challenges: most of these drugs lack target-specificity, leading to off-target side effects; these drugs get easily adsorbed onto the microvilli structure of the small intestinal epithelium, resulting in premature drug loss; and systemic drug absorption reduces CRC-targeted drug delivery.
February 18, 2025 — Source

Senolytic agent ABT-263 mitigates GI cancer risk after radiation exposure
Researchers Kamendra Kumar, Bo-Hyun Moon, Santosh Kumar, Jerry Angdisen, Bhaskar V.S. Kallakury, Albert J. Fornace Jr., and Shubhankar Suman from Georgetown University Medical Center explored whether a drug called ABT-263 could help reduce the risk of gastrointestinal (GI) cancer caused by radiation exposure. Their findings suggest that ABT-263, a senolytic agent, helps eliminate harmful aging cells in the gut, reducing inflammation and lowering cancer risk in mice. These results could lead to potential treatments for people exposed to radiation, including cancer patients and astronauts.
February 18, 2025 — Source

Study reveals racial and ethnic disparities in timely breast cancer diagnosis
Different sociodemographic groups, especially racial and ethnic minorities, are less likely to receive timely breast cancer diagnostic services after an abnormal screening mammogram, according to a study published today in Radiology, a journal of the Radiological Society of North America (RSNA).
February 18, 2025 — Source

Study shows ctDNA testing could revolutionize breast cancer treatment
For years, breast cancer treatment has been guided by genetic alterations found in tumor tissue, typically through invasive biopsies. However, the dynamic nature of cancer and limitations in tissue sampling have presented significant obstacles for clinicians. circulating tumor DNA (ctDNA), which is released into the bloodstream by tumor cells, offers a promising non-invasive alternative. It allows for real-time monitoring and comprehensive genetic profiling, providing new opportunities to track cancer progression and response to treatment without the need for repeated biopsies.
February 18, 2025 — Source

Toward improved early detection of pancreatic cancer
The discovery of a 'biomarker panel' could have a profound impact on the ability to identify patients at risk of developing PC at an earlier stage
February 18, 2025 — Source

Uncovering inequalities in breast cancer immunotherapy access
Triple-negative breast cancer (TNBC) is an aggressive form of the disease that accounts for 15% of all breast cancer cases. Black women are twice as likely as white women to be diagnosed with TNBC and 28% more likely to die from it.
February 18, 2025 — Source

WHO initiative provides free cancer drugs to African children
Zambia and five other low- and middle-income countries will receive free cancer medicines for children through a World Health Organization (WHO) initiative that promises to close the gap in cancer care access.
February 18, 2025 — Source

Health — Cancer — February 17th, 2025

AI-driven tool speeds up cancer diagnosis with precise cell imaging
A research team led by Professor Kevin Tsia, program director of the Biomedical Engineering Program under the Faculty of Engineering of the University of Hong Kong (HKU), has developed an AI-driven imaging tool that enables speedy and precise diagnosis of cancer patients, greatly enhancing the effectiveness of their medical treatment.
February 17, 2025 — Source

Antibody therapy shrinks immunotherapy-resistant lung cancer tumors in mice
An investigational therapy significantly shrank lung cancer tumors that are notoriously resistant to treatment by encouraging an attack from natural killer (NK) cells in an animal model, a study led by UT Southwestern Medical Center researchers shows. The findings, published in the Journal for ImmunoTherapy of Cancer, could lead to new types of immunotherapy that rely on this novel strategy.
February 17, 2025 — Source

Biomarker panel offers hope for early pancreatic cancer detection
Pancreatic cancer (PC) is the worst prognosis cancer globally, with just 13% of patients who are diagnosed with PC surviving for 5 years or more after initial diagnosis. In Ireland, there are approximately 900 cases of PC per year, and 820 PC-related deaths. Early detection of PC is the primary concern of most PC research, as it has the potential to make a substantial difference to the treatment and survival of patients.
February 17, 2025 — Source

Immune response that may stop breast cancer from spreading identified
A new Moffitt Cancer Center study has identified a specific immune response that may prevent the spread of breast cancer cells within the body. Published in Cancer Immunology Research, the study shows that activating certain immune cells can stop dormant cancer cells from growing into new tumors.
February 17, 2025 — Source

Inherited cancer risk: Large-scale screen homes in on 380 variants
Thousands of single changes in the nucleotides that make up the human genome have been associated with an increased risk of developing cancer. But until now, it's not been clear which are directly responsible for the uncontrolled cellular growth that is the hallmark of the disease and which are simply coincidences or minor players.
February 17, 2025 — Source

Light-activated dyes show promise in targeting cancer cells
Melanoma is one of the most aggressive skin cancers, with more than 300,000 new cases reported worldwide each year. In Europe, the number of diagnoses has been rising rapidly. However, early detection and advanced treatments can significantly improve survival rates.
February 17, 2025 — Source or Source

Magnetic nanocatalysts enhance tumor treatment via electronic density regulation
Cancer therapy has always struggled with targeting tumor cells effectively while minimizing damage to healthy tissue. Traditional treatments, such as chemotherapy and radiation, often lack precision and cause serious side effects. As a result, there is a growing interest in advanced nanomaterials with enhanced catalytic and therapeutic properties, such as nanocatalysts, which can improve cancer treatment through methods like chemical dynamic therapy (CDT) and photothermal therapy (PTT).
February 17, 2025 — Source

Pancreatic cancer reprograms nerve cells to fuel growth
Pancreatic cancer is fueled by connections to the nervous system. This is reported by scientists from the German Cancer Research Center (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) in their current publication in Nature. The team discovered that the tumor specifically reprograms the neurons for its own benefit. In mice, blocking nerve function inhibited cancer growth and increased the sensitivity of tumor cells to certain chemotherapies and immunotherapies.
February 17, 2025 — Source

Pancreatic cancer: Blocked nerves as a possible new treatment strategy
Pancreatic cancer is fueled by connections to the nervous system. This is reported by scientists from the German Cancer Research Center (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) in Nature.
February 17, 2025 — Source

Patient with nerve cell cancer in remission for 18 years following CAR-T therapy
A patient has achieved over 18 years of remission from neuroblastoma, a type of nerve cell cancer, following treatment with chimeric antigen receptor (CAR) T cell therapy and without requiring any additional treatments. The findings are published in Nature Medicine.
February 17, 2025 — Source

Radiation plus combination immunotherapy may help preserve bladder in some patients with cancer
Patients with localized muscle-invasive bladder cancer (MIBC) who received radiation plus the immune checkpoint inhibitors (ICIs) durvalumab (Imfinzi) and tremelimumab (Imjudo) had durable responses that allowed for bladder preservation, according to results from the IMMUNOPRESERVE clinical trial published in Clinical Cancer Research.
February 17, 2025 — Source

Scientists discover the 'roadmap' that aggressive cancer uses to spread
New research published in Nature Communications reveals how cancer cells are altered by their surroundings, enabling them to change their shape and break out of a tumor. The discovery, which is the culmination of almost a decade of research that began at King's, paves the way for treatments that will tackle cancer before it can spread.
February 17, 2025 — Source

Stanford researchers identify key variants linked to inherited cancer risk
Thousands of single changes in the nucleotides that make up the human genome have been associated with an increased risk of developing cancer. But until now, it's not been clear which are directly responsible for the uncontrolled cellular growth that is the hallmark of the disease and which are simply coincidences or minor players.
February 17, 2025 — Source

Urinary DNA methylation test shows some promise for noninvasive bladder cancer screening
Researchers led by the University of Ulsan College of Medicine, Korea, have checked the performance of a noninvasive urinary DNA methylation test for bladder cancer diagnosis.
February 17, 2025 — Source

What cancer screenings do you need? A quick guide
Cancer screenings can save lives by detecting cancer early, when treatment is most effective.
February 17, 2025 — Source

Health — Cancer — February 10th, 2025

Breast cancer's genomic architecture: A new classification system emerges
Breast cancers can be classified into subgroups that hint at the aggressiveness of the cancer and the likelihood that the patient will experience a recurrence years after their initial diagnosis.
February 7, 2025 — Source

Data indicate that pain is linked with a greater likelihood of tobacco and cannabis use among cancer survivors
Experiencing pain may increase the odds that cancer survivors will use cigarettes and cannabis, according to a study published online in Cancer. The study also found that cigarette smoking and pain are linked to more treatment-related side effects and worse health among cancer survivors.
February 7, 2025 — Source

Exploring how outdoor activities can help young cancer survivors
There are not many programmes designed for young people living with or surviving cancer. UiA and the Hospital of Southern Norway, in collaboration with international researchers, aim to explore how outdoor activities and time in nature can enhance health and quality of life.
February 7, 2025 — Source

Pain may lead to increased cigarette and cannabis use in cancer survivors
Experiencing pain may increase the odds that cancer survivors will use cigarettes and cannabis, according to a recent study published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society. The study also found that cigarette smoking and pain are linked to more treatment-related side effects and worse health among cancer survivors.
February 7, 2025 — Source

Health — Cancer — February 7th, 2025

3D bioprinting technology could lead to personalized gastric cancer treatment
A collaborative research team from POSTECH has successfully developed a gastric cancer model using 3D bioprinting technology and patient-derived cancer tissue fragments. This innovative model preserves the characteristics of actual patient tissues and is expected to rapidly evaluate and predict individual patient drug responses.
February 7, 2025 — Source

Building better biomaterials for cancer treatments
Modifying the physical characteristics of microscopic biomaterials to interact seamlessly with the body's tissues could unlock safer and more effective cancer treatments, according to Virginia Tech researchers at the Fralin Biomedical Research Institute at VTC.
February 7, 2025 — Source

Co-located cell types help drive aggressive brain tumors, study finds
A type of aggressive, treatment-resistant brain tumor has a distinct population of immune cells that support its growth, according to new research led by investigators at the Johns Hopkins Kimmel Cancer Center Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns Hopkins University School of Medicine.
February 7, 2025 — Source or Source

CoppaFeel!: Breast Cancer Doesn't Discriminate, So Why Should Awareness?
On World Cancer Day 2025, we spoke with Phoebe Lazell from CoppaFeel! about the 'Check In' campaign, which is not only encouraging young people to check their chests but also tackling the health inequities that contribute to later diagnoses in underrepresented communities.
February 7, 2025 — Source

Early screening and lifestyle changes are key to preventing cancer cases
Every minute, 38 people are diagnosed with cancer, and 18 people die from it globally, according to the World Health Organization, and it's estimated to increase by 77% to 35 million in 2050. But what if we could predict cancer risks before they even develop? Genetic testing helps detect cancer risks early, making it essential for cancer prevention and control.
February 7, 2025 — Source

Electronic reporting of symptoms by cancer patients can improve quality of life and reduce emergency visits
People with metastatic cancer who regularly report their symptoms via a home-based electronic monitoring system experienced improved quality of life, clinical outcomes and well-being, as well as fewer emergency department visits than those who didn't file reports. Both groups had similar overall survival rates, according to University of North Carolina Lineberger Comprehensive Cancer Center researchers and their colleagues.
February 7, 2025 — Source

Microglia reprogramming offers novel strategy to combat melanoma brain metastases
Brain metastases are one of the most severe complications of melanoma, the most aggressive type of skin cancer. Researchers at the Institute for Neurosciences (IN), a joint center of the Spanish National Research Council (CSIC) and the Miguel Hernández University (UMH) in Elche, have identified a strategy to slow their progression, which could improve the response to current treatments.
February 7, 2025 — Source

Pancreatic cancer immune landscape reveals opportunities for personalized therapies
Pancreatic cancer patients may benefit from future precision treatments as a new study shows how some tumors may potentially be more susceptible to macrophage-based therapies.
February 7, 2025 — Source or Source

Personalized cancer treatment using 3D bioprinting technology
Scientists have successfully developed a gastric cancer model using 3D bioprinting technology and patient-derived cancer tissue fragments. This innovative model preserves the characteristics of actual patient tissues and is expected to rapidly evaluate and predict individual patient drug responses.
February 7, 2025 — Source

Researchers discover strategy to slow brain metastases growth in melanoma
Brain metastases are one of the most severe complications of melanoma, the most aggressive type of skin cancer. Researchers at the Institute for Neurosciences (IN), a joint center of the Spanish National Research Council (CSIC) and the Miguel Hernández University (UMH) in Elche, have identified a strategy to slow their progression, which could improve the response to current treatments.
February 7, 2025 — Source

Weakness in lung cancer's defenses found—an enzyme that boosts cancer cell metabolism
Lung cancer is a particularly challenging form of cancer. It often strikes unexpectedly and aggressively with little warning, and it can shapeshift in unpredictable ways to evade treatment.
February 7, 2025 — Source

Health — Cancer — February 5th, 2025

Cancer vaccine shows promise for patients with stage III and IV kidney cancer
Researchers report that all nine patients in a clinical trial being treated for stage III or IV clear cell renal cell carcinoma (a form of kidney cancer), generated a successful anti-cancer immune response after initiation of a personalized cancer vaccine.
February 5th, 2025 — Source

Inhibiting a gene provides a new weapon to fight treatment-resistant melanoma
The lab of The Wistar Institute's Jessie Villanueva, Ph.D., has identified a new strategy for attacking treatment-resistant melanoma: inhibiting the gene S6K2. The team has published their findings in a paper titled "Selective abrogation of S6K2 identifies lipid homeostasis as a survival vulnerability in MAPKi-resistant NRAS^{MUT melanoma}" in the journal Science Translational Medicine.
February 5th, 2025 — Source

Light-activated compound offers hope for overcoming drug resistance in cancer treatment
A research team affiliated with UNIST has unveiled an innovative technology to eliminate drug-resistant cancer cells using light. Professors Tae-Hyuk Kwon and Duyoung Min from the Department of Chemistry at UNIST, alongside Professor Taiho Park from POSTECH, have created a photoreactive compound capable of suppressing autophagy in cancer cells—one of the key mechanisms contributing to resistance against anticancer therapies.
February 5th, 2025 — Source

Making informed decisions about acoustic neuroma treatment
Vestibular schwannomas, or acoustic neuromas, are noncancerous tumors that develop on the nerve leading from the inner ear to the brain.
February 5th, 2025 — Source

Mindful molecules—science is decoding the health benefits of meditation
Researchers are investigating the link between mindfulness and health, offering potential new options for the treatment and early detection of cancer.
February 5th, 2025 — Source

Molecular switch reverses cancerous transformation at the critical moment of transition
Professor Kwang-Hyun Cho's research team of the Department of Bio and Brain Engineering at KAIST has captured the critical transition phenomenon at the moment when normal cells change into cancer cells and analyzed it to discover a molecular switch hidden in the genetic network that can revert cancer cells back into normal cells.
February 5th, 2025 — Source

New study reveals how anticancer drugs enter cancer cells
A new study shows how an anticancer drug triggers an "outside in" signal that gets it sucked into a cancer cell. The work, published Jan. 29 in Nature Communications, reveals a new signaling mechanism that could be exploited for delivering other drugs.
February 5th, 2025 — Source

RAD51 biomarker could complement next-generation sequencing in personalizing prostate cancer treatment
Published in Cell Reports Medicine, results of a VHIO-led study support the feasibility of using RAD51 testing to complement next-generation sequencing (NGS) for precise patient stratification and treatment selection in metastatic prostate cancer (mPC).
February 5th, 2025 — Source

Study reveals how healthy stem cells transform into cancer cells
Nearly 60,000 people are diagnosed with oral cancer in the U.S. every year, according to the American Cancer Society, and the rate of new cases continues to rise. Now, researchers at University of California San Diego have discovered how healthy stem cells are transformed into cancer stem cells in the earliest stages of the disease.
February 5th, 2025 — Source

Three Years After Experimental Vaccine, These Patients Are Still Cancer-Free
A kidney cancer vaccine candidate has shown great promise in an early Phase I trial published this week.
February 5th, 2025 — Source

Health — Cancer — February 3rd, 2025

A more effective treatment for aggressive breast cancer: Two inhibitor drugs show potential
A national study seeking more effective treatment for deadly metaplastic breast cancer has identified two inhibitor drugs with the potential to interrupt disease progression.
February 3rd, 2025 — Source

AI-powered map of the abdomen could help find cancer early on
AI-powered map of the abdomen could help find cancer early on
February 3rd, 2025 — Source

Alarming rise in rates of advanced prostate cancer in California
The incidence of advanced prostate cancer in California rose markedly in the decade since doctors stopped routinely screening all men for the disease, according to a new study.
February 3rd, 2025 — Source

Anti-melanoma activity found in green-produced nanosilver-chlorhexidine complex
Melanoma is a fast-progressing skin cancer characterized by a high mortality rate after metastasis. Local chemotherapy could be considered a therapeutic approach only in stage 0 of progression (in situ melanoma) and in the postoperative phase after surgical removal of suspected skin lesions. For this purpose, drugs such as Imiquimod, 5-Fluorouracil, Dacarbazine, and Doxorubicin have been tested and shown positive effects.
February 3rd, 2025 — Source

At-home urine test shows high accuracy for prostate cancer screening
The results are important because this could enable at-home testing and increased access to testing for patients undergoing telehealth care or living in remote areas.
February 3rd, 2025 — Source

Breaking barriers in thioxanthone synthesis: A double aryne insertion strategy
Thioxanthones are fascinating organic compounds that have found their way into many industrial and everyday applications. In the printing industry, for example, they help inks dry faster when exposed to light thanks to their light-absorption properties, making the printing process quicker and more efficient.
February 3rd, 2025 — Source

California sees alarming rise in rates of advanced prostate cancer since routine screening stopped
The incidence of advanced prostate cancer in California rose markedly in the decade since doctors stopped routinely screening all men for the disease, according to a new study by UC San Francisco.
February 3rd, 2025 — Source

Computer model simplifies immune cell identification for lung cancer treatment
Researchers at the Johns Hopkins Kimmel Cancer Center and Bloomberg-Kimmel Institute for Cancer Immunotherapy have developed a computer model to help scientists identify tumor-fighting immune cells in patients with lung cancer treated with immune checkpoint inhibitors.
February 3rd, 2025 — Source

Contraceptive pill linked to 43% lower ovarian cancer risk for older users
It's a little pill with big responsibilities. But despite its primary role to prevent pregnancy, the contraceptive pill (the Pill) could also help reduce the risk of ovarian cancer, according to research from the University of South Australia.
February 3rd, 2025 — Source or Source

FDA approval expands earlier use of Enhertu for metastatic breast cancer
The U.S. Food and Drug Administration has approved Enhertu (trastuzumab deruxtecan) for the treatment of adult patients with unresectable or metastatic hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-low or HER2-ultralow breast cancer.
February 3rd, 2025 — Source

Green tea derived silver nanoparticles show promise against melanoma
Melanoma is a fast-progressing skin cancer characterized by a high mortality rate after metastasis. Local chemotherapy could be considered a therapeutic approach only in stage 0 of progression (in situ melanoma) and in the postoperative phase after surgical removal of suspected skin lesions. For this purpose, drugs such as Imiquimod, 5-Fluorouracil, Dacarbazine, and Doxorubicin have been tested and shown positive effects. Recently, metal nanoparticles as separate therapeutic units or drug carriers have also fallen into the research focus.
February 3rd, 2025 — Source

High-precision radiation therapy safe for patients with cancer that has spread throughout body, says study
A new Phase I clinical trial from London Health Sciences Centre Research Institute (LHSCRI) has found that high-precision radiation therapy is safe for use in patients with cancer that has spread to more than 10 spots in the body.
February 3rd, 2025 — Source

How a liver transplant helped one woman with bowel cancer become disease free
In a groundbreaking medical achievement in the U.K., a 32-year-old woman from Manchester has undergone the country's first liver transplant for advanced bowel cancer.
February 3rd, 2025 — Source

Microscopy approach offers new way to study cancer therapeutics at single-cell level
Understanding how tumors change their metabolism to resist treatments is a growing focus in cancer research. As cancer cells adapt to therapies, their metabolism often shifts, which can help them survive and thrive despite medical interventions. This process, known as metabolic reprogramming, is a key factor in the development of treatment resistance.
February 3rd, 2025 — Source

No evidence that CAR T cell therapy causes secondary cancers, large study shows
Within a large group of more than 700 patients treated with CAR T cell therapy, researchers found no evidence that the therapy itself caused any type of secondary cancer in the modified T cells, according to new analysis reported today in Nature Medicine from the Perelman School of Medicine at the University of Pennsylvania and Penn Medicine's Abramson Cancer Center.
February 3rd, 2025 — Source

Prostate cancer incidence rises in California following screening guideline change
Following a change in screening guidelines, the incidence went up across the state, even more than it has nationally.
February 3rd, 2025 — Source

Researchers develop model to identify tumor-fighting immune cells in lung cancer patients
Researchers at the Johns Hopkins Kimmel Cancer Center and Bloomberg~Kimmel Institute for Cancer Immunotherapy have developed a computer model to help scientists identify tumor-fighting immune cells in patients with lung cancer treated with immune checkpoint inhibitors.
February 3rd, 2025 — Source

Researchers discover key to boosting thymus regeneration after damage
A team of international researchers led by scientists at City of Hope, one of the largest and most advanced cancer research and treatment organizations in the United States, with its National Medical Center in Los Angeles ranked among the nation's top 5 cancer centers by U.S. News & World Report, have demonstrated a way to boost thymic function after damage in preclinical studies. The team's study results, published today in the journal Immunity, outline their discovery of a specific type of regulatory T cell that can home back into the thymus and repair the organ when it's damaged.
February 3rd, 2025 — Source

Researchers uncover mechanisms of initiation and progression in basal cell carcinoma
An international team, co-led by Adriana Sánchez-Danes, principal investigator of the Cancer and Stem Cell Biology Lab at the Champalimaud Foundation, in Lisbon, has shown for the first time the important role of Survivin—a protein that has key roles in regulating cell division and inhibiting apoptosis (programmed cell death)—in the initiation and formation of a basal cell carcinoma, the most common human skin cancer. Their results have now been published in Cancer Discovery.
February 3rd, 2025 — Source

Screening device detecting lung cancer biomarkers shows promise for early lung cancer detection
Scientists have created a new low-cost, fast response sensor to detect lung cancer biomarkers, paving the way for the development of screening devices to spot the disease even before symptoms occur. Similar in design to glucose monitoring devices, the sensor provides results from a blood sample in just 40 minutes. The technology has the potential to be used by clinicians to both identify patients at higher risk of lung cancer, and tailor treatments for those already diagnosed in a "precision medicine" approach.
February 3rd, 2025 — Source

Study adds to evidence that mobile phones are not associated with cancer
A World Health Organization (WHO)-commissioned systematic review published in Environment International finds no association between radio wave exposure and various cancers including leukemia, lymphoma, thyroid and oral cavity cancers.
February 3rd, 2025 — Source

Study reveals mechanism behind CAR molecule transfer in cancer therapy
Engineered immune cells called CAR-T cells are used in the treatment of cancer. Researchers from Uppsala University have now discovered that CAR molecules can be transferred from the CAR-T cells to other T cells in the tumor microenvironment. The researchers also pinpoint how this transfer is regulated, which may be used to improve the efficacy of CAR-T cell therapy. The study has been published in the journal Science Immunology.
February 3rd, 2025 — Source

The CAR T Veteran: A Journey of Resilience, Remission, and Advocacy
Laurie Adami has an extraordinary story. After a 12-year battle with stage IV Follicular Non-Hodgkin Lymphoma, Laurie found her path to remission through a groundbreaking CAR T-cell therapy trial. In this interview, she shares her journey from patient to advocate, her insights into the life-changing potential of CAR-T, and her mission to empower others facing similar battles. Laurie's story is one of survival, advocacy, and unwavering commitment to raising awareness for transformative cancer treatments.
February 3rd, 2025 — Source

The gut-brain connection in Alzheimer's unveiled with X-rays
Scientists led by the Institute of Nanotechnology in Italy, in collaboration with the ESRF, the European Synchrotron in Grenoble, France, have discovered how X-ray micro- and nano- tomography can provide clues on the processes that link the gut neurons with those in the brain and may trigger Alzheimer's.
February 3rd, 2025 — Source

Thirdhand smoke lingers in homes, posing hidden health risks for years
You likely know about the health risks associated with smoking, probably even secondhand smoke, but have you heard of thirdhand smoke? The threat of thirdhand smoke is very similar to that of secondhand smoke, with increased risk of heart disease, stroke, respiratory disease and lung cancer.
February 3rd, 2025 — Source

Health — Cancer — January 24th, 2025

A therapeutic HPV vaccine could eliminate precancerous cervical lesions, clinical trial suggests
"Nearly all premalignant cervical lesions and cervical cancers are caused by HPV infection, with HPV16 implicated in the majority of cases," said Refika Yigit, MD, principal investigator and oncological gynecologist at University Medical Center Groningen in the Netherlands.
January 24th, 2025 — Source

An Open Microfluidic Model for Tumor Cell-ECM Interactions and Anti-Metastasis Testing
A recent article in Small highlights a new method for studying tumor cell interactions and testing anti-metastatic drugs through the development of an Under-oil Open Microfluidic System (UOMS). This innovative model bridges top-down and bottom-up approaches to offer a more comprehensive way to investigate tumor behavior in a controlled environment.
January 24th, 2025 — Source

Dissolving clusters of cancer cells to prevent metastases
Successful test in breast cancer patients: the active agent digoxin, a cardiac medication, dissolves clusters of circulating breast cancer cells in the blood, thus reducing the risk of metastases formation.
January 24th, 2025 — Source or Source or Source

HPV16 vaccine shows promise in treating precancerous cervical lesions
A therapeutic vaccine targeting human papillomavirus type 16 (HPV16) induced regression in high-grade precancerous cervical lesions, according to the results from a phase II clinical trial published in Clinical Cancer Research, a journal of the American Association for Cancer Research.
January 24th, 2025 — Source

Lower dexamethasone dose does not impair survival in multiple myeloma
For patients with newly diagnosed multiple myeloma (NDMM) receiving dexamethasone induction, dose reductions do not negatively impact survival, according to a study published online Jan. 2 in Blood.
January 24th, 2025 — Source

Peptide-coated nanoparticles achieve 98% drug loading, improving cancer treatment
A team of scientists has developed a groundbreaking approach using specially designed peptides to improve drug formulations. This innovative method significantly enhances anti-tumor efficacy, as demonstrated in leukemia models. The study, published in the journal Chem, was led by researchers at the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) and Memorial Sloan Kettering Cancer Center.
January 24th, 2025 — Source

Proof-of-concept study dissolves clusters of breast cancer cells to prevent metastases
Certain tumor types do not remain at their point of origin but spread throughout the body and form metastases. This is because the primary tumor continuously releases cancer cells into the blood. These circulating tumor cells (CTCs) can join together into small clusters of up to a dozen cells and settle in other organs.
January 24th, 2025 — Source

Researchers are developing personalized vaccines that target cancer tumors
Vaccines are helpful in protecting against the flu and COVID-19, but could they also play a role in the fight against cancer? Imagine a future where every cancer treatment is personalized to each patient, precisely targeting their unique cancer cells.
January 24th, 2025 — Source

Researchers pinpoint keys to cell therapy response for leukemia
Dana-Farber Cancer Institute researchers have identified factors that determine whether donor lymphocyte infusion (DLI), a standard therapy for patients with acute myeloid leukemia (AML) who have relapsed after allogenic hematopoietic stem cell transplant, will successfully move the patient into remission. The team identified that a key cell type in the DLI product and features of the tumor microenvironment in patients both play a role.
January 24th, 2025 — Source

Researchers pioneer DNA-tagged gold nanoparticles for targeted cancer treatment
A team of researchers from the National University of Singapore (NUS) has developed a novel method to enhance the precision of cancer treatment using gold nanoparticles tagged with DNA barcodes.
January 24th, 2025 — Source or Source

Researchers uncover principles of gene expression regulation in cancer and cellular functions
A research team at KAIST has identified the core gene expression networks regulated by key proteins that fundamentally drive phenomena such as cancer development, metastasis, tissue differentiation from stem cells, and neural activation processes. This discovery lays the foundation for developing innovative therapeutic technologies.
January 24th, 2025 — Source

Study reveals novel insights into the molecular pathology of esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with poor prognosis, and understanding the molecular mechanisms underlying its progression is crucial for developing effective therapies.
January 24th, 2025 — Source

Study unveils key immune cells found to boost cancer treatment success in acute myeloid leukemia
New computational tool aims to identify immune responses to cellular therapy in AML treatments
January 24th, 2025 — Source

Targeting potassium channel shows promise for treating brain tumors
Researchers find blocking the KCNB2 gene can slow tumor growth, paving the way for next-gen treatments for childhood brain cancer.
January 24th, 2025 — Source or Source

Tool gives more accurate estimates of recurrence risk and individual chemotherapy benefit in node-positive breast cancer
A new statistical tool that combines multiple clinical and pathologic factors with a patient's 21-gene Oncotype DX Breast Recurrence Score result provides more accurate estimates about that patient's breast cancer prognosis and their potential benefit from chemotherapy than either the Recurrence Score result or clinical factors alone.
January 24th, 2025 — Source

Using AI to predict the after-effects of brain tumor surgery
Patients with a glioma, a type of malignant brain tumor, can suffer from cognitive problems after surgery. However, the true effect of surgery on complex cognitive tasks is not known. To predict the effects of surgery on cognitive tasks, Ph.D. researcher Lars Smolders developed an AI model that utilizes information about neural connections in the brain extracted from the patient's MRI images before surgery.
January 24th, 2025 — Source

Health — Cancer — January 22nd, 2025

$2.5 Million Grant Awarded to Indiana University School of Medicine, Beckman Coulter Life Sciences to Expand Leukemia and Lymphoma Testing in Africa
Beckman Coulter Life Sciences, a global leader in laboratory automation and innovation, along with the Indiana University School of Medicine, have been awarded a prestigious grant from the National Cancer Institute totaling $2.5 million over a five-year period to increase critical leukemia and lymphoma testing access in Western Kenya.
January 22nd, 2025 — Source

Biomarker algorithm for Barrett's esophagus and esophageal cancer developed
By studying biomarkers known to be involved in gastrointestinal cancers, researchers at the Johns Hopkins Kimmel Cancer Center and the Johns Hopkins University School of Medicine have developed a biomarker algorithm that, when combined with a noninvasive method to collect esophageal cells for study, could give clinicians insight into which patients [SJMM1] have esophageal cancer or precancerous conditions such as Barrett's esophagus (BE) or high-grade dysplasia.
January 22nd, 2025 — Source

Colon cancer screening: Weighing the options
Colon cancer screening is an important part of routine health care. If you're not sure which colon cancer screening test is best for you, ask yourself these questions.
January 22nd, 2025 — Source

Copper-detection tool discovers possible chelation target for lung cancer
The Chang Lab at Princeton Chemistry continues in its mission to elucidate the role of metal nutrients in human biology: last year, iron; this year, copper. The lab's first paper of 2025 showcases its development of a revelatory sensing probe for the detection of copper in human cells and then wields it to uncover how copper may be regulating cell growth in lung cancer.
January 22nd, 2025 — Source

Drug candidate eliminates breast cancer tumors in mice in a single dose
Despite significant therapeutic advances, breast cancer remains a leading cause of cancer-related death in women. Treatment typically involves surgery and follow-up hormone therapy, but late effects of these treatments include osteoporosis, sexual dysfunction and blood clots.
January 22nd, 2025 — Source

Injectable supramolecular hydrogel shows promise for neoadjuvant immunotherapy of triple-negative breast cancer
The efficacy of immunotherapy against triple-negative breast cancer (TNBC) heavily relies on intratumoral infiltration of cytotoxic T lymphocytes (CTLs). Although neoadjuvant chemotherapy together with immunotherapy has been approved for advanced TNBC, its efficacy is still unsatisfactory, possibly due to systemic treatment-induced lymphatic system disorders and upregulation of additional immune checkpoints in the tumors.
January 22nd, 2025 — Source

Melanoma study identifies a mechanism for eliminating harmful cells from cancer treatment
After treating a tumor with chemotherapy and radiotherapy, cells known as senescent cells can appear. These are cells that do not divide, are involved in the aging process, and are resistant to cell death, but are still metabolically active in the human body. When they accumulate, they can jeopardize the patients' recovery. Now, a UB-led study describes for the first time a molecular mechanism that could drive the design of strategies to eliminate senescent cells in cancer patients.
January 22nd, 2025 — Source

MRI for dense breasts: What to know
Nearly half of all women who have had a mammogram to screen for breast cancer have been identified as having dense breasts. This makes it more challenging to detect breast cancer because dense tissue and tumors both appear white on a mammogram. That's one reason why it's recommended to have an additional screening done. But which one?
January 22nd, 2025 — Source

Single dose of novel drug shows tumor-clearing potential in breast cancer models
Despite significant therapeutic advances, breast cancer remains a leading cause of cancer-related death in women. Treatment typically involves surgery and follow-up hormone therapy, but late effects of these treatments include osteoporosis, sexual dysfunction and blood clots. Now, researchers reporting in ACS Central Science have created a novel treatment that eliminated small breast tumors and significantly shrank large tumors in mice in a single dose, without problematic side effects.
January 22nd, 2025 — Source

Small cell lung cancer: Facts about the disease
There are two main types of lung cancer: small cell and non-small cell. According to the American Cancer Society, non-small cell lung cancer is often categorized in one of two stages: limited or extensive.
January 22nd, 2025 — Source

Study offers insight into how senescent cells survive after cancer treatment
After treating a tumor with chemotherapy and radiotherapy, cells known as senescent cells can appear. These are cells that do not divide, are involved in the aging process and are resistant to cell death, but are still metabolically active in the human body. When they accumulate, they can jeopardize the patients' recovery. Now, a UB-led study describes for the first time a molecular mechanism that could drive the design of strategies to eliminate senescent cells in cancer patients.
January 22nd, 2025 — Source

Virtual reality and hypnosis bring relief for patients with blood cancer
In a room at Maisonneuve-Rosemont Hospital in Montreal, a patient puts on a virtual reality (VR) headset. Bright bubbles float slowly up and down before his eyes while soothing sounds play in the background.
January 22nd, 2025 — Source

Health — Cancer — January 20th, 2025

Algorithm to spot cancer warning signs in standard blood tests to be used by EU's NHS
Scientists at the University of Exeter have found a new way of interpreting standard blood tests to help GPs spot cancer warning signs—and the test is now being integrated in an NHS trust.
January 20th, 2025 — Source

Bullying linked to anxiety, depression in teens, study reveals
A major new study by experts from The University of Manchester has found that bullying has a significant negative impact on the mental health of teenagers—particularly for boys—and has highlighted the need for more effective prevention strategies in schools.
January 20th, 2025 — Source

Clinical trial finds no benefit from aspirin in preventing colorectal cancer recurrence
A new international clinical trial led by the National Cancer Center Singapore is reporting that three years of aspirin following standard adjuvant therapy for high-risk Dukes' B and C colorectal cancer did not yield a significant advantage in preventing disease recurrence.
January 20th, 2025 — Source

GaToroid: Getting closer to affordable cancer hadron therapy
Hadron therapy is a state-of-the-art radiotherapy technique that uses proton or ion beams to target tumoral cells, while sparing surrounding healthy tissues from unwanted radiation. To achieve best results, it requires complex systems, called gantries, that rotate around the patient, carrying magnets that guide the hadron beams precisely onto tumors. Unfortunately, these are usually massive and costly machines, which represent a limiting factor for the spread of the treatment technique.
January 20th, 2025 — Source

New imaging technique improves precision in bladder cancer surgery
Bladder cancer is one of the most common malignant tumors in urinary system, and the treatment faces huge challenges. Radical cystectomy (RC) is the primary treatment for invasive cases, yet the prognosis remains grim due to lymph node metastasis. Pelvic lymph node dissection (PLND) plays a vital role in improving survival rates and optimizing treatment strategies. Despite its importance, the methods and scope of PLND remain contentious, and the procedure itself may be difficult with risks of damaging nearby organs and nerves. These challenges highlight the urgent need for more precise surgical techniques in PLND.
January 20th, 2025 — Source

New study paves way for immunotherapies tailored for childhood cancers
Researchers at Karolinska Institutet and the Astrid Lindgren Children's Hospital in Sweden have determined how children's immune systems react to different kinds of cancer depending on their age.
January 20th, 2025 — Source or Source

Study reveals how children's immune systems react to cancer
Researchers at Karolinska Institutet and the Astrid Lindgren Children's Hospital in Sweden have determined how children's immune systems react to different kinds of cancer depending on their age. The study, which is published in the journal Cell, reveals significant differences between the immune response of children and adults, and has the potential to lead to new tailored treatments for children with cancer.
January 20th, 2025 — Source

Health — Cancer — January 17th, 2025

Children with congenital heart defects found to have poorer survival following cancer diagnosis
For children battling both congenital heart defects (CHD) and cancer, the road to recovery is far more precarious than previously understood, according to a study published in the Journal of the National Cancer Institute.
January 17th, 2025 — Source

Clinical trial advances research in treatment of biliary tract cancers
The results of a clinical trial led by researchers at the University of Arizona Health Sciences and published in the Journal of Clinical Oncology show that chemotherapy combining three different types of drugs did not improve overall survival for patients with advanced stage, inoperable biliary tract cancers.
January 17th, 2025 — Source

Drug-discovery platform for high-risk leukemias in children shows promising results
Targeted therapies for high-risk leukemia in children have yet to be developed, but scientists at Universite de Montreal and its affiliated Institute for Research in Immunology and Cancer are working on a large-scale drug discovery project to get there.
January 17th, 2025 — Source

FDA approves marketing of nicotine pouches
Following an extensive scientific review, the U.S. Food and Drug Administration has authorized the marketing of 20 ZYN nicotine pouch products. Nicotine pouches—small synthetic fiber pouches containing nicotine—are designed to be placed between a person's gum and lip.
January 17th, 2025 — Source

Inflammasome proteins found to prevent cancer by regulating stem cells
A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer gene activity, according to a preclinical study by Weill Cornell Medicine investigators.
January 17th, 2025 — Source

Interdisciplinary research lays groundwork for predicting if bone cancer will spread
Bone pain. Joint pain. Bone swelling. These are symptoms that about 1,000 people in the United States begin to feel each year shortly before being diagnosed with osteosarcoma, a type of cancer that starts in the bones. Although any age can develop osteosarcoma, approximately half of diagnosed cases are in children and adolescents.
January 17th, 2025 — Source

Key enzyme identified as potential target for cancer immunotherapy
Scientists from A*STAR Genome Institute of Singapore (A*STAR GIS) have uncovered that a key enzyme—P4HA1 prolyl hydroxylase, is strongly induced in CD8+ T cells in solid cancer, the primary immune cells involved in combating cancer. P4HA1 causes disruptions in energy production within the cells, which leads to weaker immune cells that are less able to fight cancer and form long-lasting anti-cancer immunity, highlighting P4HA1 as a promising target for treating solid tumors.
January 17th, 2025 — Source

More cancer, less death? New alcohol-risk reviews offer conflicting takeaways
Two big, somewhat conflicting studies on alcohol risks will influence new guidelines.
January 17th, 2025 — Source

New clinical trial aims to extend survival for bile duct cancer patients
A new clinical trial, sponsored by UCL and UCLH, aims to extend survival for some patients with cancer in the biliary tract by treating them with therapies specifically tailored to the genetic profile of their tumor.
January 17th, 2025 — Source

Phase 2 results suggest continued study of novel first-line combo for advanced kidney cancer
In the open-label phase 2 LITESPARK-003 study, led by Dana-Farber Cancer Institute's Toni Choueiri, MD, researchers investigated for the first time the combination of cabozantinib, an anti-angiogenic agent, plus belzutifan, a first-in-class HIF-2α inhibitor. The findings are published in The Lancet Oncology journal.
January 17th, 2025 — Source

Unraveling the impact of solid tumor dissociation methods
Cancer remains one of the most complex diseases, with its diverse molecular profiles and cellular compositions posing significant challenges for treatment. Traditional methods of cancer research, such as two-dimensional cell cultures and animal models, often fail to capture the full complexity of human cancers, particularly the three-dimensional structures and microenvironmental interactions of solid tumors.
January 17th, 2025 — Source

Health — Cancer — January 13th, 2025

Bowel cancer is on the rise in those under 50. Here's what might explain the trend
Almost 2 million people are diagnosed with bowel cancer each year. Also known as colorectal cancer, it's the third most common cancer worldwide.
January 13th, 2025 — Source

Cell-free biosensors combine precision and simplicity for cancer detection
Georgia Tech researchers have developed biosensors with advanced sleuthing skills and the technology may revolutionize cancer detection and monitoring.
January 13th, 2025 — Source

Discovery of Semliki Forest virus's brain entry route opens new avenues for tumor treatment
In a recent study, researchers from Uppsala University have shown that the Semliki Forest virus enters the central nervous system by first entering the cerebrospinal fluid and then binding to a specific cell type before penetrating deeper into the brain. This finding could potentially be used to develop the Semliki Forest virus as an agent for treating brain cancer.
January 13th, 2025 — Source

DNA repair pathways reveal how tumor cells die after radiotherapy
Scientists at Children's Medical Research Institute (CMRI) have solved a big mystery in cancer research—why cells die in different ways following radiotherapy. This surprising finding opens up new opportunities to improve treatment and increase cure rates.
January 13th, 2025 — Source

Drugmaker GSK buys US firm focused on gastro cancer
British pharmaceutical company GSK on Monday said it had agreed to buy a US company that specializes in the treatment of rare gastrointestinal cancer GIST.
January 13th, 2025 — Source

Even one drink a day elevates your cancer risk—an expert breaks down a new government report
Many people use the new year to reflect on their relationship with alcohol. Just-released government guidelines are giving Americans another reason to consider a "dry January."
January 13th, 2025 — Source

Fewer delays, more launches of cancer drugs found in higher income countries
The development of new drugs is critical in treating cancer—if people have access to them. A team co-led by Penn State researchers identified cancer drugs launched between 1990 and 2022 and found that counties with higher gross national income per capita typically had more launches and shorter launch delays.
January 13th, 2025 — Source

Inflammasome protects stem cells from becoming cancerous
A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer gene activity, according to a preclinical study by Weill Cornell Medicine investigators.
January 13th, 2025 — Source

New book provides recommendations for addressing cancer among Latinos
With cancer still rising in the U.S. Latino population, leaders at The University of Texas Health Science Center at San Antonio (UT Health San Antonio) and national cancer experts have published an online book with innovative recommendations to reduce Latino cancer.
January 13th, 2025 — Source

New device shows promise in early oral cancer detection tests
A prototype of a new oral cancer diagnosis device, developed by the University of Liverpool, has demonstrated promising results during preliminary tests on histopathology specimens.
January 13th, 2025 — Source

New research sheds light on changing liver cancer trends
Liver cancer is a leading cause of cancer-related deaths worldwide, with distinct geographic patterns in its incidence. In particular, China bears a disproportionate share of the global burden. The disease is strongly associated with chronic infections from hepatitis B and C, alcohol use, and increasingly, metabolic disorders like non-alcoholic fatty liver disease (NAFLD). As obesity rates continue to rise, the progression to liver cancer becomes an even more pressing concern. Given these challenges, urgent research is needed to understand how these risk factors are shifting, particularly in China, where liver cancer rates remain alarmingly high.
January 13th, 2025 — Source

New test could predict lung cancer outcomes using tumor DNA
Scientists from the Francis Crick Institute, UCL, UCLH and Personalis have found that a test to detect circulating tumor DNA can predict lung cancer outcome in a Cancer Research UK-funded study.
January 13th, 2025 — Source

Novel Nanoplatform for Enhanced Cancer Photoimmunotherapy
In a recent Light Science & Applications article, researchers addressed a significant challenge in cancer therapy: the immunosuppressive microenvironment and the low immunogenicity of tumor cells, often leading to inadequate therapeutic outcomes.
January 13th, 2025 — Source

Obesity at cancer diagnosis linked to higher risk of death in children
A recent population-based study indicates that among children with cancer, those with obesity at the time of diagnosis may face an elevated risk of dying. The findings are published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society.
January 13th, 2025 — Source

ORACLE test enhances prediction of lung cancer outcomes
A new test, developed by researchers from UCL Cancer Institute and the Francis Crick Institute, can better predict lung cancer survival at the point of diagnosis, which could inform treatment decisions and potentially reduce the risk of the cancer returning or spreading.
January 13th, 2025 — Source

Powered by machine learning, a new blood test can enable early detection of multiple cancers
Oxford University researchers have unveiled a new blood test, powered by machine learning, that shows promise in detecting multiple types of cancer in their earliest stages, when the disease is hardest to detect.
January 13th, 2025 — Source

RAD51 testing shows promise in personalized early breast cancer treatment
Published in Clinical Cancer Research, results of a VHIO-led study underscore the potential of the RAD51 biomarker in tailoring treatment strategies in patients with early breast cancer.
January 13th, 2025 — Source

Scientists discover why cancer cells die differently after radiotherapy
Scientists at Children's Medical Research Institute (CMRI) have solved a big mystery in cancer research -- why cells die in different ways following radiotherapy. This surprising finding opens up new opportunities to improve treatment and increase cure rates.
January 13th, 2025 — Source

Seeing eye to eye: Building a cost-effective tool to visualize cancer
Cutting-edge surgical tools are often made with state-of-the-art technology, which can limit their overall accessibility. In an effort to expand surgical options for tumor removal, a team is developing a compact fluorescence-guided surgery system crafted from cost-effective, off-the-shelf components, an advance that could significantly reduce costs compared with current commercially available approaches.
January 13th, 2025 — Source

Study finds no elevated risk of thyroid cancer among GLP1-RA users
A study has found no evidence that glucagon-like peptide 1 receptor agonist (GLP1-RA) use is associated with an increased risk of thyroid cancer.
January 13th, 2025 — Source

Study finds obesity affects children's likelihood of survival after being diagnosed with cancer
A population-based study indicates that among children with cancer, those with obesity at the time of diagnosis may face an elevated risk of dying. The findings are published online in Cancer.
January 13th, 2025 — Source

Three-drug cocktail shows potential to boost CAR-T cancer therapy
Preclinical research findings from the University of North Carolina Lineberger Comprehensive Cancer Center have identified a cocktail of three different drugs that can be used to generate more robust immune system CAR-Ts (chimeric antigen receptor-T cells) to fight cancer. This finding may have a significant impact on improving the production of CAR-T cells for clinical use.
January 13th, 2025 — Source

Health — Cancer — January 10th, 2025

A battle of rafts: How molecular dynamics in CAR T cells explain their cancer-killing behavior
A study published in Science Advances shares new insights into how two of the most common types of chimeric antigen receptor (CAR) T cells kill cancer.
January 10th, 2025 — Source

AI can enhance cervical cancer detection with medical image recognition
Cervical cancer remains a major health threat for women globally, with the highest incidence in developing nations. Despite the availability of preventive measures, challenges such as limited health care resources and inadequate screening programs continue to undermine global efforts to eliminate the disease.
January 10th, 2025 — Source

Air pollution emerges as a growing concern in risk factors linked to lung cancer deaths
Even though lung and related cancer deaths decreased in the world's 10 most populous countries from 1990 to 2019, these positive statistics do not address trends in mortality linked to tobacco use, air pollution and asbestos exposure. Those areas need ongoing policy measures and research to further reduce deaths, according to a new study from researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, and collaborating organizations.
January 10th, 2025 — Source

Breakthrough microscopy technique reveals how antibodies target cancer cells
In blood cancers such as chronic lymphocytic leukemia, B cells of the immune system multiply uncontrollably. One form of therapy involves labeling the CD20 protein on the surface of the B cells with customized antibodies. This triggers a chain of immunological reactions and ultimately leads to the destruction of the cancer cells.
January 10th, 2025 — Source

Dairy products linked to lower colorectal cancer risk, thanks to calcium
Strong links between calcium intake and reduced cancer risk, alongside genetic insights into milk consumption and its protective effects
January 10th, 2025 — Source

'Explant' technique predicts a tumor's responsiveness to breast cancer treatment
Cancer researchers at the University of Leicester have developed a technique that could predict how well some breast cancer patients will respond to chemotherapy and antibody-directed cancer treatments.
January 10th, 2025 — Source

Lung cancer trial reveals 40% drop in deaths using biomarker testing
New research from the University of St Andrews School of Medicine has found that biomarker testing in individuals at risk of lung cancer led to a major reduction in deaths.
January 10th, 2025 — Source

Machine learning reveals why cancer trials fall short in real-world patients
TrialTranslator uncovers the survival gap for high-risk patients and offers a path to better cancer research.
January 10th, 2025 — Source

New drug for prostate cancer patients in clinical trials
Prostate cancer that has become resistant to hormone therapy could be treated using a new drug that is currently in clinical trials for ovarian and bile duct cancer, according to research published in the journal Clinical Cancer Research.
January 10th, 2025 — Source

Study reveals cost differences between Medicare Advantage and traditional Medicare patients in cancer drugs
A new study examining the use of high-cost drugs among patients with colorectal cancer and non-small cell lung cancer found those insured through Medicare Advantage received less expensive cancer drugs compared to others on Traditional Medicare.
January 10th, 2025 — Source

Super-resolution microscopy shows how therapeutic antibodies work against cancer cells
In blood cancers such as chronic lymphocytic leukemia, B cells of the immune system multiply uncontrollably. One form of therapy involves labeling the CD20 protein on the surface of the B cells with customized antibodies. This triggers a chain of immunological reactions and ultimately leads to the destruction of the cancer cells.
January 10th, 2025 — Source

Tongue cancer organoids reveal secrets of chemotherapy resistance
Oral cancer is an increasingly prevalent disease worldwide, with over 300,000 new cases diagnosed each year. Among oral cancers, tongue cancer (TC) is the most common type and often carries a poor prognosis.
January 10th, 2025 — Source

Why new precision oncology treatments benefit patients of some ancestries more than others
Nearly half of all new cancer drugs approved by the U.S. Food and Drug Administration (FDA) over the past quarter-century have received that approval based on their ability to target genetic changes driving tumor growth.
January 10th, 2025 — Source

Health — Cancer — January 9th, 2025

AI platform identifies which patients are likely to benefit most from a cancer clinical trial
A study led by Winship Cancer Institute of Emory University and Abramson Cancer Center of the University of Pennsylvania researchers demonstrates that a first-of-its-kind platform using artificial intelligence (AI) could help clinicians and patients assess whether and how much an individual patient may benefit from a particular therapy being tested in a clinical trial.
January 9th, 2025 — Source

Alcohol raises colorectal cancer risk while calcium protects, study finds
Researchers from the Cancer Epidemiology Unit at the University of Oxford, along with collaborators from international institutions, found significant associations between diet and colorectal cancer risk. Examining data from 542,778 women in the United Kingdom, the study identified a positive correlation between alcohol consumption and colorectal cancer and a protective role for calcium and dairy-related foods.
January 9th, 2025 — Source

Clinical trial shows 'Shared Care' model safe for patients after donor stem cell transplant
Patients undergoing a donor stem-cell transplant for leukemia or other blood-related cancer require months of specialized follow-up care, traditionally delivered at the center where they received their transplant—often a serious challenge for those who live far away. A large clinical trial by Dana-Farber Cancer Institute investigators shows that patients can fare just as well when they receive some of this care at a local hematology/oncology clinic.
January 9th, 2025 — Source

Combination treatment for liver cancer significantly improves progression-free survival in global trial
Researchers at Mount Sinai have made a breakthrough in treating a type of liver cancer called hepatocellular carcinoma (HCC). This research, led by Josep M. Llovet, MD, Ph.D., Professor of Medicine (Liver Diseases) at the Icahn School of Medicine at Mount Sinai, tested a combination of treatments that could help patients live longer without their cancer getting worse.
January 9th, 2025 — Source

Drug resistance study reveals mechanisms that enable lung cancer recurrence
A recent study uncovers how drug-resistant cancer cells induce changes in the tumor microenvironment. This phenomenon promotes cancer recurrence and explains why initially effective targeted therapies can lose their efficacy over time.
January 9th, 2025 — Source

Inhalable therapy uses mussel-inspired nanoparticles to target lung cancer cells
Researchers from POSTECH and Kyungpook National University have developed a novel inhalable therapeutic delivery system for lung cancer, leveraging mucoadhesive protein nanoparticles inspired by the adhesive properties of marine mussels.
January 9th, 2025 — Source

Interdisciplinary research lays groundwork for predicting if bone cancer will spread
Bone pain. Joint pain. Bone swelling. These are symptoms that about 1,000 people in the United States begin to feel each year shortly before being diagnosed with osteosarcoma, a type of cancer that starts in the bones. Although any age can develop osteosarcoma, approximately half of diagnosed cases are in children and adolescents.
January 9th, 2025 — Source

Kidney cancer study identifies factors for exceptional response to immunotherapy
Metastatic clear cell renal cell carcinoma (mccRCC), an aggressive type of kidney cancer, has historically presented limited treatment options. Immune checkpoint inhibitors, a form of immunotherapy, can lead to exceptional, durable responses (when the tumor substantially shrinks for a very long period of time) for some patients with mccRRC, allowing them to live longer with a better quality of life. However, the molecular reasons behind these exceptional responses have not been well defined.
January 9th, 2025 — Source

New test predicts lung cancer survival better than current standards
Researchers at the Francis Crick Institute, the UCL Cancer Institute and UCLH have shown that a test called ORACLE can predict lung cancer survival at the point of diagnosis better than currently used clinical risk factors. This could help doctors make more informed treatment decisions for people with stage 1 lung cancer, potentially reducing the risk of the cancer returning or spreading.
January 9th, 2025 — Source

New tool puts reproductive risk for BRCA carriers into perspective
"I just wish someone had told me this was a possibility." Kara Maxwell distinctly remembers the moment she heard those words eight years ago from the mother of a child with Fanconi anemia (FA). Maxwell met her at a conference focused on the rare, recessive genetic bone marrow disorder that causes myriad medical challenges, including childhood cancer. While survival is improving, the average lifespan for FA is currently only 20 to 30 years.
January 9th, 2025 — Source

Nonadherence to cancer screening varies by screening type
Ami E. Sedani, Ph.D., M.P.H., from the University of Texas Health Sciences Center at Houston, and colleagues examined the associations between individual-level social risks and nonadherence to guideline-recommended cancer screenings in a cross-sectional study using 2022 Behavioral Risk Factor Surveillance System data from 39 U.S. states and Washington, D.C.
January 9th, 2025 — Source

ORACLE lung cancer test predicts survival in early stages better than current methods
Researchers at the Francis Crick Institute, the UCL Cancer Institute and UCLH have shown that a test called ORACLE can predict lung cancer survival at the point of diagnosis better than currently used clinical risk factors. This could help doctors make more informed treatment decisions for people with stage 1 lung cancer, potentially reducing the risk of the cancer returning or spreading.
January 9th, 2025 — Source

Scientists reveal genetic drivers of metastasis across multiple cancer types
Cancer metastasis—the spread of cancer to other organs—is the leading cause of death among cancer patients. Researchers have now uncovered a "genetic signature" of 177 genes shared across multiple cancer types that drives this deadly process.
January 9th, 2025 — Source

Study links fiber consumption to epigenetic changes with anti-cancer effects
Fiber is well known to be an important part of a healthy diet, yet less than 10% of Americans eat the minimum recommended amount. A new study from Stanford Medicine might finally convince us to fill our plates with beans, nuts, cruciferous veggies, avocados and other fiber-rich foods. The research, which will be published in Nature Metabolism on Jan. 9 identified the direct epigenetic effects of two common byproducts of fiber digestion and found that some of the alterations in gene expression had anti-cancer actions.
January 9th, 2025 — Source

Talquetamab plus teclistamab shows promise in multiple myeloma
For patients with relapsed or refractory multiple myeloma, talquetamab plus teclistamab shows response in a high percentage of patients and a higher incidence of grade 3 or 4 infections than with either therapy alone, according to a study published in the New England Journal of Medicine.
January 9th, 2025 — Source

Health — Cancer — January 8th, 2025

AI improves mammography cancer detection rates in large cohort study
An observational, multicenter, real-world study conducted at 12 screening sites in Germany has reported a 17.6% higher cancer detection rate among women aged 50--69 who received AI-supported double-reading mammography screenings compared to those who received standard double-reading. Recall rates remained unchanged.
January 8th, 2025 — Source

AI-guided endoscope offers real-time precision during cancer surgery
An interdisciplinary research team in Jena, Germany, has developed an innovative endoscope that can precisely identify and selectively remove tumor tissue in real time during surgery.
January 8th, 2025 — Source

Disparities in 36 cancers across 185 countries, says secondary analysis of global cancer statistics
Cancer remains a significant public health challenge, with the GLOBOCAN 2020 report estimating a staggering 19.3 million new cancer cases and 10 million cancer-related deaths globally. This burden is anticipated to escalate due to population growth, aging, and adoption of cancer-causing lifestyles and behaviors.
January 8th, 2025 — Source

End-of-life care can be more aggressive for cancer patients with defibrillators
Patients with advanced cancer who also had cardiac defibrillators were more likely than those without these implants to receive aggressive end-of-life care, a team led by UT Southwestern Medical Center researchers found in a new study.
January 8th, 2025 — Source

How specific brain regions drive chemotherapy-induced pain response
Chronic physical pain can be debilitating, but feelings of stress, fear, and hunger can sometimes suppress painful sensations. Diverse neurons across different brain regions play a role in carefully orchestrating the pain response in animals.
January 8th, 2025 — Source

Improving cancer risk assessment and patient care: Researchers resolve uncertainty in BRCA2 testing
Findings from a multi-institutional, international study led by researchers from the Mayo Clinic Comprehensive Cancer Center have significantly advanced the understanding of genetic alterations in the BRCA2 gene, a key player in hereditary cancer risk.
January 8th, 2025 — Source

Researchers resolve uncertainty in BRCA2 testing, improving cancer risk assessment and patient care
Findings will help identify patients with breast, ovarian, pancreatic or prostate cancer who may benefit from targeted therapies
January 8th, 2025 — Source

Tracking the metabolic origins of cancer from a mosaic of cells
Yale researchers are sifting through a mosaic of cells in a living animal—both normal cells and mutated cells—to better understand how cancer grabs a foothold. But they're starting by studying tolerance.
January 8th, 2025 — Source

Understanding survival disparities in cancer care: A population-based study on mobility patterns
The study analyzed data from over 20,000 cancer patients in Shandong Province, China, to assess the impact of intra-city, local center, and national center mobility patterns on survival rates. Patients who traveled to local or national health care centers had higher five-year survival rates compared to those who remained in their residential cities for treatment. Specifically, the five-year survival rate was 69.3% for patients treated in local or national centers, compared to 65.4% for intra-city patients.
January 8th, 2025 — Source

Unique AI predicts cancer prognoses and responses to treatment by combining data from medical images with text
The melding of visual information (microscopic and X-ray images, CT and MRI scans, for example) with text (exam notes, communications between physicians of varying specialties) is a key component of cancer care. But while artificial intelligence helps doctors review images and home in on disease-associated anomalies like abnormally shaped cells, it's been difficult to develop computerized models that can incorporate multiple types of data.
January 8th, 2025 — Source

Using AI to predict the outcome of aggressive skin cancers
Artificial intelligence can determine the course and severity of aggressive skin cancers, such as Merkel cell carcinoma (MCC), to enhance clinical decision making by generating personalized predictions of treatment-specific outcomes for patients and their doctors.
January 8th, 2025 — Source

Macrophages, not T cells, may hold key to predicting which melanoma patients are more likely to respond to immunotherapy
An international team of UK and US scientists has discovered that the activity of macrophages—a type of white blood cell that engulf pathogens and cancer cells—can be used to predict whether or not a melanoma patient will respond to immunotherapy. Their findings, published in a paper in JCO Oncology Advances, will help clinicians select treatments that are most likely to be effective for their patients.
January 8th, 2025 — Source

The genes that grow a healthy brain can also fuel adult glioblastoma
UCSF scientists have discovered a stem cell in the young brain that's capable of forming the cells found in tumors. The breakthrough could explain how adult brain cells take advantage of developmental processes to instigate the explosive growth seen in deadly brain cancers like glioblastoma.
January 8th, 2025 — Source

The same gene can drive distinct medulloblastoma types in different ways
Researchers discovered that the same gene, ZIC1, can drive highly similar cancers by distinct, context-dependent mechanisms. Led by researchers at Baylor College of Medicine, Texas Children's Cancer Center, University of Toronto, St. Jude Children's Research Hospital and Mayo Clinic College of Medicine and Science, these findings have direct implications for tumor prevention and treatment.
January 8th, 2025 — Source

Health — Cancer — January 7th, 2025

Approved drug dronedarone found to inhibit the proliferation of esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is a severe health threat, being a predominant subtype of esophageal cancer and contributing significantly to cancer-related mortality globally. Despite advancements in combination therapies, patient prognosis remains poor, highlighting an urgent need for novel treatment strategies.
January 7th, 2025 — Source

Can you steam away prostate cancer? Clinical trial offers steam to potentially destroy cancer cells in patients
Steam eliminates wrinkles and germs, but can it destroy cancer cells too?
January 7th, 2025 — Source

Fewer doses of HPV vaccine may be sufficient to protect against cervical cancer
A new study shows that one or two doses of the HPV vaccine can be as effective against severe cervical changes as three doses for girls and young women. The findings could have significant implications for global efforts to eliminate cervical cancer.
January 7th, 2025 — Source

Global study reveals younger adults face rising gastric cancer risk
A global study reveals a disturbing rise in early-onset gastric cancer, a disease once predominantly affecting older adults but now increasingly impacting younger populations. This shift in disease patterns, uncovered through a 15-year analysis, calls for urgent reevaluation of global health strategies and targeted interventions.
January 7th, 2025 — Source

New AI tool uses routine blood tests to predict immunotherapy response for many cancersDoctors around the world may soon have access to a new tool that could better predict whether individual cancer patients will benefit from immune checkpoint inhibitors—a type of immunotherapy—using only routine blood tests and clinical data.
#2693
January 7th, 2025 — Source

New family of protein-based antagonists shows promise against leukemia
In a significant advancement for cancer research, a team of scientists from Max Planck Institute for Biology Tübingen, University Hospital Tübingen, and Osnabrück University successfully designed a new family of protein-based antagonists that selectively block the G-CSFR receptor, which is linked to the emergence of several blood cancers, including acute myeloid leukemia.
January 7th, 2025 — Source

Q&A: How early cancer screening could save Canada nearly half a billion dollars over patients' lifetimes
Cancer screening is key to saving patients' lives, since an earlier stage diagnosis improves survival rates, decreases morbidity, and leads to less intensive treatments. Early detection also has the potential to save Canada's health care system substantial amounts of money. The United States adopted breast cancer screening for women in their forties due to an increase in the incidence of breast cancer in younger women, with recent research from the University of Ottawa confirming this rise.
January 7th, 2025 — Source

Study identifies potential microRNA target to overcome breast cancer resistance
A new University of Cincinnati Cancer Center study has identified a particular strand of microRNA as a promising new target for overcoming breast cancer treatment resistance and improving outcomes.
January 7th, 2025 — Source

Study reveals neutrophils' dynamic role in cancer progression
Neutrophils are the most abundant white blood cells in the human body, primarily recognized for their essential roles in fighting infections and regulating inflammation. However, their involvement in cancer progression has long been a subject of intrigue and confusion. These immune cells exhibit a paradoxical behavior within tumors, where they can either promote or inhibit cancer growth. This dual functionality suggests that neutrophils are highly plastic, with their actions shaped by dynamic environmental cues within the tumor microenvironment (TME).
January 7th, 2025 — Source

Surgeon general highlights link between alcohol and cancer, urges warning labels
In a new Advisory on Alcohol and Cancer Risk, Surgeon General Vivek Murthy connects alcohol consumption to increased cancer risk and calls for updated warning labels on alcoholic beverages.
January 7th, 2025 — Source

Younger adults face increasing risk of aggressive gastric cancer
Historically, gastric cancer has been a disease primarily affecting the elderly. However, emerging research indicates a dramatic change: younger adults are now increasingly at risk, with cases becoming more aggressive in this demographic. This shift poses new challenges for prevention, diagnosis, and treatment, highlighting the urgent need to investigate environmental, genetic, and lifestyle factors that may be driving this troubling trend.
January 7th, 2025 — Source

Health — Cancer — January 6th, 2025

Biolasers light up circulating tumor cells in the bloodstream
Researchers from the University of Michigan have developed a way of detecting circulating tumor cells in the bloodstream of pancreatic cancer and lung cancer patients.
January 6th, 2025 — Source

Childhood cancer genome study reveals hidden variants
Researchers at Dana-Farber Cancer Institute collaborated with multiple institutions to pinpoint rare germline structural variants as risk factors for non-blood-related cancers in children, including tumors in various organs. Findings indicate that structural variations in both coding and noncoding regions of the genome contribute to childhood cancers such as neuroblastoma, Ewing sarcoma, and osteosarcoma.
January 6th, 2025 — Source

Compact terahertz sensor identifies cancer types with record sensitivity and 93% accuracy
Cancer screening typically requires large, expensive equipment housed in specialized facilities. Current methods rely on chemical analysis of blood samples, microscopic examination of tissue biopsies, or complex imaging machines. Each approach demands extensive infrastructure: clinical laboratories, expensive equipment, and highly trained specialists to prepare samples and interpret results.
January 6th, 2025 — Source

Decrease seen in in situ breast cancer since 2009
The incidence of in situ breast cancer has decreased since 2009, consistent with decreasing use of mammography in association with the 2009 U.S. Preventive Services Task Force (USPSTF) guideline change, according to a study published online Dec. 27 in JAMA Network Open.
January 6th, 2025 — Source

Discovery of immune-boosting fibroblasts offers hope for cancer patients
Southampton scientists working to improve survival for cancer patients have identified a key characteristic of the disease that could make treatment more effective.
January 6th, 2025 — Source

ING5 regulates metabolic reprogramming in lung cancer cells
Lung cancer, notorious for its high mortality rates, is a leading cause of cancer-related deaths globally, with metastasis being the primary contributor to poor patient outcomes. A critical factor in this devastating disease is the metabolic reprogramming exhibited by cancer cells, particularly the preference for aerobic glycolysis over oxidative phosphorylation, a phenomenon known as the Warburg effect.
January 6th, 2025 — Source

Investigating the impact of CircRNAs on cancer progression and drug resistance
The researcher has given an overview on the regulatory network of extracellular circRNAs in cancer and their impact on cancer drug resistance. In order to propagate malignancy, circRNAs shuttle through the blood circulation as cell-free molecules or in exosomes, small vesicles where they are transported to various cells. Published in ExRNA, the network of circRNAs has the potential to be used as therapeutic targets or diagnostic and prognostic biomarkers for cancer treatment strategies.
January 6th, 2025 — Source

Localized magnetic fields boost chemotherapy uptake in breast cancer treatment, researchers find
Researchers at the National University of Singapore (NUS) have developed a non-invasive method to improve the effectiveness of chemotherapy while reducing its harmful side effects.
January 6th, 2025 — Source

Lighting up cancer cells with biolasers
The technique overcomes the limitations of current cancer diagnostic tools
January 6th, 2025 — Source

Novel screening tech enhances identification of cancer-targeting T cell receptors
Researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a new screening technology, Aptamer-based T Lymphocyte Activity Screening and SEQuencing (ATLAS-seq), to better identify antigen-reactive T cells that are more likely to offer greater immune responses against cancer cells.
January 6th, 2025 — Source

NUS researchers enhance chemotherapy with magnetic field pulses
Researchers at the National University of Singapore (NUS) have developed a non-invasive method to improve the effectiveness of chemotherapy while reducing its harmful side effects.
January 6th, 2025 — Source

Researchers boost chemotherapy uptake in breast cancer treatment with localized magnetic fields
A recent study explained the mechanisms by which pulsed electromagnetic field therapy enhances doxorubicin uptake, paving the way for precision-driven cancer therapies with fewer side effects
January 6th, 2025 — Source

Study finds chemotherapy antidote could improve recovery after chemotherapy-induced kidney toxicity
An FDA-approved medication called glucarpidase could serve as an antidote to kidney toxicity in patients receiving the chemotherapy drug methotrexate (MTX), according to a new study by investigators at Mass General Brigham.
January 6th, 2025 — Source

Weill Cornell Medicine receives CDC grant to improve care for young breast cancer patients
Weill Cornell Medicine has received a five-year, $2.3 million grant from the Centers for Disease Control and Prevention to improve equitable access to care, quality of life and survival outcomes for young people with all stages of breast cancer.
January 6th, 2025 — Source

Would cancer warning labels on alcoholic beverages reduce consumption—or be ignored?
Calling alcohol the third-leading preventable cause of cancer, the U.S. surgeon general on Friday recommended that alcoholic beverages come with the same type of warning label currently used on packs of cigarettes.
January 6th, 2025 — Source

Health — Cancer — January 3rd, 2025

Advanced imaging uncovers hidden metastases in high-risk prostate cancer cases
A study led by researchers at the UCLA Health Jonsson Comprehensive Cancer Center has found that many cases of high-risk nonmetastatic hormone-sensitive prostate cancer may be more advanced than previously thought.
January 3rd, 2025 — Source or Source or Source

Alcohol Should Come With Cancer Warning Label Like Cigarettes, U.S. Surgeon General Says
Less than half of Americans know alcohol can cause cancer, prompting the U.S. surgeon general to push for clearer warning labels and public health reforms.
January 3rd, 2025 — Source

FDA approves subcutaneous opdivo qvantig for most solid tumor indications
Opdivo Qvantig is a combination product of nivolumab coformulated with recombinant human hyaluronidase. This approval is for most previously approved adult, solid tumor Opdivo indications as monotherapy, monotherapy maintenance following completion of Opdivo plus Yervoy (ipilimumab) combination therapy, or in combination with chemotherapy or cabozantinib.
January 3rd, 2025 — Source

Genetic mutation in esophageal cancer found to have dual effects
A genetic fault long believed to drive the development of esophageal cancer may in fact play a protective role early in the disease, according to new research published in Nature Cancer. This unexpected discovery could help doctors identify which individuals are at greater risk of developing cancer, potentially leading to more personalized and effective preventive strategies.
January 3rd, 2025 — Source

Improving predictions about brain cancer outcomes with the right imaging criteria
A paper published in the Journal of Clinical Oncology, titled "Comparative Analysis of Intracranial Response Assessment Criteria in Patients With Melanoma Brain Metastases Treated With Combination Nivolumab + Ipilimumab in CheckMate 204," examines how different imaging criteria can be used to assess brain tumor responses in patients with melanoma treated with immunotherapy drugs.
January 3rd, 2025 — Source

Mini-tumors from circulating breast cancer cells offer new treatment insights
Tumor cells circulating in the blood are the germ cells of breast cancer metastases. They are very rare and have not been propagated in the culture dish until now, which made research into therapy resistance difficult.
January 3rd, 2025 — Source

New guidelines for managing blood cancers in pregnancy
A new set of guidelines has been developed to assist with the diagnosis and expert management of serious blood cancers in pregnancy.
January 3rd, 2025 — Source

Researchers grow tumor organoids from blood to tackle breast cancer metastasis
Tumor cells circulating in the blood are the "germ cells" of breast cancer metastases. They are very rare and could not be propagated in the culture dish until now, which made research into therapy resistance difficult. A team from the German Cancer Research Center (DKFZ), the Heidelberg Stem Cell Institute HI-STEM and the NCT Heidelberg has now succeeded for the first time in cultivating stable tumor organoids directly from blood samples of breast cancer patients.
January 3rd, 2025 — Source

Rice researchers develop new construction kit for engineering smart cells
Rice University bioengineers have developed a new construction kit for building custom sense-and-respond circuits in human cells. The research, published in the journal Science, represents a major breakthrough in the field of synthetic biology that could revolutionize therapies for complex conditions like autoimmune disease and cancer.
January 3rd, 2025 — Source or Source

Scientists unveil surprising human vs. mouse differences in a major cancer immunotherapy target
Since its discovery in the 1990s, programmed cell death protein 1 (PD-1) has been regarded as a leading target in cancer treatments. A checkpoint receptor that often resides on the surface of immune system cells, the PD-1 molecule works as a type of "off" switch that keeps immune cells from attacking other cells.
January 3rd, 2025 — Source

Surprising 'two-faced' cancer gene role supports paradigm shift in predicting disease
A genetic fault long believed to drive the development of esophageal cancer may in fact play a protective role early in the disease, according to new research published in Nature Cancer. This unexpected discovery could help doctors identify which individuals are at greater risk of developing cancer, potentially leading to more personalized and effective preventive strategies.
January 3rd, 2025 — Source

Health — Cancer — December 30th, 2024

40 years of research into genetic causes of childhood and adolescent cancers
Cancer in children and adolescents is rare. Nevertheless, malignant diseases are still one of the most common causes of death in this age group. Survivors of childhood or adolescent cancer often suffer chronic health problems with increased morbidity and mortality rates.
December 30th, 2024 — Source

Investigating fatty acid metabolism in hepatocellular carcinoma patients
Announcing a new publication for Acta Materia Medica journal. Fatty acid (FA) reprogramming has a significant role in liver cancer. However, the contribution of FA metabolism reprogramming to the heterogeneity of hepatocellular carcinoma (HCC) has not been established. This article describes how bioinformatics analysis using single-cell sequencing, a non-negative matrix factorization (NMF) algorithm, and survival analyses were used to investigate FA metabolism reprogramming in HCC patients. Molecular targets and the progress of drug discovery were also analyzed and discussed.
December 30th, 2024 — Source

Oleanolic acid from grapes may increase chemotherapy effectiveness
Researchers describe a new potential role for oleanic acid as a modulator of the DNA damage response following camptothecin treatment. Administration of oleanic acid in combination with camptothecin for cancer chemotherapy may reduce the amount of drug needed and increase the effectiveness of treatment. The findings are part of a novel research program focused on identifying new molecules for cancer therapy derived from natural extracts.
December 30th, 2024 — Source

What Does California P65 Mean & Why Is It On Your Tech Warning Labels?
Let's say you've just purchased a shiny new piece of tech for yourself, such as a smartphone or a portable game console. You're all set to pop it out of the box and begin using it, when suddenly, you spot something on the box out of the corner of your eye: a warning. Specifically, a warning marked P65, claiming that contact with this product could cause cancer or harm to an individual's reproductive health.
December 30th, 2024 — Source

What does it feel like to have an ostomy bag?
An ostomy is a surgical procedure creating an opening, or "stoma," on the abdomen to allow waste to exit the body. This may be essential due to conditions like Crohn's disease, ulcerative colitis, or colorectal cancer. The two primary types of ostomies are:
December 30th, 2024 — Source

Health — Cancer — December 29th, 2024

What you should know about pancreatic cancer screening
Pancreatic cancer screening has advanced significantly in recent years. There are now research-based guidelines on screening for people at high risk of developing the disease, and researchers are collaborating to develop new screening approaches involving genetic testing and artificial intelligence (AI).
December 29th, 2024 — Source

Health — Cancer — December 28th, 2024

We don't all need regular skin cancer screening—but you can know your risk and check yourself
Australia has one of the highest skin cancer rates globally, with nearly 19,000 Australians diagnosed with invasive melanoma—the most lethal type of skin cancer—each year.
December 28th, 2024 — Source

Health — Cancer — December 27th, 2024

Light-guided algae microrobots deliver cancer drugs with precision and innovation
(Nanowerk Spotlight) The precise delivery of cancer drugs to tumors has remained one of medicine's most difficult challenges. Traditional chemotherapy affects the entire body indiscriminately, while newer targeted therapies often fail to penetrate deep into tumor tissue. Scientists exploring microscopic robots as a solution have faced persistent obstacles: synthetic materials trigger immune responses, chemical propulsion systems lack precise control, and complex electronics are difficult to miniaturize safely for use in the body.
December 27th, 2024 — Source

New genetic mutation found to suppress cancer growth
#2693
December 27th, 2024 — Source

Q&A: How circadian rhythms have been implicated in diseases from dementia to cancer
In this season of short days and long winter nights, it's easy to feel out of sorts. Those who suffer from seasonal affective disorder, a form of depression that's closely linked to the circadian rhythms that govern our sleep cycles, know this all too well. But those same rhythms, which are themselves governed by biological clocks, can affect much more than mood and sleep.
December 27th, 2024 — Source

UT Southwestern Medical Center researchers have identified a genetic mutation that slows the growth of melanoma and potentially other cancers by harnessing the power of the immune system. Their findings, published in the Journal of Experimental Medicine, could lead to new treatments that improve outcomes from existing cancer immunotherapies.
#2693
December 27th, 2024 — Source

Health — Cancer — December 26th, 2024

Complex interactions between nucleic acid sensors and enzymes in immune cells explained
Adenosine deaminase 2 (ADA2) has been identified as a regulator of toll-like receptor 9 (TLR9) activation in response to nucleic acids, according to a recent study. ADA2, previously known for its role in catalyzing the deamination of adenosine to inosine, is revealed to function as an intracellular DNA-binding protein that controls TLR9 activation in plasmacytoid dendritic cells (pDCs). This discovery provides insights into the functional differences among three classes of CpG oligodeoxynucleotides (ODNs) and suggests potential therapeutic strategies for modulating immune responses to infections and cancer.
December 26th, 2024 — Source

Could AI plus lasers help catch very early breast cancers?
Very early-stage breast cancers are notoriously tough to spot via mammograms, but new technology might make detection easier.
December 26th, 2024 — Source

Health — Cancer — December 20th, 2024

Experimental drug that summons 'warriors of the immune system' shows early promise against non-Hodgkin lymphoma
An investigational therapy is demonstrating preclinical promise against non-Hodgkin lymphoma by boosting natural killer cells and efficiently annihilating the malignancy without toxicity to the patient, a team of cancer biologists in France has found.
December 20th, 2024 — Source

Machine learning uncovers three osteosarcoma subtypes for targeted treatment
Researchers have been able to identify at least three distinct subtypes of a rare type of bone cancer for the first time, which could transform clinical trials and patient care.
December 20th, 2024 — Source

Promising biomarker could decode cause of aggressive breast cancer in women of color
Triple-negative breast cancer (TNBC) is an aggressive breast cancer. It spreads quickly and has few treatment options. It is also serious because of its rate of recurrence.
December 20th, 2024 — Source

Health — Cancer — December 16th, 2024

Call for targeted strategies to combat gastric cancer cause
Addressing poor management of a preventable cause of gastric cancer will lead to better outcomes and improve equity and justice in health care, a group of health professionals argues.
December 16th, 2024 — Source

Cancer one of top conditions to consider among older men with fatigue
Cancer is one of the four most likely conditions for clinicians to consider in older men who go to their GP with new-onset fatigue, a study led by UCL researchers has found.
December 16th, 2024 — Source

Clinical trial finds adding camrelizumab to neoadjuvant chemo beneficial in triple-negative breast cancer
The addition of camrelizumab to neoadjuvant chemotherapy improves pathological complete response for patients with early or locally advanced triple-negative breast cancer, according to a study published online Dec. 13 in the Journal of the American Medical Association to coincide with the annual San Antonio Breast Cancer Symposium, held from Dec. 10 to 13 in San Antonio.
December 16th, 2024 — Source

Comprehensive cell map offers insights into rare brain tumor
Craniopharyngioma (CP) is a rare brain tumor that develops in the regions close to the hypothalamus and pituitary gland. The CP tumors lead to complications like defective vision, neuronal defects, diabetes, and developmental problems.
December 16th, 2024 — Source

Dinuclear platinum(II) complexes could offer a more targeted approach to treating prostate cancer
Prostate cancer remains a global health challenge, ranking as the second most commonly diagnosed cancer among men. Although treatments like androgen deprivation therapy have been effective for early-stage prostate cancer, advanced stages, such as castration-resistant prostate cancer, present significant treatment challenges due to resistance to therapies. Current approaches targeting androgen receptor (AR) signaling, such as taxanes and newer agents, show limited success.
December 16th, 2024 — Source

Glioblastoma treatment breakthrough shows promise
Mayo Clinic announces the results of an innovative treatment approach that may offer improvement in overall survival in older patients with newly diagnosed glioblastoma while maintaining quality of life. Results of Mayo Clinic's phase 2, single-arm study are published in The Lancet Oncology.
December 16th, 2024 — Source

Living with cancer can be particularly difficult during the holiday season
For those living with the stressful reality of cancer, holidays with their emphasis on joy can be especially difficult.
December 16th, 2024 — Source

Microbial bile acids affect colon cancer risk in opposite ways
Microbes living in our guts help us digest food by reshaping the bile acids that our livers produce for breaking down fats. It turns out that two of these microbially-modified bile acids may affect our risk -; in opposite directions -; for developing colon cancer.
December 16th, 2024 — Source

New blood test evaluates nanomedicines for safer, personalized cancer treatment
Scientists from RMIT University and the Doherty Institute have developed a new blood test that could screen cancer patients to help make their treatment safer and more effective.
December 16th, 2024 — Source

Q&A: Improving liver cancer outcomes through enhanced immunotherapy
Dan G. Duda, DMD, Ph.D., of the Edwin L. Steele Laboratories for Tumor Biology and Department of Radiation Oncology at Massachusetts General Hospital, is the corresponding author of a paper published in Cancer Immunology Research, "Combination CXCR4 and PD1 Blockade Enhances Intratumoral Dendritic Cell Activation and Immune Responses Against Hepatocellular Carcinoma."
December 16th, 2024 — Source

Researchers find previously unknown links between microbial bile acids and the risk of colon cancer
Microbes living in our guts help us digest food by reshaping the bile acids that our livers produce for breaking down fats. It turns out that two of these microbially-modified bile acids may affect our risk—in opposite directions—for developing colon cancer.
December 16th, 2024 — Source

Scientists create blood test to enhance cancer treatment effectiveness
Scientists from RMIT University and the Doherty Institute have developed a new blood test that could screen cancer patients to help make their treatment safer and more effective
December 16th, 2024 — Source

Study highlights brain-preserving radiation technique for rare cancer
A recent University of Kentucky Markey Cancer Center study highlights a radiation therapy technique that treats brain tumors while preserving patients' cognitive function. The treatment approach could offer hope for patients with a rare and aggressive form of brain cancer.
December 16th, 2024 — Source

Study reveals tumor and immune cell interactions in craniopharyngiomas
Craniopharyngiomas are brain tumors that negatively impact the hormonal function of the nearby pituitary. The tumor location often prevents necessary surgical intervention. Alternative pharmacological therapy requires an in-depth understanding of the tumor molecular characteristics. To address this gap, researchers from Japan analyzed gene expression within individual tumor cells. This study reports the molecular features and interactions of tumor and immune cells associated with two craniopharyngioma subtypes that will help identify future targeted therapeutics.
December 16th, 2024 — Source

Unlocking the secrets of metastasis: Cancer cells' 'eating' ability could lead to new treatments
Cancer is one of the most formidable health challenges of our time, affecting nearly half of us during our lives. While treatments have significantly improved in recent decades, the biggest challenge remains: stopping cancer cells from spreading to other parts of the body, a process known as metastasis. Metastasis is responsible for most cancer-related deaths, therefore it is critical to understand the process in order to be able to improve treatment.
December 16th, 2024 — Source

Health — Cancer — December 13th, 2024

A low omega-6, omega-3 rich diet and fish oil may slow prostate cancer growth
A study led by UCLA Health Jonsson Comprehensive Cancer Center investigators offers new evidence that dietary changes may help reduce cancer cell growth in patients undergoing active surveillance, a treatment approach that involves regular monitoring of the cancer without immediate intervention.
December 13th, 2024 — Source

Activating the hidden pharmaceutical potential of bacteria
Researchers develop a new genetic method for the production of new active ingredients in bacteria
December 13th, 2024 — Source

AI revolutionizes cancer research with advanced tools
Significant advancements in understanding the molecular and cellular mechanisms of tumor progression have been made, yet challenges remain. Traditional imaging techniques like MRI, CT, and mammography are limited by the need for professional curation, which is time-consuming. Genetic changes associated with cancer could serve as diagnostic, prognostic, and predictive biomarkers, but their translation into clinical practice is hindered by variations in metastasis, treatment responses, and resistance.
December 13th, 2024 — Source

AI-powered blood test can spot earliest sign of breast cancer
A new screening method that combines laser analysis with a type of AI is the first of its kind to identify patients in the earliest stage of breast cancer, a study suggests.
December 13th, 2024 — Source or Source

AI's role in cancer research: Review highlights advantages and limitations
Significant advancements in understanding the molecular and cellular mechanisms of tumor progression have been made, yet challenges remain. Traditional imaging techniques like MRI, CT, and mammography are limited by the need for professional curation, which is time-consuming.
December 13th, 2024 — Source

Drug screening platform identifies compound for reinvigorating exhausted CAR-T cells
A research team led by Prof. Wang Haoyi from the Institute of Zoology (IOZ) of the Chinese Academy of Sciences has developed a chimeric antigen receptor T (CAR-T) cell exhaustion model and a functional screening platform for identifying compounds that can rejuvenate exhausted T cells.
December 13th, 2024 — Source

Gut-immune connection could boost immunotherapy effectiveness in recurrent ovarian cancer
A study led by Roswell Park Comprehensive Cancer Center provides new insight into the complex interactions of the "tumor-immune-gut axis," and its role in influencing immunotherapy responses in patients with recurrent ovarian cancer.
December 13th, 2024 — Source

Heart-related side effects of cancer treatment must be addressed as early as possible, experts say
The devastating news of a cancer diagnosis understandably makes doctors and patients focus on the cancer itself. However, experts in cardio-oncology from the European Society of Cardiology (ESC) emphasize that heart and cardiovascular health must be included as early as possible in the patient's cancer treatment plan to ensure the best possible outcomes.
December 13th, 2024 — Source

High-altitude gene variant linked to better blood cancer prognosis
Two researchers from Huntsman Cancer Institute at the University of Utah (the U) have discovered a gene variant found in high-altitude Andean populations that they believe could be a new biomarker for predicting the severity of diseases and treatment responses for certain types of blood cancer.
December 13th, 2024 — Source

High-risk breast cancer patients see improved outcomes with anthracyclines
Patients with early-stage, node-negative, hormone receptor (HR)-positive, HER2- negative breast cancer who have a high risk of recurrence based on the OncotypeDX genomic test had better outcomes when treated with adjuvant anthracycline- plus taxane-based chemotherapy regimens compared with those receiving adjuvant taxane-based chemotherapy regimens alone, according to results presented at the San Antonio Breast Cancer Symposium (SABCS), held December 10–13, 2024.
December 13th, 2024 — Source

Light-induced gene therapy disables cancer cells' energy center
In study, targeted delivery shrinks brain, breast tumors in mice
December 13th, 2024 — Source or Source

Machine learning model predicts breast cancer treatment response
A machine learning (ML) model incorporating both clinical and genomic factors outperformed models based solely on either clinical or genomic data in predicting which patients with hormone receptor (HR)-positive, HER2-negative metastatic breast cancer would have better outcomes from adding CDK4/6 inhibitors to endocrine therapy as first-line treatment, according to results presented at the San Antonio Breast Cancer Symposium (SABCS), held December 10–13, 2024.
December 13th, 2024 — Source

Mobile mammography boosts screening in underserved communities
A study by the Harvey L. Neiman Health Policy Institute demonstrates that mobile mammography is generally used by women otherwise unlikely to be screened, and thus is complementary to facility-based mammography rather than a substitute for it.
December 13th, 2024 — Source

Molecular insights unlock a targeted approach to cancer immunotherapy
Australian-led research is unlocking new ways for immunotherapy to better target cancer. Cancer immunotherapy has revolutionized treatment for patients, whereby the body's own immune system is harnessed to destroy cancer cells.
December 13th, 2024 — Source

Multi-omic profiling sheds light on chemo-immunotherapy resistance in lung cancer
Researchers use spatial transcriptomics to uncover tumor microenvironment patterns linked to treatment response in non-small-cell lung cancer
December 13th, 2024 — Source

New home testing protocol could reduce the number of women recalled for clinician-collected cervical sampling
A new protocol for the analysis of self-collected cervical samples could reduce the need for follow-up clinician screening for many women, and result in more rapid referral for gynecology assessment for others.
December 13th, 2024 — Source

New immunotherapy platform has increased potential to target cancer cells
Researchers from Children's Hospital of Philadelphia (CHOP) and Stanford University have revealed the molecular structure of TRACeR-I, a protein platform for reprogramming immune responses.
December 13th, 2024 — Source or Source

New method could improve cervical cancer screening
Analyses of self-tests for human papillomavirus (HPV) can be used to divide HPV-positive women into three risk groups, according to a new study. This method could be important for enhancing cervical cancer screening.
December 13th, 2024 — Source

New protein platform enhances cancer immunotherapy
Researchers from Children's Hospital of Philadelphia (CHOP) and Stanford University have revealed the molecular structure of TRACeR-I, a protein platform for reprogramming immune responses. A better understanding of its structure may help optimize designs for the platform, which can be used to develop cancer treatments by either directly modifying immune cells or by creating proteins that help immune cells locate cancer cells.
December 13th, 2024 — Source

Pioneering MRI method spots pre-malignant pancreatic lesions for the first time
Precursor lesions of pancreatic cancer are very difficult to characterize with magnetic resonance imaging (MRI). But now, in a new study, researchers led by Noam Shemesh and Carlos Bilreiro—respectively, head of the Preclinical MRI lab at Champalimaud Research and a doctor at the Champalimaud Clinical Center's Radiology Department—have shown, for the first time, that a particular form of MRI, called Diffusion Tensor Imaging (DTI), is capable of robustly detecting pre-malignant lesions in the pancreas.
December 13th, 2024 — Source

Q&A: Interplay between immune cells and HPV keeps skin healthy
Shadmehr (Shawn) Demehri, MD, Ph.D., of the Department of Dermatology and Center for Cancer Immunology at Massachusetts General Hospital, is the corresponding author of a paper published in Cancer Cell, "Commensal papillomavirus immunity preserves the homeostasis of highly mutated normal skin."
December 13th, 2024 — Source

SABCS: Omission of axillary staging noninferior for node-negative breast cancer
Omission of surgical axillary staging is noninferior to sentinel-lymph-node biopsy for patients with clinically node-negative, T1 or T2 invasive breast cancer, according to a study published online Dec. 12 in the New England Journal of Medicine to coincide with the annual San Antonio Breast Cancer Symposium, held from Dec. 10 to 13 in San Antonio.
December 13th, 2024 — Source

Study highlights the impact of Reiki on pain, fatigue, and anxiety in cancer outpatients
A recent study conducted at University Hospitals Connor Whole Health has evaluated a Reiki program designed for outpatients with cancer and receiving infusion treatments at two University Hospitals infusion centers.
December 13th, 2024 — Source

ZEST trial offers insights for using ctDNA to predict breast cancer recurrence
The ZEST clinical trial, designed to evaluate niraparib (Zejula) for the prevention of breast cancer recurrence in patients with circulating tumor DNA (ctDNA), failed to accrue enough patients positive for ctDNA, according to results presented at the San Antonio Breast Cancer Symposium (SABCS), held December 10–13, 2024.
December 13th, 2024 — Source

Health — Cancer — December 10th, 2024

Cancer 'fingerprint' can improve early detection
Changes are detectable with near-perfect accuracy by small, portable scanners in just a few hours
December 10th, 2024 — Source

Delivering medicines with microscopic flowers
How can medicines be directed to the precise location within the body where they need to act? Scientists have been researching this question for a long time. An example would be delivering cancer drugs directly to a tumour so that they only take effect at this specific location, without causing side effects in the rest of the body. Research is under way to identify carrier particles to which active ingredients can be bound.
December 10th, 2024 — Source or Source

How chemotherapy primes ovarian cancer for immune-based therapies
Researchers have discovered how chemotherapy can change tumors, making them more vulnerable to new types of treatments. These findings could lead to personalized therapies that target the right patients at the right time, offering hope for improving care for ovarian cancer—a highly aggressive and common malignancy.
December 10th, 2024 — Source

How this cancer drug could make radiation a slam dunk therapy
Radiation is one of the most effective ways to kill a tumor. But these therapies are indiscriminate, and they can damage healthy tissues.
December 10th, 2024 — Source

Nanopore direct RNA sequencing identifies cancer 'fingerprint'
Different types of cancer have unique molecular 'fingerprints' which are detectable in early stages of the disease and can be picked up with near-perfect accuracy by small, portable scanners in just a few hours, according to a study published today in the journal Molecular Cell ("Epitranscriptomic rRNA fingerprinting reveals tissue-of-origin and tumor-specific signatures").
December 10th, 2024 — Source

New treatment may delay cancer in high-risk myeloma
A new treatment is showing promise for people with high-risk smoldering multiple myeloma (SMM). This precancerous condition can progress to active multiple myeloma, a type of blood cancer. High-risk SMM carries a higher likelihood of progression.
December 10th, 2024 — Source

Precision medicine treatment delivers strong results for infantile fibrosarcoma and other solid tumors
Researchers at Children's Hospital of Philadelphia (CHOP) and the Children's Oncology Group (COG) found that larotrectinib, an oral drug that stops cancer-cell growth, was highly effective in pediatric patients with newly diagnosed infantile fibrosarcoma (IFS) or other solid tumors that have a neurotrophic receptor tyrosine kinase (NTRK) gene fusion without a known acquired resistance mutation.
December 10th, 2024 — Source

Study finds ultra-processed foods may increase colorectal cancer risk
Colorectal cancer, the second leading cause of cancer-related deaths in the United States, may be fueled by the food on our plates. Researchers at the University of South Florida and Tampa General Hospital Cancer Institute have uncovered a potential link between the Western diet—dominated by ultra-processed foods and unhealthy oils—and the chronic inflammation that drives tumor growth.
December 10th, 2024 — Source

Study links smoking to genetic mutations in blood cancer
Smokers with myelodysplastic syndromes (MDS) or a precursor condition had elevated levels of genetic mutations linked to the disease, a new study shows. The study also found that heavier smokers accumulated more mutations, and long-term smokers were more likely to show disease progression.
December 10th, 2024 — Source

Study reveals increase in late-stage breast cancer diagnoses in US
The number of women with late-stage, invasive breast cancer at the time of diagnosis increased significantly among U.S. women across all ages and ethnicities between 2004 and 2021, according to a study published today in Radiology.
December 10th, 2024 — Source

Ultra-processed foods may drive colorectal cancer risk, study finds
Chronic inflammation, fueled by poor dietary choices, plays a vital role in the growth and progression of colorectal cancer
December 10th, 2024 — Source

Using light to monitor blood pressure and track cancer treatment progress
Here's an experiment: Turn on your phone's flashlight and place the tip of your finger over the small beam of light. What do you see? Your finger is illuminated, but the light isn't passing entirely through. You're looking at what's called a diffusive glow, which is what happens when all the cells and molecules that make up your finger absorb and scatter the steady beam of light in an instant.
December 10th, 2024 — Source

US health panel adds self-testing option for cervical cancer screening
Women should have the option of taking their own test samples for cervical cancer screening, an influential health panel said Tuesday.
December 10th, 2024 — Source

Using 'biological age' to predict early colorectal cancer risk
New research from Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine suggests that one's biological age, which can be higher than his or her chronological age—a concept called accelerated aging—may predict who's at risk for developing colon polyps, a known risk factor for colorectal cancer.
December 10th, 2024 — Source

Treatment method does not improve survival for mantle cell lymphoma patients, clinical trial shows
Late-breaking research reveals there is no benefit from high-dose chemotherapy followed by autologous stem cell transplant (ASCT) for patients with mantle cell lymphoma (MCL) in remission following their initial treatment. The finding is from the phase 3 study EA4151, Rituximab With or Without Stem Cell Transplant in Treating Patients With Minimal Residual Disease-Negative Mantle Cell Lymphoma in First Complete Remission by the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN).
December 10th, 2024 — Source

Venetoclax could improve outcomes of CAR T therapy for patients with resistant B-cell lymphomas
About a third of patients with diffuse large B cell lymphoma (DLBCL), a fast-growing form of lymphoma, will see their disease advance or recur following treatment. Seeking a new treatment strategy that might boost the effectiveness of existing DLBCL therapies, a team from Roswell Park Comprehensive Cancer Center has been working to understand the underlying mechanisms of the targeted chemotherapy venetoclax.
December 10th, 2024 — Source

What Dolph Lundgren's journey from terminal diagnosis to 'cancer free' can tell us about cancer care
In a heartening turn of events, action movie star Dolph Lundgren recently announced that he is "Sourcefinally cancer free" after a grueling battle with the disease.
December 10th, 2024 — Source

Health — Cancer — December 6th, 2024

45 years of progress: Prevention and screening avert millions of cancer deaths
A study estimates 5.94 million deaths were prevented across five major cancers, highlighting the critical role of early detection and prevention in reducing mortality.
December 6th, 2024 — Source

AI-enhanced mammography improves cancer detection in self-pay program
More than a third of women across 10 health care practices chose to enroll in a self-pay, artificial intelligence (AI)-enhanced breast cancer screening program, and the women who enrolled were 21% more likely to have cancer detected, according to research being presented today at the annual meeting of the Radiological Society of North America (RSNA).
December 6th, 2024 — Source

Algorithm helps guide cancer treatment using circulating tumor DNA from blood samples
A breakthrough by researchers at Peter Mac will allow scientists to detect, analyze and profile cancer tumors in patients via a simple blood test. The Dawson lab at Peter Mac has developed a method that can take circulating tumor DNA (ctDNA) from the patient's blood and use an algorithm to identify cancer-related changes and patterns in their DNA.
December 6th, 2024 — Source

Auto hematopoietic cell transplant not beneficial for mantle cell lymphoma with undetectable residual disease
Autologous hematopoietic cell transplant (auto-HCT) is not beneficial for patients with mantle cell lymphoma (MCL) in first complete remission (CR) with undetectable minimal residual disease (uMRD), according to a study to be presented at the annual meeting of the American Society of Hematology, held from Dec. 7 to 10 in San Diego.
December 6th, 2024 — Source

Breakthrough in HWE reaction offers pathway for anti-cancer drug development
The Horner--Wadsworth--Emmons (HWE) reaction is a fundamental reaction in organic chemistry, widely used to create conjugated carbonyl compounds. Conjugated carbonyl compounds are used in many industries for synthesizing perfumes, plastics, and pharmaceuticals and are also involved in biological processes. Consequently, methods for improving HWE reactions are an active area of research.
December 6th, 2024 — Source

Cervical self-testing an acceptable HPV screening method, but survey reveals knowledge gap from users
Published today in the Journal of Primary Health Care, the research reveals that HPV self-testing (a vaginal swab) was widely accepted and preferred by people for cervical screening, but gaps were identified in their knowledge about the new process.
December 6th, 2024 — Source

Changes in blood cell production over the lifetime could impact leukemia outcomes
Researchers at University of California San Diego School of Medicine and their colleagues have developed the first comprehensive map of the dramatic changes that take place in the blood system over the course of the human lifetime.
December 6th, 2024 — Source

Dogs look out for one another: Study shows that dogs can smell cancer in other dogs
The results of a study into whether cancer detection dogs can smell bladder cancer in other dogs' urine suggests that this could be an effective new way to diagnose the disease in dogs. The research, involving University of Bristol researchers, is published in Veterinary and Comparative Oncology.
December 6th, 2024 — Source

E.coli toxin-producing bacteria linked to bladder and bowel cancer
Certain intestinal bacteria are found more frequently in countries such as Norway than in a number of other countries and there is also a higher incidence of bladder cancer, bowel cancer and prostate cancer. These findings may lead to new opportunities for preventing these types of cancer, according to a new study.
December 6th, 2024 — Source

Imaging technique allows rapid assessment of ovarian cancer subtypes and their response to treatment
An MRI-based imaging technique developed at the University of Cambridge predicts the response of ovarian cancer tumors to treatment, and rapidly reveals how well treatment is working, in patient-derived cell models.
December 6th, 2024 — Source

Molecular 'ZIP code' draws killer T cells to brain tumors
UCSF scientists have developed a "molecular GPS" to guide immune cells into the brain and kill tumors without harming healthy tissue.
December 6th, 2024 — Source

Photoacoustic PDA-ICG Nanoprobe for Detecting Senescent Cells in Cancer
A study in Scientific Reports evaluated a photoacoustic polydopamine-indocyanine green (PDA-ICG) nanoprobe for detecting senescent cells. Senescent cells play a role in tumor progression and therapeutic resistance, with potential adverse effects such as inflammation and tissue disruption. The PDA-ICG nanoprobe offers a method for identifying these cells, with implications for cancer diagnostics and treatment.
December 6th, 2024 — Source

Researchers discover 'crosstalk' mechanism in two key breast cancer molecules
A significant advance in breast cancer research has uncovered a key mechanism driving cancer invasion and drug resistance. A University of Liverpool study reveals how two critical molecules present in "HER2-positive" breast cancer—one of the most aggressive forms—influence breast cancer survival and its spread.
December 6th, 2024 — Source

Researchers map genetic variants associated with pancreatic cancer in Brazilian patients
Pancreatic cancer has recently been included in the list of diseases about which Brazil's National Cancer Institute (INCA) periodically publishes statistics. Although it is not the most frequent type of cancer, its high lethality makes it one of the leading causes of death from cancer in Brazil, partly owing to late diagnosis.
December 6th, 2024 — Source

Urine test uses 'zombie' cell proteins for early detection of lung cancer
Scientists in the United Kingdom have created a world-first urine test that could indicate the first possible signs of lung cancer.
December 6th, 2024 — Source

Health — Cancer — December 2nd, 2024

Calcium Carbonate Nanoparticles: Boosting T Cell Activation in Cancer Therapy
A study published in Nature Communications examined the use of calcium carbonate nanoparticles (CNPs) to improve the activation and function of cytotoxic T lymphocytes (CTLs) in cancer immunotherapy. The research focuses on enhancing T cell activation by using CNPs to modulate calcium signaling pathways essential for effective anti-tumor responses.
December 2nd, 2024 — Source

CHOP makes available AI model that can enhance tumor analysis
The new deep-learning model outperforms biomedical-imaging analysis in understanding disease progression, pediatrics researchers at Children's Hospital of Philadelphia say.
December 2nd, 2024 — Source

Critical relationship between stem cells and mechanical signals unveiled
Researchers uncover how two mechano-sensing ion channels are essential to maintain healthy stem cells.
December 2nd, 2024 — Source

Curbing plastics pollution could help reduce global burden of breast cancer, analysis suggests
A new study suggests addressing plastic pollution could play a critical role not only in protecting the environment, but also in lowering breast cancer rates, which have been increasing globally, especially in younger adults.
December 2nd, 2024 — Source

Even low levels of arsenic in drinking water raise kidney cancer risk, new study finds
New research findings from the Texas A&M University School of Public Health indicate that exposure to even low levels of arsenic poses significant health risks, including an increased risk of kidney cancer.
December 2nd, 2024 — Source or Source

Fibroblastic reticula cells can organize T cells in the fight against lung cancer
Institute of Immunobiology-led research has made a significant breakthrough in understanding how the body combats lung cancer. Their study reveals that specific cells, known as fibroblastic reticular cells (FRCs), create environments within tumors that help protect and activate immune cells to fight the cancer effectively.
December 2nd, 2024 — Source

IL-15 improves the effectiveness of GPC3 CAR T cells in targeting solid tumors
IL-15 enhances the growth and survival of GPC3 CAR T cells, improving their ability to target and fight solid tumors
December 2nd, 2024 — Source

Immunosuppression study helps understand why some prostate cancer treatments do not work as expected
A recent study reveals that immunosuppression, or reduced immune response, in prostate cancer is associated with a specialized epithelial subtype.
December 2nd, 2024 — Source

Lung cancer screening with CT can identify coronary artery calcium
Lung cancer screening with low-dose chest computed tomography (CT) may detect more than just lung cancer. As new research in CMAJ (Canadian Medical Association Journal) shows, these CTs can identify coronary artery calcium, a strong risk factor for coronary artery disease (CAD), in patients without cardiac symptoms.
December 2nd, 2024 — Source

New clinical pathway supports cancer recurrence anxiety
Researchers have developed a three-step plan to support those burdened by the intense fear of cancer recurrence. This plan offers a consistent, streamlined approach to managing recurrence anxiety, empowering patients to regain confidence and move forward with their lives.
December 2nd, 2024 — Source

New study explores heart risks of cancer immunotherapy
A cancer therapy that prompts the body's immune defenses against viruses and bacteria to attack tumors can make patients more vulnerable to heart attack and stroke. A possible explanation for this side effect is that the treatment interferes with immune regulation in the heart's largest blood vessels, a new study suggests.
December 2nd, 2024 — Source

New study explores obecabtagene autoleucel for adults with hard-to-treat leukemia
Phase 1b–2 trial evaluates the potential of CAR T-cell therapy obe-cel in relapsed or refractory B-cell ALL patients.
December 2nd, 2024 — Source

New understanding of a cancer-relevant protein reveals opportunities for drug discovery
A new approach to targeting a protein involved in cell division, which can misfunction in cancer, has revealed new insights into how it functions.
December 2nd, 2024 — Source

Newfound mechanism may explain why some cancer treatments boost risk of heart disease
A cancer therapy that prompts the body's immune defenses against viruses and bacteria to attack tumors can make patients more vulnerable to heart attack and stroke. A possible explanation for this side effect is that the treatment interferes with immune regulation in the heart's largest blood vessels, a new study suggests.
December 2nd, 2024 — Source or Source

On the rise: Stomach cancer in younger people
Rates of stomach cancer, which is also called gastric cancer, among younger people is on the rise. Typically, stomach cancer is diagnosed in patients in their 60s and 70s, but increasingly it's being diagnosed in younger patients. While rates of stomach cancer in older patients have been declining for decades, early onset stomach cancer is increasing and makes up around 30% of stomach cancer diagnoses.
December 2nd, 2024 — Source

Smoker or former smoker? Four key things you need to know
Doctors have potent new weapons against the deadliest cancer in America and they want to make sure they're on the radar of current and former smokers.
December 2nd, 2024 — Source

Study reveals how stem cells respond to environmental signals, with implications for IBD and colorectal cancer
A new study from The Hospital for Sick Children (SickKids) and Institut Curie reveals how stem cells sense and respond to their environment, with implications for inflammatory bowel disease and colorectal cancer.
December 2nd, 2024 — Source

Unhealthy diets are driving digestive diseases, research suggests
Against the backdrop of an alarming increase in the number of people under 50 being diagnosed with bowel cancer, researchers are urging people to bump up their fiber intake and improve their eating habits if they want to reduce their risk of deadly digestive cancers.
December 2nd, 2024 — Source

Health — Cancer — November 29th, 2024

Closing the gap of prostate cancer presentation disparities in Ireland
Recent findings from a study on prostate cancer in Ireland reveal diagnosis disparities, especially in urban areas and middle socioeconomic groups. Patients treated in public hospitals and urban patients were more often diagnosed through opportunistic screenings.
November 29th, 2024 — Source

Genetic study discovers mechanisms that make Ewing sarcoma more aggressive
Ewing sarcoma is a tumor of the bones and soft tissues that occurs in children and young people. Like all childhood cancers, it is rare—nine to 10 cases per million inhabitants per year—but it is very aggressive: 25% of patients do not respond well to regular therapy and they often experience relapses.
November 29th, 2024 — Source

Intracellular checkpoints for natural killer cell cancer immunotherapy
Natural killer (NK) cells are pivotal in the innate immune response against cancer and viral infections, with their presence in tumors correlating to better patient outcomes in various cancers. However, NK cells in the tumor microenvironment often become functionally exhausted, characterized by decreased numbers and impaired functions due to imbalances in immune regulatory signals.
November 29th, 2024 — Source

New insights into risk assessment of rare, aggressive tumors in children
An international research team including researchers from Augsburg University Medicine has made significant progress in the risk assessment and treatment of extracranial malign rhabdoid tumors. Recently published in the journal Clinical Cancer Research, the study, "Clinical and Molecular Risk Factors in Extracranial Malignant Rhabdoid Tumors: Toward an Integrated Model of High-Risk Tumors," shows how clinical and molecular factors can influence disease progression and contribute to improvements in individual treatment.
November 29th, 2024 — Source

Phase 1 study finds serine- and glycine-free diet boosts immune response in colorectal cancer
Early trial shows a specialized diet enhances immune cell activity and improves the effectiveness of immunotherapy in colorectal cancer patients
November 29th, 2024 — Source

Researchers identify six-gene pattern to predict drug success in multiple myeloma patients
Researchers at the Icahn School of Medicine at Mount Sinai have discovered how genetics can affect the success of venetoclax, a treatment for multiple myeloma, a rare type of blood cancer. Their study, "Predictors of Response to Venetoclax and Therapeutic Potential of CDK7 Inhibition in Multiple Myeloma," was published this month in the journal Blood Neoplasia.
November 29th, 2024 — Source

STAG₂ loss linked to increased aggression in Ewing sarcoma
Ewing sarcoma is a tumor of the bones and soft tissues that occurs in children and young people. Like all childhood cancers, it is rare -- 9 to 10 cases per million inhabitants per year -- but it is very aggressive. 25% of patients do not respond well to regular therapy and they often experience relapses.
November 29th, 2024 — Source

Health — Cancer — November 27th, 2024

A turning point for cancer treatment: Monocytes boost T-cells in immunotherapy
In recent decades, immunotherapy has transformed cancer treatment, offering effective options for diseases once considered uncurable, such as melanoma, lung, and bladder cancers. What began as laboratory research has now moved to real-world clinical applications, providing new possibilities for patients facing a range of challenging conditions.
November 27th, 2024 — Source

CAR T cells armed with IL-15 show promise in treating solid cancers
Researchers report results of the first-in-human phase 1 clinical trials of a novel immunotherapy approach for solid tumors expressing glypican-3 (GPC3). A team from Baylor College of Medicine and Texas Children's Cancer Center led the study, which tested chimeric antigen receptor (CAR) T cells enhanced with the protein interleukin-15 (IL-15).
November 27th, 2024 — Source

Cervical cancer deaths in young women plummet after introduction of HPV vaccine, finds study
Cervical cancer deaths have plunged dramatically among women under age 25, and researchers at MUSC Hollings Cancer Center believe this is likely due to HPV vaccination.
November 27th, 2024 — Source or Source

Considerable cost savings from more efficient use of CDK4/6 inhibitors in metastatic breast cancer reported
On November 27, Nature published the results of an innovative breast cancer research project from the Netherlands. This study, the SONIA trial, showed that delaying and shortening the duration of a specific anti-cancer therapy (CDK4/6 inhibitors) in patients with hormone receptor-positive advanced breast cancer leads to similar survival outcomes, while reducing toxicity and achieving substantial cost reductions: over 45 million euros per year in the Netherlands and over 5 billion dollars in the United States.
November 27th, 2024 — Source

Diabetes drug metformin might help fight lung cancer
Already the go-to drug of choice for millions with type 2 diabetes, metformin might also fight lung cancer if those patients have it as well, new research shows.
November 27th, 2024 — Source

Gold beats platinum for chemo drugs in new lab study
A new gold-based drug can slow tumor growth in animals by 82% and target cancers more selectively than standard chemotherapy drugs, according to a study by Australian and Indian researchers.
November 27th, 2024 — Source

Integrated approach elucidates the long-sought structure of a natural powerful anticancer product
A collaborative effort by the research groups of Professor Haruhiko Fuwa from Chuo University and Professor Masashi Tsuda from Kochi University has culminated in the structure elucidation and total synthesis of anticancer marine natural products, iriomoteolide-1a and -1b. These natural products were originally isolated from the marine dinoflagellate collected off the Iriomote Island, Okinawa, Japan.
November 27th, 2024 — Source

New gold-based drug proves to be more potent than standard chemotherapy
A new gold-based drug can slow tumor growth in animals by 82% and target cancers more selectively than standard chemotherapy drugs, according to a study by Australian and Indian researchers.
November 27th, 2024 — Source

Researchers reveal how aging impairs antitumor activity of CD8⁺ T cells
A research team from the Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences has revealed that aging specifically impairs the generation of CD8+ tissue resident memory T cells (TRM) and thus compromises the antitumor defensive activity of aged CD8+ T cells.
November 27th, 2024 — Source

Scientists identify a form of vitamin B6 as a means of engaging tumor-reactive immune cells
Effective immunity hinges on the ability to sense infection and cellular transformation. In humans, there is a specialized molecule on the surface of cells termed MR1. MR1 allows sensing of certain small molecule metabolites derived from cellular and microbial sources; however, the breadth of metabolite sensing is unclear.
November 27th, 2024 — Source

Should postmenopausal women eat soy? Researchers dispel myth about soy and cancer
A University of Toronto study is providing reassuring evidence about the consumption of soy foods in women who are postmenopausal.
November 27th, 2024 — Source

Steep decline in cervical cancer deaths among young women in US
HPV vaccination linked to a steep decline in cervical cancer deaths among U.S. women under 25, with mortality dropping by 62% from 2013-2021 and only 13 deaths reported in 2019-2021.
November 27th, 2024 — Source

Health — Cancer — November 25th, 2024

A molecular trap for exotic metals promises improved diagnostics and faster drug development
A group of scientists from IOCB Prague, led by Dr. Miloslav Polášek, have created compounds that are up to a million times more stable than similar substances used in contemporary medicine to treat tumors or as contrast agents for magnetic resonance imaging.
November 25th, 2024 — Source

Adding temozolomide to radiation therapy improves survival in adult patients with slow-growing brain tumor, trial finds
Both radiation and temozolomide, a generic chemotherapy treatment in pill form, have meaningful single-modality anti-tumor activity against slow-growing, low-grade gliomas. The randomized phase 3 trial E3F05 by the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) tested whether combined therapy using temozolomide alongside radiation therapy is more effective than radiation therapy alone in these patients.
November 25th, 2024 — Source

Addressing barriers to advance care planning by adults with advanced cancers: Mindfulness may improve quality of life
In one of the first studies to test the utility of mindfulness to support advance care planning by adult cancer patients and their family caregivers, researchers from Regenstrief Institute and Indiana University found that mindfulness showed promise in improving quality of life and advance care planning outcomes in patients and their family caregivers coping with advanced cancer.
November 25th, 2024 — Source

ASTRO releases updated guidelines for treating locally advanced rectal cancer
The American Society for Radiation Oncology (ASTRO) issued today an updated clinical guideline for physicians who use radiation therapy to treat patients with locally advanced rectal cancer. This update incorporates new data on patient selection and best practices from several practice-changing clinical trials published since the prior guideline was issued in 2020.
November 25th, 2024 — Source

Chromosomal chaos promotes therapy resistance in leukemia cells and opens up new treatment approaches
Chromosomal instability plays a crucial role in the progression of cancer: it shapes the properties of tumor cells and drives the development of therapy resistance. Scientists from the German Cancer Research Center (DKFZ), the Heidelberg Stem Cell Institute HI-STEM and the European Molecular Biology Laboratory (EMBL) used state-of-the-art single-cell analysis methods to analyze the cellular heterogeneity of a specific form of acute myeloid leukemia. Their data show how genetic and non-genetic factors determine the functional heterogeneity of blood cancer cells and reveal new therapeutic targets.
November 25th, 2024 — Source

Home testing kits and coordinated outreach found to substantially improve colorectal cancer screening rates
Colorectal cancer screening is an effective tool for catching the disease early when it's most treatable, yet it is underutilized in patient populations who receive primary care at federally qualified health centers (FQHC).
November 25th, 2024 — Source

How breast cancer patients respond to tamoxifen may be linked to the gut microbiome
A new study has shown that variation in the microbiota of the human gut impacts the pharmacokinetics of tamoxifen and thus the effectiveness of the drug. The finding, published in the journal mBio of the American Society for Microbiology, suggests that in the future, doctors may use a simple test on a patient's stool to check for certain bacteria in the gut that might help predict whether tamoxifen will work for them.
November 25th, 2024 — Source

How race impacts patients' response to cancer immunotherapy: Treatment proves effective for Black patients
Clinical trials testing cancer immunotherapies have significantly under-represented Black patients. So while these treatments have resulted in dramatically improved outcomes for some patients, researchers from the University of Michigan Rogel Cancer Center wanted to understand whether that success holds true for patients who are Black.
November 25th, 2024 — Source

How the body's own cannabinoids may influence the symptoms and treatment of ADHD
Cannabis—whether marijuana itself or various products containing cannabinoids and/or THC, the main psychoactive compound in weed—have been touted as panaceas for everything from anxiety and sleep problems to epilepsy and cancer pain.
November 25th, 2024 — Source

IASLC and LCRF announce first grant recipient for lung cancer research
The International Association for the Study of Lung Cancer (IASLC) and The Lung Cancer Research Foundation (LCRF) announce the first grant recipient of the IASLC LCRF Team Science Research Grant on the Next Step in the Cure of Oncogene-Driven Lung Cancers Award. Patients with oncogenic-driven lung cancer account for approximately 40-50% of the lung cancer population. Oral pills are effective at controlling the disease, but patients are not cured due to the development of drug resistance.
November 25th, 2024 — Source

More patients opting for close monitoring of early stage prostate cancer
Prostate cancer is the second most commonly diagnosed cancer in men (behind skin cancer), with varying levels of aggressiveness. It's also the second leading cause of cancer death, behind only lung cancer.
November 25th, 2024 — Source

Mursla Bio's EvoLiver surpasses current standards in liver cancer surveillance, data presented at AASLD Liver Meeting 2024
Mursla Bio, a leader in Extracellular Vesicle (EV) science on a mission to significantly improve cancer outcomes for at-risk patients through the power of dynamic biopsy technology, today announced results of its multi-center clinical study, MEV01, in collaboration with leading academic institutes including University College London, Imperial College London, University Hospital of Santa Maria and the Medical University of Graz.
November 25th, 2024 — Source

Psychological therapy offers new hope for young Latino testicular cancer survivors
Cancer survivorship researchers from the UC Irvine Joe C. Wen School of Population & Public Health found that young adult Latino testicular cancer survivors could better manage distress, pursue life goals, and regulate emotions following their cancer treatment after a psychological intervention: Goal-focused Emotion regulation Therapy (GET).
November 25th, 2024 — Source

Researchers call for inclusive cancer trials and treatments to address overlooked source of structural racism
Researchers from Harvard University and Queen Mary University of London have proposed policy changes in cancer care to take account of a common genetic variation.
November 25th, 2024 — Source

Researchers identify gene signature for high-risk form of T-cell acute lymphoblastic leukemia
Researchers from Children's Hospital of Philadelphia (CHOP) have discovered the underlying biology that identifies a subset of patients with acute lymphoblastic leukemia who have a higher risk version of the disease and are more likely to relapse despite treatment. The findings have allowed researchers to identify new potential therapeutic treatments for patients with this specific form of cancer with a high risk of recurrence.
November 25th, 2024 — Source

Scientists discover why breast cancer drug works better for some people
A new study has shown that variation in the microbiota of the human gut impacts the pharmacokinetics of tamoxifen and thus the effectiveness of the drug. The finding, published in the journal mBio, suggests that in the future, doctors may use a simple test on a patient's stool to check for certain bacteria in the gut that might help predict whether tamoxifen will work for them.
November 25th, 2024 — Source

Scientists find why tamoxifen works better for some people
Tamoxifen is a common and important treatment to prevent breast cancer from recurring. A new study shows that variation in a patient's gut microbiome can impact how effective the treatment is.
November 25th, 2024 — Source

Survey shows most people don't know that alcohol raises cancer risk
Although the Centers for Disease Control and Prevention (CDC) says that you can "lower your risk for cancer by drinking less alcohol or not drinking at all," Annenberg Public Policy Center (APPC) data show that less than half of Americans know that regularly drinking alcohol increases the risk of later developing cancer.
November 25th, 2024 — Source

This week's space station science: Leads on cancer drugs, satellite sustainability, glass from magnesium silicates
Space-grown crystals could lead to targeted cancer drugs
November 25th, 2024 — Source

Yoga helps women deal with the mental stress of cancer, research shows
A cancer diagnosis can bring overwhelming stress and depression to women, but new research suggests yoga can help ease that emotional toll.
November 25th, 2024 — Source

Health — Cancer — November 24th, 2024

Yes, you still need to use sunscreen, despite what you've heard on TikTok
Summer is nearly here. But rather than getting out the sunscreen, some TikTokers are urging followers to chuck it out and go sunscreen-free.
November 24th, 2024 — Source

Health — Cancer — November 23rd, 2024

Cancer prevention: 7 tips to reduce your risk
Concerned about cancer prevention? Take charge by making changes such as eating healthy foods and getting regular screenings.
November 23rd, 2024 — Source

Health — Cancer — November 21st, 2024

AI method can measure cancer severity using pathology reports to shorten selection process for clinical trials
A group of investigators led by Cedars-Sinai have developed and successfully tested a new artificial intelligence (AI) method to make launching cancer clinical trials easier and faster. The method uses patients' pathology reports to automate the classification of patients by the severity of their cancers, potentially shortening the process of selecting candidates for clinical trials.
November 21st, 2024 — Source

Brain tumor research identifies source of glioma's deadly transformation
Gliomas are the most common brain tumors, and many start off growing slowly as "low-grade" tumors before inevitably becoming aggressive, lethal, and "high grade." New research offers an explanation for this deadly transformation.
November 21st, 2024 — Source

Camouflage detection boosts neural networks for brain tumor diagnosis
Neural networks trained with a camouflage detection step show enhanced accuracy and sensitivity in identifying brain tumors from MRI scans, mimicking expert radiologists.
November 21st, 2024 — Source

In aggressive form of breast cancer, response to therapy may contribute to tumor regrowth, study finds
A recent study by a team of researchers at Vanderbilt University found that response to radiation therapy for triple negative breast cancer (TNBC)—one of the most aggressive forms of the disease—may contribute to tumor recurrence.
November 21st, 2024 — Source

New structure gives insight into mRNA export and cancers, and how viruses hijack the process to infect their host
The central dogma of biology defines the flow of genetic information: It describes how proteins are made from mRNA templates, which are in turn made from DNA. Exporting the mRNA from inside the nucleus to the site of protein translation in the cytoplasm is a critical step for life for eukaryotes like us.
November 21st, 2024 — Source

Researchers discover new combination therapy approach for metastatic ovarian cancer
The Wistar Institute's Nan Zhang, Ph.D., assistant professor in the Ellen and Ronald Caplan Cancer Center's Molecular and Cellular Oncogenesis Program, and colleagues have discovered a new approach to treating ovarian cancer, that in preclinical laboratory testing, shrinks tumors and improves survival rates while simultaneously making tumors more receptive to chemotherapy treatment.
November 21st, 2024 — Source

Scientists can predict how long prostate cancer patients will respond to olaparib
Scientists have worked out a way of predicting how long a prostate cancer patient will continue to respond to the PARP inhibitor drug olaparib, according to new research published in the journal Cancer Cell.
November 21st, 2024 — Source

Small brain-penetrating molecule offers hope for treating aggressive brain tumors
Researchers identify gliocidin, a blood-brain barrier-penetrating prodrug, that targets glioblastoma's unique metabolic vulnerability, offering a promising therapeutic strategy and extended survival in preclinical models.
November 21st, 2024 — Source

Spatial interactomics tool maps protein interactions to fight lung cancer
As Ahmet F. Coskun and his team of researchers continue their mission to create a 3D atlas of the human body, mapping cells and tissues, they're making discoveries that could lead to better treatments for the most common type of lung cancer.
November 21st, 2024 — Source

Study reveals how glioblastoma evades treatment; identifies potential new treatment strategy
A new study from scientists at the UCLA Health Jonsson Comprehensive Cancer Center helps explain why glioblastoma, one of the most aggressive forms of brain cancer, becomes resistant to treatment, and introduces a new approach that paves the way for more personalized treatment strategies for patients with this deadly brain tumor.
November 21st, 2024 — Source

Using gas bubbles to precisely deliver nanomedicines shows promise for lung cancer treatment
The delivery of nanomedicines using gas bubbles has shown itself to be a unique way of transporting cytotoxins to the lungs of cancer patients. The method enables precise and focused treatments, and the local action of the drugs also prevents a range of side-effects.
November 21st, 2024 — Source

Why asbestos is still being found in some cosmetics
Asbestos, a notorious carcinogen, was in widespread use throughout the 20th century—from building materials to brake pads and even fake snow on film sets including The Wizard of Oz and White Christmas.
November 21st, 2024 — Source

Health — Cancer — November 18th, 2024

AI analysis of immune cells can predict breast cancer prognosis
Researchers at Karolinska Institutet have investigated how well different AI models can predict the prognosis of triple-negative breast cancer by analyzing certain immune cells inside the tumor. The study, published in the journal eClinicalMedicine, is an important step toward using AI in cancer care to improve patient health.
November 18th, 2024 — Source

Birth control shots caused brain tumors and speech issues for Nevada mom, lawsuit says
A mother says years of painful headaches and speech issues from brain tumors were caused by prolonged use of a Pfizer birth control shot, according to a lawsuit filed Nov. 14 in Nevada Federal District Court.
November 18th, 2024 — Source

Does Fluoride Cause Cancer, IQ Loss, and More? Fact-Checking Robert F. Kennedy Jr.’s Claims
President-elect Donald Trump’s incoming administration could try to remove fluoride from drinking water, according to Robert F. Kennedy Jr.
November 18th, 2024 — Source

High-dose IV vitamin C plus chemotherapy doubles survival in advanced pancreatic cancer
Approach also improves survival in clinical trial for glioblastoma
November 18th, 2024 — Source or Source

Is it ever OK for scientists to experiment on themselves?
A virologist named Beata Halassy recently made headlines after publishing a report of successfully treating her own breast cancer by self-administering an experimental treatment.
November 18th, 2024 — Source

Jumping genes for early detection of gastric cancer
Gastric cancer (GC) is a lethal malignancy with worldwide occurrence, and is considered endemic in eastern Asian, eastern European and South American countries. Indeed, in my home country, Chile, GC is the leading cause of cancer death in men.
November 18th, 2024 — Source

Mobile 'Man Van' spots prostate cancer more quickly and cheaply than via GPs
Mobile testing "Man Van" can diagnose prostate cancer in at-risk groups earlier and more affordably than GPs, according to new research.
November 18th, 2024 — Source

Mouth cancer cases hit new record in England and Scotland—what you need to know
Cases of mouth cancer have reached a record high in England and Scotland, a new report shows. Last year, there were more than 10,000 new cases.
November 18th, 2024 — Source

Norway study finds incidence of thin melanoma is increasing faster than that of other kinds
Norway ranks third in the world when it comes to the incidence of melanoma (formerly called mole cancer) and has the highest mortality from this disease in Europe.
November 18th, 2024 — Source

Study: Suicide rates for young male cancer survivors triple in recent years, with ages 15–39 seeing highest rate
New research published in JAMA Network Open from USC Norris Comprehensive Cancer Center, part of Keck Medicine of USC, suggests that among all cancer survivors, male adolescents and young adults (AYA) have the highest rate of death by suicide.
November 18th, 2024 — Source

T-cell dysfunction increases cancer risk in obese populations, researchers say
Researchers at Saint Louis University's School of Medicine say T-cell dysfunction is leading to an increased risk of cancer in obese populations.
November 18th, 2024 — Source

Health — Cancer — November 17th, 2024

New therapeutic vaccine gives hope against an aggressive breast cancer
An experimental vaccine could offer fresh hope to women diagnosed with an aggressive and hard-to-treat form of breast cancer, new research suggests.
November 17th, 2024 — Source

Health — Cancer — November 16th, 2024

New microfluidic device shows tumor shape predicts cancer aggressiveness
Researchers at the University of Toronto's Faculty of Applied Science & Engineering have designed a new microfluidic platform that allows for unprecedented control and manipulation of tumor shapes—a largely unexplored area with great potential to advance cancer research.
November 16th, 2024 — Source

Selenoproteins open new strategies for treating certain cancers in children
Selenoproteins are crucial for several biological functions, including the breakdown of harmful substances, immune system support, and regulating metabolic processes. However, in specific contexts, these proteins can be misused and shield cancer cells from death. One such protein, glutathione peroxidase 4 (GPX4), is vital in supporting cellular protection and cancer cell survival.
November 16th, 2024 — Source

Health — Cancer — November 15th, 2024

Cancer while pregnant is rare, but is becoming more common. Here's what researchers think is behind the rise
Former winner of TV show Alone Australia Gina Chick was diagnosed with breast cancer just days after finding out she was pregnant. She describes in her recent book her experience with chemotherapy and what followed.
November 15th, 2024 — Source

Meta-analysis links high-risk Epstein-Barr virus lineage to nasopharyngeal cancer in southern China
Researchers have discovered a significant association between specific Epstein-Barr virus (EBV) variants and nasopharyngeal carcinoma (NPC). NPC is a cancer notably prevalent in southern China, where it is 20 times more common than in non-endemic regions of the world.
November 15th, 2024 — Source

Neuro-oncology experts reveal how to use AI to improve brain cancer diagnosis, monitoring, treatment
An international team of leading neuro-oncology researchers and clinicians has released new recommendations for good clinical practice regarding the use of artificial intelligence methods to more accurately diagnose, monitor and treat brain cancer.
November 15th, 2024 — Source

New possibilities for treating intractable brain tumors unveiled
Immunotherapy, which enhances the immune system's T cell response to eliminate cancer cells, has emerged as a key approach in cancer treatment. However, in the case of glioblastoma, an aggressive and treatment-resistant brain tumor, numerous clinical trials have failed to confirm its efficacy.
November 15th, 2024 — Source

Novel selenium carrier protein regulates ferroptosis in tumors and the brain
Researchers at Helmholtz Munich, in collaboration with colleagues at Tohoku University, have identified a specific redox protein as a critical regulator of ferroptosis—a form of regulated oxidative cell death. Ferroptosis has garnered strong interest due to its therapeutic potential in addressing therapy-resistant and metastasizing cancers, and its involvement in neurodegenerative diseases.
November 15th, 2024 — Source

Research concentrates on genes that cause tumors in the Meibomian gland
Dr. Cornelia Peterson is dedicated to finding treatments for cancer by researching tumors that develop in Meibomian glands, the specialized oil-secreting glands of the eyelid. She joined Cummings School of Veterinary Medicine at Tufts University's faculty a year and a half ago as an assistant professor of anatomic pathology in the Department of Comparative Pathobiology, establishing her own lab at Cummings School to advance research in comparative ocular pathology.
November 15th, 2024 — Source

Scientists develop novel plug-and-play test to evaluate T cell immunotherapy effectiveness
This breakthrough test requires only a small blood sample to track modified T cells in patients over time, ensuring therapies remain effective. This plug-and-play approach is set to accelerate the development of more T-cell-based therapies and vaccines.
November 15th, 2024 — Source or Source

Selenium carrier proteins: New starting point for cancer research
A recent study unveiled a key enzyme involved in producing selenoproteins, opening new strategies for treating certain types of cancer in children.
November 15th, 2024 — Source

Trial finds adding immunotherapy to neoadjuvant chemoradiation may improve outcomes in esophageal cancer
A study published inClinical Cancer Research found that in patients with unresectable, locally advanced esophageal cancer, the triple combination of radiation, chemotherapy, and immunotherapy made tumors more amenable to surgery, which was associated with significantly improved outcomes.
November 15th, 2024 — Source

Health — Cancer — November 12th, 2024

23andMe is ending its cancer research program and slashing over 200 jobs
The genetic testing firm plans to license or sell the therapies it's developing.
November 12th, 2024 — Source

AI tools measure 'immunological fitness' to personalize cancer therapies
Researchers from the Data Science and Artificial Intelligence Institute (DATAI) at the University of Navarra have developed artificial intelligence (AI) models to personalize immune therapies for oncology patients.
November 12th, 2024 — Source

Combination approach shows promise for treating rare, aggressive cancers
A research team led by UCLA Health Jonsson Comprehensive Cancer Center investigators has shown that combining pembrolizumab, an immunotherapy drug, with standard chemotherapy can improve treatment outcomes for patients with small cell bladder cancer and small cell/neuroendocrine prostate cancer.
November 12th, 2024 — Source

Georgia Tech researchers create lab-grown models of human immune systems
To better understand why some cancer patients struggle to fight off infections, Georgia Tech researchers have created tiny lab-grown models of human immune systems.
November 12th, 2024 — Source

Glioblastoma: New treatment uses CAR-T cells to attack brain tumors from multiple angles
Glioblastoma is the most common kind of malignant brain tumor in adults. So far, no treatment has been able to make this aggressive tumor permanently disappear. The tumor cells are too varied, and the microenvironment is too tumor-friendly. Researchers at the University of Basel and University Hospital Basel have now developed an immunotherapy that not only attacks the tumor—it also turns its microenvironment against it.
November 12th, 2024 — Source

Inhibiting METTL3 protein shows promise for high-risk neuroblastoma
Blocking the METTL3 protein can increase sensitivity to chemotherapy in neuroblastoma, according to research from the University of Gothenburg. The study shows how specific RNA modifications affect gene expression in the early development of neuroblastoma.
November 12th, 2024 — Source

Key reason why some cancers do not respond to immunotherapy identified
Researchers identify SLC13A3 as a key player in tumor cell survival and immune therapy resistance, highlighting its potential as a target to improve cancer treatment outcomes.
November 12th, 2024 — Source

Medicaid enrollment continuity tied to lymphoma stage at diagnosis
Continuous enrollment in Medicaid was associated with a lower rate of a late-stage lymphoma diagnosis in children and adolescents/young adults (AYAs). However, fewer than half of Medicaid-insured patients in these age ranges were continuously enrolled before diagnosis, according to a study published in SourceBlood Advances.
November 12th, 2024 — Source

Mitochondria's division of labor sheds light on how cancer cells survive harsh conditions
New research reveals how mitochondria adapt to nutrient scarcity, offering insights into cancer cell survival mechanisms.
November 12th, 2024 — Source

'Moonlighting' enzymes may lead to new cancer therapies
Researchers at the Center for Genomic Regulation (CRG) reveal that metabolic enzymes known for their roles in energy production and nucleotide synthesis are taking on unexpected "second jobs" within the nucleus, orchestrating critical functions like cell division and DNA repair.
November 12th, 2024 — Source

New blood test offers early detection of drug-induced tissue damage in cancer patients
A team of researchers have applied a novel blood test that can detect early signs of potentially fatal lung damage in cancer patients taking antibody--drug conjugates (ADCs). This breakthrough method aims to offer a safer, simpler way to monitor patients for drug-induced lung disease, potentially reducing the need for frequent scans.
November 12th, 2024 — Source

New cancer therapy strategy targets GLUT3 in regulatory T cells to supercharge anti-tumor immunity
Scientists at Pohang University of Science and Technology (POSTECH) and ShanghaiTech University have achieved a breakthrough in cancer immunotherapy research. Led by Professors Sin-Hyeog Im and Dipayan Rudra, the research team, with Dr. Amit Sharma as the first author, has identified GLUT3, a glucose transporter, as essential to the suppressive function of regulatory T cells (Tregs) in the tumor microenvironment (TME).
November 12th, 2024 — Source

New study links air pollution with higher rates of head and neck cancer
A recent study published in the journal Scientific Reports correlates higher levels of pollutant particulate matter to higher occurrences of head and neck aerodigestive cancer.
November 12th, 2024 — Source

New treatment combination improves outcomes for small cell bladder and prostate cancer patients
A research team led by UCLA Health Jonsson Comprehensive Cancer Center investigators has shown that that combining pembrolizumab, an immunotherapy drug, with standard chemotherapy can improve treatment outcomes for patients with small cell bladder cancer and small cell/neuroendocrine prostate cancer.
November 12th, 2024 — Source

Nomic® and Parker Institute for Cancer Immunotherapy (PICI) launch large-scale protein profiling to investigate immunotherapy responses in RADIOHEAD study
Nomic Bio Inc. (Nomic), a proteomics company with the highest-throughput platform for multiplexed protein quantification, and the Parker Institute for Cancer Immunotherapy (PICI), a collaborative consortium of the world's leading immuno-oncology experts, today announced a research collaboration to quantify circulating protein biomarkers that are associated with patient responses to immunotherapy across cancer types.
November 12th, 2024 — Source

Only half of young cancer patients report a discussion on fertility preservation, researchers find
Only half of people with early-onset cancers reported discussing fertility preservation options prior to their oncology treatments, according to results of a cross-sectional study published Nov. 12 in JAMA Network Open.
November 12th, 2024 — Source

Researchers discover why taking a mushroom supplement slows or prevents prostate cancer from getting worse
Researchers at City of Hope now understand why taking an investigational white button mushroom supplement shows promise in slowing and even preventing prostate cancer from spreading among men who joined a phase 2 clinical trial studying "food as medicine."
November 12th, 2024 — Source

Stand Up To Cancer partners with Johnson & Johnson to explore new treatment for AL amyloidosis
Stand Up To Cancer® (SU2C) today announced a collaboration with Johnson & Johnson aimed at supporting research testing a combination of two types of targeted therapies, teclistamab and daratumumab, to treat a rare disease called AL amyloidosis. Affecting approximately 4,500 people annually in the U.S., AL amyloidosis can be associated with blood cancers, particularly multiple myeloma as well as lymphomas or chronic lymphocytic leukemia.
November 12th, 2024 — Source

Study finds 81% of cancer cures touted by TikTok videos are fake
As many as 81% of cancer cures touted by content creators on TikTok are fake, according to new research from City St George's, University of London.
November 12th, 2024 — Source

Study identifies new approach to overcome docetaxel resistance in patients with advanced prostate cancer
The treatment landscape for patients with prostate cancer, especially individuals with advanced disease, has dramatically changed in recent years. However, aside from drug or hormonal therapies, other targets to treat prostate cancer are still necessary to prolong life and slow the progression of this potentially lethal disease.
November 12th, 2024 — Source

Treatment target for aggressive leukemia discovered by disrupting its genome organization
Researchers have identified a key weakness in acute myeloid leukemia, offering a promising new strategy to delay the progression of this aggressive blood cancer. The discovery focuses on disrupting the function of a certain protein complex that cancer cells, including leukemia cells, rely on to maintain their abnormal growth.
November 12th, 2024 — Source

Using CRISPR to decipher whether gene variants lead to cancer
In recent years, scientists have created a range of new methods based on CRISPR-Cas technology for precisely editing the genetic material of living organisms. One application is in cell therapy: A patient's immune cells can be specifically reprogrammed to fight cancer more effectively.
November 12th, 2024 — Source

Health — Cancer — November 10th, 2024

A Horrific Caterpillar Fungus Might Hold Cancer-Fighting Potential
Researchers have found that the fungus Cordyceps militaris contains a key ingredient that could be used to attack tumor cells.
November 10th, 2024 — Source

Health — Cancer — November 8th, 2024

Advancements in liquid biopsy for detecting pancreatic incidentalomas
In recent research published in eGastroenterology, Dr. J-Matthias Löhr and colleagues provide an in-depth review of diagnostic methods for pancreatic incidentaloma-; incidental findings often detected during imaging scans intended for other conditions. These pancreatic lesions, which vary in severity, can occasionally signal pancreatic cancer in its earliest stages. However, traditional methods, including MRI and CT scans, are limited by invasiveness, cost, and variable sensitivity to early pancreatic changes.
November 8th, 2024 — Source or Source

Cancer-killing virus treatment shows promise in brain tumor trial
Researchers from Queen Mary University of London, the Chinese Academy of Sciences and Capital Medical University in Beijing have tested a virus treatment in eight patients with glioblastoma. The treatment was safe and effective below a maximum dose, with complete remission achieved in one patient, supporting progression to phase II clinical trials.
November 8th, 2024 — Source

Circulating tumor cells as a tool for early detection of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a significant global health concern, particularly in regions like the Asia-Pacific, where chronic viral hepatitis and liver diseases contribute to its high incidence and mortality. Despite medical advancements, the late-stage diagnosis of HCC remains a major challenge, which underscores the need for more effective early detection strategies.
November 8th, 2024 — Source

Genetic variant discovery could lead to early detection and treatment of aggressive prostate cancer
QUT scientists have uncovered functionality of a genetic variant in the prostate specific antigen (PSA) gene to improve the current diagnostic test to help distinguish aggressive from non-aggressive prostate cancers and the level of treatment the patient needs.
November 8th, 2024 — Source

Groundbreaking research unlocks precision therapy for drug-resistant leukaemia
Scientists investigated how an inherited genetic variation common among East Asians contributes to drug resistance in cancer cells, driving more aggressive cancer growth. The team trialled a precision therapy for this group by blocking the action of a protein called MCL-1, successfully killing many of the cancer cells in laboratory studies.
November 8th, 2024 — Source

How physical activity before and after cancer treatment improves outcomes
Physical activity is beneficial before, during and after chemotherapy treatment. New doctoral research has taken a closer look at those who opt out.
November 8th, 2024 — Source

Increased psoriasis risk found in cancer patients treated with immune checkpoint inhibitors
Researchers from the National Defense Medical Center in Taiwan have identified an increased risk of psoriasis in patients with cancer undergoing immune checkpoint inhibitor (ICI) treatments, with implications for other immune-related adverse events.
November 8th, 2024 — Source

IUDs still 'very safe' in light of new research on breast cancer risk, experts say
Intrauterine devices are one of the most effective reversible forms of birth control, despite the pain many go through during the insertion.
November 8th, 2024 — Source

Many cancer survivors struggle to maintain an active lifestyle
"Those who cope best with cancer treatment are often those who had an active lifestyle before diagnosis. It reduces the risk of delayed injury and complications," says Benedikte Western.
November 8th, 2024 — Source

New option for treating prostate cancer
Innovative strategy reduces tumor growth and strengthens the immune system against tumor cells
November 8th, 2024 — Source

New take on immunotherapy reinvigorates T cells by blocking uptake of energy-sapping cancer byproducts
As cancer cells grow, they pump out metabolic byproducts such as lactic acid into the tumor microenvironment. Exhausted T cells—which have lost their cancer-fighting oomph—consume this lactic acid, which further saps their energy, according to new research from the University of Pittsburgh and UPMC Hillman Cancer Center.
November 8th, 2024 — Source or Source

Researchers announce updated findings in preventive breast cancer vaccine study
Cleveland Clinic researchers are presenting updated findings from their novel study of a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease.
November 8th, 2024 — Source

Researchers discover new treatment target for triple-negative breast cancer
University of Kentucky Markey Cancer Center researchers identified a protein that could be key to developing new treatments for triple-negative breast cancer.
November 8th, 2024 — Source

Researchers uncover metabolic blockade that impedes cancer treatment response
The immune system is a major target for cancer treatments. Immune checkpoint inhibitors and CAR-T cell therapy can dramatically improve outcomes for many cancers. But for about 70% of patients, these therapies don't work.
November 8th, 2024 — Source

Signaling pathway strategy offers a new approach for treating prostate cancer
Prostate cancer is the second most common cancer in men worldwide. Despite medical advances in recent years, this type of tumor is still responsible for one in eight male cancer deaths in Austria alone.
November 8th, 2024 — Source

Study finds critical shortages in cancer treatment resources across ex-Soviet Union countries
A new study led by Oxford University and involving Swansea University has found that the treatment of cancer in twelve former Soviet Union countries is being impacted by shortages and inconsistencies in equipment and staff.
November 8th, 2024 — Source

Targeting ferroptosis for overcoming chemoresistance in digestive tract tumors
The global burden of digestive tract tumors is profound, with these cancers accounting for nearly half of all malignant tumors worldwide. Despite advancements in endoscopic diagnostic methods, which enable earlier detection and treatment, a large portion of patients still receive diagnoses at later stages.
November 8th, 2024 — Source

Travel time to tanning facilities negatively linked to melanoma incidence
There is a negative association between travel time to tanning facilities and county-level melanoma incidence rates, according to a study published online Nov. 7 in the Journal of Investigative Dermatology.
November 8th, 2024 — Source

Trial finds exercise during cancer treatment reduces cardiovascular risk
A new randomized controlled trial out of the Baker Heart and Diabetes Institute has found that combining structured exercise training with reductions in sitting time protects against heart damage and declines in cardiovascular fitness in adults receiving stem cell transplantation for blood cancers.
November 8th, 2024 — Source

Virtual screening identifies potential small molecule drugs for cancer immunotherapy
The process of identifying promising small molecule drug candidates that target cancer checkpoints may become faster and smarter through virtual screening, according to Weill Cornell Medicine researchers.
November 8th, 2024 — Source

Your friend has been diagnosed with cancer—here are 6 things you can do to support them
Across the world, one in five people are diagnosed with cancer during their lifetime. By age 85, almost one in two Australians will be diagnosed with cancer.
November 8th, 2024 — Source

Health — Cancer — November 7th, 2024

A 36-gene predictive score of anti-cancer drug resistance anticipates cancer therapy outcomes
In 1937, President Franklin Roosevelt signed the National Cancer Act, launching a nationwide effort to combat the disease. Eighty-seven years later, despite significant progress, cancer treatment often falls short, with 50% to 80% of patients not responding to treatment and more than 600,000 cancer deaths annually in the United States.
November 7th, 2024 — Source

Caterpillar fungus chemical can slow down growth of cancer cells, researchers discover
New research into a chemical produced by a caterpillar fungus that has shown promise as a possible cancer treatment has revealed how it interacts with genes to interrupt cell growth signals. The discovery is an important step towards developing new drugs that could be less damaging to healthy tissues than most currently available treatments.
November 7th, 2024 — Source

Combining gene expression signature with liquid biopsy may improve response prediction to immunotherapy
Results of a study recently published in the journal JCO Precision Oncology show that in the clinical trial context, combined analysis of the inflammatory status of the tumor microenvironment classified by the VIGex gene expression signature and circulating tumor DNA (ctDNA) by liquid biopsy may improve response prediction to immunotherapy in patients with advanced solid tumors.
November 7th, 2024 — Source

Cutaneous malignant melanoma incidence increasing among the elderly
From 1987 to 2016, there was a considerable increase in the incidence of cutaneous malignant melanoma (CMM) among the elderly in the United States, according to a study published online Oct. 28 in Cancer Screening and Prevention.
November 7th, 2024 — Source

Drug combo strategy makes glioblastoma cells visible to attacking immune cells
Even treated with the most advanced therapies, patients with glioblastoma—an aggressive brain cancer—typically survive less than two years after diagnosis. Efforts to treat this cancer with the latest immunotherapies have been unsuccessful, likely because glioblastoma cells have few—if any—natural targets for the immune system to attack.
November 7th, 2024 — Source

Evidence suggests tanning bed access and usage is driving higher rates of melanoma in specific regions
Melanoma accounts for only 1% of skin cancers in the United States but results in the largest number of skin cancer deaths. Investigators evaluated the potential link between the availability and use of tanning beds and the rising rates of melanoma in New England.
November 7th, 2024 — Source

Fluorescence-guided imaging technique could improve head and neck cancer surgery
Head and neck squamous cell carcinoma (HNSCC) ranks as one of the most common cancers globally, with over 650,000 new cases reported each year. Surgical intervention is often the primary treatment, but surgeons face a difficult challenge: they must completely remove the cancer while preserving as much surrounding healthy tissue as possible. This balance is crucial, as damage to nearby nerves can lead to significant post-surgical complications, affecting patients' quality of life.
November 7th, 2024 — Source

Genomic sequencing leads to personalized cancer care for majority of patients, finds study
More than half of midlands-based cancer patients whose genomes were successfully sequenced through the 100,000 Genomes Project, received clinical recommendations according to a new study.
November 7th, 2024 — Source

How physical force affects cancer treatment: Research explores mechanics of programmed cell death
Programmed cell death-1, or PD-1, has become a headline-grabbing molecule best known for its role in cancer immunotherapies called checkpoint inhibitors. A study from Georgia Tech and Emory University researchers is offering an improved understanding of why these inhibitors work—and how to make them effectively fight cancer for more patients.
November 7th, 2024 — Source

Inhibiting specific protein action could lead to precision therapy for some patients with drug-resistant leukemia
Scientists from Duke-NUS Medical School and their collaborators have identified an inherited genetic variation prevalent among East Asians that contributes to drug resistance, driving the aggressive growth of cancer cells in patients with chronic myeloid leukemia.
November 7th, 2024 — Source

Long-term risks from prostate cancer treatment detailed in new report
The risks of adverse effects and complications from treatment for prostate cancer are substantial and continue for years after treatment ends. The largest comprehensive analysis reporting long-term risks from such treatment relative to the risks faced by a control group of untreated men has just been published in the journal JAMA Oncology.
November 7th, 2024 — Source

Metabolic mechanism provides a new target for improving cancer immunotherapy effectiveness
The immune system is a major target for cancer treatments. Immune checkpoint inhibitors and CAR-T cell therapy can dramatically improve outcomes for many cancers. But for about 70% of patients, these therapies don't work.
November 7th, 2024 — Source

Mitochondrial dynamics provide clues for halting the metastatic progression of breast cancer
Mitochondria have long been known as the tiny organelles that act as the battery packs inside our cells while also serving as internal sensors and communicators. But relatively little is understood about how their energy-producing activities in soupy cellular interiors impacts metastatic cancer, which occurs when cancerous cells spread in the body.
November 7th, 2024 — Source

New NCCN guidelines include expanded genetic risk assessment for various cancers
The National Comprehensive Cancer Network® (NCCN®)-;an alliance of leading cancer centers focusing on maintaining evidence-based expert consensus driven guidelines for care-;announces the publication of the expanded NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, and Prostate. This closely follows the recent publication of the expanded NCCN Guidelines® for Genetic/Familial High-Risk Assessment: Colorectal, Endometrial, and Gastric.
November 7th, 2024 — Source

Plant engineering method promises to dramatically improve biofuel and bioproduct development
The ability to genetically engineer plants is largely thanks to a microscopic helper: a bacterium called Agrobacterium tumefaciens. Agrobacterium in the wild causes damaging tumors in flowering plants, including some economically important crops, but its ability to insert its own DNA into host plants is what makes it both a pest to farmers and a powerful tool for biotechnology.
November 7th, 2024 — Source

Q&A: How a 'switchable' CAR-T therapy sets its sights on deadly brain cancer
UC San Francisco treated its first brain cancer patient with an experimental new CAR-T therapy discovered and manufactured at the university earlier this year. The treatment, known as E-SYNC, is a form of "switchable" CAR-T therapy that can be turned on and off to better target cancer and reduce side effects.
November 7th, 2024 — Source

Research shows caterpillar fungus can slow down growth of cancer cells
New research into a chemical produced by a caterpillar fungus that has shown promise as a possible cancer treatment has revealed how it interacts with genes to interrupt cell growth signals. The discovery is an important step towards developing new drugs for the treatment of the disease.
November 7th, 2024 — Source

Study explores new insights into innate resistance for immunotherapies in colorectal cancer
A new study from the USC Norris Comprehensive Cancer Center has found evidence that targeting CD47, a protein that is part of the innate immune system, could be a key step in fighting colorectal cancer.
November 7th, 2024 — Source

Study highlights long-term risks of prostate cancer treatment
The risks of adverse effects and complications from treatment for prostate cancer are substantial and continue for years after treatment ends. The largest comprehensive analysis reporting long-term risks from such treatment relative to the risks faced by a control group of untreated men has just been published in the journal JAMA Oncology.
November 7th, 2024 — Source

Study links tanning bed use to rising melanoma rates in New England
Melanoma accounts for only 1% of skin cancers in the United States but results in the largest number of skin cancer deaths. Investigators evaluated the potential link between the availability and use of tanning beds and the rising rates of melanoma in New England. They found compelling evidence linking tanning bed usage to increased melanoma risk. Their spatial epidemiologic study in the Journal of Investigative Dermatology, published by Elsevier, provides critical insights to inform public health strategies and reduce melanoma incidence.
November 7th, 2024 — Source

Study sheds light on copper's role in driving kidney cancer
A new study led by University of Cincinnati Cancer Center researchers details how the accumulation of copper helps clear cell renal cell carcinoma (ccRCC)—the most common kidney cancer—grow and advance in stage.
November 7th, 2024 — Source

Surge in global cancer by 2050 with widening disparities projected by study
An international research effort led by Charles Sturt University, Australia, is projecting a significant rise in global cancer cases and deaths by 2050. They identify widening disparities between low Human Development Index (HDI) and very high HDI countries, sounding the alarm for urgent action in cancer prevention and care worldwide.
November 7th, 2024 — Source

The role of molecular residual disease in operable non-small cell lung cancer with gene fusions
In operable non-small cell lung cancer (NSCLC), molecular residual disease (MRD) detection via circulating tumor DNA (ctDNA) has emerged as a promising approach to identify individuals at high risk of disease recurrence and potentially guide adjuvant therapy decisions.
November 7th, 2024 — Source

Uncovering a new mechanism for drug resistance in pancreatic cancer
Researchers at the University of Virginia have discovered a new mechanism driving drug resistance in pancreatic ductal adenocarcinoma, one of the deadliest cancers. Their findings could lead to more effective treatments, providing hope for patients facing this aggressive disease.
November 7th, 2024 — Source

Understanding gut microbial imbalance in pancreatic cancer development and treatmentPancreatic ductal adenocarcinoma (PDAC) is recognized as one of the most lethal cancers, with an estimated five-year survival rate of approximately 10%. This poor prognosis is largely attributed to the challenges in early diagnosis, aggressive tumor biology, and limited treatment options. Most PDAC cases are diagnosed at advanced stages due to its typically asymptomatic onset, making only a small percentage of patients eligible for potentially curative surgical resection.
#2693
November 7th, 2024 — Source

Virtual screening yields small molecules to enhance cancer immunotherapy
The process of identifying promising small molecule drug candidates that target cancer checkpoints may become faster and smarter through virtual screening, according to Weill Cornell Medicine researchers.
November 7th, 2024 — Source

Health — Cancer — November 5th, 2024

7 Signs of Colon Cancer and How to Reduce Your Risk
Colorectal cancer affects young adults, too. Here's what to know about it and ways you can reduce your risk.
November 5th, 2024 — Source

Canada's breast cancer screening guidelines fail to address racial and ethnic disparities
Canada's current national screening guidelines for breast cancer are less appropriate for women of certain race and ethnicity groups since they are diagnosed at younger ages with more advanced stages of the disease. The new findings from a University of Ottawa research team underscore the urgent need to reevaluate screening guidelines to account for racial and ethnic differences and ensure equitable healthcare access, including earlier screening, to improve outcomes for all women.
November 5th, 2024 — Source or Source

Case study describes potential breakthrough in treatment of aggressive type of prostate cancer
Researchers from the George Washington University and the Washington DC Veterans Affairs Medical Center have published a case report that signifies a potential breakthrough in the treatment of an aggressive type of prostate cancer.
November 5th, 2024 — Source

Experts suggest Michelangelo depicted breast cancer in the Sistine Chapel fresco
Led by forensic pathologist Andreas G. Nerlich of Ludwig-Maximilians-University in Munich, a team of international experts propose that Michelangelo's fresco "The Flood" in the Sistine Chapel portrays a young woman exhibiting signs consistent with breast cancer.
November 5th, 2024 — Source

'Foam cells' that accelerate tumor growth in glioblastoma can be inhibited, researchers discover
A research team at Lund University in Sweden has discovered a certain type of cell—foam cells—in patients with the aggressive brain tumor glioblastoma. It has been shown how these cells accelerate the cancer's growth and that this can be successfully inhibited using a drug developed for arteriosclerosis.
November 5th, 2024 — Source

p>How hypoxia helps cancer spread: Scientists identify 16 genes that aid cancer cell survival in low-oxygen regions
Scientists at the Johns Hopkins Kimmel Cancer Center have identified 16 genes that breast cancer cells use to survive in the bloodstream after they've escaped the low-oxygen regions of a tumor. Each is a potential therapeutic target to stop cancer recurrence, and one—MUC1—is already in clinical trials.
November 5th, 2024 — Source

Integrative palliative care is critical to improving mental health among pancreatic cancer patients
For patients facing a pancreatic cancer diagnosis, a compassionate approach to care can be transformative. Yet, a new study published in Healthcare reveals that palliative care, a service focused on enhancing the quality of life for those with serious illnesses, remains significantly underutilized among pancreatic cancer patients in the United States.
November 5th, 2024 — Source

Medical oncologist explains how breast cancer screening can save lives
Breast cancer screening helps people live longer. Screening can catch cancer early, either in the precancerous stage or when it's localized to a very small part of the body. When we can catch it early and decrease the risk of it coming back in the future, patients not only live longer, but they also may live with fewer symptoms and breast cancer or cancer treatment-related concerns.
November 5th, 2024 — Source

Moderate expression of CD39 in GPC3-CAR-T cells shows high efficacy against hepatocellular carcinoma
In the quest to enhance the efficacy of chimeric antigen receptor T (CAR-T) cell therapy against hepatocellular carcinoma (HCC), a study in Frontiers of Medicine has identified a pivotal role for CD39 expression in modulating the function of CAR-T cells.
November 5th, 2024 — Source or Source

New classification of gastrointestinal stromal tumors guides precision treatment
A recent study offering a comprehensive view of the genome and transcriptome of gastrointestinal stromal tumors (GISTs) has introduced a new, multi-omics-based molecular classification of these tumors.
November 5th, 2024 — Source

Health — Children & Kids — November 5th, 2024

A quick return to school and light exercise may help kids recover from concussions
During cheerleading practice in April, Jana Duey's sixth grade daughter, Karter, sustained a concussion when she fell several feet headfirst onto a gym floor mat. Days after, Karter still had a headache, dizziness, and sensitivity to light and noise.
November 5th, 2024 — Source

Babies born to mothers with PCOS and obesity are smaller in size
Women with polycystic ovary syndrome (PCOS) and obesity are at a higher risk of giving birth to smaller babies in terms of birth weight, length, and head circumference, according to a recent study conducted at the Norwegian University of Science and Technology (NTNU).
November 5th, 2024 — Source

Hormonal changes during puberty may affect kidney health in girls, study finds
New research has shown that puberty plays a key role in shaping kidney health in adolescent girls, revealing a surprising shift in how the kidneys respond to injury. Although estrogen is known to protect against kidney damage in adult women, a recent study has found that the hormonal surge during puberty may instead increase the risk of kidney injury in adolescent girls, raising important questions about how sex hormones influence kidney health throughout life.
November 5th, 2024 — Source

Health — Diabetes — November 5th, 2024

Diabetes can damage your eyes' retinas: An expert explains
People with diabetes face a number of health challenges related to their chronic condition, and loss of vision due to retinal damage is one of them.
November 5th, 2024 — Source

Primary care involves more than GPs. A new review shows how patients can better access care
Australians today are more likely than previous generations to live with complex and chronic diseases, such as diabetes, heart disease and depression.
November 5th, 2024 — Source

Study finds regular physical activity slows biological aging in type 2 diabetes patients
Consistent exercise linked to reduced phenotypic age acceleration, highlighting the importance of tailored physical activity for healthy aging in type 2 diabetes.
November 5th, 2024 — Source

Health — Diet & Weight — November 5th, 2024

Guidance issued for safe use of GLP-1 RAs in the perioperative period
In a multisociety clinical practice guidance document, published online Oct. 29 in Surgery for Obesity and Related Diseases, recommendations are presented for the safe use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in the perioperative period.
November 5th, 2024 — Source

Improvement seen in some features of PCOS with weight loss interventions
Weight loss interventions are associated with improvement in some features of polycystic ovary syndrome (PCOS), according to a study published online Nov. 5 in the Annals of Internal Medicine.
November 5th, 2024 — Source

Meal timing may be crucial for night shift workers' health, study reveals
An Australian study published in Diabetologia has found that overnight eating may be putting night shift workers at higher risk of chronic health conditions.
November 5th, 2024 — Source

Medicaid covers GLP-1 meds for obesity in just 13 states, analysis finds
Poorer folks' access to blockbuster weight-loss drugs through Medicaid remains limited, a new KFF analysis has found. Only 13 states currently allow Medicaid to cover treatment of obesity using glucagon-like peptide-1 agonist (GLP-1) medications, researchers discovered.
November 5th, 2024 — Source

Research links ultra-processed foods to accelerated biological aging
A study conducted by the Research Unit of Epidemiology and Prevention at the I.R.C.C.S. Neuromed in Pozzilli, in collaboration with the LUM University of Casamassima, shows that high consumption of ultra-processed foods is associated with the acceleration of biological aging, regardless of the nutritional quality of the diet.
November 5th, 2024 — Source

Shaping sustainable diets: U.K. study finds that smaller portions are key to reducing meat intake
Reducing meat portions has the greatest impact on consumption decline in the UK, study shows, highlighting the need for targeted strategies to achieve environmental and health benefits.
November 5th, 2024 — Source

Shrinking portions drive fall in meat consumption in the UK, research finds
Reduced portion sizes are the main driver of the decline in meat consumption in the U.K., outpacing other behaviors such as meat-free days, a study shows.
November 5th, 2024 — Source

Study investigates how higher BMI lowers disability after stroke
Slightly overweight stroke survivors have a lower risk of sustaining disabilities. The Kobe University finding adds another aspect to the obesity paradox but also highlights the importance of considering the population's normal when recommending best practices.
November 5th, 2024 — Source or Source

Researchers awarded Synergy Grant to target tumor vessels and boost immunotherapy
Targeting and customizing blood vessels in tumors to increase T cell infiltration and maintain their function may represent the next breakthrough in cancer therapy. The European Research Council has recognized this by awarding a prestigious Synergy Grant to the project VASC-IMMUNE, where three researchers, each possessing complementary expertise in this research topic, will synergize to advance the field.
November 5th, 2024 — Source

Researchers uncover focal adhesions as subcellular signaling hubs in PI3K-AKT pathway
The phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway is one of the most critical and extensively investigated signaling pathways. It is the central regulator of various cellular processes including cell growth, proliferation, metabolism, and survival. Hyperactivation of PI3K-AKT signaling is highly related to a significant number of human diseases, particularly cancers.
November 5th, 2024 — Source

Scientists film footage of alien, shimmering creature in the remote ocean
A "sassy sparkler."
November 5th, 2024 — Source

Smog sickness: India's capital struggles as pollution surges
The toxic smog season in India's capital has just begun, but those unable to escape cancer-causing poisonous fumes say the hazardous impact on health is already taking its toll.
November 5th, 2024 — Source

Health — Cancer — November 2nd, 2024

Can a mammogram identify heart disease risk?
When people check in for their annual mammogram these days, some may face a surprising question: In addition to reviewing the mammogram for breast cancer, would the patient like the radiologist to examine the images for heart disease risk?
November 2nd, 2024 — Source

The four types of systemic therapy for breast cancer
Treatment for breast cancer can come in many forms. In addition to surgery to remove cancerous tissue and radiation therapy, breast cancer is also commonly treated with drugs that are taken orally or intravenously, as an infusion into a vein.
November 2nd, 2024 — Source

Health — Cancer — November 1st, 2024

AI model predicts progression of breast cancer better than standard hospital tests, study claims
A team of AI and medical researchers at startup Ataraxis AI, who are also affiliated with a host of institutions across the U.S., has announced the development of an AI model that they claim is more accurate at predicting the progression rate of breast cancer than standard tests now administered in hospitals.
November 1st, 2024 — Source

Cancer research reinforces calls for menthol cigarette restrictions
Nationwide, fewer people smoke than did a decade ago, but the proportion who smoke menthol-flavored cigarettes is on the rise.
November 1st, 2024 — Source

Comprehensive analysis of breast cell types helps better understand how the cancers start, grow and spread
October is Breast Cancer Awareness Month, and fittingly, University of New Mexico Comprehensive Cancer Center biologist Curt Hines, Ph.D., has published a pair of papers that comprehensively describe the 12 major types of cells in the human breast.
November 1st, 2024 — Source

Glucagon-like peptide-1 receptor agonists tied to lower risk for early-onset colorectal cancer
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) can decrease the risk for developing early-onset colorectal cancer (EO-CRC) in patients with diabetes regardless of weight, according to a study presented at the annual meeting of the American College of Gastroenterology, held from Oct. 25 to 30 in Philadelphia.
November 1st, 2024 — Source

How understanding the complex world of herpesviruses can help fight cancer
At UC Davis Comprehensive Cancer Center, one scientist's sleepless nights are driven by the mysteries of virus-host interactions. Researcher Yoshihiro Izumiya is delving into the complex world of herpesviruses. These viruses often lie dormant for years, then wake up to wreak havoc on their hosts, causing severe diseases and complications.
November 1st, 2024 — Source

Novel immunotherapy combo shows promise in melanoma
Pre-surgery treatment with the novel drug vidutolimod and the PD-1 checkpoint inhibitor nivolumab led to tumor control in 55% of patients with stage 3 cutaneous melanoma, according to the results of a single-arm phase 2 clinical trial led by the University of Pittsburgh, UPMC Hillman Cancer Center and the National Cancer Institute (NCI).
November 1st, 2024 — Source

Quitting smoking after cancer diagnosis can add years to patient lives
Quitting smoking within six months after a cancer diagnosis adds an average of two years to a patient's life.
November 1st, 2024 — Source

Research reveals benefits of optimal diabetes control in reducing the risk of colorectal and liver cancer
Colorectal cancer and liver cancer are the second and fifth most common cancers in Hong Kong, respectively, and both are associated with notably high mortality rates. This underscores the urgent need to develop effective strategies to combat these formidable diseases.
November 1st, 2024 — Source

Health — Cancer — October 30th, 2024

3D maps of tumor 'neighborhoods' open door to future treatment strategies
A new analysis led by researchers at Washington University School of Medicine in St. Louis has revealed detailed 3D maps of the internal structures of multiple tumor types. These cancer atlases reveal how different tumor cells—and the cells of a tumor's surrounding environment—are organized, in 3D, and how that organization changes when a tumor spreads to other organs.
October 30th, 2024 — Source or Watch Video

Blocking THBS1 protein with antibodies may heal radiotherapy-induced skin injury
A new study by researchers at Karolinska Institutet and KI University Hospital shows that radiotherapy (RT) creates an "epigenetic memory" in skin fibroblasts, which impairs skin healing in cancer survivors. They also found that by targeting this memory with antibodies the damage could be reversed.
October 30th, 2024 — Source

Computational method links one mammal's striking longevity and cancer resistance to 'dark genome'
All mammals can develop cancer, the rapid growth of harmful cells that can overtake normal cells and compromise their ability to function. Scientists have long observed that a species of nearly-hairless subterranean rodents from eastern Africa are surprisingly long-lived and demonstrate a pronounced resistance to cancer.
October 30th, 2024 — Source

Determining precise timing of cellular growth to understand the origins of cancer
Cancers are diseases of abnormal cellular growth, and although many are treatable or even curable, their origins are not necessarily clear. Understanding the precise timing of cellular events—as cells transition from normal to cancerous conditions—is key to uncovering new treatments or diagnostic opportunities.
October 30th, 2024 — Source

Eating more protein could help chemotherapy patients with colorectal cancer keep crucial muscle mass
Eating higher amounts of protein could help people with colorectal cancer keep crucial muscle mass while undergoing chemotherapy, new University of Alberta research shows.
October 30th, 2024 — Source

Implantable microparticles can deliver two cancer therapies at once
The combination of phototherapy and chemotherapy could offer a more effective way to fight aggressive tumors
October 30th, 2024 — Source

Lack of health insurance coverage adds to disparities in advanced-stage diagnosis of multiple cancers, large study finds
A new, large study led by American Cancer Society (ACS) researchers found that lack of health insurance coverage accounts for a significant proportion of racial and ethnic disparities in advanced-stage diagnosis of multiple cancers.
October 30th, 2024 — Source

Newly identified RNA molecules could help doctors predict if a patient's bowel cancer will return
A University of Otago—Ōtākou Whakaihu Waka-led study could enable health professionals to separate colorectal cancer patients, who present at an early stage, into groups of those who will and won't go on to develop metastasis and disease recurrence.
October 30th, 2024 — Source

NIH-funded scientists uncover clues to precancer and tumor biology
New insights from multiple studies provide critical information on how cancer tumors develop, spread, and respond to treatments. The 10 studies from the Human Tumor Atlas Network (HTAN), a National Institutes of Health (NIH)-funded Cancer Moonshot℠ initiative to construct three-dimensional maps of human tumors, will be published Oct. 31, 2024, across several Nature journals.
October 30th, 2024 — Source

Researchers discover cancer mechanism that can eliminate tumors—even those resistant to immunotherapy
A technological breakthrough by medical researchers at Tel Aviv University enabled the discovery of a cancer mechanism that prevents the immune system from attacking tumors. The researchers were surprised to find that reversing this mechanism stimulates the immune system to fight the cancer cells, even in types of cancer considered resistant to prevailing forms of immunotherapy.
October 30th, 2024 — Source

Researchers map communities of single cells in metastatic breast cancers
A single biopsy from a metastatic breast cancer tumor contains hundreds of thousands of cells—some cancerous and others part of the complex web of immune cells, blood vessels, and supportive tissue that surround a tumor. Researchers have typically analyzed these cells as a mixed-together group, but this approach can miss rare cell types, and makes it difficult to draw conclusions about how cells interact to drive the disease.
October 30th, 2024 — Source

Small-molecule drug triggers rapid cell death in cancer models
A team of researchers at Broad Institute of MIT and Harvard, in a long-term project that has included industry collaborators at Bayer and Trueline Therapeutics, has developed a compound called BRD-810 that holds promise as a therapeutic candidate for cancer. This small molecule reactivates the apoptosis cascade in tumor cells while sparing healthy cells in animal models.
October 30th, 2024 — Source

Study finds eczema-linked protein helps ovarian cancer survive, suggesting potential for skin drug-based treatment
Researchers at the Icahn School of Medicine at Mount Sinai have discovered a way that ovarian cancer tumors manipulate their environment to resist immunotherapy and identified a drug target that could overcome that resistance.
October 30th, 2024 — Source

Unraveling colorectal cancer metastasis: Study provides new insights and potential therapeutic opportunities
Metastasis remains the primary challenge to reducing cancer deaths worldwide, says Memorial Sloan Kettering Cancer Center (MSK) gastrointestinal oncologist Karuna Ganesh, MD, Ph.D.. That's when a primary tumor—colorectal cancer, for example—spreads to a new part of the body, such as the brain, liver, or bones.
October 30th, 2024 — Source

Weill Cornell Medicine teams receive funding from Starr Cancer Consortium
Three teams led by Weill Cornell Medicine scientists have received awards from the Starr Cancer Consortium in its 17th and final annual grant competition. The grants will fund research on the deep mechanisms of common cancers and related treatment strategies.
October 30th, 2024 — Source

Why some prostate cancers shouldn't be called 'cancer'
Men could benefit from fewer unnecessary treatments and reduced anxiety if their doctors stopped calling certain changes in the prostate "cancer," according to prominent UC San Francisco prostate cancer expert Matthew Cooperberg, MD, MPH. In fact, the changes are a low-grade, extremely common condition among older men that won't metastasize or kill, but should be actively monitored, he says.
October 30th, 2024 — Source

Health — Cancer — October 28th, 2024

AI overreliance results in less accurate cancer diagnosis, says new study

A new study has found that cancer diagnosis can be less accurate when AI is used to help, with people over relying on AI rather than their own opinion.
October 28th, 2024 — Source

Breast cancer in Africa: Myths that need to be debunked

There are many myths about breast cancer, particularly in Africa with its rich diversity of people, different genetic backgrounds and ancestral histories.
October 28th, 2024 — Source

Cancer care in Africa: Translations of key words convey fear and need to change, says researcher

Language can give people the power to take an active part in their own health care, or it can create barriers.
October 28th, 2024 — Source

Cellular couriers: Body's 'delivery trucks' could lead to new cancer blood test

Researchers have found a potential new diagnostic marker that could be used to better detect the level of tissue damage in our bodies.
October 28th, 2024 — Source or Source

Don't skip colonoscopy for new blood-based colon cancer screening, study says

Newly available blood tests to screen for colorectal cancer sound far more appealing than a standard colonoscopy. Instead of clearing your bowels and undergoing an invasive procedure, the tests require only a simple blood draw. But are the tests effective?
October 28th, 2024 — Source

Laboratory simulation finds smaller nanoparticles are subject to enhanced agglomeration in gastrointestinal tract

In a laboratory set-up simulating the human stomach and intestine, researchers at the University of Amsterdam have explored the fate of plastic nanoparticles during gastrointestinal digestion. In their paper published in the October issue of Chemosphere, they report how a range of model plastic nanoparticles interact with digestive enzymes and form agglomerates.
October 28th, 2024 — Source

Medicaid enrollment associated with higher risk of cancer death

Enrollment in Medicaid was associated with higher risk of death from a central nervous system (CNS) tumor, with an almost two-fold higher risk for young CNS tumor patients enrolled at diagnosis, finds a study from the Brown School at Washington University in St. Louis.
October 28th, 2024 — Source

New insights into cancer risks from chemicals in fire smoke

Derek Urwin has a special stake in his work as a cancer control researcher. After undergraduate studies in applied mathematics at UCLA, he became a firefighter. His inspiration to launch a second career as a scientist was the loss of his brother, Isaac, who died of leukemia at only 33 despite no history of cancer in their family. Working with Anastassia Alexandrova, a professor of chemistry and biochemistry at UCLA College, he earned his doctorate.
October 28th, 2024 — Source

New insights show ASCL1's role in neuroendocrine prostate cancer, an aggressive and treatment-resistant type

A scientist whose discoveries about prostate cancer have led to lifesaving treatments is now shedding light on an emerging and deadlier form of the disease: neuroendocrine prostate cancer (NEPC).
October 28th, 2024 — Source

Researchers use genomic technology to investigate aggressive skin cancer linked to burn scars

Researchers utilized specialized genomic technology at the University of Calgary to enhance our understanding of Marjolin's ulcer (MU), a rare, highly aggressive skin cancer that affects chronic wounds that can often arise from established scars like those caused by severe burns.
October 28th, 2024 — Source

Rapid liquid biopsy method to capture extracellular vesicles offers avenue to affordable cancer diagnosis

There are billions of tiny packets of cellular material called extracellular vesicles (EVs) that are produced by cells and released into each person's blood, saliva, and other bodily fluids. EVs contain invaluable information, such as proteins and genetic material, from their original cell, which can provide insight about the status of the body. Scientists have been trying to leverage EVs for their diagnostic and therapeutic potential but have struggled to do so in a fast and cost-effective way.
October 28th, 2024 — Source

Researchers identify previously unknown pathway that allows cancer to grow unchecked

A new study from MUSC Hollings Cancer Center researchers shows, for the first time, that a receptor called PPAR δ, or peroxisome proliferator-activated receptor delta, is an important player in a pathway that disables the immune system so that T-cells can't kill cancer cells.
October 28th, 2024 — Source

Scientists explore HDAC6 inhibition for breast cancer treatment

Scientists from the University of Sharjah say they have good news for breast cancer patients, particularly those afflicted with the most aggressive types of the malignant tumor known as triple-negative breast cancer.
October 28th, 2024 — Source

Study highlights benefits of plant-based diet in cancer risk reduction

Research has shown that eating a plant-based diet may provide a healthier alternative to the standard American diet, which is typically high calorie, loaded with red meat, high-fat dairy products, heavily processed foods, fast foods, refined carbohydrates, added sugars and salt. The American Institute for Cancer Research promotes a plant-based diet.
October 28th, 2024 — Source

Health — Cancer — October 25th, 2024

Advancing Colorectal Cancer Treatment with Nano-PROTACs

In a recent article published in Signal Transduction and Targeted Therapy, researchers introduced polymer-based nano-PROteolysis Targeting Chimeras (PROTACs) to address ongoing challenges in targeted cancer therapies.
October 25th, 2024 — Source

Colon cancer risk linked to p53 gene in ulcerative colitis

Researchers in the lab of Michael Sigal at the Max Delbrück Center and Charite—Universitätsmedizin Berlin have elucidated the role of the p53 gene in ulcerative colitis. The study, published in Science Advances, suggests a potential new drug target to stop disease progression to cancer.
October 25th, 2024 — Source

Emails Reveal How Health Departments Struggle To Track Human Cases of Bird Flu

Bird flu cases have more than doubled in the country within a few weeks, but researchers can't determine why the spike is happening because surveillance for human infections has been patchy for seven months.
October 25th, 2024 — Source

HIMSSCast: What's next for clinical informatics and decision support?

From EHR optimization to AI-enabled CDS, big advancements are happening with biomedical informatics. Dr. Chris Harle, researcher at Regenstrief Institute and professor at IU, discusses data science, provider experience, patient safety and more.
October 25th, 2024 — Source

Immune cell discovery offers new potential for cancer immunotherapy

Researchers at Winship Cancer Institute of Emory University have identified a novel type of immune cell, called the stem-like CD4 T cell, that plays a pivotal role in anti-tumor immunity.
October 25th, 2024 — Source

Lymph node-like structures may trigger the demise of cancer tumors

A newly described stage of a lymph node-like structure seen in liver tumors after presurgical immunotherapy may be vital to successfully treating patients with hepatocellular carcinoma, according to a study by researchers from the Johns Hopkins Kimmel Cancer Center.
October 25th, 2024 — Source

Most non-cancer pain opioid prescriptions are for musculoskeletal conditions, study finds

Nearly three quarters of new non-cancer pain opioid prescriptions were for patients with musculoskeletal conditions, despite limited evidence of the drug's efficacy, according to the largest U.K. study of its kind.
October 25th, 2024 — Source

Multi-million dollar smart hospital emergency system projects in South Korea and more briefs

Also, Bangkok Dusit Medical Services has partnered with Samsung Medison for medical imaging and AI
October 25th, 2024 — Source

New lung cancer screening model removes barriers for central Texas' most vulnerable

A new lung cancer screening initiative has made significant strides in overcoming barriers to care for low-income, uninsured and minority populations in Central Texas—a critical step toward reducing disparities in lung cancer outcomes.
October 25th, 2024 — Source

NewYork-Presbyterian launches $2B campaign focused on AI, digital innovation

In addition to capital projects such as leading-edge ambulatory and inpatient clinical spaces, the effort is focused on harnessing artificial intelligence and other emerging technologies for oncology, cardiology and more.
October 25th, 2024 — Source

Regulations of m6A and other RNA modifications and their roles in cancer

Cancer, a disease with global impact, is intricately linked to dysregulated gene expression, which is influenced by both genetic mutations and epigenetic changes, including RNA modifications.
October 25th, 2024 — Source

Self-assembling nanoscale drug system shows promise for large tumor treatment

Most cancer patients are diagnosed after tumors have already grown large or spread, posing major challenges for treatment. Traditional therapies, such as surgery, chemotherapy, and radiation, often struggle to completely eliminate larger tumors, and side effects can significantly impact patients.
October 25th, 2024 — Source

Study finds novel role of BRCA1 in tumor suppression

A new study led by The University of Texas Health Science Center at San Antonio (UT Health San Antonio) is shedding light on a novel role of breast cancer gene 1 (BRCA1) in tumor suppression.
October 25th, 2024 — Source

Tracing cancer back to birth uncovers promising biomarkers for prevention, targeted treatment of childhood leukemia

A new study has uncovered molecular markers in blood at birth that are linked to later development of acute lymphoblastic leukemia (ALL), the most common cancer type that affects children.
October 25th, 2024 — Source

White House OMB is reviewing proposed cybersecurity updates to HIPAA

The Office of Management and Budget will consider HHS' approach to modernizing requirements for HIPAA covered entities charged with protecting ePHI against healthcare cybersecurity threats. Reports say the rule could be published by year's end.
October 25th, 2024 — Source

Health — Cancer — October 22nd, 2024

Breast cancer: Why it's difficult to treat and what new approaches are on the horizon

Breast cancer is the number one cancer among women: more than 2 million cases were diagnosed worldwide in 2022. It is also particularly challenging to treat. Physiologist Anna-Mart Engelbrecht, who heads the Cancer Research Group at Stellenbosch University, explains why this is so and how precision medicine could help.
October 23rd, 2024 — Source

Cancer detection recovered following pandemic disruptions

Overall, cancer detection in the United States recovered meaningfully in 2021 following substantial disruptions in 2020, according to a study published online Oct. 14 in JAMA Network Open.
October 23rd, 2024 — Source

Chris Hoy reveals that he has terminal cancer—here's how to spot early signs of prostate cancer

Sir Chris Hoy, an inspiration to so many of us, has just revealed he has terminal prostate cancer aged just 48 years old.
October 23rd, 2024 — Source

Cutting off cancer cells' access to fats may enhance cancer therapy

Cutting off cancer cells' access to fat may help a specific type of cancer treatment work more effectively, reports a study by Van Andel Institute scientists.
October 23rd, 2024 — Source

Metformin for rare skin cancer treatment: Research shows drug's unique ability to impact immune pathways

Dermatofibrosarcoma protuberans (DFSP) is a rare skin sarcoma known for its high recurrence rates, making treatment particularly challenging. While surgery remains the standard option, it often leads to scarring and other complications.
October 23rd, 2024 — Source

MRI can save rectal cancer patients from surgery, study suggests

MRI can predict the risk of rectal cancer reccurring or spreading for patients who have undergone chemotherapy and radiation, new research indicates.
October 23rd, 2024 — Source or Source or Source

Nanoparticle technology demonstrates selective destruction of leukemia cancer cells

A research team, affiliated with UNIST has developed nanoparticles that effectively treat acute myeloid leukemia (AML), offering the potential to reduce side effects while enhancing therapeutic efficacy by selectively targeting and eliminating leukemia cells.
October 23rd, 2024 — Source

Researchers use human-centered design to improve mammography process, patient experience

When you order a pizza, an online tracker can provide real-time data that lets you know when your pizza enters the oven, is boxed and is then on the way to your house.
October 23rd, 2024 — Source

Rising rates of head and neck cancers in England

A new report has revealed a concerning rise in the number of people diagnosed with head and neck cancers in England.
October 23rd, 2024 — Source

Starving cancer cells of fat may improve cancer treatment

Cutting off cancer cells' access to fat may help a specific type of cancer treatment work more effectively, reports a study by Van Andel Institute scientists. The findings, published in Cell Chemical Biology, lay the groundwork for developing tailored dietary strategies to help anti-cancer medications better kill malignant cells.
October 23rd, 2024 — Source

Health — Cancer — October 20th, 2024

Do IUDs cause breast cancer? Here's what the evidence says
A new study has found a link between hormonal intrauterine devices (IUDs) and breast cancer.
October 20th, 2024 — Source

Immunotherapy yields complete response in stage IV lung cancer
A new case report was published in Oncoscience (Volume 11) on October 8, 2024, entitled, "Complete and long-lasting response to immunotherapy in a stage IV non-small cell lung cancer with brain metastasis."
October 20th, 2024 — Source

Researchers to explore light and ultrasound therapy for melanoma treatment in pigs
Texas A&M University researchers are collaborating on a new project that studies how ultrasound and light can treat melanomas in pigs.
October 20th, 2024 — Source

Health — Cancer — October 18th, 2024

Cancer diagnoses linked to lasting financial challenges, studies find

A diagnosis of cancer can take a toll on more than a person's health. Researchers at Beth Israel Deaconess Medical Center and Harvard Medical School in Boston found that financial fallout can follow patients with cancer and their families in the form of bankruptcy, lower credit scores, and other forms of financial challenges years after a cancer diagnosis.
October 18th, 2024 — Source

Family, friends crucial to whether you get screened for cancer

Having close family and friends who care about their health makes women more likely to get regularly screened for cancer, a new study has found.
October 18th, 2024 — Source

In vitro model helps show why breast cancer spreads to bone

Researchers from Tampere University, Finland, and Izmir Institute of Technology, Turkey, have developed an in vitro cancer model to investigate why breast cancer spreads to bone. Their findings hold promise for advancing the development of preclinical tools to predict breast cancer bone metastasis.
October 18th, 2024 — Source

Online post analysis reveals emotional and financial concerns of breast cancer patients are often unmet

Although breast cancer is the most common non-skin cancer diagnosed in women, finding support during treatment and through survivorship can be incredibly challenging. An analysis of posts from breast cancer patients on the popular online forum Reddit found that many breast cancer patients often struggle with several unmet emotional and financial concerns during treatment and long after.
October 18th, 2024 — Source

Q&A: How research can make immunotherapy effective in an increasing number of breast cancers

Immunotherapy has become the most promising strategy for treating cancer, but its effectiveness is still very uneven. In the month of breast cancer, the most common tumor in women—almost 2.5 million cases are diagnosed worldwide each year—three researchers present the main advances and challenges in the application of immunotherapy to this tumor at the Spanish National Cancer Research Center (CNIO).
October 18th, 2024 — Source

Powerful new analyses could improve breast cancer risk assessment on a massive scale

Imagine that you have a history of breast cancer in your family, and you want a better idea of what your personal risk is. You consult your physician, and they recommend that you test to see if you have a genetic variant that would increase your chances of developing breast cancer. After weeks of nervously waiting, the results come in and you learn that your variants of BRCA 1 and 2, the genes associated with breast cancer risk, are… of "unknown clinical significance."
October 18th, 2024 — Source

Scientists map the genetic landscape of drug resistance in cancers

All cancer mutations that cause drug resistance fall into one of four categories. New research has detailed each type, helping to uncover targets for drug development and identify potential effective second-line therapies.
October 18th, 2024 — Source

Single-molecule imaging reveals aberrant DNA-binding dynamics of cancer-linked chromatin remodelers

Biophysical chemists from the National University of Singapore (NUS) have uncovered a previously hidden landscape that governs the intracellular organization and dynamics of SWI/SNF chromatin remodelers, an important class of protein complexes that control genome access inside the cell.
October 18th, 2024 — Source

Some IUDs may raise the odds for breast cancer, but overall risk remains low

Intrauterine devices (IUDs) may raise the chances of a breast cancer diagnosis for women who use the hormonal birth control method, but that risk remains low, new research finds.
October 18th, 2024 — Source

Health — Cancer — October 16th, 2024

Adaptive ferroelectric materials show promise for energy-efficient supercomputing
Researchers have revealed an adaptive response with a ferroelectric device, which responds to light pulses in a way that resembles the plasticity of neural networks. This behavior could find application in energy-efficient microelectronics.
October 16th, 2024 — Source

Biochar nanocomposite enhances detection of acetaminophen and uric acid in urine
In recent years, the excessive use of acetaminophen (APAP) has become a significant human hazard and social burden. Rapid and automated electrochemical detection has emerged as a crucial method for measuring APAP concentration in human urine.
October 16th, 2024 — Source

Breast cancer drug shows potential for rare appendix cancer
Researchers at University of California San Diego School of Medicine found an FDA-approved drug used to treat breast cancer has the potential to be an effective therapeutic for a specific type of appendix cancer.
October 16th, 2024 — Source

Cancer cell populations segregate to favor metastasis or antitumor inflammation, study reveals
Understanding in depth how tumors evolve to become malignant is the objective of a study recently published in the journal Nature Cancer. The findings demonstrate that within each tumor, groups of cells receive instructions to spread malignantly throughout the body. Other groups of cells are responsible for combating the damage caused by the cancerous tumor.
October 16th, 2024 — Source

FDA approves Itovebi for locally advanced, metastatic breast cancer
The U.S. Food and Drug Administration has approved Itovebi (inavolisib), in combination with palbociclib (Ibrance) and fulvestrant, for the treatment of adults with endocrine-resistant, PIK3CA-mutated, hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, locally advanced or metastatic breast cancer.
October 16th, 2024 — Source

Immunotherapy boosts survival of advanced Hodgkin lymphoma in clinical trial
A treatment that rallies the immune system to destroy cancer raised the survival rate for advanced Hodgkin lymphoma patients to a remarkable 92%, suggesting a new standard therapy for the disease. The New England Journal of Medicine published the innovative clinical trial results.
October 16th, 2024 — Source

Molecular chaperones as key players in tumor suppressor stability
A new review was published in Oncotarget's Volume 15 on October 1, 2024, entitled, "Molecular chaperones: Guardians of tumor suppressor stability and function."
October 16th, 2024 — Source

Nanoparticle therapy offers new hope for prostate cancer patients
Prostate cancer is the second leading cause of cancer death among American men. A recent study, conducted by researchers from the University of Virginia, Mount Sinai, the University of Michigan, the University of Texas and others, has demonstrated the clinical success of a new nanoparticle-based, laser-guided therapy for prostate cancer treatment.
October 16th, 2024 — Source

New AI tool could enhance and personalize brain tumor imaging
A new artificial intelligence (AI) tool developed by researchers at UCL and UCLH can analyze scans more quickly than experienced neuroradiologists and provide greater patient-personalized detail to aid treatment.
October 16th, 2024 — Source

New study offers revolutionary method for analyzing cell interactions in cancer
A new paper from Elham Azizi's lab and collaborators has been accepted for publication in Genome Research, marking a significant advancement in the study of dynamic single-cell interactions.
October 16th, 2024 — Source

Personalized bacterial vaccine shows promise as cancer immunotherapy
Columbia researchers have engineered probiotic bacteria that educate the immune system to destroy cancer cells, opening the door for a new class of cancer vaccines that take advantage of bacteria's natural tumor-targeting properties. These microbial cancer vaccines can be personalized to attack each individual's primary tumor and metastases, and may even prevent future recurrences.
October 16th, 2024 — Source

'Pincer attack' on transcription factors offers new possibilities for future blood cancer therapies
The simultaneous inhibition of the transcription factors Myc and JunB could represent a pioneering therapeutic option for the treatment of multiple myeloma (MM), the second most common type of blood cancer.
October 16th, 2024 — Source

Protein interactions: Who is partying with whom and who is ruining the party?
Using a new method, researchers at ETH Zurich can measure alterations in the social network of proteins in cells. This work lays the foundation for the development of new drugs to treat diseases such as cancer and Alzheimer's.
October 16th, 2024 — Source

Quick introduction to Large Language Models for Android developers
Android has supported traditional machine learning models for years. Frameworks and SDKs like LiteRT (formerly known as TensorFlow Lite), ML Kit and MediaPipe enabled developers to easily implement tasks like image classification and object detection.
October 16th, 2024 — Source

Researchers achieve tunable coherent population trapping in a double quantum dot system
A research team has achieved coherent population trapping (CPT) in a semiconductor double quantum dot (DQD) system.
October 16th, 2024 — Source

Researchers develop yeast-based alternative to hydroxyurea for DNA study
Researchers at Colorado State University have identified an alternate method to study changes during the DNA replication process in lab settings using genetically modified yeast. The new approach offers a clearer window than current drug methods used to understand cell cycle arrest—a fundamental mechanism that is key to treating cancers and genetic issues.
October 16th, 2024 — Source

Researchers have identified the origin of ovarian cancer that develops in the fallopian tube, which opens doors to discovering new methods for diagnosing the disease and potential therapies.

October 16th, 2024 — Source

Scientists use CRISPR tools to safely disable gene mutation linked to treatment-resistant melanomaIn a potential advance for melanoma patients, researchers at ChristianaCare's Gene Editing Institute have used CRISPR gene editing tools to disable a gene mutation often seen in aggressive forms of this dangerous skin cancer that renders promising treatments ineffective.

October 16th, 2024 — Source

Starving cancer cells: Researchers unveil new function of ganoderic acid
Recently, Prof. Huang Qing's group from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences studied the new functions of ganoderic acids. They discovered that a compound, ganoderic acid A (GAA), could help fight cancer by targeting glucose transporters, proteins that cancer cells use to take in sugar.
October 16th, 2024 — Source

Team identifies origin of deadly ovarian cancer
Researchers have identified the origin of ovarian cancer that develops in the fallopian tube, which opens doors to discovering new methods for diagnosing the disease and potential therapies.
October 16th, 2024 — Source

Health — Cancer — October 12th, 2024

Breast cancer patients find hope and connection through YouTube
A study by the University of the Basque Country (UPV/EHU) has identified the most relevant YouTube videos on this disease and the concerns of the people who post comments.
October 12th, 2024 — Source

Dense breasts can make it harder to spot cancer on a mammogram
When a woman has a mammogram, the most important finding is whether there's any sign of breast cancer.
October 12th, 2024 — Source

New computational pipeline revolutionizes personalized cancer vaccine designLudwig Cancer Research scientists have developed a full, start-to-finish computational pipeline that integrates multiple molecular and genetic analyses of tumors and the specific molecular targets of T cells and harnesses artificial intelligence algorithms to use its output to design personalized cancer vaccines for patients.

October 12th, 2024 — Source

Why a diabetes drug fell short of anticancer hopes
Studies suggested it could treat cancer, but the clinical trials were a bust.
October 12th, 2024 — Source

Health — Cancer — October 11th, 2024

An AI-powered pipeline for personalized cancer vaccines
Ludwig Cancer Research scientists have developed a full, start-to-finish computational pipeline that integrates multiple molecular and genetic analyses of tumors and the specific molecular targets of T cells and harnesses artificial intelligence algorithms to use its output to design personalized cancer vaccines for patients.
October 11th, 2024 — Source

Cancer drug could be used to save the limbs of peripheral artery disease patients, pre-clinical study suggests
Researchers at the Heart Research Institute (HRI) have made a new discovery, finding an existing drug used to kill tumor cells in cancer patients could also be used to save the limbs of patients with blocked arteries in their legs.
October 11th, 2024 — Source

Dual immunotherapy plus chemotherapy found to benefit specific subset of patients with lung cancer
Researchers from The University of Texas MD Anderson Cancer Center have demonstrated that patients with metastatic non-squamous non-small cell lung cancer (NSCLC) harboring specific mutations in the STK11 and/or KEAP1 tumor suppressor genes were more likely to benefit from adding the immunotherapy tremelimumab to a combination of durvalumab plus chemotherapy to overcome treatment resistance typically seen in this patient population.
October 11th, 2024 — Source

Neural network models help predict immunotherapy efficacy in small cell lung cancer/span>
As immunotherapy makes breakthrough progress in the treatment of small cell lung cancer (SCLC), predicting treatment outcomes has become a focal point in clinical practice. Immunotherapy combined with chemotherapy has been approved as first-line therapy for small cell lung cancer due to its survival benefit in randomized controlled trials. However, predicting its efficacy remains a challenge in the absence of currently available biomarkers.
October 11th, 2024 — Source

One in three cases of oral cancer are due to smokeless tobacco, study reveals
A new study by the International Agency for Research on Cancer (IARC), with contribution from Karolinska Institutet, has revealed that one in three cases of oral cancer globally is linked to smokeless tobacco and areca nut use.
October 11th, 2024 — Source

Researchers clarify role of VGLL3 in DNA double-strand break repair and chemotherapy
A research group led by Prof. Guo Caixia from the Beijing Institute of Genomics of the Chinese Academy of Sciences (CAS) and Tang Tie-Shan from the Institute of Zoology of CAS have discovered that VGLL3 modulates chemosensitivity through promoting DNA double-strand break repair.
October 11th, 2024 — Source

Researchers develop precision surgical technique for lymph node removal in endometrial cancer
A joint research team has announced that it is possible to detect and precisely remove metastatic lymph nodes during endometrial cancer surgery using neo-mannosyl human serum albumin-indocyanine green (MSA-ICG) and a laparoscopic fluorescence imaging system.
October 11th, 2024 — Source

Researchers find cord blood cells can build a better human immune system into mice
Immunity plays a central role in the fight against cancer. Many of the current immunotherapies aim at helping the patient's immune system to better recognize cancer cells—by using engineered antibodies—or by simply providing it with new cells, pre-equipped to search and destroy cancer. Either way, what is paramount is a deep understanding of how the immune system works and confronts tumors.
October 11th, 2024 — Source

Study identifies genetic factors crucial in acute myeloid leukemia survival for Black patients
Researchers have led a global study that identified molecular predictors of survival among Black patients with acute myeloid leukemia (AML). The study suggests a need to modify current AML risk layers by including ancestry-specific genetic factors and testing those in clinical trials.
October 11th, 2024 — Source

Targeting 'undruggable' diseases: Researchers reveal new levels of detail in targeted protein degradation
Researchers at the University of Dundee have revealed in the greatest detail yet the workings of molecules called protein degraders which can be deployed to combat what have previously been regarded as "undruggable" diseases, including cancers and neurodegenerative diseases.
October 11th, 2024 — Source

YouTube content can help some people cope with breast cancer diagnosis, Spanish study finds
A study by the University of the Basque Country (UPV/EHU) has identified the most relevant YouTube videos on breast cancer and the concerns of the people who post comments.
October 11th, 2024 — Source

Health — Cancer — October 10th, 2024

A look into 'mirror molecules' may lead to new medicines
A University of Texas at Dallas chemist and his colleagues have developed a new chemical reaction that will allow researchers to synthesize selectively the left-handed or right-handed versions of "mirror molecules" found in nature and assess them for potential use against cancer, infection, depression, inflammation and a host of other conditions.
October 10th, 2024 — Source

Aerobic physical activity reduces depression in patients with cancer
Aerobic physical activity (APA) is associated with a small but significant reduction in depression among adults with cancer, according to a review published online Oct. 8 in JAMA Network Open.
October 10th, 2024 — Source

AI analysis finds more than a third of cancer-related crowdfunding campaigns cite financial or social needs
In a new, large comprehensive analysis led by the American Cancer Society (ACS), researchers, using a form of Artificial Intelligence (AI), found that more than one-third of fundraising stories on the GoFundMe crowdfunding platform in the United States explicitly shared experiences of medical financial hardships and health-related social needs (HRSNs).
October 10th, 2024 — Source

Disrupting Asxl1 gene prevents T-cell exhaustion to improve immunotherapy, researchers discover
Immunotherapy, using a patient's own immune system to treat disease, has shown promise in some patients with cancer but has not worked in most. New research from St. Jude Children's Research Hospital and colleagues has found that disrupting Asxl1, a gene in T cells, improved sensitivity to a type of immunotherapy called immune checkpoint blockade and improved long-term tumor control in model systems.
October 10th, 2024 — Source

Combination therapy may improve treatment response in pancreatic cancer
Northwestern Medicine investigators have discovered that a novel combination therapy promotes cancer cell death and tumor regression in mouse models of pancreatic cancer, according to a recent study published in the journal Cancer Research.
October 10th, 2024 — Source

Early prostate cancer surgery linked to improved survival rates
The survival rate of men with prostate cancer who had their entire prostate gland removed immediately after the tumor was detected increased by 17 percentage points compared with those who did not have treatment until the tumor began to cause symptoms. On average, they also lived more than two years longer.
October 10th, 2024 — Source

Exploring the cross-talk between innate and adaptive immunity
A new review by Dr. Ruyuan Wang and an international team of researchers explores the complex interactions between the innate and adaptive immune systems, shedding light on regulatory mechanisms in infection, cancer, and autoimmune diseases.
October 10th, 2024 — Source

Faster, more sensitive lung cancer detection from a blood draw
(Nanowerk News) A new way of diagnosing lung cancer with a blood draw is 10 times faster and 14 times more sensitive than earlier methods, according to University of Michigan researchers.
October 10th, 2024 — Source

Glioblastoma: A mechanism that helps tumor cells multiply discovered
Chloride ion flows that enter the cells play an important role in the duplication of glioblastoma cells, a highly aggressive brain tumor. This is the finding of research recently published in the journal Molecular Cancer Research, led by research teams from SISSA (Scuola Internazionale Superiore di Studi Avanzati) in collaboration with IOM-CNR, the University of Trieste, University Hospital of Udine, the University of Udine and GlioGuard S.r.l.
October 10th, 2024 — Source

Global advances and future trends in cervical cancer research from 2013 to 2022
With ongoing advancements in cervical cancer research, the global scientific community has gained a more comprehensive understanding of this significant threat to women's health.
October 10th, 2024 — Source

Increasing amount of breast cancer-specific death due to stage 1, 2 disease
Patients with stage I/II breast cancers have excellent prognosis, but account for more than 60 percent of breast cancer-specific death (BCSD) because of their large absolute volumes, according to a study published online Sept. 30 in the Journal of the National Cancer Institute.
October 10th, 2024 — Source

Large-scale study identifies prostate cancer genetic risk factors in a diverse group of African men
Researchers have identified the genetic risk factors that contribute to prostate cancer in a diverse group of African men. Although research and treatment are scant, this first large-scale African genomics study could signal new treatment possibilities.
October 10th, 2024 — Source

Long-term study shows early prostate cancer surgery extended life
The survival rate of men with prostate cancer who had their entire prostate gland removed immediately after the tumor was detected increased by 17 percentage points compared with those who did not have treatment until the tumor began to cause symptoms. On average, they also lived more than two years longer.
October 10th, 2024 — Source

Metabolic syndrome factors linked to increased bowel cancer risk
Metabolic disorders such as obesity, high blood pressure and non-alcoholic fatty liver diseases have been directly linked to an increased risk of developing bowel cancer, warn Flinders University researchers.
October 10th, 2024 — Source

Researchers look into how cancer misinformation spreads online
One of the first things a patient just diagnosed with cancer might do is look for more information online, especially regarding alternative therapies.
October 10th, 2024 — Source

Risk for second melanoma up for those with first melanoma diagnosis
Patients with a first melanoma diagnosis have an increased risk for a second melanoma diagnosis, regardless of race and ethnicity, according to a research letter published online Oct. 9 in JAMA Dermatology.
October 10th, 2024 — Source

Stem cell discovery highlights importance of DNA methylation in cancer
A study led by Umeå University, Sweden, presents new insights into how stem cells develop and transition into specialized cells. The discovery can provide increased understanding of how cells divide and grow uncontrollably so that cancer develops.
October 10th, 2024 — Source

Study determines higher dosage of radioembolization to treat liver cancer improves survival rates
A study led by clinician-scientists and researchers from the National Cancer Centre Singapore (NCCS) and Singapore General Hospital (SGH) has determined the benefits of using a higher dosage of radioembolization treatment using yttrium-90 (Y-90) microspheres, than previously recommended, for liver cancer. Patients who received this elevated dose had significantly better outcomes than those who did not.
October 10th, 2024 — Source

Study reveals 85% of women prefer choice between self-sampling and traditional cervical screening
A study led by researchers at Queen Mary University of London reveals women would welcome the option to choose between self-sampling and traditional screening done by a nurse or doctor for human papillomavirus (HPV)-based cervical screening.
October 10th, 2024 — Source

Health — Cancer — October 8th, 2024

A new technique that makes competition between tumor cells visible can help personalize treatments for multiple myeloma
A new tool detects the evolutionary advantages of multiple myeloma cells over the different treatments available. The information it provides can help prevent the tumor from becoming resistant to drugs.
October 8th, 2024 — Source

AI could help identify women at risk for future breast cancer
Artificial intelligence (AI) scores may be able to estimate the risk for future breast cancer and lead to earlier diagnosis, according to a study published online Oct. 3 in JAMA Network Open.
October 8th, 2024 — Source

Cell line models identify cause of melanoma with drug resistance
Melanoma is a type of cancer that originates from melanocytes, the cells responsible for producing skin pigment, and is known as the most lethal form of skin cancer due to its high rates of metastasis and recurrence. With the global trend of aging populations, the number of melanoma patients is rapidly increasing, and it is projected that by 2040, approximately 100,000 people worldwide will die from melanoma annually.
October 8th, 2024 — Source

DAPK3 emerges as a new regulator of migration of triple-negative breast cancer cells
Triple-negative breast cancer (TNBC) is the subtype of breast cancer that is the hardest to treat. TNBC patients account for more than 20,000 cases of this condition annually in the U.S. alone. They experience worse outcomes than patients with other breast cancer subtypes—their five-year mortality rate is about 40%. The high mortality rate is thought to result from the propensity of the cancer cells to spread or metastasize to other organs and the lack of effective cancer-specific therapies.
October 8th, 2024 — Source

Failure in a CAR T cell trial could unlock multiple treatments for acute myeloid leukemia
In the clinical battle against leukemia, recent breakthroughs in chimeric antigen receptor T cells (CAR T) have given patients and doctors an unprecedented weapon. CAR T cell therapy has demonstrated efficacy in treating B-cell malignancies, achieving high response rates and durable remissions. However, translating this success to acute myeloid leukemia (AML) has proven difficult.
October 8th, 2024 — Source

New strategy could turn intravenous medicines into pills
For many people with cancer, intravenous (IV) infusions of chemotherapy are their best chance at a cure. But these infusions can be inconvenient or inaccessible to patients, and some complications arise not from the active drug itself, but the infusion. Turning these drugs into pills could be transformative.
October 8th, 2024 — Source

New technique that makes competition between tumor cells visible can help personalize treatments for multiple myeloma
Not all cells within the same cancer are the same. They all have genetic errors that turn them into tumor cells, but these errors are not identical. In each cancer, there are populations of cells with different mutations, and it is important to know each population, because one of them can become more dominant and cause the cancer to resist treatment. However, research seeking to understand the properties of each group of cells in a tumor has progressed very slowly so far.
October 8th, 2024 — Source

Platform combines graphene oxide with antibodies to enhance CAR-T cell therapy
Imagine a world where your own immune cells are transformed into cancer-fighting superheroes. This is the promise of CAR-T cell therapy, a groundbreaking treatment that's already saving lives.
October 8th, 2024 — Source

Prostate cancer prevention: Ways to reduce your risk
There's no proven prevention strategy for prostate cancer. But you may reduce your risk of prostate cancer by making healthy choices, such as exercising and eating a healthy diet.
October 8th, 2024 — Source

Prostate cancer Q&A: Improving detection and reducing overtreatment
Prostate cancer is the most common cancer among men in Sweden, with about 10,000 new cases diagnosed annually. Despite advancements in diagnostics and treatments, managing prostate cancer remains challenging due to its often silent progression and the complexities surrounding early detection.
October 8th, 2024 — Source

Q&A: Pathologist discusses another reason to vaccinate teens against HPV
In 2006, a vaccine became available to protect against infections associated with two strains of the human papillomavirus (HPV). It was a potential game-changer: These strains cause 70% of cervical cancers, 90% of anal cancers, and about 75% of the cancers that affect the throat.
October 8th, 2024 — Source

Researchers reveal rare neurological symptoms in youth following CAR-T therapy
Researchers at Children's Hospital of Philadelphia (CHOP) revealed for the first time that children, adolescents and young adults may experience very rare neurological issues of paraparesis and quadriparesis following chimeric antigen receptor T-cell (CAR-T) therapy, a type of immunotherapy used to treat B-cell Acute Lymphoblastic Leukemia (B-ALL).
October 8th, 2024 — Source

Significant worldwide disparities seen in availability and timeliness of new cancer drugs
Despite considerable progress in the discovery and development of new cancer drugs, there are significant disparities in both the availability and timeliness of these medicines worldwide, with poorer countries missing out, suggests a global analysis of new drug launches between 1990 and 2022, published in the open access journal BMJ Global Health.
October 8th, 2024 — Source

What we can learn from hungry yeast cells
Scientists have discovered a curious way in which cells adapt to starvation -- a mechanism with potential cancer implications
October 8th, 2024 — Source

Health — Cancer — October 7th, 2024

AI model shows potential for identifying sex-specific risks associated with brain tumors
For years, cancer researchers have noticed that more men than women get a lethal form of brain cancer called glioblastoma. They've also found that these tumors are often more aggressive in men. But pinpointing the characteristics that might help doctors forecast which tumors are likely to grow more quickly has proven elusive. University of Wisconsin–Madison researchers are turning to artificial intelligence to reveal those risk factors and how they differ between the sexes.
October 7th, 2024 — Source

Analysis reveals improved cancer survival for young adults after passage of Affordable Care Act
The federal Patient Protection and Affordable Care Act (ACA) passed in 2010 includes a Dependent Coverage Expansion (DCE) provision that permits dependents to remain on their parents' health insurance plans from age 19 to 25 years, the age group that has historically had the highest uninsured rate in the United States.
October 7th, 2024 — Source

Cancer biologists discover a new mechanism for an old drug
Study reveals the drug, 5-fluorouracil, acts differently in different types of cancer -- a finding that could help researchers design better drug combinations.
October 7th, 2024 — Source

Cancer biologists discover the drug, 5-fluorouracil, acts differently in different types of cancer
Since the 1950s, a chemotherapy drug known as 5-fluorouracil has been used to treat many types of cancer, including blood cancers and cancers of the digestive tract.
October 7th, 2024 — Source

Cancer, cardiovascular drugs tipped for Nobel as prize week opens
Cancer research or drugs treating cardiovascular illnesses could win a Nobel Prize on Monday when a week of laureate announcements kicks off, bringing a ray of optimism to a world beset by crises.
October 7th, 2024 — Source

Discovery of key gene offers new hope in treating chronic myeloid leukemia
A key gene that could enhance the treatment success rates of chronic myeloid leukemia (CML) has been discovered by researchers.
October 7th, 2024 — Source

Epigenetic test could help predict efficacy of immunotherapy in multiple myeloma
Multiple myeloma is a type of blood cancer that appears mainly after the age of 60. Its incidence, therefore, increases with the aging of the population. In this pathology, the bone marrow, the porous structure within the bones that produces normal blood cells, is invaded by an overgrowth of the so-called plasma cells. These cells, which in healthy conditions are part of the immune system and help prevent infections, have been transformed and, in addition to destroying the bone marrow, end up escaping and causing lesions in other locations such as the spine, skull, pelvis and ribs.
October 7th, 2024 — Source

Harnessing natural killer T cells to advance cancer immunotherapy for solid tumors
In the fight against cancer, chimeric antigen receptor T cell (CAR-T) therapy has achieved notable success in treating blood cancers. However, it has been largely ineffective against solid tumors.
October 7th, 2024 — Source

New cell therapy offers effective treatment for patients with T-cell acute lymphoblastic leukemia
A new cell therapy, targeting CD7 on leukemia cells, gives a potentially effective treatment for patients with T-cell acute lymphoblastic leukemia (T-ALL) who have exhausted all standard treatment options. Published in the prestigious medical journal Nature Medicine on 3 September 2024, the study highlights the effectiveness of a new chimeric antigen receptor (CAR) T-cell therapy.
October 7th, 2024 — Source

New immunotherapy shows complete responses in mantle cell lymphoma
Patients with a rare blood cancer that has relapsed or become resistant to treatment have shown a high response rate to a potent new immunotherapy drug, in a Peter Mac-led clinical trial.
October 7th, 2024 — Source

One-dose HPV vaccination could eliminate cervical cancer in Canada
Canadian vaccination programs could switch to a 1-dose gender-neutral human papillomavirus (HPV) vaccination approach and eliminate cervical cancer, suggests new modeling in CMAJ (Canadian Medical Association Journal).
October 7th, 2024 — Source

Personalized radiotherapy for people with bladder cancer shows promise
Researchers are a step closer to revolutionizing how doctors use radiotherapy to treat patients with muscle-invasive bladder cancer.
October 7th, 2024 — Source

Promising cell therapy offers hope for relapsed or refractory T-cell leukemia
A new cell therapy, targeting CD7 in leukemia cells, gives a potentially effective treatment for patients with T-cell acute lymphoblastic leukemia (T-ALL) who have exhausted all standard treatment options. Published in the journal Nature Medicine on 3 September 2024, the study highlights the effectiveness of a new chimeric antigen receptor (CAR) T-cell therapy.
October 7th, 2024 — Source

Revealing disparities in hepatitis C care for reproductive-aged women to break cycle of viral transmission
Most pediatric cases of hepatitis C virus (HCV) infection are perinatal, meaning the virus is transmitted from birthing parent to child during pregnancy or birth, according to the Centers for Disease Control and Prevention. If left untreated, hepatitis C infection can lead to worse outcomes later in life, such as chronic liver disease, liver failure, and liver cancer.
October 7th, 2024 — Source

Scientists discover that special immune cells stop metastatic cancer
Metastatic disease—when cancer spreads from the primary tumor to other parts of the body—is the cause of most cancer deaths. While researchers understand how cancer cells escape the primary site to seed new tumors, it's not well understood why some of these wayward cancer cells spawn new tumors—sometimes decades later—while others do not.
October 7th, 2024 — Source

Study explores novel therapeutic treatment for glioblastoma
Glioblastoma (GBM) is the most lethal brain tumor, with a median survival rate of merely 12-16 months after diagnosis. Despite surgical, radiation and chemotherapy treatments, the two-year survival rate for GBM patients is less than 10%.
October 7th, 2024 — Source

Study shows cancer vaccine blocks tumor progression at early lesion stage
A cancer vaccine that had little success in clinical trials for patients with advanced tumors could potentially have efficacy if administered earlier in the treatment cycle, according to a study from Vanderbilt researchers.
October 7th, 2024 — Source

Updated findings provide insights into radiation exposure's impact on cancer risk
A major update was made to the International Nuclear Workers Study (INWORKS), an international epidemiological study of workers in the nuclear sector to assess their risks of cancer and non-cancerous diseases.
October 7th, 2024 — Source

Uterine cancer rates are increasing: What can you do to protect yourself?/span>
Uterine cancer is the most common type of gynecologic cancer. It's estimated that about 67,880 new cases will be diagnosed in 2024. Approximately 13,250 people will die from this disease in the U.S. in 2024, according to the National Cancer Institute.
October 7th, 2024 — Source

When CDK12/13 stalls, healthy prostate cells take a malignant turn
Breakthrough research sheds light on the genetic mutation behind aggressive prostate cancer.
October 7th, 2024 — Source

Health — Cancer — October 6th, 2024

Breast cancer deaths fall 44% since 1989 despite rising cases
Breast cancer rates in the United States are increasing significantly, with younger women and Asian Americans experiencing the most notable rises, according to a study released on Tuesday.
October 6th, 2024 — Source

Health — Cancer — October 5th, 2024

Fear of cancer recurrence common decades after surviving childhood cancer
A third of childhood cancer survivors experience fear of recurrence even decades later, according to a study published online Oct. 3 in JAMA Network Open.
October 5th, 2024 — Source

What you need to know after a breast cancer diagnosis
Breast cancer strikes 1 in 8 women in the United States, but being diagnosed with the disease can still make you feel alone.
October 5th, 2024 — Source

Health — Cancer — September 29th, 2024

Access to a GP can make all the difference in surviving lung cancer—and that is a problem for Māori
Surviving lung cancer in Aotearoa New Zealand could depend on whether you can access a GP—raising questions about equity in the country's health system.
September 29th, 2024 — Source

Make Room, mRNA: What to Know About the Novavax COVID Vaccine
In addition to Pfizer and Moderna's new formulas, Novavax's protein-based shot is an option for COVID vaccination this season.
September 29th, 2024 — Source

Radiopharmaceutical therapy offers promise for people with tough-to-treat meningioma brain tumors
A radiopharmaceutical therapy that has successfully extended progression-free survival for patients with neuroendocrine tumors shows early promise for delivering similar benefits to patients with difficult-to-treat meningioma, a type of brain tumor.
September 29th, 2024 — Source

What is CAR-T cell therapy? Oncologist explains
Roughly 635,000 new cases of lymphoma were diagnosed worldwide, according to the World Cancer Research Fund International's most recent report. Survival rates for aggressive lymphomas have improved significantly thanks to advances in treatment, such as chimeric antigen receptor-T cell therapy (CAR-T cell therapy).
September 29th, 2024 — Source

Your cells are dying. All the time.
Some go gently into the night. Others die less prettily.
September 29th, 2024 — Source

Health — Cancer — September 28th, 2024

Circadian disruption, gut microbiome changes linked to colorectal cancer progression
Research from the University of California, Irvine has revealed how disruption of the circadian clock, the body's internal, 24-hour biological pacemaker, may accelerate the progression of colorectal cancer by affecting the gut microbiome and intestinal barrier function. This discovery offers new avenues for prevention and treatment strategies.
September 28th, 2024 — Source

Health — Cancer — September 25th, 2024

Combination treatment improves response to immunotherapy for lung cancer
Researchers have tested a combination of treatments in mice with lung cancer and shown that these allow immunotherapies to target non-responsive tumors.
September 25th, 2024 — Source or Source

Combining treatments to boost tumor response in lung cancer
Researchers at the Francis Crick Institute, in collaboration with Revolution Medicines, have tested a combination of treatments in mice with lung cancer and shown that these allow immunotherapies to target non-responsive tumors.
September 25th, 2024 — Source

Optimized nanoadjuvants enhance in situ tumor vaccine for ovarian cancer
This new article publication from Acta Pharmaceutica Sinica B, discusses how molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH.
September 25th, 2024 — Source

Engineers use bioprinted blood vessels to model deadly brain tumors
Glioblastoma is a brain cancer with very poor survival outcomes. Most drugs can't cross the blood-brain barrier, which means that unlike other cancers, there just aren't that many therapies available for brain tumors.
September 25th, 2024 — Source

Research provides first evidence of mitochondrial genetics' role in Gulf War illness
A first-of-its kind study by researchers at University of California San Diego has revealed that Gulf War illness (GWI), a chronic fatigue illness affecting veterans of the 1990-1991 Gulf War, is linked to genetic variants in mitochondria, the energy-producing structures of cells. The findings shed new light on how GWI, which is thought to be triggered by environmental toxins, develops. The findings could also have implications for other diseases with environmental triggers, such as Parkinson's disease and certain types of cancer.
September 25th, 2024 — Source

Researchers establish largest stem cell repository focused on centenarians
Individuals who display exceptional longevity provide evidence that humans can live longer, healthier lives. Centenarians (greater than 100 years of age) provide a unique lens through which to study longevity and healthy aging, as they have the capacity to delay or escape aging-related diseases such as cancer, cardiovascular disease and Alzheimer's disease, while markedly avoiding disability.
September 25th, 2024 — Source

Ru5 identified as potent antitumor agent targeting mitochondrial ATPase
A research team identified Ru5 as a potent antitumor agent by screening a panel of ruthenium(II) polypyridine complexes containing β-carboline derivatives as ligands. By employing a photoaffinity tag and utilizing the photoaffinity-based protein profiling technology, the researchers successfully elucidated mitochondrial ATPase as the primary molecular target of Ru5.
September 25th, 2024 — Source or Source

Study helps predict how long it will take for testosterone to return to normal after prostate cancer treatment
A study led by researchers from the UCLA Health Jonsson Comprehensive Cancer Center sheds light on testosterone recovery following androgen deprivation therapy (ADT) in men undergoing radiotherapy for prostate cancer, providing key insights for optimizing patient care.
September 25th, 2024 — Source

Study reveals why children with Down syndrome have higher risk of leukemia
People with Down syndrome face a higher risk of developing leukemia. Now researchers from the University of Copenhagen and Stanford University explain why, by identifying specific changes in blood cells of people with Down syndrome.
September 25th, 2024 — Source

Wearable tied to better physical activity recovery following lung cancer surgery
A postoperative wearable device may improve physical activity and patient-reported dyspnea at six months after lung cancer surgery, according to a study published online Sept. 20 in JAMA Network Open.
September 25th, 2024 — Source

Health — Cancer — September 23rd, 2024

ACBI3 molecule offers new hope for targeting KRAS mutations in cancer
KRAS is the most mutated gene in cancer with mutations occurring in 17%--25% of all cancers, affecting millions of patients worldwide. It plays a crucial role in tumor growth, as it is important for driving uncontrolled proliferation of tumor cells. Targeting KRAS function is a primary focus of cancer drug discovery.
September 23rd, 2024 — Source

B-cells hold promise for treating glioblastoma
Harnessing the body's B-cells to fight tumors may be a promising treatment for glioblastoma, according to a Northwestern Medicine study recently published in the Journal of Clinical Investigation.
September 23rd, 2024 — Source

Biological findings open the door to improved outcomes for young adults with sarcoma
A recent study has answered the long-standing question of why improvements in survival outcomes for young people with cancerous soft tissue tumors have lagged behind those of their pediatric and older adult counterparts. By analyzing the protein profiles of different types of soft tissue tumors, known as sarcomas, researchers have shown that there are distinct biological differences between these age groups.
September 23rd, 2024 — Source

Chemotherapy linked to increased cardiovascular risks in older cancer survivors
A study based on clinical trial data found higher risks of stroke, heart attack, and hospital admission for heart failure in older cancer survivors. In the analysis published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society, chemotherapy was also linked to elevated rates of these conditions.
September 23rd, 2024 — Source

Copper-based nanocapsules enhance radiotherapy effectiveness
In a study published in Nature Nanotechnology ("A cuproptosis nanocapsule for cancer radiotherapy"), Prof. GU Zhanjun from the Institute of High Energy Physics of the Chinese Academy of Sciences, in collaboration with Dr. YAN Junfang and Dr. ZHANG Fuquan from the Peking Union Medical College Hospital, discovered that cuproptosis may serve as a new target for radiosensitization in re-irradiation.
September 23rd, 2024 — Source

Do cancer and cancer-related treatments increase cardiovascular disease risk in older cancer survivors?
A study based on clinical trial data found higher risks of stroke, heart attack, and hospital admission for heart failure in older cancer survivors. In the analysis published in the journal Cancer, chemotherapy was also linked to elevated rates of these conditions.
September 23rd, 2024 — Source

Innovative model provides valuable insights into prostate cancer spread
A new preclinical model using CRISPR, an advanced technology that allows scientists to cut and edit genes, has given researchers a deeper insight into how prostate cancer spreads or metastasizes.
September 23rd, 2024 — Source or Source

New AI tool could reshape prostate cancer care by identifying those at higher risk of rapid disease progression
Researchers at the Icahn School of Medicine at Mount Sinai have developed an advanced artificial intelligence (AI)-driven tool to improve the management and prognosis of prostate cancer. Details on the findings were reported in European Urology.
September 23rd, 2024 — Source

New CRISPR model offers deeper insight into prostate cancer metastasis
A new preclinical model using CRISPR, an advanced technology that allows scientists to cut and edit genes, has given Weill Cornell Medicine researchers and their colleagues a deeper insight into how prostate cancer spreads or metastasizes.
September 23rd, 2024 — Source

Paving the way for new treatments
Researchers have created a computer program that can unravel the mysteries of how proteins work together -- giving scientists valuable insights to better prevent, diagnose and treat cancer and other diseases. The tool uses artificial intelligence (AI) to build the three-dimensional atomic structure of large protein complexes.
September 23rd, 2024 — Source or Source

Potential breakthrough for hard to treat cancers
Scientists have developed a breakthrough small-molecule drug, a 'protein degrader'
September 23rd, 2024 — Source

Q&A: Donor funding falls short for Africa's digital health
As African countries struggle with overburdened health care systems, limited resources, and an increasing prevalence of chronic diseases such as cancer, digital health innovations are essential.
September 23rd, 2024 — Source

Researchers discover tumors inherited by generations of jellyfish-like creatures
Researchers from the CANECEV laboratory, an international collaboration between Deakin University and the University of Montpellier, have observed for the first time the birth of transmissible tumors in freshwater brown hydras—tiny, jellyfish-like creatures.
September 23rd, 2024 — Source

Scientists uncover limits of metabolic flexibility in squamous cell skin cancer
Scientists at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have identified key metabolic mechanisms that squamous cell skin cancers use to resist treatment, offering new insights into how to potentially stop cancer growth.
September 23rd, 2024 — Source

Small-molecule drug shows potential for hard to treat cancers
Experts from the University of of Dundee's Centre for Targeted Protein Degradation (CeTPD), working with Boehringer Ingelheim scientists, have developed a breakthrough small-molecule drug, a "protein degrader."
September 23rd, 2024 — Source

Tech Moves: Madrona expands Bay Area team, Microsoft vet returns, Veeam adds tech experts
Anna Chen is joining Madrona's Bay Area office as the longtime Seattle investment firm strengthens its presence in Silicon Valley.
September 23rd, 2024 — Source

Three facts about acute lymphocytic leukemia in children
September is Childhood Cancer Awareness Month. The most common type of childhood cancer is acute lymphocytic leukemia (ALL), a blood and bone marrow cancer that creates immature white blood cells that can't perform their typical functions. Because of this, the disease worsens quickly.
September 23rd, 2024 — Source

Health — Cancer — September 19th, 2024

As blood cancer treatments evolve, so does the patient journey
Treatment for blood cancers is advancing, giving more options to people living with the disease.
September 19th, 2024 — Source

Considering race in colon cancer prediction algorithms reduces disparities, researchers find
Taking race into account when developing tools to predict a patient's risk of colorectal cancer leads to more accurate predictions when compared with race-blind algorithms, researchers find./span>
September 19th, 2024 — Source

Hypoxia's hidden role in boosting anti-cancer immunity
In the complex landscape of cancer, tumors create their own microenvironment, often marked by low oxygen levels, a condition known as hypoxia. Hypoxia arises as tumors grow rapidly, outpacing their blood supply due to the lack of an efficient vascular system within the tumor. This oxygen-starved environment forces cancer cells and surrounding tissues to adapt in ways that typically promote tumor survival and growth.
September 19th, 2024 — Source

Low oxygen levels in tumors could enhance some of the body's immune responses against cancer
In the complex landscape of cancer, tumors create their own microenvironment, often marked by low oxygen levels, a condition known as hypoxia. Hypoxia arises as tumors grow rapidly, outpacing their blood supply due to the lack of an efficient vascular system within the tumor. This oxygen-starved environment forces cancer cells and surrounding tissues to adapt in ways that typically promote tumor survival and growth.
September 19th, 2024 — Source

Non-invasive method can help predict survival in patients with liver cancer
Hepatocellular carcinoma or HCC is the most commonly observed form of liver cancer and the fourth leading cause of cancer-related death worldwide. For patients with an advanced form of HCC, there are different types of systemic treatments available, which travel through the bloodstream and target cancer cells across the body.
September 19th, 2024 — Source

Palliative medicine for cancer patients explained
Patients undergoing cancer treatments often use palliative medicine to cope with nausea, fatigue and other bothersome symptoms.
September 19th, 2024 — Source

Researchers seek to revolutionize rectal cancer treatment with AI
With a new four-year, $1.14 million grant from the U.S. Department of Veterans Affairs, researchers at Case Western Reserve University and the Louis Stokes Cleveland VA Medical Center, will use artificial intelligence (AI) to determine the best personalized treatment for Veterans with rectal cancer.
September 19th, 2024 — Source

Study reveals racial and socioeconomic disparities in lung cancer testing
A new Mount Sinai study published in the Journal of the National Cancer Institute on September 10, 2024, has found that people with lung cancer face big differences in getting important tests based on their race and income. This study, led by Emanuela Taioli, MD, Ph.D., and her team at the Institute for Translational Epidemiology at the Icahn School of Medicine at Mount Sinai, shows a serious concern in cancer care.
September 19th, 2024 — Source

What you should know about prostate cancer screening
The prostate is a small gland in males that aids in reproduction. Prostate cancer is one of the most common types of cancer, and when it's detected early, often by a simple blood test, it has the best chance for successful treatment.
September 19th, 2024 — Source

Health — Cancer — September 16th, 2024

Clinical trial: Preventing heart injury caused by anticancer drugs
The RESILIENCE clinical trial has been designed to explore the effectiveness and safety of remote ischemic conditioning (RIC) used to prevent the cardiotoxic effects of anthracycline-based chemotherapy in patients with lymphoma.
September 16th, 2024 — Source

Combination immunotherapy yields 10-year survival for metastatic melanoma patients
Long-term data from a landmark international trial show about half of patients with metastatic melanoma treated with a combination of immune checkpoint inhibitors survive cancer-free for 10 years or more, according to a new report from Weill Cornell Medicine and Dana-Farber Cancer Center investigators and their colleagues.
September 16th, 2024 — Source

Combination treatment improves symptoms of agitated delirium in end-of-life cancer patients
Treatment with a combination of haloperidol and lorazepam reduced symptoms of agitated delirium, a common end-of-life condition for patients with advanced cancers, compared with haloperidol alone, according to a new study led by researchers at The University of Texas MD Anderson Cancer Center.
September 16th, 2024 — Source

Experimental drug helps cancer patients regain weight, study shows
Pfizer Inc.'s experimental drug for cancer weight loss was shown to help patients regain weight in a mid-stage study, offering fresh promise for treating the dangerous muscle-wasting condition.
September 16th, 2024 — Source

Global trial ends 20-year debate over gastro-esophageal cancer treatment
Cancer patients could avoid unnecessary radiation therapy as a result of an international clinical trial, led by Peter Mac researcher Prof Trevor Leong. The TOPGEAR study demonstrated that radiotherapy does not improve survival outcomes for patients with operable gastric and gastro-esophageal junction cancer when compared to chemotherapy alone.
September 16th, 2024 — Source

High-dose vitamin D3 cannot be recommended as treatment for metastatic colon cancer
Study title: SOLARIS (Alliance A021703): A multicenter double-blind phase III randomized clinical trial of vitamin D combined with standard chemotherapy plus bevacizumab in patients with previously untreated metastatic colorectal cancer.
September 16th, 2024 — Source or Source

Immunotherapy after surgery helps people with high-risk bladder cancer live cancer-free longer
NIH clinical trial results expand treatment options for this disease.
September 16th, 2024 — Source

Immunotherapy shows promise for men with specific types of prostate cancer
New research has shown that immunotherapy can be effective in treating prostate cancer in men who are selected based on the genetic characteristics of their tumors.
September 16th, 2024 — Source

Modified nano-sized cell particles found to boost cancer immunotherapy, reduce side effects
Immunotherapy is a type of cancer treatment that uses the body's own immune system to help fight cancer. This is by stimulating the immune response to recognize and attack cancer cells more effectively.
September 16th, 2024 — Source

New Covalent Organic Frameworks Engineered for Precision Drug Delivery in Cancer Therapy
A group of researchers at NYU Abu Dhabi (NYUAD) have created crystalline organic polymers called nanoscale covalent organic frameworks (nCOFs) that have been modified with peptides to treat triple-negative breast cancer (TNBC), the most aggressive type of breast cancer.
September 16th, 2024 — Source

Reprogramming cancer cells to attack themselves
A team of health and medical researchers affiliated with a host of institutions across Sweden has tested the possibility of reprogramming cancer cells into cDC1 cells as a means for destroying the protective shield around tumors, allowing the immune system to kill them.
September 16th, 2024 — Source

Scientists discover key features of language sites that could help preserve function after brain surgery
When surgeons perform brain surgery on people with brain tumors or epilepsy, they need to remove the tumor or abnormal tissue while preserving parts of the brain that control language and movement.
September 16th, 2024 — Source

Study links neighborhood environment to prostate cancer risk in men with West African genetic ancestry
According to a study led by researchers at the National Institutes of Health (NIH), West African genetic ancestry was associated with increased prostate cancer among men living in disadvantaged neighborhoods but not among men living in more affluent neighborhoods.
September 16th, 2024 — Source

Study offers hope of a new treatment for rare endometrial cancer
A team of researchers at the University of Alberta has found that digoxin, a drug widely used to treat congestive heart failure, is an effective therapy for a rare and aggressive form of endometrial cancer.
September 16th, 2024 — Source

Waiting is the hardest part: Medical field should address uncertainty for cancer patients under active surveillance
Patients with low-risk cancers undergoing active surveillance face a favorable long-term prognosis. David Haggstrom, M.D., MAS, makes the case that it's time for the medical field to help manage the anxiety caused by waiting.
September 16th, 2024 — Source

Health — Cancer — September 15th, 2024

ESMO: Combination therapy reduced agitated delirium in patients with advanced cancers
Treatment with a combination of haloperidol and lorazepam reduced symptoms of agitated delirium, a common end-of-life condition for patients with advanced cancers, compared with haloperidol alone, according to a new study led by researchers at The University of Texas MD Anderson Cancer Center.
September 15th, 2024 — Source

Long-term metastatic melanoma survival dramatically improves on immunotherapy, clinical trial finds
Long-term data from a landmark international trial show about half of patients with metastatic melanoma treated with a combination of immune checkpoint inhibitors survive cancer-free for 10 years or more, according to a new report from Weill Cornell Medicine and Dana-Farber Cancer Center investigators and their colleagues.
September 15th, 2024 — Source

Health — Cancer — September 13th, 2024

Cancer cases in the US continued to be underdiagnosed during the second year of the COVID-19 pandemic
Cancer diagnosis rates improved in 2021, but gaps from 2020 still remain
September 13th, 2024 — Source

Cellular map of the pancreas could lead to better treatments against pancreatic cancer and diabetes
Pancreatic diseases, such as diabetes or pancreatic cancer, are usually severe and have a strong impact on patients. Unfortunately, today, there are no specific or effective treatments for pancreatic cancer, so the survival rate of patients is very low. In the case of diabetes, the development of new cell replacement therapies for insulin-producing cells seems to be the future cure of insulin-dependent patients.
September 13th, 2024 — Source

Hypofractionation proven safer and more convenient for breast cancer treatment
Giving higher doses per fraction of radiation therapy over a shorter time after breast cancer surgery significantly reduces the risk of side effects and improves quality of life compared with a conventional schedule, finds a study published by The BMJ today.
September 13th, 2024 — Source

Melanoma incidence and mortality may eventually decrease among the entire Swedish population
Study finds significant drop in incidence and mortality among 30 to 49-year-olds
September 13th, 2024 — Source

Novel drug delivery system aims to prevent hearing loss from cisplatin chemotherapy
The chemotherapy drug cisplatin is a lifesaver for many adults and children diagnosed with cancer, but it often causes hearing loss, a side effect that can diminish quality of life following treatment. To prevent hearing damage during cancer treatment, a University of Oklahoma researcher created a novel drug delivery system that transports medications to the inner ear; her studies about the promising innovation are published in the Journal of Controlled Release and the Journal of Nanobiotechnology.
September 13th, 2024 — Source

Salt can boost antitumor responses of T cells
Sodium in tumor microenvironments found to heighten T-cell activation, suggesting new cancer treatment avenues
September 13th, 2024 — Source

Study finds 'supercharging' T cells with mitochondria enhances their antitumor activity
Fighting cancer is exhausting for T cells. Hostile tumor microenvironments can drain their mitochondrial activity, leading to a condition known as T cell exhaustion. This phenomenon also hinders adoptive cell therapies, in which healthy, tumor-targeting T cells are infused into patients with cancer.
September 13th, 2024 — Source

The potential benefits of aged black garlic on inflammation and prostate cancer
Study shows anti-inflammatory effects on prostate cancer cells, but further research needed
September 13th, 2024 — Source

Health — Cancer — September 10th, 2024

Cancer fatigue: Why it occurs and how to cope
The exact causes of cancer fatigue and how best to treat it aren't always clear. Find out what healthcare professionals know about cancer fatigue and what you can do about it.
September 10th, 2024 — Source

Experimental nanomedicine delivers chemo drugs directly to tumors in mice
Researchers at the University of Chicago Medicine Comprehensive Cancer Center have developed a nanomedicine that increases the penetration and accumulation of chemotherapy drugs in tumor tissues and effectively kills cancer cells in mice.
September 10th, 2024 — Source

Get Your Creativity Flowing at the Office With This 3D Printer
Explore the world of 3D printing with the X-Maker, a user-friendly, powerful tool designed to get your creative juices flowing.
September 10th, 2024 — Source

Iron-doped carbon-based nanoparticles boost cancer treatment with enhanced precision and safety
Recently, a collaborative research team led by Prof. Wang Hui and Prof. Qian Junchao from Hefei Institutes of Physical Science of the Chinese Academy of Sciences designed a catalytically active, photoresponsive, Fe-doped carbon nanoparticle (FDCN) for second near-infrared (NIR-II) window, photothermal-enhanced chemodynamic therapy.
September 10th, 2024 — Source

Microbiome and diagnostics startup Viome lands $25M and hires former Amazon leader as COO
Viome, a company selling microbiome products and health diagnostics, announced Tuesday that it raised $25 million from investors and hired Kal Raman as its chief operating officer.
September 10th, 2024 — Source

New AI model creates virtual colorations of cancer tissue for enhanced diagnostics
A recent study published in Nature Machine Intelligence introduces an advanced artificial intelligence (AI) model capable of creating virtual colorations of cancer tissue. The study, co-led by scientists at the Universities of Lausanne and Bern, is a major step forward enhancing pathology analysis and diagnostics of cancer.
September 10th, 2024 — Source

New law regulating out-of-pocket drug spending saves cancer patients more than $7,000 a year, study finds
As prescription oral chemotherapies have become a common form of cancer treatment, some patients were paying more than $10,000 a year for medications. A new study finds that efforts to cap prescription drug spending are yielding significant out-of-pocket savings for these patients.
September 10th, 2024 — Source

Novel bone cancer therapy has 99% success rate, tests show
Bioactive glasses, a filling material which can bond to tissue and improve the strength of bones and teeth, has been combined with gallium to create a potential treatment for bone cancer. Tests in labs have found that bioactive glasses doped with the metal have a 99 percent success rate of eliminating cancerous cells and can even regenerate diseased bones.
September 10th, 2024 — Source

Palliative low-dose radiotherapy improves pain in hepatic cancer
For adults with hepatocellular carcinoma or liver metastases, low-dose liver radiotherapy plus best supportive care improve pain compared with best supportive care alone, according to a study published online Sept. 5 in The Lancet Oncology.
September 10th, 2024 — Source

Pathway tied to cancer-driving genome alterations identified
Cancer cells appear to hijack a genetic pathway involved in DNA repair to drive malignancy and overcome treatment, a study led by UT Southwestern Medical Center researchers shows.
September 10th, 2024 — Source

Proof-of-concept study demonstrates novel strategy to develop liver-targeting chimeras for disease treatment
Liver cancer ranks as the fourth most common cancer and the second leading cause of cancer-related deaths in China, with hepatocellular carcinoma (HCC) being the most prevalent type. Current treatments for liver cancer encounter several significant challenges, including limited target availability, severe side effects, low response rates, and the emergence of acquired drug resistance.
September 10th, 2024 — Source

Researchers customize top-of-the-line microscopy method with AI to better understand glioblastoma tumors
Imagine building a traffic surveillance camera that could detect trouble-making cells speeding around in your brain before their cellular gang could commit "crimes." Most importantly, this camera could catch some of the biggest interlopers of all—cancer cells.
September 10th, 2024 — Source

Scholar aims to reverse-engineer cancer with 3D tool
To study how cancer develops, Dr. Chen Cao is building tumors in the lab.
September 10th, 2024 — Source

Health — Cancer — September 9th, 2024

AI tool reveals cardiac risk for patients undergoing cancer therapy
In a new study published in Circulation: Cardiovascular Quality and Outcomes, researchers at Yale School of Medicine say an artificial intelligence (AI) tool can use electrocardiographic (ECG) images to define the risk of cardiac dysfunction for patients undergoing cancer treatments.
September 9th, 2024 — Source

BAY 2927088 demonstrates 'rapid, substantial and durable responses' in patients with HER2-mutant NSCLC
BAY 2927088 demonstrates 'rapid, substantial and durable responses' in patients with HER2-mutant NSCLC
September 9th, 2024 — Source

Breast cancer rises among Asian American and Pacific Islander women
About 11,000 Asian American and Pacific Islander women were diagnosed with breast cancer in 2021 and about 1,500 died. The latest federal data shows the rate of new breast cancer diagnoses in Asian American and Pacific Islander women—a group that once had relatively low rates of diagnosis—is rising much faster than that of many other racial and ethnic groups.
September 9th, 2024 — Source

Cancer cells may be using lipids to hide from the immune system
Once alerted, the body's defenses can swoop in, destroying rogue cells before they can do much damage. Lying at the heart of this early warning system are lipids, fatty compounds previously seen by cancer biologists primarily as a fuel source for burgeoning tumors.
September 9th, 2024 — Source

Combination treatment improves survival in advanced prostate cancer with genetic mutations
A combination therapy improved progression-free survival in patients with metastatic castration-resistant prostate cancer with distinct genetic mutations compared to either therapy alone or sequentially, according to results from a Northwestern Medicine-led multi-center clinical trial published in the journal Clinical Cancer Research.
September 9th, 2024 — Source

Computational tool reveals untapped efficacy of cancer drug, leveling up cancer fight
Research from Purdue University in collaboration with the National Institutes of Health (NIH) reveals that, thanks to a new computational tool, a cancer drug dismissed by traditional testing methods may be effective in treating bladder cancer.
September 9th, 2024 — Source

Coping with a cancer diagnosis can contribute to psychological and cardiovascular problems in family members
New research suggests that a family member's cancer diagnosis may increase first-degree relatives' and spouses' risks of developing psychological and cardiovascular illnesses.
September 9th, 2024 — Source

Developing Ultra-Sensitive Blood Test for Cancer Diagnosis
According to a study published in Small Science, Dr. Min-young Lee and Dr Sung-gyu Park of KIMS's Advanced Bio and Healthcare Materials Research Division have created a method based on plasmonic nanomaterials for optical signal amplification that can identify cancer mutant genes in blood with the highest sensitivity in the world—0.000000001%.
September 9th, 2024 — Source

'Draw me a cell': Generative AI takes on clinical predictions in cancer
A study published in Nature Machine Intelligence introduces an advanced artificial intelligence (AI) model capable of creating virtual colorations of cancer tissue. The study, co-led by scientists at the Universities of Lausanne and Bern, is a major step forward in enhancing pathology analysis and diagnostics of cancer.
September 9th, 2024 — Source

Glitch in protein synthesis could affect tumor growth
During protein synthesis, or translation, genetic information transcribed in the cell's mRNA directs the stringing together of amino acids—the building blocks of proteins. As the translation machinery carouses along the string of nucleotides that make up the mRNA, it recognizes them in groups of three, called codons. Each codon corresponds to a specific amino acid.
September 9th, 2024 — Source

How the scars of demolished brain tumors seed relapse
A Ludwig Cancer Research study has discovered that recurrent tumors of the aggressive brain cancer glioblastoma multiforme (GBM) grow out of the fibrous scars of malignant predecessors destroyed by interventions such as radiotherapy, surgery and immunotherapy.
September 9th, 2024 — Source

Ifinatamab deruxtecan shows promising results in advanced small cell lung cancer
The antibody–drug conjugate ifinatamab deruxtecan (I-DXd) showed clinically meaningful responses in pretreated patients with extensive-stage small cell lung cancer (ES-SCLC), according to an interim analysis of the Phase 2 IDeate-Lung01 study. The data was presented today at the International Association for the Study of Lung Cancer (IASLC) 2024 World Conference on Lung Cancer.
September 9th, 2024 — Source

Iron-doped carbon nanoparticles boost cancer treatment with enhanced precision and safety
(Nanowerk News) A collaborative research team, led by Prof. WANG Hui and Prof. QIAN Junchao from the Hefei Institutes of Physical Science at the Chinese Academy of Sciences, has successfully developed catalytically active, photoresponsive Fe-doped carbon nanoparticles (FDCN) using the Stable High Magnetic Field Facility. These nanoparticles were specifically designed for second near-infrared (NIR-II) photothermal-enhanced chemodynamic therapy.
September 9th, 2024 — Source

Leveraging the power of iPS cell technology to study myeloid neoplasm
Using iPS cells generated from a patient with a myeloid neoplasm caused by a rare chromosomal rearrangement between the MECOM and MYC genes, a team of researchers led by Associate Professor Yoshinori Yoshida and Clinical Assistant Professor Kazuhisa Chonabayashi (Department of Growth and Differentiation) successfully modeled the cancer to gain a better understanding of its pathogenic mechanisms and test potential drug therapies.
September 9th, 2024 — Source

Men often confused about prostate cancer screening, survey shows
A new survey finds the majority of American men believe the first step in prostate cancer screening is an invasive rectal exam by their doctor.
September 9th, 2024 — Source

Promising pathway for predictive biomarkers in lung cancer immunotherapy revealed
A study presented today at the International Association for the Study of Lung Cancer 2024 World Conference on Lung Cancer demonstrated a promising pathway toward developing predictive biomarkers for immune checkpoint inhibitors.
September 9th, 2024 — Source

Protein NSD2 found to drive early prostate cancer development
Researchers at the University of Michigan Health Rogel Cancer Center have uncovered a key reason that a typically normal protein goes awry and fuels cancer.
September 9th, 2024 — Source

Q&A: Researchers discuss statin, metformin, and aspirin use with hepatocellular carcinoma
Erik Almazan, MD, of the Department of Medicine at Brigham and Women's Hospital and Raymond T. Chung, MD, of the Liver Center at Massachusetts General Hospital, are the authors of a paper titled "Association of Statin, Metformin, and Aspirin Use with Hepatocellular Carcinoma in the All of Us Research Program, published in Gastro Hep Advances.
September 9th, 2024 — Source

Radnet’s DeepHealth and HOPPR forge partnership to advance AI in healthcare
DeepHealth, a wholly-owned subsidiary of RadNet, Inc. and a global leader in AI-powered radiology and health informatics, today announces a data and AI development partnership with HOPPR. This collaboration will commercialize a pioneering Medical-Grade Generalized Foundational Model and foster the development of Fine-Tuned models for breast, prostate, and lung cancer detection, leveraging generative medical imaging-focused AI and robust, diverse data sets.
September 9th, 2024 — Source

Research confirms safety of breastfeeding for breast cancer survivors with BRCA mutations
According to two international studies presented at the ESMO Congress 2024, women who breastfeed after receiving treatment for breast cancer, including those with a germline BRCA mutation (an inherited change in BRCA genes that significantly increases the risk of developing certain cancers, especially breast cancer), do not face an increased risk of recurrence or developing new breast cancers.
September 9th, 2024 — Source

Researchers identify factor that drives prostate cancer-causing genes
Factor previously known to play a role in advanced cancer is fundamental in early stages of cancer development
September 9th, 2024 — Source

Researchers uncover mechanism fueling prostate cancer
Researchers at the University of Michigan Health Rogel Cancer Center have uncovered a key reason why a typically normal protein goes awry and fuels cancer.
September 9th, 2024 — Source

Scientists learn how to drug wily class of disease-causing enzymes
UCSF scientists have discovered how to target a class of molecular switches called GTPases that are involved in a myriad of diseases from Parkinson's to cancer and have long been thought to be "undruggable."
September 9th, 2024 — Source

Studies provide first evidence that breastfeeding after breast cancer is safe
According to two international studies presented at the ESMO Congress 2024, women who breastfeed after receiving treatment for breast cancer, including those with a germline BRCA mutation (an inherited change in BRCA genes that significantly increases the risk of developing certain cancers, especially breast cancer), do not face an increased risk of recurrence or developing new breast cancers.
September 9th, 2024 — Source

Sweden reports drop in skin cancer rates for under 50s
The risk of skin cancer, malignant melanoma, now appears to be decreasing in Sweden - at least in those under 50, according to a new study.
September 9th, 2024 — Source or Source

'Synthetic immune niche' approach enhances T-cell proliferation without compromising cancer-killing ability
Cellular immunotherapy, a leading form of cancer treatment, enlists the "warriors" of our immune system, our T-cells, in the war on cancer. During preparations for the treatment, doctors take a sample of T-cells from the patient and activate them to make them divide rapidly and form a massive army of cancer-killing cells that is then injected back into the patient.
September 9th, 2024 — Source

Trial demonstrates firmonertinib is a potential therapy for patients with NSCLC with EGFR PACC mutations
The tyrosine kinase inhibitor firmonertinib showed promising efficacy in patients with non-small cell lung cancer across a broad range of EGFR PACC mutations in the first-line metastatic setting with CNS antitumor activity, according to research presented at the International Association for the Study of Lung Cancer 2024 World Conference on Lung Cancer.
September 9th, 2024 — Source

Understanding athletes with lymphoma
One July evening, Allison Rosenthal, D.O., received a flurry of texts with exclamations like, "Yo, my doctor friend is famous!"
September 9th, 2024 — Source

Women with liver cancer less likely than men to receive liver transplant
Women with hepatocellular carcinoma (HCC) are less likely to receive a deceased-donor liver transplant (DDLT) and more likely to die while wait-listed than men, according to a study published online Sept. 4 in JAMA Surgery.
September 9th, 2024 — Source

Zongertinib demonstrates promising efficacy in patients with HER2-mutant non-small cell lung cancer
The HER2-specific tyrosine kinase inhibitor zongertinib was well tolerated and demonstrated promising efficacy in patients with HER2 mutation-positive non-small cell lung cancer, meeting the primary endpoint of the Beamion LUNG-1 Phase Ib Cohort 1 study, according to research presented at the International Association for the Study of Lung Cancer 2024 World Conference on Lung Cancer.
September 9th, 2024 — Source

Health — Cancer — September 7th, 2024

Antibody--drug conjugate I-DXd shows meaningful response in patients with extensive-stage small cell lung cancer
The antibody--drug conjugate ifinatamab deruxtecan (I-DXd) has shown clinically meaningful responses in pretreated patients with extensive-stage small cell lung cancer (ES-SCLC), according to an interim analysis of the Phase 2 IDeate-Lung01 study.
September 7th, 2024 — Source

Artificial intelligence method could advance gene mutation prediction in lung cancer
Research presented today suggests an artificial intelligence tool called DeepGEM may provide an advancement in genomic testing that offers an accurate, cost-effective, and timely method for gene mutation prediction from histopathology slides.
September 7th, 2024 — Source

Does intermittent fasting increase or decrease risk of cancer?
Research over the years has suggested intermittent fasting has the potential to improve our health and reduce the likelihood of developing cancer.
September 7th, 2024 — Source

Research shows pathway to developing predictive biomarkers for immune checkpoint inhibitors
A study presented today at the International Association for the Study of Lung Cancer 2024 World Conference on Lung Cancer demonstrates a promising pathway toward developing predictive biomarkers for immune checkpoint inhibitors.
September 7th, 2024 — Source

Survey reveals progress and persistent barriers in lung cancer biomarker testing
Despite significant improvements in the perception of biomarker testing compared to a 2018 survey, substantial barriers to implementation persist globally, according to results of the 2024 IASLC Global Survey on Biomarker Testing released today at the International Association for the Study of Lung Cancer (IASLC) World Conference on Lung Cancer 2024.
September 7th, 2024 — Source

Health — Cancer — September 6th, 2024

Age-related changes in male fibroblasts increase treatment-resistant melanoma, study finds
Age-related changes in the fibroblasts, cells that create the skin's structure, contribute to the development of aggressive, treatment-resistant melanoma in males, according to research in mice by the Johns Hopkins Kimmel Cancer Center.
September 6th, 2024 — Source

Breakthrough technology detects cancer mutant genes with unprecedented sensitivity
Dr. Min-young Lee and Dr. Sung-gyu Park of the Advanced Bio and Healthcare Materials Research Division at KIMS have developed a technology that can detect cancer mutant genes in blood with the world's highest sensitivity of 0.000000001% based on plasmonic nanomaterials for optical signal amplification.
September 6th, 2024 — Source or Source or Source

Cancer tool 'unable to accurately predict' toxicity levels in older UK patients
Experts from the University's School of Medicine have revealed that the Cancer Aging Research Group (CARG) score—a tool used to estimate the risk of severe chemotherapy-related side effects for patients—is not robust when used in an older U.K. population.
September 6th, 2024 — Source

Chemical screen identifies PRMT5 as therapeutic target for paclitaxel-resistant triple-negative breast cancer
In a study published in Cell Chemical Biology, a research team led by Prof. Tan Weihong and Prof. Wu Qin from the Hangzhou Institute of Medical of the Chinese Academy of Sciences has identified protein arginine methyltransferases (PRMTs), crucial regulators of RNA splicing and chromatin stability, as a new therapeutic target for overcoming paclitaxel resistance in triple-negative breast cancer (TNBC).
September 6th, 2024 — Source

ISS experiments reveal new advances in biosensing for cancer diagnostics
The University of Notre Dame is leading a series of groundbreaking experiments onboard the International Space Station (ISS) to revolutionize early cancer detection. This research, featured in the latest issue of Upward, official magazine of the ISS National Laboratory®, demonstrates how bubbles formed in microgravity can significantly enhance biosensing technology by concentrating microscopic substances more effectively than on Earth.
September 6th, 2024 — Source

Major funding boost aims to advance research on bone metastasis in breast and prostate cancers
Breast Cancer Now and Prostate Cancer Research have joined forces to fund up to £600,000 of new research to tackle the spread of both cancers to the bones, known as bone metastasis.
September 6th, 2024 — Source

Researchers develop mechanism that predicts severity of aggressive form of breast cancer
Scientists at Huntsman Cancer Institute at the University of Utah (the U), the National Cancer Institute-designated cancer center for the Mountain West, have made a significant breakthrough in predicting the prognosis of triple-negative breast cancer (TNBC), a particularly aggressive disease.
September 6th, 2024 — Source

Study finds dysfunctional white blood cells linked to heightened melanoma risk
About 8 to 10 million Americans over age 40 have an overabundance of cloned white blood cells, or lymphocytes, that hamper their immune systems. Although many who have this condition—called monoclonal B-cell lymphocytosis (MBL)—do not experience any symptoms, a new study shows they may have an elevated risk for several health complications, including melanoma, a form of skin cancer.
September 6th, 2024 — Source

Study finds TGF-beta and RAS signaling are both required for lung cancer metastasis
When it comes to cancer metastasis, it takes two to tango. That was one of the key findings of a new study led by researchers at Memorial Sloan Kettering Cancer Center (MSK): The TGF-beta and RAS signaling pathways work together to spur the spread of cancer in lung adenocarcinoma, a leading cause of cancer deaths around the world.
September 6th, 2024 — Source

Unfold AI outperforms conventional methods in prostate cancer risk prediction
A recently published study in BJUI Compass confirms the groundbreaking potential of Unfold AI™, an FDA-cleared artificial intelligence (AI) algorithm developed by Avenda Health, a leader in personalized prostate cancer care. In conjunction with UCLA, the study used Unfold AI's technology to map 3D cancer probability and estimate extracapsular extension (ECE) risk, comparing it to conventional methodologies such as MRI, PSMA PET/CT imaging and nomograms.
September 6th, 2024 — Source

Health — Cancer — September 3rd, 2024

3D-printed mini-tumors mimic human tissue for cancer immunotherapy tests
Leiden researchers have developed a model to advance cancer immunotherapy. Using a 3D printer, they create mini-tumors within an environment that closely mimics human tissue. They have also developed a method to monitor real-time interactions of these mini-tumors with immune cells during tests.
September 3rd, 2024 — Source

Australian researchers attribute drop in melanoma rates to increasingly diverse population
Researchers from QIMR Berghofer have found that declining melanoma rates among young Australians have been influenced by the country's increasingly diverse population and more varied skin tones.
September 3rd, 2024 — Source

Gene found in ovarian cancer cells identified as potential new target for treatment
A University of Alberta research team has found a potential new treatment target for ovarian cancer. Their new research is the first to comprehensively investigate the elevated expression of a gene called ZIC2 in ovarian cancer cells, finding that it is associated with poor survival rates of ovarian cancer patients and testing ways to inactivate the gene.
September 3rd, 2024 — Source

Hundreds of new cancer driver genes predicted by algorithm
Researchers at the Centre for Genomic Regulation (CRG) have discovered hundreds of potential new cancer driver genes. The findings, published in the journal Nature Communications, significantly expands the list of possible therapeutic targets to monitor and tackle the disease.
September 3rd, 2024 — Source

Researchers develop stable compound for targeted alpha therapy in prostate cancer
Compounds containing astatine-211 (211At) can be used in targeted radiotherapies for prostate cancer, but deastatination in the body remains a significant hurdle. Now, researchers from Japan have developed a new molecule with a neopentyl glycol structure that effectively prevents deastatination.
September 3rd, 2024 — Source

Health — Cancer — September 2nd, 2024

Blood-based assay shows promise for detecting IDH1.R132H-mutant gliomas
Glioma represents the most common central nervous system cancer in adults. The current classification scheme uses molecular alterations, particularly IDH1.R132H, to stratify lesions into distinct prognostic groups.
September 2nd, 2024 — Source

Novel light-based technique shows 90% accuracy in early prostate cancer detection
An Aston University researcher has used light to develop the first step towards a quicker, cheaper and less painful technique to detect cancer.
September 2nd, 2024 — Source

Scientists use exosomes secreted by living cells to successfully target TKI-resistant cancer
In a new study, clinician-scientists and researchers from the National Cancer Center Singapore (NCCS) have demonstrated the use of exosomes to successfully target squamous cell cancer tumors that are usually resistant to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs).
September 2nd, 2024 — Source

Health — Cancer — August 31st, 2024

Residing in poverty tied to worse breast cancer outcomes
Women residing in persistently impoverished neighborhoods have worse breast cancer outcomes, according to a study published online Aug. 29 in JAMA Network Open.
August 31st, 2024 — Source

Health — Cancer — August 27th, 2024

AI enhances understanding of radiation-induced cardiac arrhythmia risk in lung cancer patients
Researchers from Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, have used artificial intelligence tools to accelerate the understanding of the risk of specific cardiac arrhythmias when various parts of the heart are exposed to different thresholds of radiation as part of a treatment plan for lung cancer.
August 27th, 2024 — Source

AI spots cancer and viral infections with nanoscale precision
Researchers have developed an artificial intelligence which can differentiate cancer cells from normal cells, as well as detect the very early stages of viral infection inside cells.
August 27th, 2024 — Source

Colorectal cancer: New approach for better efficacy of immunotherapies
The most common form of colorectal cancer, microsatellite-stable colorectal cancer (MSS CRC), can currently only be treated to a limited extent with modern immunotherapies. A research team led by MedUni Vienna has now identified the possible cause of treatment failure and thus found a way to improve treatment for patients.
August 27th, 2024 — Source

Common chemotherapy supplement weakens the pancreatic cancer's defenses in mice
The fight against cancer is an arms race, and one of the most effective weapons in clinicians' arsenals is immunotherapy. Immune checkpoint therapy has become the standard for treating several types of cancer. However, the Nobel Prize-winning strategy is ineffective for most pancreatic ductal adenocarcinoma (PDAC) patients.
August 27th, 2024 — Source

Enhancing Antitumor Immunity: A Novel Cancer Vaccine Combining Nano-11 and ADU-S100
In a recent article published in npj Vaccines, researchers detailed the development of a novel cancer vaccine that combines a plant-derived nanoparticle adjuvant, Nano-11, with a clinically tested STING agonist, ADU-S100. The primary objective was to enhance antitumor immunity through an innovative intradermal vaccination approach.
August 27th, 2024 — Source

EPA Thought Industry-Funded Scientists Could Support Its Conclusion that a Long-Regulated Pesticide Is Not a Cancer Risk
The consultants, who worked for Dow, the pesticide's manufacturer, help corporate interests defend their products against environmental and health regulations.
August 27th, 2024 — Source

New insights on how melanoma cells resist cancer immunotherapy
How would you summarize your study for a lay audience?
August 27th, 2024 — Source

New study supports annual breast cancer screening for women over 40
Women diagnosed with breast cancer who had regular screening mammograms every year were less likely to have late-stage cancer and had higher overall survival than those who received screening every other year or less often, according to new research.
August 27th, 2024 — Source

UQ study unlocks potential for advanced bladder cancer immunotherapy
University of Queensland research could lead to a more effective immunotherapy treatment against bladder cancer.
August 27th, 2024 — Source

Health — Cancer — August 26th, 2024

Cancer survivor launches Oncology Ventures to improve care
Ben Freeberg was an associate at venture firm Alpha Partners when he suddenly passed out in the middle of the day. He sought medical help, and after running a few diagnostic tests, doctors didn’t find anything wrong with him.
August 26th, 2024 — Source

Key discovery advances fight to reduce breast cancer recurrence
In looking for new ways to fight breast cancer, scientists from Duke-NUS Medical School have unmasked a surprising role of a protein generally associated with cancer growth. They have discovered that in estrogen receptor-positive (ER+) breast cancer, this protein acts as a tumor suppressor instead.
August 26th, 2024 — Source

Man Receives World's First Lung Cancer Vaccine
This 67-year-old cancer patient is the first human to receive BioNTech's experimental mRNA immunotherapy.
August 26th, 2024 — Source

New prognostic biomarker identified in small cell lung cancer
Small cell lung cancer (SCLC) is a fast-growing and highly malignant subtype of lung cancer. One of the biggest challenges doctors face is the cancer's resistance to platinum-based chemotherapy, the standard treatment for SCLC patients.
August 26th, 2024 — Source

New study supports annual breast cancer screening for women over 40
Women diagnosed with breast cancer who had regular screening mammograms every year were less likely to have late-stage cancer and had higher overall survival than those who received screening every other year or less often, according to new research from the University of Pittsburgh and UPMC published in the Journal of Clinical Oncology.
August 26th, 2024 — Source

Old chemo drug, new pancreatic cancer therapy?
The fight against cancer is an arms race, and one of the most effective weapons in clinicians' arsenals is immunotherapy. Immune checkpoint therapy has become the standard for treating several types of cancer. However, the Nobel Prize-winning strategy is ineffective for most pancreatic ductal adenocarcinoma (PDAC) patients.
August 26th, 2024 — Source or Source

South Florida's Hispanic communities see fewer late-stage lung cancer diagnoses
When it comes to cancer disparities, community may count. A study published Aug. 21 in the Journal of the National Cancer Institute showed that although Hispanic non-small cell lung cancer patients tend to be diagnosed at later stages than white patients, that disadvantage disappears in South Florida.
August 26th, 2024 — Source

Structural racism in neighborhoods linked to risk of cancer from traffic-related air pollution
High levels of traffic-related air pollutants have been linked with elevated risks of developing cancer and other diseases. New research indicates that multiple aspects of structural racism—the ways in which societal laws, policies, and practices systematically disadvantage certain racial or ethnic groups—may contribute to increased exposure to carcinogenic traffic-related air pollution.
August 26th, 2024 — Source

Study reveals how cancer outsmarts immunity—and how to potentially turn the tables
A new study led by researchers at Beth Israel Deaconess Medical Center (BIDMC) and Boston Children's Hospital and published in Nature Immunology shows how tumors grow by avoiding the immune system.
August 26th, 2024 — Source

Synthetic immunology: Approaching a turning point in the treatment and prevention of disease
Heidelberg researchers describe a new field of research to engineer precise immune responses from molecular constituents
August 26th, 2024 — Source

Total neoadjuvant therapy shows promising results in routine care for advanced rectal cancer
In a recent prospective observational cohort study published in eClinicalMedicine, researchers evaluated a modified regimen of total neoadjuvant treatment (TNT) in high-risk locally advanced rectal cancer (LARC) patients in Sweden.
August 26th, 2024 — Source

Health — Children & Kids — August 26th, 2024

Approach developed for guideline-concordant phototherapy in newborns
In a technical report published online Aug. 26 in Pediatrics, a standardized approach is presented for the use of guideline-concordant phototherapy for the management of hyperbilirubinemia in newborn infants.
August 26th, 2024 — Source

Children and adolescents experience unique long COVID symptoms
In a recent study published in the journal JAMA, researchers attempted to characterize childhood long COVID by investigating its most common disease symptoms in children (6-11 yrs; n = 898) and adolescents (12-17; n = 4,478).
August 26th, 2024 — Source

Chronic cough can be passed down from parents to children, a new study suggests
In a recent study published in ERJ Open Research, researchers investigated the heritability of chronic cough, considering different types of cough (productive vs. nonproductive).
August 26th, 2024 — Source

Don't give smartphones to kids under 11, UK mobile phone firm says
One of Britain's biggest mobile network operators said on Sunday it will warn parents they should not give smartphones to children under the age of 11.
August 26th, 2024 — Source

Pediatrician explains how to help build resilience in children
Life can be complicated and unpredictable. And while there is no such thing as a "perfect parent," there are strategies that can help your child become better able to deal with difficult circumstances as they arise.
August 26th, 2024 — Source

Physician shares four ideas for avoiding the 'freshman 15'
The term "freshman 15" often refers to weight gain by students during their first year in college. Many times, it's their first time away from home and their normal routines.
August 26th, 2024 — Source

Short-duration, light-intensity exercises improve cerebral blood flow in children, research reveals
Cognitive functions, also known as intellectual functions, encompass thinking, understanding, memory, language, computation, and judgment, and are performed in the cerebrum. The prefrontal cortex (PFC), located in the frontal lobe of the cerebral cortex, handles these functions.
August 26th, 2024 — Source

Why children can't pay attention to the task at hand
Scientists have learned that children find it hard to focus on a task, and often take in information that won't help them complete their assignment. But the question is, why?
August 26th, 2024 — Source

Why 'socializing' your young child is so important
When you have a young child, you can wind up spending most of your time changing diapers and feeding them, but one expert suggests that socialization is also important for your child's future well-being.
August 26th, 2024 — Source

Health — Cancer — August 22nd, 2024

A modified peptide shows promise for fighting tumors
The growth of healthy tissues in the body depends on the development of new blood vessels, a process called angiogenesis, that enables proper blood flow, meaning nutrients and oxygen are delivered while toxic metabolic products are removed.
August 22nd, 2024 — Source

A small molecular glue that increases P53 level and suppresses tumor growth in vivo
Molecular glues are typically small chemical molecules that act on the interface between the target protein and the degradation machinery to trigger ternary complex formation. Identification of molecular glues is challenging, and there has been a lack of target-upregulating molecular glues, which are desired for many targets such as tumor suppressor proteins (TSPs).
August 22nd, 2024 — Source

Cancer drug could treat early-stage Alzheimer's disease, study shows
A type of drug developed for treating cancer holds promise as a new treatment for neurodegenerative diseases such as Alzheimer's, according to a study by researchers at Penn State, Stanford University and an international team of collaborators.
August 22nd, 2024 — Source

Detective algorithm predicts best drugs for genetic disorders and cancer
A computational model built by researchers at the Institute of Research in Biomedicine (IRB Barcelona) and the Centre for Genomic Regulation (CRG) can predict which drugs will be most effective in treating diseases caused by mutations that can bring protein synthesis to a halt, resulting in unfinished proteins.
August 22nd, 2024 — Source

Finding new treatments for genetic tumor-predisposition syndrome
A new report describes a promising approach to studying neurofibromatosis type 1 (NF1), a genetic condition with limited treatment options. The condition causes a number of different cancerous and non-cancerous tumors to form throughout the body. Among these tumors are cutaneous neurofibromas, benign tumors that grow from nerve terminals in the skin.
August 22nd, 2024 — Source

Immune cells have a metabolic backup plan for accessing their anti-cancer playbook
Immune cells use two different routes to produce acetyl-CoA, an essential metabolite required to fight infection and cancer, reports a study led by Van Andel Institute scientists.
August 22nd, 2024 — Source

New work validates targets for personalized cancer immunotherapy
What are the characteristics of a cancer cell that are recognized by the immune system? Knowledge of the potential target structures for the immune cells is a basic prerequisite for the development of personalized cancer immunotherapies.
August 22nd, 2024 — Source

Novel AI algorithm assists in breast cancer screening
Researchers at the University of Eastern Finland have developed a novel artificial intelligence-based algorithm, MV-DEFEAT, to improve mammogram density assessment. This development holds promise for transforming radiological practices by enabling more precise diagnoses.
August 22nd, 2024 — Source

Novel AI-based algorithm could improve mammogram density assessment
Researchers at the University of Eastern Finland have developed a novel artificial intelligence-based algorithm, MV-DEFEAT, to improve mammogram density assessment. This development holds promise for transforming radiological practices by enabling more precise diagnoses.
August 22nd, 2024 — Source

Olaparib may be effective without hormone therapy for some men with biochemically recurrent prostate cancer
The anti-cancer drug olaparib may be effective in treating biochemically recurrent prostate cancer without accompanying hormone therapy for men who have mutations in genes such as BRCA2, according to results of a Phase II clinical trial of 51 patients conducted at the Johns Hopkins Kimmel Cancer Center and three other sites.
August 22nd, 2024 — Source

Potential antitumoral effects of Manuka honey in breast cancer models
In a recent study published in the Nutrients, a group of researchers evaluated the antitumor activity of Manuka honey (MH) on human breast cancer (BC) cells and its underlying molecular mechanisms in both in vitro and in vivo preclinical models.
August 22nd, 2024 — Source

Promising treatment for rectal cancer confirmed in major study
A new treatment for locally advanced rectal cancer shows favorable results in that surgery can sometimes be avoided completely. It also reduces the risk of recurrence. The method has been confirmed as effective in a comprehensive study conducted at Uppsala University and published in eClinicalMedicine.
August 22nd, 2024 — Source

Research identifies 31 additional cancers potentially linked to obesity
In a recent study published in The Lancet Regional Health - Europe, researchers evaluated the associations between body mass index (BMI) and the risk of obesity-related cancers.
August 22nd, 2024 — Source

Research suggests Americans face disparities in exposure to tobacco on streaming platforms
Tens of millions of Americans are being exposed to tobacco content on streaming services, according to new research from The University of Texas MD Anderson Cancer Center. The researchers found that the odds of encountering tobacco products being advertised, marketed or promoted on these platforms increased based on race, ethnicity, socioeconomic status and smoking habits.
August 22nd, 2024 — Source

Salivary CD44, total protein ID recurrence risk in head and neck cancer
Elevated salivary levels of CD44 and total protein (TP) can identify head and neck cancer patients with an increased risk for cancer recurrence, according to a study published online Aug. 15 in JAMA Otolaryngology-Head and Neck Surgery.
August 22nd, 2024 — Source

Study reveals RNA's role in regulating gene expression in cancer cells
Scientists have discovered how interactions between RNA and the TOP1 essential enzyme, which is overexpressed in many human cancers, regulate DNA during transcription and may inform the creation of new cancer therapies, according to a Northwestern Medicine study published in Molecular Cell.
August 22nd, 2024 — Source

The link between asbestos and pleural cancer in offshore petroleum workers
Men who work offshore and have been in contact with asbestos in their working environment have a higher risk of developing pleural cancer.
August 22nd, 2024 — Source

Traveling to die: The latest form of medical tourism
In the 18 months after Francine Milano was diagnosed with a recurrence of the ovarian cancer she thought she'd beaten 20 years ago, she traveled twice from her home in Pennsylvania to Vermont. She went not to ski, hike, or leaf-peep, but to arrange to die.
August 22nd, 2024 — Source

Tumor cell-coated carbon nanohorn for efficient delivery of drugs in cancer therapy
(Nanowerk News) Cancer remains one of the most challenging diseases to treat due to its complexity and tendency to metastasize (spread into, or invade, nearby tissues or distant places in the body to form new tumors).
August 22nd, 2024 — Source

Health — Cancer — August 21st, 2024

Benefits and downside of fasting
Fasting helps intestinal stem cells to regenerate and heal injuries but also leads to a higher risk of cancer in mice
August 21st, 2024 — Source

Chulalongkorn University Hosts International Conference on Nanotechnologies for Health and Well-being
Chulalongkorn University organized an international academic conference titled "Cutting-edge Nanotechnologies for Good Health and Well-being" to present nanotechnology innovations as new alternatives for cancer treatment. The conference was held from July 9 to 12, 2024, at the Music Hall, Art and Culture Building, Chulalongkorn University, and the Mandarin Hotel, Bangkok.
August 21st, 2024 — Source

Cognitive behavioral therapy found to have clear benefits for cancer survivorsA recent analysis of all relevant published studies reveals clear benefits of cognitive behavioral therapy (CBT) for improving mental health and quality of life in cancer survivors. The findings, which are published in Cancer Medicine, extend CBT's effects beyond what has long been known in the general population.

August 21st, 2024 — Source

Early interventions may improve long-term academic achievement in young childhood brain tumor survivors
Scientists have found infants and young children treated for brain tumors fell behind early in academic readiness, which predicted falling behind in later school years.
August 21st, 2024 — Source or Source

Fasting and ketogenic diet reveal new vulnerability of pancreatic tumors to existing cancer drug
In a recent study published in Nature, researchers examine the role of fasting and ketogenesis in regulating protein synthesis and its potential implications for cancer therapy.
August 21st, 2024 — Source

Improved survival found for breast cancer patients with dose-dense chemotherapy
Dose-dense adjuvant chemotherapy can improve survival for patients with high-risk breast cancer, according to a team of researchers that includes the Karolinska Institutet. The international PANTHER trial, which studied more than 2,000 patients where 97% had metastasis to the lymph nodes in the armpit, compared two different chemotherapy regimens and found that the dose-intensive treatment reduced the risk of recurrence and spread of the disease.
August 21st, 2024 — Source

Leukemia cells depend on P-bodies for growth and survival
An international team of scientists has uncovered a mechanism by which acute myeloid leukemia (AML) cells sustain their growth.
August 21st, 2024 — Source or Source

Ovarian cancer discovery: Targetable variant RAD51D found in Chinese patients
Researchers from BGI Genomics and Fudan University have published new findings on ovarian cancer (OV) among Chinese patients in JCO Global Oncology.
August 21st, 2024 — Source

P-bodies sustain acute myeloid leukemia
An international team of scientists has uncovered a mechanism by which acute myeloid leukemia (AML) cells sustain their growth. AML cells prevent the synthesis of proteins that suppress their growth by forcibly isolating the mRNAs that encode such proteins within structures known as P-bodies.
August 21st, 2024 — Source

Researchers discuss disrupting NKG2A:HLA-E interactions for enhanced anti-cancer immunity
A new editorial titled "Strategies to disrupt NKG2A:HLA-E interactions for improved anti-cancer immunity" has been published in Oncotarget.
August 21st, 2024 — Source

Suicide attempt, death up for spouses of patients with cancer
Spouses of patients with cancer have an increased risk for suicide attempt and suicide death, especially during the first year after diagnosis, according to a study published online Aug. 15 in JAMA Oncology.
August 21st, 2024 — Source

Targeted cancer cell therapy may slow endometrial cancer
There may be a way to slow the growth of endometrial cancer through targeted cancer cell therapy, according to new research from the University of Missouri School of Medicine.
August 21st, 2024 — Source

Health — Cancer — August 16th, 2024

New guidelines on how to report clinical sequencing data help doctors make decisions about cancer treatment
Personalized medicine is transforming cancer treatment by tailoring therapies to the genomic profile of each tumor. Next-generation sequencing (NGS) is key to this approach, but its complexity and inconsistent reporting have been hurdles.
August 16th, 2024 — Source

Study: Rare cancer patients nearly three times more likely to develop anxiety and depression than common cancer patients
A recent study of the psychological outcomes of over 57,470 patients with rare cancers showed that they have higher risk of developing mental health issues compared to patients with common cancers.
August 16th, 2024 — Source

Health — Cancer — August 14th, 2024

A study of fasting and the ketogenic diet reveals a new vulnerability of pancreatic tumors to an existing cancer drug.

August 14th, 2024 — Source

Ketogenic diet can boost efficacy of pancreatic cancer therapy
A study of fasting and the ketogenic diet reveals a new vulnerability of pancreatic tumors to an existing cancer drug.
August 14th, 2024 — Source

New cobalt complex triggers ferroptosis in cancer cells
In programmed cell death, certain signaling molecules initiate a kind of suicide program to cause cells to die in a controlled manner. This is an essential step to eliminate damaged cells or to control the number of cells in certain tissues, for example. Apoptosis has long been known as a mechanism for programmed cell death.
August 14th, 2024 — Source

Researchers discover 'switch' for the desire to engage in physical activity
Exercising is healthy, but not always appealing. Research led by Guadalupe Sabio from the National Cancer Research Center (CNIO) may have found a "switch" that activates the desire to get moving, as it shows that during exercise the muscle activates proteins which encourage further activity.
August 14th, 2024 — Source

Researchers identify malignant cells responsible for relapse in high-risk neuroblastoma
Researchers at Children's Hospital of Philadelphia (CHOP) announced a significant breakthrough in understanding chemotherapy resistance in high-risk neuroblastoma, a common and potentially deadly childhood cancer arising within the peripheral nervous system.
August 14th, 2024 — Source

Small-town patients face big hurdles as rural hospitals cut cancer care
For rural patients, getting cancer treatment close to home has always been difficult. But in recent years, chemotherapy deserts have expanded across the United States, with 382 rural hospitals halting services from 2014 to 2022, according to a report published this year by Chartis, a health analytics and consulting firm.
August 14th, 2024 — Source

Study of fasting and ketogenic diet reveals a new vulnerability of pancreatic tumors
Scientists at UC San Francisco have discovered a way to get rid of pancreatic cancer in mice by putting them on a high fat, or ketogenic, diet and giving them cancer therapy.
August 14th, 2024 — Source

Health — Cancer — August 8th, 2024

A simple test can predict whether smokers will manage to quit
Data from nearly 6,000 smokers with cancer show that it may be easier to predict who will stop smoking than was previously thought.
August 8th, 2024 — Source

Breakthrough discovery could boost stem-cell transplants by improving cell mobilization
A discovery by a three-member Albert Einstein College of Medicine research team may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells, which produce all the body's different blood cells.
August 8th, 2024 — Source

Cannabis dependence associated with increased occurrence of head and neck cancer
A study from the USC Head and Neck Center, part of Keck Medicine of USC and the USC Caruso Department of Otolaryngology -- Head and Neck Surgery, suggests that cannabis, the most commonly used illicit substance worldwide, is associated with an increased occurrence of head and neck cancer.
August 8th, 2024 — Source

Cannabis use tied to head and neck cancer
A study from the USC Head and Neck Center, part of Keck Medicine of USC and the USC Caruso Department of Otolaryngology—Head and Neck Surgery, suggests that cannabis, the most commonly used illicit substance worldwide, is associated with an increased occurrence of head and neck cancer.
August 8th, 2024 — Source

Computer simulations clarify how breast cancer spreads
Using a combination of computer simulations and experimental studies, a team of researchers is uncovering vital clues into how breast cancer cells invade breast tissue.
August 8th, 2024 — Source

Deciphering inflammation-induced tumorigenesis: Unveiling gastric cancer's trail with network and AI
In a pioneering venture, researchers have harnessed AI and multi-omics to shed light on the intricate pathways of gastric inflammation-induced tumorigenesis. This study heralds a new era in early detection and personalized medicine, identifying key biological triggers of tumorigenesis and laying down a robust framework for innovative gastric cancer therapies.
August 8th, 2024 — Source

Drinking's cancer link is underrated—especially by women
Now that the vast majority of Americans don't smoke, it's hard to know what we're supposed to do about the recent news that 40% of cancer cases are preventable. Drinking alcohol is one of the top risk factors—and yet doctors aren't talking to patients about its connection to cancer.
August 8th, 2024 — Source

Drug shows promise for treating brain tumors resulting from breast cancer, trial reports
A drug effective in treating breast cancer shows new promise in addressing breast cancer with brain metastases or recurrent glioblastoma, as reported by results of a prospective window-of-opportunity trial at the University of Texas Health Science Center at San Antonio (UT Health San Antonio).
August 8th, 2024 — Source

FDA approves Darzalex Faspro for treating multiple myeloma
The U.S. Food and Drug Administration has approved Johnson & Johnson's Darzalex Faspro (daratumumab and hyaluronidase-fihj) in combination with bortezomib, lenalidomide, and dexamethasone (D-VRd) for induction and consolidation in patients with newly diagnosed multiple myeloma (MM) who are eligible for an autologous stem cell transplant (ASCT).
August 8th, 2024 — Source

Fibroblast functionality: A pivotal piece in cancer's spreading puzzle
A new study reviews how cancer-associated fibroblasts (CAFs) influence lymph node metastasis. Researchers identified various CAF subsets that interact with the tumor microenvironment, promoting cancer spread.
August 8th, 2024 — Source

Gene activity can predict severe side effects from melanoma treatment
An activity pattern in certain genes responsible for building proteins known as spleen tyrosine kinases can predict which melanoma patients are likely to have severe side effects from immunotherapy designed to treat the most deadly skin cancer, a new study shows.
August 8th, 2024 — Source

How a patient's role in a clinical trial for acute lymphocytic leukemia brought a cancer-free diagnosis, FDA approval
The first time Becky Yu saw the Philadelphia skyline lit up at night was the evening she and her husband, Brian Currie, drove from their home in Delaware to Penn Medicine to begin her treatment for acute lymphocytic leukemia (ALL), a type of blood cancer that affects bone marrow.
August 8th, 2024 — Source

Individualized cancer therapy demonstrates safety and sustained immune responses in Phase I trial
For decades, researchers have worked to develop therapies that can prime the immune system to recognize and attack proteins on the surface of tumor cells. However, success has been limited due to the technological challenge of engineering therapies that provide specific enough "training" to the immune system to identify a given patient's neoantigens.
August 8th, 2024 — Source

Individualized neoantigen cancer therapy demonstrates safety and efficacy in early trials
For decades, researchers have worked to develop therapies that can prime the immune system to recognize and attack proteins on the surface of tumor cells.
August 8th, 2024 — Source

Large-scale pathology foundation models show promise on a variety of cancer-related tasks
Imagine if pathologists had tools that could help predict therapeutic responses just by analyzing images of cancer tissue. This vision may someday become a reality through the revolutionary field of computational pathology. By leveraging AI and machine learning, researchers are now able to analyze digitized tissue samples with unprecedented accuracy and scale, potentially transforming how we understand and treat cancer.
August 8th, 2024 — Source

New insights into the role of cancer-associated fibroblasts in promoting lymphatic metastasis
Lymph node metastasis is a crucial factor in cancer progression, significantly affecting patient prognosis and treatment outcomes. The tumor microenvironment, particularly cancer-associated fibroblasts (CAFs), plays a vital role in this process. CAFs influence the metastatic landscape through interactions with other cells and secretion of signaling molecules.
August 8th, 2024 — Source

Newly discovered mechanism halts tumor cell replication
A research group at the University of Bologna has identified, for the first time, the specific location and genomic context where DNA breaks occur due to the inhibition of the topoisomerase I, a protein crucial for many biological processes in cells.
August 8th, 2024 — Source

Potential new approach to enhancing stem-cell transplants
A discovery by a three-member Albert Einstein College of Medicine research team may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells, which produce all the body's different blood cells.
August 8th, 2024 — Source

Researchers develop pioneering immunotherapy for aggressive brain cancer
QIMR Berghofer researchers have developed super-charged immune cells that could potentially improve glioblastoma survival by fighting the deadly brain cancer and preventing its recurrence.
August 8th, 2024 — Source

Scientists unravel how the BCG vaccine leads to the destruction of bladder cancer cells
Using zebrafish "avatars," an animal model developed by the Cancer Development and Innate Immune Evasion lab at the Champalimaud Foundation (CF), led by Rita Fior, Mayra Martínez-López—a former Ph.D. student at the lab now working at the Universidad de las Americas in Quito, Ecuador—and colleagues studied the initial steps of the Bacillus Calmette-Guerin (BCG) vaccine's action on bladder cancer cells.
August 8th, 2024 — Source

Study reveals previously unknown genetic causes of colorectal cancer
A pioneering study, has provided the most comprehensive analysis to date of the genetic makeup of colorectal cancer (CRC).
August 8th, 2024 — Source

Study shows a distinct pattern in protein production can predict severe side effects from skin cancer treatment
An activity pattern in certain genes responsible for building proteins known as spleen tyrosine kinases can predict which melanoma patients are likely to have severe side effects from immunotherapy designed to treat the most deadly skin cancer, a study, publishing in the journal Clinical Cancer Research online Aug. 8, shows.
August 8th, 2024 — Source

TCR CDR3s and renalase-1 linked to increased melanoma survival
A new research paper titled "Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival" has been published in Oncotarget.
August 8th, 2024 — Source

Tpex cells: A game-changer in targeted tumor immunotherapy
Progenitor exhausted CD8+ T (Tpex) cells have emerged as a pivotal component in tumor immunotherapy due to their unique ability to self-renew and rapidly proliferate. These cells have shown promise in expanding and differentiating into functional exhausted CD8^{+ T cells, significantly enhancing clinical outcomes. Understanding and leveraging Tpex cells can revolutionize immunotherapeutic strategies against cancer.}
August 8th, 2024 — Source

Health — Cancer — August 6th, 2024

Age impacts pharmacogenomics and treatment outcomes for most common form of leukemia
Acute lymphoblastic leukemia (ALL) affects both children and adults, but children have better chances to be cured, with long-term survival rates of over 85% compared to 50%--75% in adults.
August 6th, 2024 — Source

AI model effective in detecting prostate cancer
A deep learning model performs at the level of an abdominal radiologist in the detection of clinically significant prostate cancer on MRI, according to a study published today in Radiology. The researchers hope the model can be used as an adjunct to radiologists to improve prostate cancer detection.
August 6th, 2024 — Source

Immune landscape and response to oncolytic virus-based immunotherapy
Oncolytic virus (OV)-based immunotherapy has emerged as a promising strategy for cancer treatment, offering a unique potential to selectively target malignant cells while sparing normal tissues.
August 6th, 2024 — Source

New study shows 1 in 10 cancer patients are spending $10,000 in out-of-pocket health care costs in Australia
The financial burden of health care in Australia can be high, particularly for people diagnosed with cancer. A new study from the Daffodil Centre has shown one in ten people with cancer in NSW spends more than $10,000 on health care in the first year following diagnosis.
August 6th, 2024 — Source

Prostate cancer: Can AI help to avoid unnecessary biopsies?
When the PSA is elevated: for which men is a biopsy necessary to confirm or rule out suspected prostate cancer? In a retrospective study, scientists from the German Cancer Research Center (DKFZ) and the Department of Urology at Heidelberg University Hospital have shown that the combination of risk markers, systematic evaluation of MRI images and artificial intelligence (AI) can predict the risk of prostate cancer more accurately than before.
August 6th, 2024 — Source

Researchers reveal why vaccines have lower efficacy in patients with multiple myeloma
Research carried out by a group from Cima and the Clínica Universidad de Navarra has described the composition of the immune system in blood samples from patients with multiple myeloma, by generating a new immunological atlas, and has revealed how changes in immune cells themselves can influence the efficacy of vaccines such as that against COVID-19.
August 6th, 2024 — Source

Study shows INT-1B3 inhibits distant tumor metastasis and significantly prolongs survival
A research paper has been published in Oncotarget titled, "INT-1B3, an LNP formulated miR-193a-3p mimic, promotes anti-tumor immunity by enhancing T cell mediated immune responses via modulation of the tumor microenvironment and induction of immunogenic cell death."
August 6th, 2024 — Source

Study shows Meteorin-like protein drains energy from T cells, limiting immune system's power to fight cancer
A protein called Meteorin-like (METRNL) in the tumor microenvironment saps energy from T cells, thereby severely limiting their ability to fight cancer, according to new research directed by investigators at the Johns Hopkins University School of Medicine and the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.
August 6th, 2024 — Source

US spends $43 billion annually on cancer screening
Screening for cancer saves lives, but a new report shows it comes with a hefty price tag: The United States spends at least $43 billion annually on tests that check for five major cancers.Screening for cancer saves lives, but a new report shows it comes with a hefty price tag: The United States spends at least $43 billion annually on tests that check for five major cancers.
August 6th, 2024 — Source

Health — Cancer — August 4th, 2024

Daily aspirin cuts odds for colon cancer: who benefits most?
It's long been known that a daily dose of low-dose aspirin helps keep colon cancer at bay.
August 4th, 2024 — Source

Health — Cancer — August 3rd, 2024

Rural cancer patients and health care providers face challenges beyond access and distance
Rural Americans have higher rates of lung, colorectal and cervical cancers and higher cancer death rates overall compared to their metropolitan counterparts. They also have lower access to cancer screening, treatment and specialty care, are less likely to have access to reliable transportation and health insurance and have higher prevalence of cancer risk factors, like smoking and obesity.
August 3rd, 2024 — Source

Health — Cancer — August 2nd, 2024

Breakthrough research identifies pathway used by glioblastoma to infiltrate the brain
A new pathway that is used by cancer cells to infiltrate the brain has been discovered by a team of Canadian and American research groups led by the Singh Lab at McMaster University. The research also reveals a new therapy that shows promise in blocking and killing these tumors.
August 2nd, 2024 — Source

Circular RNAs—the new frontier in cancer research
Unraveling the complexities of circular RNAs (circRNAs) in cancer biology has positioned scientists on the cusp of revolutionary breakthroughs in the diagnosis and treatment of cancer.
August 2nd, 2024 — Source

Drug developed for pancreatic cancer shows promise against most aggressive form of medulloblastoma
A drug that was developed to treat pancreatic cancer has now been shown to increase symptom-free survival in preclinical medulloblastoma models—all without showing signs of toxicity.
August 2nd, 2024 — Source

FDA Approves Blood Test for Colon Cancer: What to Know About Colorectal Warning Signs
The new test gives adults a new option for colon cancer screening. Here's what to know about colorectal cancer and how to reduce risk.
August 2nd, 2024 — Source

FDA approves CAR T cell treatment for resistant mantle cell lymphoma
Mantle cell lymphoma (MCL) is a rare and sometimes ruthless form of non-Hodgkin lymphoma. Even when treatment appears to be successful, the cancer often returns and is difficult to cure.
August 2nd, 2024 — Source

Novel approach to study hypoxia enables identification of a marker for ovarian cancers
In a new study, the team led by etienne Gagnon, Professor in the Department of Microbiology, Infectious Diseases and Immunology at the Universite de Montreal and Director of IRIC's Cancer Immunobiology Research Unit, has developed a cell culture protocol that accurately reproduces the characteristic conditions of primary tumors.
August 2nd, 2024 — Source

Overcoming the limits of immunotherapies
CAR-T cells are highly effective in treating selected blood cancers. However, challenges remain with this new therapy, which was first approved in 2017 in the U.S. and a year later in Europe for treating acute lymphoblastic leukemia (ALL). For instance, no effective CAR-T cell therapies for solid tumors exist.
August 2nd, 2024 — Source

Researchers develop promising therapy treatment that can kill glioblastoma cells in newly-discovered brain pathway
A new pathway that is used by cancer cells to infiltrate the brain has been discovered by a team of Canadian and American research groups led by the Singh Lab at McMaster University. The research also reveals a new therapy that shows promise in blocking and killing these tumors.
August 2nd, 2024 — Source

Researchers devise novel solution to preventing relapse after CAR T-cell therapy
Even as they have revolutionized the treatment of certain forms of cancer, CAR T-cell therapies have been shadowed by a significant limitation: Many patients, including those whose cancer goes into full remission, eventually relapse. In a new study, Dana-Farber Cancer Institute researchers report on a technique with the potential to eliminate that problem.
August 2nd, 2024 — Source

Scientists create cost-effective, easy-to-use test to categorize a child's cancer and guide better treatment
Scientists at St. Jude Children's Research Hospital have created a panel that is able to provide a diagnosis for more than 90% of pediatric cancer patients by sequencing 0.15% of the human genome. The panel is a cost-effective way to test and classify childhood malignancies and to help guide patient treatment.
August 2nd, 2024 — Source

Study uncovers the role of NETO2-mediated regulation in melanoma progression
Cong Peng and others at the Department of Dermatology, Xiangya Hospital, Central South University, China, conducted a study titled "NETO2 promotes melanoma progression via activation of the Ca2+/CaMKII signaling pathway," which investigated the role of Neuropilin and tolloid-like 2 (NETO2) in melanoma, a deadly form of skin cancer.
August 2nd, 2024 — Source

Using advanced CRISPR to boost efficiency of CAR-T cell therapies
CAR-T cells are highly effective in treating selected blood cancers. However, challenges remain with this new therapy, which was first approved in 2017 in the USA and a year later in Europe for treating acute lymphoblastic leukemia (ALL).
August 2nd, 2024 — Source

Health — Cancer — July 31st, 2024

Early menopause appears raise odds of breast cancer, study reports
Women who underwent menopause at an age younger than 46 were nearly twice as likely to have breast cancer compared to others their age, researchers found.
July 31st, 2024 — Source

Education level, social media skills linked to cancer fatalism
More educated people who are skilled at finding reliable information through social media don't always see cancer as fatal while those with less schooling and social media awareness hold more fatalistic beliefs about the disease, researchers at UT Southwestern Medical Center found.
July 31st, 2024 — Source

Gut microbes implicated in bladder cancer
At any given time, over 10 trillion microbes call our guts their home. From breaking down nutrients in our food to strengthening our immunity against pathogens, these microbes play an essential role in how we interact with the world. This includes—as shown in a new study by EMBL researchers and collaborators at the University of Split, Croatia—the way the body responds to carcinogens and develops cancer.
July 31st, 2024 — Source

Improving transplant success and single cell analysis revealing cell state changes in prostate cancer
New research from Memorial Sloan Kettering Cancer Center (MSK) showed giving chemotherapy shortly after a stem cell or bone marrow transplant from a less than perfectly matched donor greatly reduces the chances that the patient will develop graft-versus-host disease (GVHD); and sheds new light on cell state changes in prostate cancer.
July 31st, 2024 — Source

New AI tool predicts risk for chronic pain in cancer patients
A third of cancer patients face chronic pain—a debilitating condition that can dramatically reduce a person's quality of life, even if their cancer goes into remission.
July 31st, 2024 — Source

Real-time, cost-effective monitoring of neutron beams used in boron neutron capture therapy
Researchers from the Health Research and Technology Group at ANSTO and the University of Wollongong have developed a new device that could improve the quality control of accelerator-based boron neutron capture therapy, a promising radiation therapy for treating aggressive cancers.
July 31st, 2024 — Source

Researchers shed light on cancer drug resistance, potential to expand use of PARP inhibitors across cancer types
A research team led by Professor Ying Wai Chan from the School of Biological Sciences at The University of Hong Kong (HKU) has made a significant breakthrough in understanding how cancer cells develop resistance to a class of cancer drugs known as PARP inhibitors.
July 31st, 2024 — Source

Scientists solve mystery of DNA damage detection and repair caused by sunlight, alcohol, and pollution
A collaboration between researchers at the Laboratory of Medical Sciences (LMS) in London and the Laboratory of Molecular Biology (LMB) in Cambridge, has solved a decades-old mystery which could pave the way to better cancer treatments in the future.
July 31st, 2024 — Source

Study finds nearly half of top cancer centers required universal masking during last winter's COVID-19 surge
Nearly half of the nation's National Cancer Institute (NCI)-designated cancer centers required universal masking in key clinical areas during the winter 2023--2024 COVID-19 surge, according to a study by Tulane University researchers.
July 31st, 2024 — Source

Health — Cancer — July 29th, 2024

Advancing hepatic cell carcinoma treatment through mitochondrial DNA targeting
Hepatic cell carcinoma (HCC), the fifth most prevalent malignancy worldwide and the fourth leading cause of cancer-related mortality, poses significant therapeutic challenges. Despite advancements in medical research, late-stage HCC patients have a dismal five-year survival rate of less than 20%.
July 29th, 2024 — Source

Better cancer trial representation begins with speaking one's language
Underrepresentation of racial and ethnic minority populations in cancer clinical trials persists partly because translation and interpretation services and resources are unavailable or inadequate in the United States, according to a Children's Oncology Group (COG) study led by Columbia University School of Nursing.
July 29th, 2024 — Source

FDA approves another blood test for colon cancer screening
The U.S. Food and Drug Administration on Monday approved a new blood test that can spot colon cancer.
July 29th, 2024 — Source

Loss of Gα13 in B-cells linked to increased lymphoma risk due to dietary glutamine
In a recent study published in the journal Nature Immunology, researchers investigate the effects of microenvironment signals on selection in mucosal germinal centers and their role in the development of B-cell lymphomas.
July 29th, 2024 — Source

Mutations in DNA damage repair genes associated with response to cisplatin in bladder cancer
An analysis of pre-treatment tumor specimens from 105 patients with localized muscle-invasive bladder cancer found that the presence of a mutation in any one of three genes, all known to be involved in DNA damage repair, was associated with complete pathologic response to cisplatin-based neoadjuvant chemotherapy as measured by pathological downstaging at the time of bladder surgery.
July 29th, 2024 — Source

New drug candidate blocks resistance to cancer therapies
A team of researchers at the University of Michigan Health Rogel Cancer Center has designed a molecule that impairs signaling mediated by two key drivers of cancer therapy resistance. The design and preclinical evaluation of the inhibitor, MTX-531, was published in Nature Cancer.
July 29th, 2024 — Source

One type of non-statin cholesterol-lowering drug linked to lower liver cancer risk
Past studies have suggested that taking cholesterol-lowering statin drugs may lower individuals' risk of developing liver cancer. In a new study of non-statin cholesterol-lowering medications, one type was linked to lower risks of liver cancer.
July 29th, 2024 — Source

Overcoming cancer relapse with CAR-Enhancer therapy
Even as they have revolutionized the treatment of certain forms of cancer, CAR T-cell therapies have been shadowed by a significant limitation: many patients, including those whose cancer goes into full remission, eventually relapse. In a new study, Dana-Farber Cancer Institute researchers report on a technique with the potential to eliminate that problem.
July 29th, 2024 — Source

Preclinical study explores approved drug for ovarian cancer
An iron-binding drug that is already approved for treatment of other diseases could provide a novel way to attack ovarian tumors, according to a new study led by Weill Cornell Medicine researchers.
July 29th, 2024 — Source

Researchers find the effect of pesticides on increased cancer risk is comparable to smoking for some cancers
In a recent study published in Frontiers in Cancer Control and Society, researchers comprehensively evaluated the impact of pesticide use on cancer development in the United States (US).
July 29th, 2024 — Source

Study finds gaps in access to proton beam therapy for cancer patients
A new University of Kentucky Markey Cancer Center study reveals that many people with cancer in the U.S. do not have equal access to facilities that offer an advanced form of radiation treatment.
July 29th, 2024 — Source

Study identifies non-statin cholesterol drugs with potential to lower liver cancer risk
Past studies have suggested that taking cholesterol-lowering statin drugs may lower individuals' risk of developing liver cancer. In a new study of non-statin cholesterol-lowering medications, one type was linked to lower risks of liver cancer. The findings are published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society.
July 29th, 2024 — Source

YAP/TAZ interactions can confer resistance to anti-tumor drug indisulam
In a healthy human body, tissue growth and development are coordinated by many different mechanisms. Within our bodies, these mechanisms regulate the healthy growth of cells, limit their size and number, and control the timing of cell death through apoptosis.
July 29th, 2024 — Source

Health — Cancer — July 27th, 2024

Panasonic Registers a New Camera - Model Code P2403A
Panasonic has registered a new camera with a wireless certification agency. , the P2403A (dual band WiFi + Bluetooth) on July 12, 2024. The P2302A is the GH7 and the P2304A is the S9. This camera has dual-band Wi-Fi, So, from the basic stats it's obvious that it's not an entry-level model, it is most probably a high-end camera.
July 27th, 2024 — Source

Health — Cancer — July 26th, 2024

BRCA1/2: Why men should be screened for the 'breast cancer gene'
More and more studies show that men face risks of cancer from BRCA1 and BRCA2 genetic mutations that are most often associated with breast and ovarian cancers in women.
July 26th, 2024 — Source

Double mastectomy may offer no survival benefit to women with breast cancer
Women who are diagnosed with breast cancer in one breast, even in the early stages, sometimes opt for a double mastectomy, due to the fear that the cancer will migrate to the other breast.
July 26th, 2024 — Source

Kids from poorer families less likely to survive cancer, study shows
A childhood cancer patient's risk of dying within five years of their diagnosis increases 4% for every one-point increase in their neighborhood's Area Deprivation Index (ADI), researchers found.
July 26th, 2024 — Source

New nanoparticles boost immune system in mice to fight melanoma and breast cancer
Vanderbilt researchers have developed a set of nanoparticles that stimulate the immune system in mice to fight cancer and may eventually do the same in humans.
July 26th, 2024 — Source

Health — Cancer — July 24th, 2024

Cancer cells pretend to be 'super fit' to outsmart normal cells and invade the body
Scientists have discovered that some cancer cells pretend to be "super fit" to fool normal healthy cells into giving them their nutrients, allowing them to expand and spread around the body.
July 24th, 2024 — Source

Clinical trial shows improved survival with blinatumomab in B-cell precursor leukemia subtype
A significant survival improvement finding for adults with newly diagnosed BCR::ABL1-negative B-cell precursor acute lymphoblastic leukemia appears in the New England Journal of Medicine.
July 24th, 2024 — Source

FDA-mandated CAR-T monitoring period could be halved, say researchers
In patients with diffuse large B-cell non-Hodgkin lymphoma (DLBCL), the two hallmark post-chimeric antigen receptor (CAR)-T therapy toxicities are extremely rare after two weeks, supporting a shorter, more flexible toxicity monitoring period, according to a study published in Blood Advances.
July 24th, 2024 — Source

Lower dose prostate cancer treatments found to retain efficacy while improving tolerability
Two reduced dose radiopharmaceutical therapy approaches for advanced stage metastatic castrate-resistant prostate cancer have been shown to be just as effective as the standard dose, according to new research published in the July issue of The Journal of Nuclear Medicine.
July 24th, 2024 — Source

Method can analyze individual, still-living cells that may contain biomarkers for cancer and other deadly diseases
The Ivanov Lab at Northeastern University is paving the way to a whole variety of diagnostic tests that are possible off of a single blood draw, including—someday—cancer.
July 24th, 2024 — Source

Research sheds light on the role of PTPRK in tissue repair and cancer
Receptor protein tyrosine phosphatases are cell membrane-localized proteins. They are regulators of cell-cell contacts and are also considered likely to be tumor suppressors, but the specifics of how they function are unknown.
July 24th, 2024 — Source

Researchers uncover how colorectal cancer cells colonize the liver
In cases where cancer is fatal, 9 out of 10 times the culprit is metastasis. This is when the primary tumor has sent out cells, like seeds, and invaded other organs of the body. While medicine has made great progress in treating primary tumors, it is still largely helpless in the face of metastasis.
July 24th, 2024 — Source

When tumors collide: Analysis of mixed-type breast cancer reveals complexity
As part of a breast cancer diagnosis, pathologists take cells from a biopsy and check them under a microscope. Most cancerous cells form roundish clumps, known as no special type, or invasive ductal carcinoma (IDC). In fewer patients, the abnormal cells are more dispersed, growing as spider web-like tendrils throughout the breast tissue.
July 24th, 2024 — Source

Health — Cancer — July 22nd, 2024

AI model identifies certain breast tumor stages likely to progress to invasive cancer
Ductal carcinoma in situ (DCIS) is a type of preinvasive tumor that sometimes progresses to a highly deadly form of breast cancer. It accounts for about 25% of all breast cancer diagnoses.
July 22nd, 2024 — Source

And improved method for anti-cancer drug detection: How tiny tumor models could transform drug testing
A team of researchers from Henan University of Science and Technology have introduced a novel method for improving drug testing for esophageal cancer (EC) using advanced three-dimensional (3D) cell culture technology. The authors created a tumor spheroid model on a chip by using inverse opal hydrogel scaffolds to better mimic the in vivo environment of tumors.
July 22nd, 2024 — Source

Challenges and opportunities in rare tumor research
Ning Li et al., at Chinese Academy of Medical Sciences and Peking Union Medical College, China, provides a comprehensive review on the challenges and opportunities in the field of rare tumor research and management. Despite advances in sequencing technologies and therapies extending the lives of many cancer patients, rare tumors remain a significant challenge in modern oncology.
July 22nd, 2024 — Source

DDX41 and its unique contribution to myeloid leukemogenesis
In an editorial paper published in Oncotarget titled, "DDX41 and its unique contribution to myeloid leukemogenesis," researcher Hirotaka Matsui from the National Cancer Center Hospital in Tokyo, Japan, and Kumamoto University discusses myeloid neoplasms.
July 22nd, 2024 — Source

Monoclonal antibodies from space: Improved crystallization under microgravity during manufacturing in orbit
Monoclonal antibodies (mAbs) have revolutionized cancer therapy due to their ability to specifically target tumor cells while sparing healthy ones. These biologics have become indispensable in treating various cancers, offering improved specificity and fewer side effects compared to traditional chemotherapy.
July 22nd, 2024 — Source

Neuromuscular training cuts onset of chemo-induced peripheral neuropathy
Neuromuscular training reduces the onset of chemotherapy-induced peripheral neuropathy (CIPN), according to a study published online July 1 in JAMA Internal Medicine.
July 22nd, 2024 — Source

Researchers turn the body's B cells into tiny surveillance machines, antibody factories
USC scientists have discovered a way to turn the body's B cells into tiny surveillance machines and antibody factories that can pump out specially designed antibodies to destroy cancer cells or HIV, two of medicine's most formidable foes.
July 22nd, 2024 — Source

Sensing ultraviolet light with the help of molecular switches
The old saying "the dose makes the poison" also holds true for ultraviolet (UV) light. While UV light is essential for vitamin D production, it is also important in phototherapy, several industrial processes, and plant growth. It also has harmful effects such as premature skin aging and cancer.
July 22nd, 2024 — Source

Study: Pembrolizumab combined with soluble EphB4-HSA shows promise in HPV-negative HNSCC
A new research paper published in Oncotarget is titled "Improved efficacy of pembrolizumab combined with soluble EphB4-albumin in HPV-negative EphrinB2 positive head neck squamous cell carcinoma."
July 22nd, 2024 — Source

Taking a closer look at eye cancer: Research offers new insight into high rate of metastasis
New research from Edith Cowan University (ECU) is one step closer to understanding why uveal melanoma, the deadliest form of eye cancer, has such a high rate of metastasis.
July 22nd, 2024 — Source

Unveiling Cancer's Fingerprint with Folded DNA and Light
Engineers from Johns Hopkins University have developed a novel optical instrument that may enhance cancer imaging. SPECTRA is a strategy that helps clinicians distinguish between locally located tumors and those that are metastatic, or have the ability to spread throughout the body.
July 22nd, 2024 — Source

Women with endometriosis have a significantly increased ovarian cancer risk, study finds
In a recent population-based cohort study published in the Journal of the American Medical Association (JAMA), researchers from the United States of America investigated the potential association between different subtypes of endometriosis and the incidence of ovarian cancer.
July 22nd, 2024 — Source

Health — Cancer — July 20th, 2024

Prevalence of skin cancer varies for sexual minority, heterosexual adults
With respect to their lifetime prevalence of skin cancer, sexual minority (SM) adults differ across racial and ethnic groups and among males and females, according to a study published online July 17 in JAMA Dermatology.
July 20th, 2024 — Source

Health — Cancer — July 19th, 2024

Computational tool integrates transcriptomic data to enhance breast cancer diagnosis and treatment
Addressing problems with diagnosing and treating breast cancer, scientists at EPFL have developed EMBER, a tool that integrates breast cancer transcriptomic data from multiple databases. EMBER can improve precision oncology by accurately predicting molecular subtypes and therapy responses.
July 19th, 2024 — Source

Does hormone-modulating therapy for breast cancer treatment affect risk for Alzheimer disease and related dementias?
In a recent study published in JAMA Network Open, researchers investigated the association between hormone-modulating therapy (HMT) for breast cancer treatment and the risk of developing Alzheimer's disease and related dementias (ADRD) (a group of cognitive disorders causing memory loss and impaired thinking) in women aged 65 years or older.
July 19th, 2024 — Source

Eliminating senescent cells could help treat breast, pancreatic cancers
Two studies from Washington University School of Medicine in St. Louis focused on breast cancer and pancreatic cancer suggest that specific types of senescent cells—cells that have stopped dividing and drive inflammation—may play important roles in suppressing the immune system and allowing such tumors to grow unchecked.
July 19th, 2024 — Source

Long-term results from testicular cancer treatment are positive, study shows
A new study shows that by combining different chemotherapy drugs, testicular cancer remains highly treatable and often curable, even after first-line treatment fails.
July 19th, 2024 — Source

New tech addresses manufacturing bottlenecks for a lifesaving blood cancer treatment
Researchers from the University of South Australia have developed a new technique to significantly enhance a powerful treatment for leukemia and other blood cancers.
July 19th, 2024 — Source

Physical modulation of the tumor microenvironment to enhance cancer therapy
Announcing a new article publication for BIO Integration journal. The tumor microenvironment (TME) has a crucial role in tumor development, metastasis, and recurrence.
July 19th, 2024 — Source

Preclinical study shows promise of systemic targeted therapy in a rare form of cancer
Pseudomyxoma peritonei is a rare and poorly understood cancer, characterized by the progressive accumulation of mucin in the abdominal cavity. Mainstay treatments are surgery and chemotherapy but disease recurrence and death after relapse frequently occur. The development of new, more effective therapeutic strategies represents an unmet clinical need.
July 19th, 2024 — Source

Researchers learn how cancer cells divide despite treatment
Researchers in the lab of Jean Cook, Ph.D., chair and professor in the Department of Biochemistry and Biophysics, have identified the cellular processes that occur when you take a cancer drug meant to stop rapid cell growth in tumors.
July 19th, 2024 — Source

Study finds tumor growth fueled by nucleotide salvage
Cancer cells salvage purine nucleotides to fuel tumor growth, including purines in foods we eat, an important discovery with implications for cancer therapies from research by Children's Medical Center Research Institute at UT Southwestern published in Cell.
July 19th, 2024 — Source

Tumor-infiltrating lymphocyte therapy marks a milestone in cancer treatment, researchers say
The recent U.S. Food and Drug Administration approval of lifileucel, the first commercial tumor-infiltrating lymphocyte (TIL) therapy for advanced melanoma, marks a significant breakthrough in cancer therapy. In a new commentary published in Cancer Cell, Moffitt Cancer Center scientists provide a comprehensive overview of the therapy's development and highlight its transformative potential.
July 19th, 2024 — Source

Health — Cancer — July 18th, 2024

Distinct signaling pathway drives the transformation of epithelial cells into aggressive tumors
A distinct signaling pathway called TNF-α drives the transformation of epithelial cells into aggressive tumor cells. During cancer progression, cells activate their own TNF-α program and become invasive. This finding could help to improve early detection and treatment of patients with cancers in skin, esophagus, bladder or colon, as UZH researchers state.
July 18th, 2024 — Source

Drug-like molecules show early success in targeting breast cancer brain metastases
Researchers from Drexel's College of Medicine have identified new drugs that show early success in shrinking breast cancer tumors that have metastasized in the brain. The discovery marks the first time that targeting a key metabolic enzyme in cancer cells in the brain has shrunk tumors in a mouse model.
July 18th, 2024 — Source

Exploring CAR T-cell therapy for aggressive follicular lymphoma
CAR T-cell therapy is an effective treatment for aggressive subtypes of follicular lymphoma, according to a clinical trial published in Nature Medicine.
July 18th, 2024 — Source

Findings reveal unexpected role of protein OTX2 that drives aggressive medulloblastoma
In a report published in Nature Cell Biology, researchers at Baylor College of Medicine, Texas Children's Hospital, the University of Manitoba and collaborating institutions have revealed an unexpected way in which the protein OTX2 drives the progression of medulloblastoma—the most common aggressive childhood brain cancer.
July 18th, 2024 — Source

Harnessing ctDNA measurements for response assessment in metastatic castration resistant prostate cancer
A new editorial paper was published in Oncotarget's Volume 15 on July 2, 2024, entitled, "Using early on-treatment circulating tumor DNA measurements as response assessment in metastatic castration resistant prostate cancer."
July 18th, 2024 — Source

New technique to diagnose cancer metastasis uses origami nanoprobes
Johns Hopkins engineers have created a new optical tool that could improve cancer imaging. Their approach, called SPECTRA, uses tiny nanoprobes that light up when they attach to aggressive cancer cells, helping clinicians distinguish between localized cancers and those that are metastatic and have the potential to spread throughout the body.
July 18th, 2024 — Source

Novel drug application shows improved survival for patients with relapsed and refractory acute myeloid leukemia
Relapsed/refractory acute myeloid leukemia (AML), a blood cancer, has an extremely poor prognosis because of resistance to anti-cancer drugs and frailty of the patient's organ functions. A type of anti-tumor immunotherapy called allogeneic hematopoietic cell transplantation, which can exert anti-cancer effect accompanied by severe toxicity, is often performed for patients who are hard to treat with chemotherapy, but relapse still remains.
July 18th, 2024 — Source

Novel therapy can improve the prognosis of relapsed/refractory acute myeloid leukemia
Relapsed/refractory acute myeloid leukemia (AML), a so-called blood cancer, has an extremely poor prognosis because of resistance to anti-cancer drugs and frailty of the patient's organ functions. A type of anti-tumor immunotherapy called allogeneic hematopoietic cell transplantation, which can exert anti-cancer effect accompanied by severe toxicity, is often performed for patients who are hard to treat with chemotherapy, but relapse still remains.
July 18th, 2024 — Source

Research points the way toward an exhaled-breath test for lung cancer
The foundational science to develop an exhaled-breath test for detection of lung diseases, including lung cancer, is underway, according to new research published by a laboratory at the Hackensack Meridian Center for Discovery and Innovation (CDI).
July 18th, 2024 — Source

Seattle biotech startup Bonum upgrades offices, expands team in its pursuit of cancer drugs
Bonum Therapeutics is moving into new offices near Seattle's South Lake Union neighborhood and plans to double its headcount in pursuit of immunotherapy drugs. The biotech startup will occupy the 11th floor of the Alexandria's new life science tower at 1150 Eastlake Ave. E.
July 18th, 2024 — Source

Self-sampling HPV kits could screen an extra million people in England for cervical cancer
Do-it-yourself human papillomavirus (HPV) tests could enable more than a million more women in England to participate in cervical screening over the next three years.
July 18th, 2024 — Source

Western diets pose greater risk of cancer and inflammatory bowel disease, study finds
Western diets pose a greater risk of inflammatory bowel disease (IBD) and colorectal cancer, according to a milestone review of what people eat around the world.
July 18th, 2024 — Source

Health — Cancer — July 9th, 2024

A rare voice box transplant helped a cancer patient speak again, part of a pioneering study
A Massachusetts man has regained his voice after surgeons removed his cancerous larynx and, in a pioneering move, replaced it with a donated one.
July 9th, 2024 — Source

Blocking nidogen-2 enhances chemotherapy efficacy in pancreatic cancer
Researchers at the Garvan Institute of Medical Research have identified a potential new therapeutic target for pancreatic cancer, one of the most lethal cancer types with limited treatment options. Published in the journal Science Advances, the study shows that blocking the molecule nidogen-2 enhanced the effectiveness of chemotherapy and reduced the cancer's spread in mouse models.
July 9th, 2024 — Source

Cancer care by UK's National Health Service at tipping point, says study
To improve the delivery of cancer care by the UK's National Health Service (NHS), ten time-critical issues must be addressed, according to a review of current services led by nine cancer specialists.
July 9th, 2024 — Source

Implantable LED device uses light to treat deep-seated cancers
Certain types of light have proven to be an effective, minimally-invasive treatment for cancers located on or near the skin when combined with a light-activated drug. But deep-seated cancers, surrounded by tissue, blood and bone, have been beyond the reach of light's therapeutic effects.
July 9th, 2024 — Source

New weight-loss and diabetes drugs linked to lower risk of 10 cancers
For diabetes patients, GLP-1 drugs linked to lower cancer risks compared to insulin.
July 9th, 2024 — Source

Q&A: New strategy can improve cell therapy against cancer
Researchers at the Center for Infectious Medicine at the Department of Medicine, Huddinge have developed a new strategy that can make cell therapy against cancer work longer in patients. The results are published in the journal Cell Stem Cell.
July 9th, 2024 — Source

Stem cell-derived therapy shows promise against treatment-resistant liver cancer
Researchers at University of California San Diego have found that the most common form of liver cancer—one with a high mortality rate—can be better targeted and treated using an innovative new stem cell-derived therapy, according to a recently published study in Cell Stem Cell.
July 9th, 2024 — Source

Scientists trick cancer cells into self-destructing through genetic editing
Injecting tumors with a genetic Trojan horse
July 9th, 2024 — Source

Tool predicts nerve damage from breast cancer treatment
Many women treated for breast cancer using taxanes, a type of cytostatic drug, often experience side effects in the nervous system. Researchers at Linköping University have developed a tool that can predict the risk level for each individual. The tool could help doctors adapt treatment to avoid persistent side effects in those at the greatest risk.
July 9th, 2024 — Source

We know what to eat to stay healthy. So why is it so hard to make the right choices?
A healthy diet protects us against a number of chronic diseases, including heart disease, diabetes and cancer.
July 9th, 2024 — Source

What is the difference in risk of early prostate cancer death between men at higher versus lower genetic risk?
In a two-decade-long study published in JAMA Network Open, researchers analyzed the risk of early prostate cancer death among men with higher versus lower genetic risk, using data from two prospective cohort studies in Sweden and the United States of America (US).
July 9th, 2024 — Source

Health — Cancer — July 6th, 2024

Diabetes drugs like Ozempic lower cancer risks: Study
A class of diabetes medications, which include the best-selling drug Ozempic, are associated with a reduced risk of certain obesity-related cancers, according to a study released Friday.
July 6th, 2024 — Source

Health — Cancer — July 5th, 2024

Advancing cervical cancer prevention in China: New insights and future strategies
As the fourth most commonly diagnosed cancer among women worldwide, cervical cancer places a significant burden on low and middle-income countries. Although China reports lower incidence and mortality rates compared to the global average, the stark contrast in mortality rates with developed nations like the U.S. and the U.K. underscores the urgent need for enhanced prevention strategies.
July 5th, 2024 — Source

Cancer patient forced to make terrible decision after Qilin attack on London hospitals
Skin-sparing mastectomy and breast reconstruction scrapped as result of ransomware at supplier
July 5th, 2024 — Source

Could a deadly brain cancer someday be managed like a chronic condition? Some researchers think so
Every two days, Lynn Oxenberg leans over her bathroom sink while her husband shaves the shadow of auburn hair beginning to cover her head.
July 5th, 2024 — Source

Development of new techniques and clinical applications of liquid biopsy in lung cancer management
In clinical practice, traditional tumor-node-metastasis (TNM) staging has difficulty achieving accuracy in prognosis stratification at the individual patient level. In a study published in the journal Science Bulletin, researchers have therefore proposed to introduce blood minimal residual disease (MRD) status and proposed a new tumor-node-metastasis-blood (TNMB) staging system to more accurately and individually define the postoperative status of lung cancer patients.
July 5th, 2024 — Source

DNA repair mutations act as a switch for bowel cancer
Bowel cancer cells have the ability to regulate their growth using a genetic on-off switch to maximize their chances of survival, a phenomenon that's been observed for the first time by researchers at UCL and University Medical Center Utrecht.
July 5th, 2024 — Source

Genomic variants study points to improved detection of thyroid cancer
Researchers from Sinai Health and the University of Toronto have gleaned new insights into how thyroid cancer could be more effectively treated.
July 5th, 2024 — Source

Research confirms circZFR is a promising biomarker for colorectal cancer diagnosis and prognosis
In a study published in the journal Science China Life Sciences, a research team identified circZFR using circRNA microarray and competing endogenous RNA (ceRNA) microarray, and they confirmed that circZFR is a promising biomarker for colorectal cancer (CRC) diagnosis and prognosis.
July 5th, 2024 — Source

Researchers map the effects of all potential changes in key cancer gene
Researchers at the Francis Crick Institute have mapped all the possible outcomes of changes to a tumor-suppressing gene called VHL, the first step in a huge research endeavor to unpick the outcomes of tens of thousands of genetic variations in genes associated with cancer.
July 5th, 2024 — Source or Source

Scientists identify thousands of high-risk cancer gene variants
More than 5,000 genetic variants that enable certain cancers to thrive have been identified by scientists, along with a potential therapeutic target to treat or even prevent these cancers from developing.
July 5th, 2024 — Source

Survey shows men need to do more to prevent cancer
American men are blowing their best chance to head off cancer or spot it early, when it's easiest to treat, a new survey warns.
July 5th, 2024 — Source

Health — Cancer — July 4th, 2024

Epilepsy drug could keep chemotherapy for stomach cancer working for longer
Cancer's resistance to chemotherapy could be reversed by targeting lactate—the product that builds up as cancer cells convert nutrients to energy, according to new research published in Nature.
July 4th, 2024 — Source

Re-engineering cancerous tumors to self-destruct and kill drug-resistant cells
Treating cancer can sometimes feel like a game of Whac-A-Mole. The disease can become resistant to treatment, and clinicians never know when, where and what resistance might emerge, leaving them one step behind. But a team led by Penn State researchers has found a way to reprogram disease evolution and design tumors that are easier to treat.
July 4th, 2024 — Source

Reversing chemotherapy resistance in pancreatic cancer
Pancreatic cancer is a particularly aggressive and difficult-to-treat cancer, in part because it is often resistant to chemotherapy. Now, researchers at Stanford have revealed that this resistance is related to both the physical stiffness of the tissue around the cancerous cells and the chemical makeup of that tissue.
July 4th, 2024 — Source

Target discovered for the treatment of pancreatic cancer
A team at the Institute of Biochemistry at Kiel University has found a way to inhibit the function of the tumor-causing protein MYC. This can be used to develop new drugs.
July 4th, 2024 — Source

Health — Cancer — July 2nd, 2024

American Indian/Alaska Native patients less likely to undergo breast reconstruction
American Indian/Alaska Native (AI/AN) women with breast cancer have consistently lower rates of breast reconstruction after mastectomy compared to non-Hispanic White women, reports a paper in the July issue of Plastic and Reconstructive Surgery.
July 2nd, 2024 — Source

Benefits of thymectomy in treating myasthenia gravis
The first-ever randomized study of the removal of the thymus gland in treating myasthenia gravis was conducted in 2016. Led by Gil I. Wolfe, MD, SUNY Distinguished Professor and the Irvin and Rosemary Smith Professor of Neurology in the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, that study definitively confirmed the benefit of thymectomy, even in MG patients without a chest tumor.
July 2nd, 2024 — Source

Engineered plasma cells show long-lasting antileukemic activity in mice
Researchers show for the first time that engineered human plasma B cells can be used to treat a disease—specifically leukemia—in a humanized animal model. The results mark a key step in the realization of ePCs as therapies to treat cancer, auto-immune disorders, and protein deficiency disorders. The results appear July 2 in the journal Molecular Therapy.
July 2nd, 2024 — Source

Genetic test improves clinical care for children with cancer in England
Whole genome sequencing has improved clinical care of some children with cancer in England by informing individual patient care.
July 2nd, 2024 — Source

New Nanocomplex DOX/TPOR4@CB[7]4 Shows Potent Anti-Cancer Properties in Preclinical Studies
In a recent article published in Pharmaceutics, researchers introduced a self-assembled nanocomposite designed for enhanced synergistic photodynamic therapy and chemotherapy in neuroblastoma.
July 2nd, 2024 — Source

Pain Doesn't Belong on a Scale of Zero to 10
Over the past two years, a simple but baffling request has preceded most of my encounters with medical professionals: "Rate your pain on a scale of zero to 10."
July 2nd, 2024 — Source

Racial differences seen in financial hardship among older cancer survivors
Income and area-level disadvantage are the largest contributors to racial differences in financial hardship among older U.S. adults with cancer, according to a study published online June 18 in Cancer.
July 2nd, 2024 — Source

Researchers examine cancer drug guidelines and FDA approvals
Drugs for serious or life-threatening diseases can receive expedited U.S. Food and Drug Administration (FDA) review, allowing patients to receive faster access to promising new treatments. Under the expedited review pathway of accelerated approval, drugs can be FDA-approved based on surrogate markers or proxy measures such as changes in imaging or lab tests that are "reasonably likely" to predict whether patients improve in how they feel, function, or survive.
July 2nd, 2024 — Source

Study describes how insulinomas, a rare type of pancreatic beta cell tumor, form
A study led by Pompeu Fabra University describes the mechanism whereby insulinomas, a rare type of neuroendocrine tumor that affects pancreatic beta cells, form. According to the study, insulinomas are the result of the accumulation of rare mutations that lead to a homogeneous change in the epigenetic profile of pancreatic beta cells.
July 2nd, 2024 — Source

Whole genome sequencing can improve clinical care of childhood cancer
Whole genome sequencing has improved clinical care of some children with cancer in England by informing individual patient care.
July 2nd, 2024 — Source

Health — Cancer — June 28th, 2024

AI identifies new high-risk subtype in endometrial cancer
In a recent study published in Nature Communications, a team of researchers used artificial intelligence (AI) to classify histopathological images and differentiate between endometrial cancer subtypes. The tool identified a subtype of endometrial cancer known as NSMP or No Specific Molecular Profile, which is characterized by aggressive disease and low survival rates.In a recent study published in Nature Communications, a team of researchers used artificial intelligence (AI) to classify histopathological images and differentiate between endometrial cancer subtypes. The tool identified a subtype of endometrial cancer known as NSMP or No Specific Molecular Profile, which is characterized by aggressive disease and low survival rates.
June 28th, 2024 — Source

Breakthrough research makes cancer-fighting viral agent more effective
When a cancer cell doesn't respond to traditional therapies, doctors may turn to a sort of viral biological warfare, by deploying "troops" in the form of viral agents that are specifically engineered to target and eliminate cancer cells. The mode of attack is to transform the tumor into an immunologically "hot" environment, making it more visible and recognizable to our immune system.
June 28th, 2024 — Source

Chemical conjugation mitigates immunotoxicity of chemotherapy of lipid nanoparticles
While chemotherapy can stimulate antitumor immunity, it may also impair immune cell function and induce lymphodepletion, reducing the effectiveness of subsequent immunotherapy. Thus, nanoparticle-based drug delivery systems have been developed for their improved drug biodistribution and reduced toxicity, striking a delicate balance between efficacy and safety.
June 28th, 2024 — Source

Chemo drug may cause significant hearing loss in longtime cancer survivors
An interdisciplinary study led by researchers at the University of South Florida and Indiana University has uncovered significant findings on the long-term effects of one of the most common forms of chemotherapy on cancer survivors.
June 28th, 2024 — Source

Europe's new clinical guidelines enable better understanding of childhood bone cancer
New clinical guidelines enabling a better understanding of childhood bone cancer will revolutionize treatment for these young patients across Europe, according to a leading researcher from the University of East Anglia.
June 28th, 2024 — Source

Feature-domain Fourier ptychographic microscopy promotes pathological screening and analysis
Pathological analysis has been the gold standard of disease detection, especially in tumor diagnosis. Traditional digital pathology relies on high-precision movement of a high numerical aperture (NA) objective to obtain the entire field of view (FOV) for a tissue slide, whose high cost severely hinders its widespread applications.
June 28th, 2024 — Source

Long-term effects of chemotherapy on hearing and quality of life in testicular cancer survivors
An interdisciplinary study led by researchers at the University of South Florida and Indiana University has uncovered significant findings on the long-term effects of one of the most common forms of chemotherapy on cancer survivors.
June 28th, 2024 — Source

Study suggests changing the gut microbiome improves health outcomes for newly-diagnosed metastatic kidney cancer
Physician scientists from City of Hope, one of the largest cancer research and treatment organizations in the United States, found that people with metastatic kidney cancer who orally took a live biotherapeutic product called CBM588 while in treatment with immunotherapy and enzymatic tyrosine kinase inhibitors experienced improved health outcomes.
June 28th, 2024 — Source

Using liver biopsies to identify predictors of pancreatic cancer metastasis
Researchers at Weill Cornell Medicine with an international team have used liver biopsies to identify cellular and molecular markers that can potentially be used to predict whether and when pancreatic cancer will spread to an individual's liver or elsewhere, such as the lung.
June 28th, 2024 — Source

Health — Cancer — June 26th, 2024

Chemotherapy could disrupt gut microbiome in patients with breast cancer
Chemotherapy is known to cause behavioral side effects, including cognitive decline. Notably, the gut microbiome communicates with the brain to affect behavior, including cognition.
June 26th, 2024 — Source

Combining genomic analyses and outcome data is promising strategy for prostate cancer treatment
Combining genomic analyses with information about clinical outcomes is a highly promising strategy to understanding prostate cancer and its treatment. Researchers say it could change how the disease is predicted and make treatment timelier and more personalized.
June 26th, 2024 — Source

Higher intake of ultra-processed foods found to increase cancer mortality risk
In a recent study published in Nutrients, researchers investigated the association between ultra-processed food (UPF) consumption and gastrointestinal (GI) cancers and other causes of mortality in Southern Italy.
June 26th, 2024 — Source

Improving prostate cancer screening for transgender women
Transgender women are still at risk for prostate cancer. A new study led by Cedars-Sinai Cancer investigators, published in JAMA concludes that current screening guidelines could miss early-stage prostate cancer in transgender women on hormone therapy.
June 26th, 2024 — Source

In a recent study published in Nutrients
A large analysis of data from nearly 400,000 healthy U.S. adults followed for more than 20 years has found no association between regular multivitamin use and lower risk of death. The study, "Multivitamin Use and Mortality Risk in 3 Prospective US Cohorts" led by researchers at the National Institutes of Health's National Cancer Institute, was published June 26, 2024, in JAMA Network Open.
June 26th, 2024 — Source

Melanoma messages: Social media a useful tool for skin cancer communication
Melanoma messages: Social media a useful tool for skin cancer communication
June 26th, 2024 — Source

New survey finds cancer drug shortage management remains a moving target, impacting clinical trials
The National Comprehensive Cancer Network (NCCN)—a nonprofit alliance of leading cancer centers—is publishing new results for its latest survey on cancer drug shortages in the United States. This follows data published one year ago, and six months ago, illustrating how up to 93% of centers surveyed were experiencing shortages of the crucial chemotherapy carboplatin at its peak.
June 26th, 2024 — Source

Researchers find biomarker Ki67 useful for personalized treatment of malignant tumors
The nuclear protein Ki67 is a meaningful biomarker for tumor aggressiveness and for the success of surgical therapy in pleural mesothelioma, a malignant disease of the pleura. This is the clear and promising result of an international study now published in Cancers by Karl Landsteiner University of Health Sciences (KL Krems) in collaboration with Gazi University, Ankara, Turkey.
June 26th, 2024 — Source

Scientists discover high-risk form of endometrial cancer—and how to test for it—using AI
A discovery by researchers at the University of British Columbia promises to improve care for patients with endometrial cancer, the most common gynecologic malignancy.
June 26th, 2024 — Source

Study identifies high-risk type of childhood acute leukemia and potential treatment strategy
Understanding the molecular characteristics of cancer that impact patient outcomes is essential to identifying novel treatment strategies for the most intractable pediatric malignancies. Many of these diseases are difficult to study, however, due to the small number of patients diagnosed each year.
June 26th, 2024 — Source

Health — Cancer — June 24th, 2024

A new path toward microbiome-informed precision nutrition
Short-chain fatty acids (SCFAs) are beneficial molecules created by the bacteria residing in our gut that are closely tied to improved host metabolism, lower systemic inflammation, better cardiovascular health, lower cancer risk, and more. However, SCFA profiles can vary widely between individuals consuming the same exact diet and we currently lack tools for predicting this inter-individual variation.
June 24th, 2024 — Source

Acupuncture reduces hot flashes and side effects of endocrine therapy in women with breast cancer
In a pooled analysis of three clinical trials, acupuncture significantly reduced hot flashes and other hormonal side effects of endocrine therapy taken by Sourcewomen with breast cancer. The analysis of data from the United States, China, and South Korea is published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society.
June 24th, 2024 — Source

Improving advanced care planning for late-stage cancer
Multilevel care interventions improved clinician--documented advanced care planning (ACP) compared with a clinician-level intervention alone for patients with genitourinary cancer, according to findings published in JAMA Oncology.
June 24th, 2024 — Source

Lanthanide catalysts enable one-step synthesis of complex drug precursors
Hydrocarbazole is a crucial compound in organic chemistry, serving as a building block for various biologically active compounds, including pesticides such as strychnine and anticancer drugs such as vinblastine and minovincine. Consequently, the development of synthesis methods for these compounds is a crucial research topic.
June 24th, 2024 — Source

Leveraging gold nanostars for precision laser interstitial thermal therapy
A new editorial paper titled "Leveraging gold nanostars for precision laser interstitial thermal therapy" has been published in Oncotarget.
June 24th, 2024 — Source

Mozilla is trying to push me out because I have cancer, CPO says in bombshell lawsuit
Steve Teixeira, said to be CEO-in-waiting, now sues Firefox maker for discrimination, retaliation
June 24th, 2024 — Source

Nonsignificant survival benefit seen for dabrafenib, trametinib in melanoma
For patients with resected stage III melanoma, adjuvant therapy with dabrafenib plus trametinib is associated with a nonsignificant benefit in terms of overall survival, according to a study published in the New England Journal of Medicine.
June 24th, 2024 — Source

Post-transplant cyclophosphamide GVHD prophylaxis beneficial in leukemia
For patients with acute myeloid leukemia (AML) undergoing allogeneic stem cell transplantation, posttransplant cyclophosphamide (PTCy) graft-versus-host-disease (GVHD) prophylaxis yields comparable relapse incidence (RI) and significantly lower incidence of GVHD than conventional prophylaxis, according to a study published online June 10 in the American Journal of Hematology.
June 24th, 2024 — Source

Researchers win $2.78 million grant to harness AI for precision treatment in rectal cancer
With a new five-year, $2.78 million grant from the National Institutes of Health and National Cancer Institute, researchers at Case Western Reserve University(CWRU), Cleveland Clinic and University Hospitals (UH) will use artificial intelligence (AI) to better treat rectal cancer patients.
June 24th, 2024 — Source

Scientists identify potential driver of aggressive lung cancer in patients living in violent neighborhoods
Scientists have identified a potential driver of aggressive lung cancer tumors in patients who live in areas with high levels of violent crime. Their study found that stress responses differ between those living in neighborhoods with higher and lower levels of violent crime, and between cancerous and healthy tissues in the same individuals.
June 24th, 2024 — Source

Study reveals new opportunities to develop cancer treatments
Study reveals new opportunities to develop cancer treatments
June 24th, 2024 — Source

Study reveals same genes that can drive cancer also guide neural-circuit growth
Many people are familiar with oncogenes—genes long known to be involved in cancers in humans, such as the gene Src. What's less widely understood is that oncogenes didn't evolve just to cause cancer in species, but rather to control events of normal growth and differentiation.
June 24th, 2024 — Source

Study uncovers multiple molecular subgroups in liver cancer with most aggressive driving clinical outcomes
A study led by clinician-scientists and scientists from the National Cancer Centre Singapore (NCCS) and A*STAR's Genome Institute of Singapore (GIS) has discovered unexpected molecular heterogeneity even within the same liver tumors.
June 24th, 2024 — Source

UQ-led project to test technology-driven solutions for rural skin cancer screening
A University of Queensland-led project will test a combination of technologies to improve the early detection of potentially fatal skin cancers in patients in regional and rural Australia.
June 24th, 2024 — Source

Unlocking the secrets of the fibrotic fortress that surrounds and protects pancreatic cancer
While the overall five-year survival rate for pancreatic cancer is slowly improving, it remains discouragingly low—just 13%, according to the American Cancer Society. And the odds are even worse if the cancer is discovered after it has spread to other organs.
June 24th, 2024 — Source

Will it soon be possible for doctors to use AI to detect and diagnose cancer?
In a recent study published in Biology Methods and Protocols, researchers developed binary and multiclass machine learning models to distinguish cancer from non-cancerous tissue samples
June 24th, 2024 — Source

Health — Cancer — June 21st, 2024

3 major upgrades coming to Apple Watch X
Welcome to The Core — our new weekly rundown of the week in Apple news.
June 21st, 2024 — Source

AI outperforms peers in medical oncology quiz, yet some mistakes could be harmful
In a recent study published in the JAMA Network Open, researchers evaluated the accuracy and safety of large language models (LLMs) in answering medical oncology examination questions.
June 21st, 2024 — Source

Artificial variants of Withanolides act highly specifically against leukemia cells
Nightshade plants produce a diverse array of compounds with therapeutic potential. Researchers at CeMM have now identified an artificial variant inspired by the Withanolides group that acts highly specifically against leukemia cells. Using state-of-the-art chemical and genetic high-throughput analyses, the team led by Georg Winter not only confirmed its effectiveness but also elucidated its mechanism of action: the molecule disrupts the cholesterol metabolism of tumor cells.
June 21st, 2024 — Source

Breast cancer vaccine study begins with first patient
An innovative study of a breast cancer vaccine is officially underway, as University of Pittsburgh Medical Center announced on June 20 that the first participant had received her full course of the vaccine.
June 21st, 2024 — Source

Children genetically prone to cancer benefit from early standardized surveillance
Recent advances in genomic sequencing have revealed that 5--15% of children with cancer have an underlying genetic predisposition. Although genetic predispositions increase the risk for new tumors, it has been unclear when to begin surveillance for these tumors.
June 21st, 2024 — Source

Exposure to greenspace may lower risk of certain cancers
A University of Queensland-led study has found a link between exposure to gardens and a lower risk of being diagnosed with obesity-related cancer.
June 21st, 2024 — Source

FDA approves augtyro for NTRK-positive advanced solid tumors
The U.S. Food and Drug Administration has approved Augtyro (repotrectinib), a next-generation tyrosine kinase inhibitor (TKI), for the treatment of patients with neurotrophic tyrosine receptor kinase (NTRK)-positive locally advanced or metastatic solid tumors.
June 21st, 2024 — Source

New challenges in cancer care: cardiovascular disease and environmental factors
A recent study published in JAAC CardioOncology reviewed preclinical and epidemiologic evidence linking air pollution to cardio-oncology.
June 21st, 2024 — Source

New urine test can improve accuracy for early detection of bladder cancer in patients with hematuria
One of the first signs of bladder cancer can be blood in the urine (hematuria). Investigators developed and analyzed the results of a streamlined and simplified DNA-based urine test to improve the accuracy of early detection of bladder cancer in patients with hematuria.
June 21st, 2024 — Source

Reduced infections seen in CLL and NHL patients undergoing immunoglobulin testing and replacement therapy
Patients with chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphomas (NHLs) who received frequent tests for immunoglobulin G (IgG) were less likely to experience severe infections compared with those who didn't, according to a study published in Blood Advances.
June 21st, 2024 — Source

Researchers develop new compound designed to treat drug-resistant acute myeloid leukemia
Researchers at Purdue University's College of Science have developed a patent-pending compound called HSN748 to treat drug-resistant acute myeloid leukemia (AML). AML is a cancer that begins in bone marrow and sometimes metastasizes to the central nervous system, liver, lymph nodes, spleen and testicles.
June 21st, 2024 — Source

Slowing inflammation may boost immunotherapy's effectiveness against advanced lung cancer
Adding an anti-inflammatory drug to anti-PD1 checkpoint inhibitor immunotherapy has shown great promise as a new strategy against advanced lung cancer, based on results from a small clinical trial led by investigators at the Abramson Family Cancer Center at the University of Pennsylvania Perelman School of Medicine.
June 21st, 2024 — Source

Study shows childhood cancers not on the rise in parts of Australia, but disparity remains for Indigenous children
Despite national and global reports of rising incidences of cancer affecting children and young people, a new analysis has found rates of childhood cancer have remained unchanged over the last 30 years in South Australia and the Northern Territory.
June 21st, 2024 — Source

Team finds exportin 1 governs immunosuppressive functions of myeloid-derived suppressor cells in tumors
A team of Roswell Park Comprehensive Cancer Center experts led by Hemn Mohammadpour, DVM, Ph.D., has conducted research that offers new insights into tumor biology and may lay the groundwork for more effective cancer immunotherapy.
June 21st, 2024 — Source

Vegetable gardening can improve health outcomes for cancer survivors, study finds
Gardening is a great way to get outdoors and soak in vitamin D while also providing fresh vegetables to enjoy. Dietary guidelines recommend adults eat 2--3 cups of vegetables daily to prevent obesity and cardiovascular diseases and help with immune function.
June 21st, 2024 — Source

Health — Cancer — June 20th, 2024

A new 'one-two punch' method for improving checkpoint inhibitor therapy for cancers, including Hodgkin lymphoma
Checkpoint inhibitor therapies can be thought of as the molecular "brake release" for the immune system. These drugs eliminate the protein barriers that impede the immune system from recognizing and targeting cancer cells in the body. While there are multiple checkpoint inhibitors approved to treat different types of cancer, many patients don't respond or develop resistance to available regiments.
June 20th, 2024 — Source

Among cancer survivors, LGBTQ+ individuals report higher prevalence of chronic health conditions, disabilities
Cancer survivors who identify as lesbian, gay, bisexual, transgender, queer, or anything other than straight and cisgender (LGBTQ+) experience more chronic health conditions, disabilities, and other physical and cognitive limitations than non-LGBTQ+ cancer survivors; however, the prevalence of most conditions was highest among transgender or gender non-conforming (TGNC) individuals.
June 20th, 2024 — Source

Black patients more likely to experience MACE after ADT for prostate cancer
Black patients are more likely to experience adverse cardiovascular outcomes after systemic androgen deprivation therapy (ADT) for prostate cancer, according to a study published online June 18 in JACC: CardioOncology.
June 20th, 2024 — Source

Chemotherapy before surgery benefits some patients with pancreatic cancer, study finds
Patients with pancreatic cancer who received chemotherapy both before and after surgery experienced longer survival rates than would be expected from surgery followed by chemotherapy, according to a new study from researchers at Yale Cancer Center (YCC) and Yale School of Medicine.
June 20th, 2024 — Source

Combination targeted treatment produces lasting remissions in people with resistant aggressive B-cell lymphoma
Combination therapy developed by NIH researchers demonstrates the power of precision medicine.
June 20th, 2024 — Source or Source

Combining JAK inhibitors with checkpoint inhibitors improves cancer immunotherapy response
Because not all cancer patients respond to a leading type of cancer immunotherapy drug, known as an immune checkpoint inhibitor, scientists explored whether adding janus kinase (JAK) inhibitors -- drugs that treat chronic inflammation -- could help. In two separate clinical studies, researchers found that adding JAK inhibitors did improve patients' responses to cancer checkpoint inhibitor immunotherapies.
June 20th, 2024 — Source

Deep learning shows promise for soft tissue sarcoma management
Soft tissue sarcomas (STSs) represent a diverse group of tumors that pose significant diagnostic and therapeutic challenges. In a recent review published in the journal Meta-Radiology, a team of researchers from The Second Xiangya Hospital at Central South University in Changsha, China, explored the potential application of deep learning (DL) in revolutionizing the management of these complex tumors.
June 20th, 2024 — Source

Doctors may soon be able to use AI for cancer detection
A new paper in Biology Methods & Protocols, published by Oxford University Press, indicates that it may soon be possible for doctors to use artificial intelligence (AI) to detect and diagnose cancer in patients, allowing for earlier treatment. Cancer remains one of the most challenging human diseases, with over 19 million cases and 10 million deaths annually. The evolutionary nature of cancer makes it difficult to treat late-stage tumours.
June 20th, 2024 — Source

Kids from disadvantaged communities may die sooner from cancerous brain tumors
Children with inoperable brain tumors may die sooner if they live in areas with lower average income and education levels, a Michigan Medicine-led study finds.
June 20th, 2024 — Source

Lack of health care screening puts gender diverse people at greater cancer risk, say researchers
The lack of culturally safe health screening for people who are transgender and gender diverse (TGD) is putting them at greater risk of cancer going undetected, but nurse practitioners could be trained to help close the gap.
June 20th, 2024 — Source

Modified form of chemotherapy before and after surgery enhances survival in pancreatic cancer patients
Patients with pancreatic cancer who received chemotherapy both before and after surgery experienced longer survival rates than would be expected from surgery followed by chemotherapy, according to a new study from researchers at Yale Cancer Center (YCC) and Yale School of Medicine.
June 20th, 2024 — Source

Noninvasive urine test enhances early detection of bladder cancer in patients with hematuria
One of the first signs of bladder cancer can be blood in the urine (hematuria). Investigators developed and analyzed the results of a streamlined and simplified DNA-based urine test to improve the accuracy of early detection of bladder cancer in patients with hematuria. They report in The Journal of Molecular Diagnostics, published by Elsevier, that this noninvasive test provides more accurate and earlier detection of bladder cancer, potentially reducing the need to refer patients for more invasive cystoscopy.
June 20th, 2024 — Source

Research reports improvements in survival rates in patients with metastatic prostate cancer
Research from Saint Louis University School of Medicine finds improvements in survival in both veterans and men across the country over the last 20 years in metastatic prostate cancer, which correlate with new hormonal treatments.
June 20th, 2024 — Source

Study highlights importance of early detection in bile duct cancer for patients with rare liver disease
Primary sclerosing cholangitis (PSC) is a rare progressive liver disease that damages bile ducts and significantly increases the risk of bile duct cancer, particularly a type called cholangiocarcinoma (CCA). This cancer is aggressive, and curative surgery is uncommon. Liver transplantation is a potential treatment option for some PSC-CCA patients, especially if the cancer is caught early. Early diagnosis is essential for successful treatment.
June 20th, 2024 — Source

Study identifies mechanism behind glioblastoma's immunotherapy resistance
The cells of a rare, deadly cancer are resistant to immunotherapy. Now researchers may have found the cause, paving the way for a new type of treatment.
June 20th, 2024 — Source

Study shows CAR NK cells with CD28 costimulation improve cell persistence and antitumor activity
Adding CD28 costimulation to cord blood-derived chimeric antigen receptor (CAR) natural killer (NK) cells targeting CD70+ cancers significantly enhanced antitumor efficacy and long-term cytotoxicity of the CAR NK cells, according to researchers from The University of Texas MD Anderson Cancer Center.
June 20th, 2024 — Source

WEHI spinout aims to revolutionize the development of cancer drugs
Australia has cemented its role in becoming a major player in the next generation of medicines with the launch of Ternarx -- a globally competitive biotechnology company dedicated to finding new treatments for hard-to-treat cancers.
June 20th, 2024 — Source

Health — Cancer — June 17th, 2024

Combination therapy shows promise in subset of breast cancers
Combining two cancer drugs may be a promising treatment for advanced metastatic breast cancer, according to the results of a clinical trial published in JAMA Oncology.
June 17th, 2024 — Source

Cross-border tumor boards enhance care for rare gynecological cancers across Europe
Cross-border tumor boards of cancer specialists from different European countries meeting virtually to review the management of individual patients with complex rare gynecological cancers from across Europe resulted in new treatment recommendations and increased access to clinical trials, according to results from a six-year study that will be presented at the ESMO Gynaecological Cancers Congress 2024.
June 17th, 2024 — Source

CSHL researchers reveal MED12 as key player in basal-like pancreatic cancer
Things aren't always as they seem. Take pancreatic cancer, for example. In up to one in 10 cases, researchers have documented a peculiar characteristic. Some of the pancreatic cells appear to have lost their identity. It's as if they forget what they are.
June 17th, 2024 — Source or Source

'Dual Action' Treatment to Enhance Lung Cancer Treatment
In a study published in Science Advances, researchers at Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, created a new nanomedicine therapy that delivers anticancer drugs to lung cancer cells while also improving the immune system's ability to fight cancer.
June 17th, 2024 — Source

FDA official: The risk of secondary cancer from CAR-T therapy is less than feared
The risk of secondary cancer after CAR-T therapy, pioneered at Penn, is less than regulators feared last year, an FDA official said June 14 at cell and gene therapy conference in King of Prussia.
June 17th, 2024 — Source

Finnish researchers discover mechanism behind breast cancer cell reactivation
Treatment outcomes for breast cancer have become better over the years, but proportion of breast cancers still recur even after long periods without signs of cancer remaining dormant in the body. Finnish cancer researchers discovered a mechanism that wakes up these dormant breast cancer cells and demonstrated that preventing the mechanism can significantly improve treatment outcomes in experimental models.
June 17th, 2024 — Source

Nanomaterials in Cancer Therapy: Advancing Ferroptosis Induction
In a recent review article in Life Sciences, researchers from India, the UK, and the USA highlight advancements in using nanomaterials to induce ferroptosis in cancer cells, focusing on molecular dynamics and innovative cancer therapy strategies.
June 17th, 2024 — Source

New approach uses oxidative photocatalysis on membranes to trigger cell death in cancer cells
A research team, led by Professors Tae-Hyuk Kwon and Duyoung Min from the Department of Chemistry at UNIST, has achieved a significant breakthrough in the battle against cancer through the utilization of reactive oxygen species (ROS) generated via water oxidation.
June 17th, 2024 — Source

Past-year pap testing rates were lower in 2022 than 2019
Past-year Papanicolaou testing rates were lower in 2022 than in 2019, overall, and lower rates were seen in rural versus urban women, according to a study published in online June 14 in JAMA Network Open.
June 17th, 2024 — Source

PTEN Delivery via Carbon Nanotubes in Breast Cancer
In a recent article in Molecules, researchers from Greece investigated using multiwalled carbon nanotubes (CNTs) as carriers for PTEN (phosphatase and tensin homolog deleted on chromosome 10) and its truncated fragments in breast cancer cells.
June 17th, 2024 — Source

Health — Cancer — June 15th, 2024

Microrobots made of algae carry chemo directly to lung tumors, improving cancer treatment
Tumors that travel to the lungs, or lung metastases, pose a formidable challenge in the realm of cancer treatment. Conventional chemotherapy often falls short because it's inefficient. It doesn't directly target the lungs or accumulate in a high enough concentration to kill tumors.
June 15th, 2024 — Source

Some CRISPR screens may be missing cancer drug targets
CRISPR/Cas9 gene editing has made possible a multitude of biomedical experiments, including studies that systematically turn off genes in cancer cells to look for ones that the cancer cells heavily depend on to survive and grow. These genes, or "cancer dependencies," are often promising drug targets. But new research shows that many of these CRISPR screening experiments rely on components, called CRISPR/Cas9 guides, that do not perform equally well in cells from people of all ancestries, which can cause CRISPR screens to miss cancer dependencies.
June 15th, 2024 — Source

Health — Cancer — June 14th, 2024

Fasting primes the immune system's natural killer cells to better fight cancer, new study in mice finds
Periods of fasting reprogram the immune system's natural killer cells to better fight cancer, according to a new study in mice from researchers at Memorial Sloan Kettering Cancer Center (MSK).
June 14th, 2024 — Source

Successful trial for new colorectal cancer treatment highlights promising immunotherapy drugs
Results from a new trial indicate that immunotherapy could successfully be used to treat the most common form of colorectal cancer, also known as bowel cancer.
June 14th, 2024 — Source

Ultrasensitive liquid biopsy tech spots cancer earlier than standard methods
An artificial intelligence-powered method for detecting tumor DNA in blood has shown unprecedented sensitivity in predicting cancer recurrence, in a study led by researchers at Weill Cornell Medicine, NewYork-Presbyterian, the New York Genome Center (NYGC) and Memorial Sloan Kettering Cancer Center (MSK).
June 14th, 2024 — Source

Health — Cancer — June 12th, 2024

AI better detects prostate cancer on MRI than radiologists
Computer detects prostate cancer more often and has reduced false alarm
June 12th, 2024 — Source

Anlotinib plus STUPP: A new hope for glioblastoma patients
Glioblastoma multiforme (GBM) is among the most aggressive forms of brain tumors, with few effective treatment options and a bleak prognosis. The current standard of care (SOC), known as the STUPP regimen, includes surgical resection, radiotherapy, and temozolomide chemotherapy. Despite this rigorous approach, median progression-free survival (PFS) and overall survival (OS) are typically low.
June 12th, 2024 — Source

Boosting CAR-T cell therapies from under the skin
Subcutaneous biodegradable scaffolds for restimulating the antitumor activity of preadministered CAR-T cells
June 12th, 2024 — Source or Source

CAR T cell therapy for advanced prostate cancer demonstrates positive results in Phase I clinical trial
Treating prostate cancer with immunotherapy is currently difficult to do. But results from a first in-human Phase I trial using a chimeric antigen receptor (CAR) T cell therapy developed by researchers from City of Hope, showed that patients with advanced prostate cancer can be treated safely with the cellular immunotherapy with promising therapeutic activity, according to the study published in Nature Medicine.
June 12th, 2024 — Source

Case study reveals important new details about rare second cancers related to CAR-T therapy
A new detailed analysis of a patient's second cancer after receiving CAR-T therapy for the initial cancer provides rare but important insights intended to offer helpful guidance for oncologists and pathologists about the clinical presentation and pathologic features involved in a CAR-T related second cancer.
June 12th, 2024 — Source

Inherited genetic factors may predict the pattern of X chromosome loss in older women
Researchers have identified inherited genetic variants that may predict the loss of one copy of a woman's two X chromosomes as she ages, a phenomenon known as mosaic loss of chromosome X, or mLOX. These genetic variants may play a role in promoting abnormal blood cells (that have only a single copy of chromosome X) to multiply, which may lead to several health conditions, including cancer.
June 12th, 2024 — Source

New technique reveals earliest signs of genetic mutations
Mutations are changes in the molecular 'letters' that make up the DNA code, the blueprint for all living cells. Some of these changes can have little effect, but others can lead to diseases, including cancer. Now, a new study introduces an original technique, called HiDEF-seq, that can accurately detect the early molecular changes in DNA code that precede mutations.
June 12th, 2024 — Source or Source

New thesis on biomarkers for hepatocellular carcinoma
Robin Zenlander from the Gastroenterology and Rheumatology Unit at the Department of Medicine, Huddinge, is defending his thesis titled "Biomarkers in hepatocellular carcinoma," on 13 June, 2024.
June 12th, 2024 — Source

Obesity-cancer connection discovery suggests strategies for improving immunotherapy
Immune system cells called macrophages play an unexpected role in the complicated connection between obesity and cancer, a Vanderbilt University Medical Center-led research team has discovered.
June 12th, 2024 — Source or Source

Research pair finds Gen X people more susceptible to many types of cancers than prior generations
A pair of biostatisticians at the U.S. National Cancer Institute, has found that members of Generation X are more susceptible to many kinds of cancers than their parents or grandparents were.
June 12th, 2024 — Source

Researchers find survival improves with open radical hysterectomy in early-stage cancer
Early-stage cervical cancer patients see better survival and decreased recurrence rates after open radical hysterectomy than minimally invasive laparoscopic approaches, according to a five-year study led by Houston Methodist researchers and published in the Journal of Clinical Oncology.
June 12th, 2024 — Source

Risk of secondary cancers after CAR-T cell therapy low, according to large study
A large study by researchers at Stanford Medicine has found that the risk of secondary blood cancers after CAR-T cell therapy—a cell-based cancer treatment that exploded on the scene in 2017 as a treatment for intractable blood cancers—is low, despite a Food and Drug Administration warning.
June 12th, 2024 — Source

Study reveals unexpected mechanism of drug resistance in kidney cancer
For nearly two decades, how kidney cancer becomes resistant to rapalog drugs has baffled the scientific community. Now a study by researchers at UT Southwestern Medical Center's Kidney Cancer Program sheds light. Published in the Proceedings of the National Academy of Sciences, the study "Unconventional Mechanism of Action and Resistance to Rapalogs in Renal Cancer" provides evidence for an unanticipated role for nontumor cells in mediating the therapeutic effects of rapalogs in kidney cancer.
June 12th, 2024 — Source

Study suggests hypoxia overexpression causes pericytes to contribute to pulmonary hypertension
Pericytes, the multifunctional cells that work within the walls of capillaries, have been a subject of focus in the study of vascular development, cerebral blood flow, cancer, and neurodevelopment diseases.
June 12th, 2024 — Source

Swimming microrobots deliver cancer-fighting drugs to metastatic lung tumors in mice
Engineers at the University of California San Diego have developed microscopic robots, known as microrobots, capable of swimming through the lungs to deliver cancer-fighting medication directly to metastatic tumors.
June 12th, 2024 — Source or Source

The HPV vaccine reduces risk of cancer for all, not just women, new data show—so why isn't everyone rushing to get it?
One of the big headlines from a major scientific meeting recently: The HPV vaccine not only prevents cervical cancer but reduces the risk of multiple other cancers and even pre-malignant lesions.
June 12th, 2024 — Source

Health — Cancer — June 10th, 2024

Glowing marker dye gives medics a 'second pair of eyes' during prostate cancer surgery
A glowing marker dye that sticks to prostate cancer cells could help surgeons to remove them in real-time, according to a study funded by Cancer Research UK.
June 10th, 2024 — Source

Lung cancer screening found to prolong lives in real-world study
Among US veterans diagnosed with lung cancer through the Veterans Health Administration health care system, those who underwent screening before diagnosis were more likely to be diagnosed with earlier stage disease and had a higher cure rate than those who had not been screened.
June 10th, 2024 — Source

Lung cancer screening yields early diagnoses and increased cure rates in veterans
Among US veterans diagnosed with lung cancer through the Veterans Health Administration healthcare system, those who underwent screening before diagnosis were more likely to be diagnosed with earlier stage disease and had a higher cure rate than those who had not been screened. The findings come from an observational study published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society.
June 10th, 2024 — Source

Your head aches: What could it mean, and what can be done about it
Headache in and of itself is not a common sign of a tumor, because the brain itself doesn't feel pain, said Dr. John Messmer, medical director at Penn State Health Medical Group. Though a headache might develop if a tumor is causing spinal fluid to build up, most of the time a headache is a headache.
June 10th, 2024 — Source

Health — Cancer — June 8th, 2024

Research identifies issues with booking new appointments at clinics for cancer treatment
Researchers at the University of Michigan are finding that many patients may be encountering significant barriers to cancer care, even from their first phone call to a clinic.
June 8th, 2024 — Source

Health — Cancer — June 7th, 2024

Advancements in protein engineering offer hope for cancer therapies
Cancer is one of the most devastating diagnoses that a person can receive, and it is a society-wide problem. According to the National Cancer Institute, an estimated 2,001,140 new cases of cancer will be diagnosed in the United States and 611,720 people will die from the disease this year.
June 7th, 2024 — Source

Advancing cancer tracking: DiFC detects rare cells noninvasively
In the relentless fight against cancer, a new technology promises to shed light on how we track and understand the spread of this disease within the body. A research team from Northeastern University and Dartmouth College recently developed a remarkable tool called "diffuse in vivo flow cytometry" (DiFC), which allows for the noninvasive detection and counting of rare cancer cells circulating in the bloodstream.
June 7th, 2024 — Source

Here's What to Know About Colon Cancer, Its Warning Signs and Ways to Reduce Risk
People of all ages, including young adults, should be aware of the symptoms of colorectal cancer.
June 7th, 2024 — Source

Lymphedema—a lesser-known breast cancer treatment side effect with lifelong impacts
The journey of a cancer survivor often extends far beyond the triumphant ringing of a brass bell, signaling the end of treatment. Sonya Goins received treatment at Mayo Clinic for HER-2-positive breast cancer in 2020.
June 7th, 2024 — Source or Watch Video

Researchers discover new therapeutic target for the treatment of melanoma resistant to targeted therapies
An international research team led by scientists from the University of Liège has discovered an interesting new therapeutic target for the treatment of melanoma resistant to targeted therapies. Inhibition of the VARS enzyme could prevent this therapeutic resistance by resensitizing tumors resistant to these targeted therapies.
June 7th, 2024 — Source

Researchers say resistance exercise boosts outcomes after early-stage breast cancer surgery
Early resistance exercise following surgery for early-stage breast cancer improves shoulder range of motion (ROM) and strength at one month and six months postsurgery, according to a study published online June 5 in JAMA Surgery.
June 7th, 2024 — Source

Researchers tie higher county-level prostate cancer screening to better outcomes
Higher county-level prevalence of prostate-specific antigen (PSA) screening is associated with lower odds of advanced disease, all-cause mortality, and prostate cancer-specific mortality, according to a study published online June 4 in JAMA Network Open.
June 7th, 2024 — Source

Scientists develop new CRISPR gene editing platform for precision medicine and cancer treatment
Researchers at Columbia University College of Dental Medicine have developed an exosome-based platform, "safeEXO-Cas," that significantly enhances the delivery of CRISPR/Cas9 genome editing components to specific cells and tissues.
June 7th, 2024 — Source

Targeting epigenetic enzymes in dendritic cells to improve cancer immunotherapy
Immunotherapy is one of the pillars in the fight against cancer and aims to enable the body's own immune system to fight a tumor. A recent study now shows that removing certain enzymes that regulate epigenetic processes from the so-called dentritic cells of the immune system influences their development and thus improves anti-tumor immunity. This finding could lead to new therapeutic strategies in immunotherapy.
June 7th, 2024 — Source

Types of brain tumors and treatments
A brain tumor can significantly affect a person's quality of life, not just length of life. In 2023, approximately 25,000 people living in the U.S. were diagnosed with a brain tumor. There are different types of brain tumors and ways to treat them that a health care team may consider.
June 7th, 2024 — Source

Health — Cancer — June 6th, 2024

Engineered bacteria deliver chemotherapy directly to tumors
Traditional chemotherapy often poses significant challenges, including severe side effects, damage to healthy tissue and limited efficacy.
June 6th, 2024 — Source

Enzyme research reveals why some cancer drugs cause severe side effects
Some cancer drugs cause severe side effects because they are not working accurately enough. A team at the University of Würzburg led by biochemist Caroline Kisker has now discovered why.
June 6th, 2024 — Source

Molecules derived from sea sponge show promising effects in cancer, mitochondrial function
A groundbreaking study led by the USC Leonard Davis School of Gerontology in collaboration with Dominican University of California explores how small molecules derived from sea sponges affect energy production in mitochondria and details their remarkably targeted effects on various types of cancers.
June 6th, 2024 — Source

New glioblastoma treatment reaches human brain tumor and helps immune cells recognize cancer cells
In a major advance for the treatment of the deadly brain cancer glioblastoma, Northwestern Medicine scientists have used ultrasound technology to penetrate the blood-brain barrier and provide a small dose of a chemotherapy and immunotherapy drug cocktail. The study found that this treatment boosted the immune system's recognition of the cancer cells and could lead to a new treatment approach.
June 6th, 2024 — Source

Researchers identify a key metabolic gene as target for improved cancer immunotherapy
Researchers at the VIB-KU Leuven Center for Cancer Biology have identified a potential target for cancer immunotherapy. The team, led by Professor Massimiliano Mazzone found that the CDA gene is among the top upregulated metabolic genes in immunotherapy-resistant tumors.
June 6th, 2024 — SourceSource

World-first study into precision medicine for high-risk childhood cancer yields promising results
In a world-first, Australian researchers and clinicians have shown that precision medicine—where treatment is tailored to an individual child's cancer—leads to significantly improved outcomes in children with high risk cancer.
June 6th, 2024 — Source

Health — Cancer — May 31st, 2024

Common types of skin cancer explained
Skin cancer is the most common cancer in the U.S., affecting millions worldwide. This cancer comes in two main types: melanoma, which is less common but more deadly, and non-melanoma skin cancers, which include basal cell carcinoma and squamous cell carcinoma.
May 31st, 2024 — Source

Pandemic had temporary negative effect on breast cancer screening
The COVID-19 pandemic had a transient negative effect on breast cancer screening overall and a prolonged negative effect on follow-up screening, according to a study published in the May/June issue of the Annals of Family Medicine.
May 31st, 2024 — Source

Pfizer drug extends life for people with rare form of lung cancer
A Pfizer lung cancer drug has been shown to greatly reduce tumor progression and improve survival outcomes for people in the advanced stages of a rare form of the disease, according to trial results published Friday.
May 31st, 2024 — Source

Study says stress, discrimination add to cancer burden for LGBTQ+ Americans
While LGBTQ+ people have higher risk factors for cancer, they are apt to face discrimination when in need of high-quality medical care, a new report shows.
May 31st, 2024 — Source

Study shows most doctors endorsing drugs on X are paid to do so
A team of medical researchers affiliated with several institutions in the U.S. has found that a high percentage of doctors posting endorsements regarding drugs on the social media site X were paid to do so by the makers of the drugs.
May 31st, 2024 — Source

Tackling the hurdle of tumor formation in stem cell therapies
Pluripotent stem cells (PSCs) are a type of stem cell capable of developing into various cell types. Over the past few decades, scientists have been working towards the development of therapies using PSCs. Thanks to their unique ability to self-renew and differentiate (mature) into virtually any given type of tissue, PSCs could be used to repair organs that have been irreversibly damaged by age, trauma, or disease.
May 31st, 2024 — Source

Team finds new potential causes of rare and lethal bone cancer
Little is known about the genetics and biology of chordoma, a rare and aggressive bone tumor. Chordomas occur in approximately one in a million people in the U.S. a year and 5% of these are in children. These tumors can arise anywhere along the spine in adults. However, in children, these tumors occur mostly at the base of the skull, making complete surgical removal challenging or impossible.
May 31st, 2024 — Source

Health — Cancer — May 30th, 2024

Altering cancer treatment dosing could reduce climate impact, study finds
Model estimates potential to reduce greenhouse gas emissions by delivering treatment every 6 weeks
May 30th, 2024 — Source

Cancer can be caused by reversible molecular changes, study shows
Though 1 in 2 people will develop some form of cancer in their lifetime, there's still much we don't know about this disease. But thanks to continued research efforts, we keep learning more about the biology of cancer. One of these recent discoveries could even transform our understanding of how cancers develop.
May 30th, 2024 — Source

Chicken feathers to deliver chemotherapy drugs and repair enzymes
(Nanowerk News) A new method of drug delivery using proline, an amino acid found in chicken feathers and skin tissue, could be used to limit the side effects of chemotherapy and repair important enzymes, new research suggests.
May 30th, 2024 — Source

Clinical trials: A significant part of cancer care
A cancer diagnosis is an emotional experience. Learning that you have cancer can create feelings of hopelessness, fear and sadness. This is especially true if your cancer is advanced or available treatments are unable to stop or slow its growth.
May 30th, 2024 — Source

Drugs can reduce recurrence after bowel cancer surgery, new thesis suggests
A thesis at Umeå University shows that certain non-steroidal anti-inflammatory drugs, known as NSAIDs, can help patients who have undergone surgery for colorectal cancer. These patients suffer fewer recurrences of cancer and fewer leaks at the surgical site, so-called anastomotic leakage.
May 30th, 2024 — Source

Engineered DNA 'warhead' targets a common cancer mutation
Tumor protein P53 (TP53) plays an important role in suppressing the growth of tumors. Mutations in the gene for TP53 can have a disastrous effect, hampering the body's ability to fight tumors and even encouraging their growth. Because these are the most common mutations in cancers, TP53 has long been an interesting therapeutic target.
May 30th, 2024 — Source

Existing drug alleviates symptoms of a rare genetic syndrome
A drug approved to treat certain autoimmune diseases and cancers successfully alleviated symptoms of a rare genetic syndrome called autoimmune polyendocrine syndrome type 1 (APS-1). Researchers identified the treatment based on their discovery that the syndrome is linked to elevated levels of interferon-gamma (IFN-gamma), a protein involved in immune system responses, providing new insights into the role of IFN-gamma in autoimmunity.
May 30th, 2024 — Source

Existing drug shows promise as treatment for rare genetic disorder
A drug approved to treat certain autoimmune diseases and cancers successfully alleviated symptoms of a rare genetic syndrome called autoimmune polyendocrine syndrome type 1 (APS-1). Researchers identified the treatment based on their discovery that the syndrome is linked to elevated levels of interferon-gamma (IFN-gamma), a protein involved in immune system responses, providing new insights into the role of IFN-gamma in autoimmunity.
May 30th, 2024 — Source

Killing cancer with gold nanoclusters and a trick of the light
(Nanowerk News) RIKEN chemists have demonstrated a gold nanocluster system that carries two components of a drug in a controlled ratio for maximum cancer-cell killing effect (Chemical Science, "Clickable bisreactive small gold nanoclusters for preparing multifunctionalized nanomaterials: application to photouncaging of an anticancer molecule"). The active drug remains safely masked until red light triggers its release, minimizing collateral damage to healthy cells near the tumor.
May 30th, 2024 — Source

Identifying the initial steps in colorectal cancer formation
Research provides new evidence that most colorectal cancers begin with the loss of intestinal stem cells, even before cancer-causing genetic alterations appear. The results overturn the prevailing theory for colorectal tumor initiation and suggest new ways to diagnose the disease before it has a chance to become established.
May 30th, 2024 — Source

ISS research shows spaceflight affects tumor-bearing fruit fly hosts and their parasites
Like humans, fruit flies (a model organism for spaceflight research) also exhibit immune system dysfunction in space. Despite decades of studies on fruit flies and wasps, little was known about how their immune systems interact with natural parasites in space. Drosophila parasitoid wasps modify blood cell function to suppress host immunity.
May 30th, 2024 — Source

Light-activated antitumor drug could inspire new cancer treatments that have minimal side effects
RIKEN chemists have demonstrated a gold-nanocluster system that carries two components of a drug in a controlled ratio for maximum cancer-cell killing effect. The active drug remains safely masked until red light triggers its release, minimizing collateral damage to healthy cells near the tumor. The study is published in Chemical Science.
May 30th, 2024 — Source

New chemotherapy approach for treating stomach cancer
Stomach cancer is caused by an uncontrolled growth of cells that starts in the stomach. Most stomach cancers are found when the disease has spread beyond the stomach, when a cure is less likely.
May 30th, 2024 — Source

New method advances cancer detection by counting tiny blood-circulating particles
A University of Houston researcher is reporting a new method to detect cancer which could make cancer detection as simple as taking a blood test. With a 98.7% accuracy rate, the method—which combines PANORAMA imaging with fluorescent imaging—has the potential to detect cancer at the earliest stage and improve treatment efficacy.
May 30th, 2024 — Source

New research platform assesses brain cancer mutations during surgery
Brain cancer is difficult to treat when it starts growing, and a prevalent type, known as a glioma, has a poor five-year survival rate. In a new study published in Proceedings of the National Academy of Sciences, Mayo Clinic researchers report on a new surgical platform used during surgery that informs critical decision-making about tumor treatment within minutes. Time is of the utmost importance when dealing with aggressive malignant tumors.
May 30th, 2024 — Source

Q&A: How to make sustainable products faster with artificial intelligence and automation
By modifying the genomes of plants and microorganisms, synthetic biologists can design biological systems that meet a specification, such as producing valuable chemical compounds, making bacteria sensitive to light, or programming bacterial cells to invade cancer cells.
May 30th, 2024 — Source

Q&A: Understanding protein mutations that affect gene expression to promote cancer progression
Graduate student Hillary Layden studies transcriptional control of cancer in the lab of Scott Hiebert, Hortense B. Ingram Chair in Cancer Research and professor of biochemistry.
May 30th, 2024 — Source

Scientists developing at-home swab tests for endometrial, ovarian cancer
Early detection improves treatment outcomes for endometrial and ovarian cancers, yet far too often women are diagnosed in advanced stages of these diseases. Unlike many other cancers, there are no standard screenings for early detection of endometrial and ovarian cancers. The incidence rate for endometrial cancer is expected to rise, driven by environmental factors, obesity and diabetes.
May 30th, 2024 — Source

Scientists find 'Goldilocks' binding strength determines anti-cancer T-cell efficacy and fate
Immunotherapy, treatments that reinvigorate immune cells' anti-cancer activity or reprogram T cells to target cancer, has shown promise in treating leukemias but has not yet been realized in solid tumors. One reason for the stymied success is the conversion of potential cancer-killing T cells into an inactive "exhausted" state near the tumor.
May 30th, 2024 — Source

Statins may block an inflammation pathway involved in the development of cancer
A new study led by investigators from Mass General Cancer Center, a founding member of the Mass General Brigham healthcare system, reveals that statins-;commonly used cholesterol-lowering drugs-;may block a particular pathway involved in the development of cancer that results from chronic inflammation.
May 30th, 2024 — Source

Study finds suicide rates among cancer patients are falling
Even as suicide rates have risen among Americans generally, one group appears to be bucking that trend: People diagnosed with cancer.
May 30th, 2024 — Source

Study results indicate that pitavastatin inhibits interleukin-33 to suppress skin and pancreatic cancers
A new study led by investigators from Mass General Cancer Center reveals that statins—commonly used cholesterol-lowering drugs—may block a particular pathway involved in the development of cancer that results from chronic inflammation. The findings are published in Nature Communications.
May 30th, 2024 — Source

Study reveals that gastric cancer surgery may reduce heart disease risk
Gastric cancer, also known as stomach cancer, is a highly prevalent and aggressive form of the disease that increases the risk of cardiovascular diseases. Depending on the stage of the cancer, treatment typically involves the surgical removal of cancer-affected tissue.
May 30th, 2024 — Source

Study shows cannabis terpenes may relieve chemotherapy-induced neuropathic pain
A University of Arizona Health Sciences study published in the journal Pain found that Cannabis sativa terpenes were as effective as morphine at reducing chronic neuropathic pain and a combination of the two analgesics further enhanced pain relief without negative side effects.
May 30th, 2024 — Source

Study: Access to targeted lung cancer drug is cost-prohibitive globally
Many countries with national health care systems or payers such as insurance companies use cost-effectiveness analyses to decide whether to cover new medicines, balancing treatment costs with potential health benefits.
May 30th, 2024 — Source

Valar Labs debuts AI-powered cancer care prediction tool and secures $22M
Putting AI to work in the healthcare industry is a tricky business; it"s even more so in oncology, where the stakes are especially high. Biotech startup Valar Labs is aiming high but starting small with a tool that accurately predicts certain treatment outcomes, potentially saving precious time for patients.
May 30th, 2024 — Source

Health — Cancer — May 29th, 2024

Amino acid found in chicken feathers could deliver chemotherapy drugs and repair enzymes
A new method of drug delivery using proline, an amino acid found in chicken feathers and skin tissue, could be used to limit the side effects of chemotherapy and repair important enzymes, new research suggests.
May 29th, 2024 — Source

An antibacterial protein provides a new therapeutic target against pancreatic cancer
Immunotherapy represents a new hope in the fight against cancer; however, not all tumors respond to this treatment. Pancreatic cancer is a type of tumor that does not respond to currently approved drugs and is therefore lethal for 9 out of every 10 people diagnosed.
May 29th, 2024 — Source

Antibody--peptide inhibitor conjugates: A new path for cancer therapy
Tumor cells often hijack normal physiological processes to support their growth, exploiting proteins that are in charge of essential cell functions. It is therefore important to block the activity of these proteins only in cancer cells without affecting their crucial roles in healthy tissues. For this reason, classical approaches using small molecules that induce systemic inhibition across all cells in the body can lead to severe side effects.
May 29th, 2024 — Source

Breast cancer surgeon runs a farm where the only crop is wellness
Monique Gary, a breast cancer surgeon, is a self-described "Philly girl" who was born in Jefferson Einstein hospital and graduated from Philadelphia High School for Girls.
May 29th, 2024 — Source

Combo therapy boosts survival for advanced colon cancer
People battling advanced colon cancers might have a new treatment option that could extend their survival, a new trial finds. The findings were present the at the annual meeting of the American Society of Clinical Oncology in Chicago, and should be considered preliminary until published in a peer-reviewed journal.
May 29th, 2024 — Source

Drug resistance discovery could 'move the field forward' for breast cancer treatment
Research recently published in Drug Resistance Updates has revealed a previously unknown biological process through which breast tumor cells develop resistance to standard treatment, which could open the door for cancer scientists around the world to further target this vulnerability in hopes of creating more effective therapies for disease.
May 29th, 2024 — Source

How AI can boost cancer, depression and perioperative care
IEEE Fellow Chenyang Lu shows where artificial intelligence can be deployed clinically to improve patient outcomes -- and discusses the challenges and future of AI throughout healthcare.
May 29th, 2024 — Source

Improving cell therapy by creating T-cell 'super soldiers'
A new proof-of-concept study by researchers at the Herbert Irving Comprehensive Cancer Center (HICCC) shows that changing only a single letter in the DNA code of selected genes in T cells may lead to improved cell therapy. The researchers, led by Benjamin Izar, a member of the HICCC, used novel CRISPR-dependent base editing to "supercharge" cell therapies, making them potentially more effective for more patients.
May 29th, 2024 — Source

Novel method creates antibody-peptide inhibitor conjugates with enhanced therapeutic efficacy
Tumor cells often hijack normal physiological processes to support their growth, exploiting proteins that are in charge of essential cell functions. It is therefore important to block the activity of these proteins only in cancer cells without affecting their crucial roles in healthy tissues. For this reason, classical approaches using small molecules that induce systemic inhibition across all cells in the body can lead to severe side effects.
May 29th, 2024 — Source

Researchers develop microneedle patch that can detect skin cancer early
Researchers at Karolinska Institutet have developed a new method for detecting malignant melanoma. A new type of patch equipped with microneedles can identify the biomarker tyrosinase directly in the skin, according to a study published in Advanced Materials.
May 29th, 2024 — Source

Researchers discover vaccine originally created for HIV may also combat cancer
An Oregon Health & Science University-developed platform for cytomegalovirus-based vaccines shows promise as a "shield" against cancer. The findings were recently published in the journal Science Advances.
May 29th, 2024 — Source

Researchers overturn the prevailing theory for colorectal tumor initiation
Research led by Weill Cornell Medicine provides new evidence that most colorectal cancers begin with the loss of intestinal stem cells, even before cancer-causing genetic alterations appear. The results, published on May 29 in Developmental Cell, overturn the prevailing theory for colorectal tumor initiation and suggest new ways to diagnose the disease before it has a chance to become established.
May 29th, 2024 — Source

Plasmonic nanodarts for cancer therapy and antimicrobial treatment
Developing multifunctional nanomaterials has been a long-standing goal in the field of biomedical research. Over the years, scientists have explored various strategies to engineer nanostructures that can synergistically combine different properties to address complex medical challenges.
May 29th, 2024 — Source

Health — Cancer — May 28th, 2024

Bacterial model helps reveal how our bodies prevent population explosions—and cancer
For the size of any population to remain stable over time, its birth and death rates must be balanced. If the birthrate is too high, there could be a population explosion; if it is too low, the population will shrink. This kind of balance exists, for example, among the 10,000 billion or so cells that make up our body.
May 28th, 2024 — Source

Conjugated equine estrogen may increase risk for ovarian cancer
Conjugated equine estrogen (CEE) taken alone for menopause may increase the risk for developing and dying from ovarian cancer, according to a study presented at the annual meeting of the American Society of Clinical Oncology, held from May 31 to June 4 in Chicago.
May 28th, 2024 — Source

Deep leaning technology shows potential in photodynamic therapy
In contrast to traditional cancer treatments such as surgery, chemotherapy, and radiotherapy, photodynamic therapy (PDT) is emerging as a novel method that uses specific wavelengths of light to activate photosensitizers. This activation generates reactive oxygen species that effectively destroy tumor cells.
May 28th, 2024 — Source

Effective lymph node transfer eases arm swelling in breast cancer patients
A recent study led by Dr. Zhaohua Jiang from the Shanghai Ninth People's Hospital has brought advancements in the treatment of lymphedema in breast cancer survivors. Through a procedure known as vascularized lymph node transfer (VLNT), Jiang and his team successfully demonstrated the restoration of lymphatic function in patients suffering from this painful condition.
May 28th, 2024 — Source

For some endometriosis-related ovarian cancers, timing is everything
Two types of endometriosis-related ovarian cancer arise from the same cells but likely at different stages of the menstrual cycle—a nuance that significantly influences treatment response, reports a recent study led by Van Andel Institute and University of British Columbia scientists.
May 28th, 2024 — Source

Mathematical model exploits cancer cell plasticity to guide adaptive therapy
Cancer poses significant challenges due to the development of resistance and the likelihood of relapse. Resistance may arise from permanent genetic changes in cancer cells or non-genetic alterations in cancer cell behavior induced by treatment. Standard of care in cancer treatments typically involves administering the maximum tolerated dose of a drug to eradicate drug-sensitive cells effectively.
May 28th, 2024 — Source

New approach uses 'cloaked' proteins to deliver cancer-killing therapeutics into cells
An interdisciplinary collaboration has designed a way to "cloak" proteins so that they can be captured by lipid nanoparticles, which are akin to tiny bubbles of fat. These bubbles are small enough to sneak their hidden cargo into living cells, where the proteins uncloak and exert their therapeutic effect.
May 28th, 2024 — Source

New subset of T cells may enhance cancer immunotherapy NewsGuard 100/100 Score
A team of cancer researchers, led by the University of Houston, has discovered a new subset of T cells that may improve the outcome for patients treated with T-cell therapies.
May 28th, 2024 — Source

Researchers develop mathematical model to predict effective dosage range of cancer treatment
Cancer poses significant challenges due to the development of resistance and the likelihood of relapse. Resistance may arise from permanent genetic changes in cancer cells or non-genetic alterations in cancer cell behavior induced by treatment. Standard of care in cancer treatments typically involves administering the maximum tolerated dose of a drug to eradicate drug-sensitive cells effectively.
May 28th, 2024 — Source

Specific microbial hallmarks in vagina could indicate gynecological cancers
A simple vaginal swab could reveal the presence of early-stage gynecological cancers, according to a new, wide-ranging study published in Open Life Sciences. The study is the first to assess the diagnostic potential of vaginal microbes using a large sample of women with a range of gynecological cancers, making the results generalizable across a wider population.
May 28th, 2024 — Source

Study points to new combination strategy for pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is the most common form of pancreatic cancer and is projected to become the second-leading cause of cancer-related death by 2030. Although progress has been made in improving outcomes, the five-year survival rate remains stubbornly low at just 13%.
May 28th, 2024 — Source

Study reveals circadian clock can be leveraged to enhance cancer immunotherapy
A multidisciplinary research team at the University of California, Irvine has revealed that the circadian clock—the biological pacemaker that governs daily rhythms in physiological processes, including immune functions—can be leveraged to enhance the efficacy of checkpoint inhibitor cancer therapy. Checkpoint inhibitors block different proteins from binding to tumor cells, allowing the immune system's T cells to kill the tumor.
May 28th, 2024 — Source

Study reveals pivotal role of the circadian clock in enhancing checkpoint inhibitor cancer therapy
A multidisciplinary research team at the University of California, Irvine has revealed that the circadian clock -- the biological pacemaker that governs daily rhythms in physiological processes, including immune functions -- can be leveraged to enhance the efficacy of checkpoint inhibitor cancer therapy.
May 28th, 2024 — Source

Study reveals significant link between rosacea and malignant melanoma
In a recent study published in Scientific Reports, researchers investigated if rosacea, a common skin condition widely considered to be only a cosmetic issue, could be associated with several comorbidities, including melanomas.
May 28th, 2024 — Source

Study shows overlooked lipid is connected to ancient cellular pathway with links to cancer
Within the family of cell membrane lipids known as phosphoinositides and the kinase enzymes that regulate them, phosphoinositide 3-kinases (PI3Ks) have been cast in a starring role as scientists study their involvement in cancer, diabetes and many cellular activities.
May 28th, 2024 — Source

Targeting 'monster cancer cells' could reduce recurrence rates after cancer therapy
MUSC Hollings Cancer Center researchers have unlocked a discovery that could help to explain why cancer can recur in patients who have undergone chemotherapy or radiotherapy.
May 28th, 2024 — Source

The importance of integrated therapies on cancer: Silibinin, an old and new molecule
A new review paper titled "The importance of integrated therapies on cancer: Silibinin, an old and new molecule" has been published in Oncotarget.
May 28th, 2024 — Source or Watch Video

Health — Cancer — May 27th, 2024

Had a joint replaced? Study suggests infection risk may rise after chemotherapy
If you're one of the millions of Americans walking around with a new knee or hip, your odds for an infection in that joint rise if you ever have to undergo cancer chemotherapy, researchers report.
May 27th, 2024 — Source

Living nanomedicine with hybrid bacteria and nanoparticles enhances tumor therapy
Cancer remains one of the most devastating and difficult to treat diseases, responsible for millions of deaths each year worldwide. While early screening and new targeted therapies have improved survival rates for some cancer types in recent decades, many tumors remain highly resistant to current treatments. This is often due to their ability to thrive in hypoxic environments with low oxygen deep within tumor tissues that many drugs cannot effectively reach.
May 27th, 2024 — Source

New therapy proven effective against rejection in kidney transplantation
Antibody-mediated rejection (AMR) is one of the most common causes of kidney transplant failure. To date, however, no treatment has proven effective in combating this complication in the long term.
May 27th, 2024 — Source

Osaka University to pioneer world-first clinical trial for refractory prostate cancer with alpha-ray therapy
A research team at Osaka University will start an investigator-initiated clinical trial for refractory prostate cancer patients after the successful development of a new alpha-ray therapeutic agent ([At-211] PSMA-5) and confirmation of its efficacy in animal models. This will be a world-first in-human clinical trial with [At-211] PSMA-5.
May 27th, 2024 — Source

Research indicates kidneys from deceased donors who were on dialysis are suboptimal
Receipt of a kidney from a deceased donor who underwent dialysis is associated with an increased incidence of delayed graft function, according to a study published online May 23 in JAMA.
May 27th, 2024 — Source

Sanfilippo syndrome: Research team resolves structure of crucial enzyme for the first time
For the first time, a team co-led by CHU Sainte-Justine researcher and professor in the Faculty of Medicine at Universite de Montreal, Alexey Pshezhetsky has succeeded in resolving the unique structure of the HGSNAT enzyme, a deficiency of which causes Sanfilippo syndrome, a rare pediatric disease affecting the central nervous system.
May 27th, 2024 — Source

Study examines metabolic reprogramming of breast cancer tumors during neoadjuvant chemotherapy
In a study published in Nature Communications, scientists have made significant strides in understanding the complex interplay between the immune system and cancer metabolism in breast cancer treatment. The research offers new insights into how the immune state and cancer metabolism evolve during neoadjuvant chemotherapy (NAC).
May 27th, 2024 — Source

Health — Cancer — May 24th, 2024

2024 ASCO annual meeting: Patient care takes center stage
The 2024 American Society of Clinical Oncology (ASCO) Annual Meeting is being held May 31 to June 4, 2024, in Chicago and online.
May 24th, 2024 — Source

AI might help spot breast cancer's spread without biopsy
New AI can help detect breast cancer that is spreading to other parts of the body, without the need for biopsies, a new study finds.
May 24th, 2024 — Source

Autonomous medical intervention extends 'golden hour' for traumatic injuries with emergency air transport
For the first time, a closed loop, autonomous intervention nearly quadrupled the "golden hour" during which surgeons could save the life of a large animal with internal traumatic bleeding while in emergency ground and air transport.
May 24th, 2024 — Source

Colon cancers are rising among the young: New study outlines the warning sign
Colon cancer is increasingly hitting Americans under the age of 50, and a new study outlines the warning signs that these young patients first encounter.
May 24th, 2024 — Source

Common heartburn medications may help fight cancer and other immune disorders in dogs, researchers find
Researchers at the Texas A&M School of Veterinary Medicine and Biomedical Sciences (VMBS) have discovered that proton pump inhibitors (PPIs)—medications commonly used to treat heartburn and acid reflux in people and animals—may be effective at fighting cancer and other immune disorders in dogs, building on similar ongoing research in human medicine.
May 24th, 2024 — Source

Immunotherapy-chemotherapy combo boosts survival for patients with metastatic colorectal cancer
A study led by UCLA Health Jonsson Comprehensive Cancer Center researchers found that using a combination of experimental immunotherapy drugs with chemotherapy significantly improves progression-free survival and overall survival for patients with metastatic colorectal cancer who have previously undergone standard chemotherapy treatment when compared to those who received the targeted therapy regorafenib alone.
May 24th, 2024 — Source

Liver lesions at risk of transformation into hepatocellular carcinoma in cirrhotic patients: Study
Hepatocellular carcinoma (HCC) represents a significant global health burden as one of the most common malignancies in individuals with chronic liver disease or cirrhosis. This malignancy evolves through a multistep process, beginning with dysplastic nodules (DNs) and early HCC, progressing to overt HCC.
May 24th, 2024 — Source

New advances in cancer viral immunotherapy
A new strain of vaccinia virus is able to induce so-called immunogenic cell death in tumor cells
May 24th, 2024 — Source

New mechanism of immune evasion in squamous cell carcinoma offers potential for improved treatment
A research group has revealed the tumor-extrinsic function of master regulator transcription factor-TP63 in promoting immune evasion and affecting immunotherapy efficacy in squamous cancer.
May 24th, 2024 — Source

Q&A: Quadruple therapies and the future of multiple myeloma treatment
The treatment landscape for multiple myeloma, the second most common blood cancer, is shifting rapidly, with newly diagnosed patients increasingly being treated with a four-part drug combination that includes a new immunotherapy agent.
May 24th, 2024 — Source

Rates of severe multiple drug intolerance syndrome up in fibromyalgia, IBS
Patients with fibromyalgia and irritable bowel syndrome (IBS) have increased rates of severe multiple drug intolerance syndrome (MDIS), according to a study published in the May issue of the Journal of Allergy and Clinical Immunology: In Practice.
May 24th, 2024 — Source

Research shows new treatment may enable more patients with high-risk blood cancers to receive stem cell transplants
A new treatment approach using an older drug may enable more patients with high-risk blood cancers to receive transplanted stem cells from unrelated, partially matched donors, according to a study conducted by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and colleagues.
May 24th, 2024 — Source

Tattoos could be a risk factor for lymphoma, study suggests
A new study from Lund University in Sweden suggests that tattoos could be a risk factor for cancer in the lymphatic system, or lymphoma. Now, the researchers underline the need for more research on the topic.
May 24th, 2024 — Source

Phase 1 trial for EBC-129 progresses into dose expansion
The Experimental Drug Development Centre (EDDC), Singapore's national platform for drug discovery and development, is pleased to announce that the Phase 1 trial for EBC-129 has progressed into dose expansion.
May 24th, 2024 — Source

Predicting cancer risks on the basis of national health data
Scientists are predicting individual risks for 20 different types of cancer with a high degree of accuracy. The prediction model could help to identify people with a high risk of cancer, for whom individualized early detection programs could be tested in studies.
May 24th, 2024 — Source

PKMYT1, a potential 'Achilles heel' of treatment resistant ER+ breast cancers with the poorest prognosis
Up to 80% of breast cancer deaths occur in patients with tumors that express estrogen receptor-alpha. Although these estrogen receptor-positive (ER+) breast cancers often initially respond to standard treatment that combines endocrine therapies with CDK4/6 inhibitors, drug resistance often develops leading to lethal metastatic disease that spreads from the breast and does not respond to available treatments.
May 24th, 2024 — Source

Possible association between tattoos and lymphoma revealed
Our knowledge regarding the long-term health effects of tattoos is currently poor, and there is not a lot of research within this area. Now a research group at Lund University has investigated the association between tattoos and lymphoma.
May 24th, 2024 — Source

Scientists uncover new treatment pathway for rare 'spider web' childhood brain tumors
Researchers have identified the unique features of an exceptionally rare set of childhood brain tumors—a discovery that could pave the way for more effective treatments.
May 24th, 2024 — Source

Study identifies differences in prostate cancer genomics among a racially and ethnically diverse cohort of US veterans
A new study led by a UCLA-VA collaborative team looking at the landscape of genomic alterations in more than 5,000 veterans with metastatic prostate cancer uncovered differences in the genomic makeup of cancer cells that were associated with race and ethnicity.
May 24th, 2024 — Source

Update on the STING signaling pathway in developing nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver condition worldwide, affecting about 25% of the global population due to the increasing rates of obesity and metabolic syndrome. NAFLD encompasses a spectrum of liver conditions ranging from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH), which can progress to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC).
May 24th, 2024 — Source

Virtual scribes reduce physicians' time spent on electronic health records
A team, led by Lisa Rotenstein, MD, of the Department of Medicine at Brigham and Women's Hospital, sought to understand the impact of virtual scribes (human scribes who are not physically present in the exam room with the physician and patient) on how physicians spend their time and which characteristics are associated with physicians responding best to scribes.
May 24th, 2024 — Source

What is a virtual emergency department? And when should you 'visit' one?
For many Australians the emergency department (ED) is the physical and emblematic front door to accessing urgent health-care services.
May 24th, 2024 — Source

Health — Cancer — May 23rd, 2024

AI enabled body composition analysis predicts outcomes for patients with lung cancer treated with immunotherapy
Tafadzwa Chaunzwa, MD, a researcher in the Artificial Intelligence in Medicine (AIM) Program at Mass General Brigham and a senior resident physician at the Harvard Radiation Oncology Program, is the lead author of a paper published in JAMA Oncology.
May 23rd, 2024 — Source

Inhibiting a metabolic pathway provides new approach to Epstein-Barr virus and resulting diseases
The Epstein-Barr virus can cause a spectrum of diseases, including a range of cancers. Emerging data now show that inhibition of a specific metabolic pathway in infected cells can diminish latent infection and therefore the risk of downstream disease, as reported by researchers from the University of Basel and the University Hospital Basel in the journal Science.
May 23rd, 2024 — Source

Low-income teens at higher risk of obesity: WHO
Teens from less affluent families in Europe are at greater risk of obesity, inactivity and poor diet, which are risk factors for cancer, cardiovascular disease and diabetes, the WHO said Thursday.
May 23rd, 2024 — Source

Most young women treated for breast cancer can have children, study shows
New research by Dana-Farber Cancer Institute investigators has encouraging news for young women who have survived breast cancer and want to have children.
May 23rd, 2024 — Source

Propensity score matching offers more efficient biomarker discovery in cancer research
Thanks to advances in molecular sequencing, scientists have generated a wealth of data from the genome, transcriptome, proteome and metabolome. However, these "-omics" datasets are complex and there is currently no standard method for parsing through the data to separate specific biomarkers from possibly confounding variables.
May 23rd, 2024 — Source

Quantitative imaging reveals collagen changes in melanoma tumors during immunotherapy
Collagen, a major component of the extracellular matrix, plays a crucial role in tumor development. During the development of tumors ("tumorigenesis"), collagen fibers become linearized and densely deposited, hindering immune cell infiltration and promoting tumor metastasis. However, quantifying these collagen changes during melanoma progression has been challenging.
May 23rd, 2024 — Source

Review: Clinical management of thyroid nodules with atypia of undetermined significance
Fine needle aspiration cytology (FNAC) is a cost-efficient technique for the management of thyroid nodules. Changes in the World Health Organization classification of thyroid tumors can influence reliability of cytology. The 2023 Bethesda System for Reporting Thyroid Cytopathology has adapted cytological nomenclature to these changes. The aim of this paper was to review the management of atypia of undetermined significance (AUS) in our institution.
May 23rd, 2024 — Source

Scientists predict cancer risk on the basis of national health data
Scientists from EMBL's European Bioinformatics Institute (EMBL-EBI) and the German Cancer Research Center (DKFZ) have used Danish health registries to predict individual risks for the 20 most common types of cancer.
May 23rd, 2024 — Source

Study finds no significant survival benefit from participating in cancer clinical trials
In a recent study published in JAMA, researchers determined whether patient involvement in cancer trials is associated with improved survival rates compared to regular therapy.
May 23rd, 2024 — Source

Study further illuminates ability of cancer drug to lower blood sugar
University of Oklahoma researchers have deepened their understanding of a drug's ability to prevent fat buildup in the liver, a condition that often occurs with obesity and can lead to serious fatty liver disease. Their findings—which illustrate the complexity of metabolic disorders—are published in The Proceedings of the National Academy of Sciences.
May 23rd, 2024 — Source

Study: Surgical intervention improves quality of life for patients with acoustic neuroma
Researchers at University of California San Diego School of Medicine found that using an innovative surgical approach to remove an acoustic neuroma, a slow-growing, benign brain tumor, improved hearing preservation and quality of life for patients while also presenting excellent facial nerve outcomes.
May 23rd, 2024 — Source

Tumor mutations may not predict response to immunotherapy, study finds
The number of mutations in the DNA of cancerous tumors may not be an indicator of how well patients will respond to immune checkpoint inhibitors (ICIs), a commonly prescribed type of immunotherapy, a team led by UT Southwestern Medical Center researchers reported in a retrospective study.
May 23rd, 2024 — Source

Who's to blame when AI makes a medical error?
In the realm of gastrointestinal (GI) endoscopy, artificial intelligence (AI) is becoming an essential tool, especially in the computer-aided detection of precancerous colon polyps during screening colonoscopy. This integration marks a significant advancement in gastroenterology care. However, the inevitability of errors persists, and in some cases, AI algorithms themselves could contribute to medical errors.
May 23rd, 2024 — Source

Health — Cancer — May 21st, 2024

Biden leans into health care, asking voters to trust him over Trump NewsGuard 100/100 Score
Angling to tap into strong support for the sweeping health law he helped pass 14 years ago, one of President Joe Biden's latest reelection strategies is to remind voters that former President Donald Trump tried to repeal the Affordable Care Act.
May 21st, 2024 — Source

Clarifying the cellular mechanisms underlying periodontitis with an improved animal model
Tokyo Medical and Dental University (TMDU) researchers have developed a technique that allows a detailed analysis of periodontitis development over time.
May 21st, 2024 — Source

Cyberattack forces Michigan hospitals to switch to paper documentation, divert some patients elsewhere
A cyberattack against Michigan Ascension hospitals continues to cause issues, forcing it to divert some ambulances to other hospitals for certain medical issues, delay diagnostic imaging and affecting its ability to fill prescriptions.
May 21st, 2024 — Source

High Price of Popular Diabetes Drugs Deprives Low-Income People of Effective Treatment
For the past year and a half, Tandra Cooper Harris and her husband, Marcus, who both have diabetes, have struggled to fill their prescriptions for the medications they need to control their blood sugar.
May 21st, 2024 — Source

Latest advances in gastric cancer and other cancer-related studies to be presented at DDW 2024
Cancer-related studies, including a diagnostic tool for gastric cancer and trends in gallbladder and colorectal cancers, will be presented this week at Digestive Disease Week (DDW) 2024. Abstracts are available to registered media, and press releases are available where noted. Studies are embargoed until 12:01 a.m. EDT the day of presentation, unless otherwise noted.
May 21st, 2024 — Source

Listen to the Latest ‘KFF Health News Minute"
This week on the KFF Health News Minute: A 1930s law is keeping cutting-edge sunscreen off the shelf in the United States, and survivors of gun violence often have to decide what to do with the bullets still in their bodies.
May 21st, 2024 — Source

Lung cancer study offers further evidence on importance of screening
Researchers from the University of Liverpool and Queen Mary University of London have published the first study in the UK to demonstrate the benefits of lung cancer screening across socioeconomic groups. Evidence in the new study illustrates the value and importance of screening, especially for those who live in areas of economic deprivation.
May 21st, 2024 — Source

New discovery could lead to a treatment for visceral leishmaniasis
Leishmaniasis is a tropical disease affecting a growing number of people worldwide. Each year, between 700,000 and 1 million new cases are reported. Caused by a protozoan parasite of the genus Leishmania, which is transmitted to humans by the simple bite of a sand fly, leishmaniasis comprises three clinical forms, of which the visceral form is the most serious. If left untreated, visceral leishmaniasis, also known as black fever, is almost always fatal. Most cases occur in Bangladesh, Brazil, Ethiopia, India, Nepal, and Sudan.
May 21st, 2024 — Source

No association found for autoimmune disease, monoclonal gammopathy
In a systematically screened population, there is no association between autoimmune disease and monoclonal gammopathy of undetermined significance (MGUS), according to a study published online May 21 in the Annals of Internal Medicine.
May 21st, 2024 — Source

Nursing homes wield pandemic immunity laws to duck wrongful death suits
In early 2020, with reports of COVID-19 outbreaks making dire headlines, Trever Schapers worried about her father's safety in a nursing home in Queens.
May 21st, 2024 — Source

Pandemic agreement would not infringe state sovereignty: WHO
A global agreement on pandemic prevention, preparedness and response, which is still in negotiation, would not encroach on state sovereignty, the World Health Organization insisted Tuesday.
May 21st, 2024 — Source

Promising results of helium plasma jet therapy: Ruptured Achilles tendon shows faster repair
What is the largest ligament in the human body? It might surprise some people that it is the Achilles tendon. Even though it is also considered the toughest ligament, the Achilles tendon can rupture, with many such injuries involving sports enthusiasts in their 30s or 40s. Surgery might be required, and a prolonged period of rest, immobilization, and treatment can be difficult to endure.
May 21st, 2024 — Source

Researchers develop wireless electronic suture for postoperative long-term monitoring of soft tissue
A research team led by Professor Jaehong Lee of the Department of Robotics and Mechanical Electronics (DGIST) has developed a new human implantable, wireless, health monitoring electronic suture system through joint research with a team from Yonsei University and Korea University. The developed wireless electronic suture can be easily applied in the medical field and is expected to be used in various orthopedic fields, such as patient-customized rehabilitation.
May 21st, 2024 — Source

Senator urges Biden administration to thwart fraudulent Obamacare enrollments
Stronger actions are needed immediately to thwart insurance brokers who fraudulently enroll or switch people in Affordable Care Act coverage, Sen. Ron Wyden, chairman of the powerful Senate Finance Committee, said Monday.
May 21st, 2024 — Source or Source

'Space at your fingertips': Research unlocks the potential of touch for 3D spatial perception
A study published in iScience from researchers from the Ivcher Institute for Brain, Cognition, and Technology at Reichman University offers a new perspective towards the plasticity of the brain, and integration of the senses, paving the way for the enhancement of prosthetics and assistive technologies, and even our interactions with virtual and augmented realities.
May 21st, 2024 — Source

Strengthening health systems through surgery
Surgeons must provide leadership in transforming health care across the Global South—by integrating surgery into the global health agenda and advocating for simple and cost-effective surgical procedures that support overall health system strengthening.
May 21st, 2024 — Source

Swiss startup creates modular device for on-demand cell therapy manufacturing
Limula has raised $6.8mn seeking to make cell therapies more accessible
May 21st, 2024 — Source

The Cedars-Sinai AI story, from primary care to dataset training
The health system"s Cedars-Sinai Connect primary care application has been especially effective, says CIO Craig Kwiatkowski, who describes how he measures an app"s success and how his team is protecting against AI biases.
May 21st, 2024 — Source

WA injects $133M for state EMR, IT infra and more briefs
Also, an approval management functionality has been added to NSW's real-time prescription monitoring platform.
May 21st, 2024 — Source

Wellstar Health adds secure check-in through Epic
Integration with the Clear identity platform in electronic health records enables the Georgia health system to roll out streamlined patient registration and on-site check-ins via selfies at kiosks.
May 21st, 2024 — Source

What to expect during rehab after hip replacement
Hip replacement is a major, arduous elective surgery, and rehabilitation afterwards takes time, according to an expert from Johns Hopkins Medicine in Baltimore.
May 21st, 2024 — Source

Health — Cancer — May 17th, 2024

Anti-diabetic treatment associated with reduced risk of developing blood cancer
People who use metformin are less likely to develop a myeloproliferative neoplasm (MPN) over time, indicating that the treatment may help prevent the development of certain types of cancers, according to a study published in Blood Advances.
May 17th, 2024 — Source or Source

FDA approves new drug for deadly lung cancer
The U.S. Food and Drug Administration on Thursday approved a new drug to treat patients with an advanced form of deadly lung cancer.
May 17th, 2024 — Source

Gut bacteria enhance cancer immunotherapy in mouse study
Roughly one in five cancer patients benefit from immunotherapy—a treatment that harnesses the immune system to fight cancer. Such an approach to beating cancer has seen significant success in lung cancer and melanoma, among others. Optimistic about its potential, researchers are exploring strategies to improve immunotherapy for cancers that don't respond well to the treatment, with the hope of benefiting more patients.
May 17th, 2024 — Source

New guideline: Barrett's esophagus precedes esophageal cancer, but not all patients need abnormal cell removal
The American Gastroenterological Association's (AGA) new evidence-based Clinical Practice Guideline on Endoscopic Eradication Therapy of Barrett's Esophagus and Related Neoplasia, published today in Gastroenterology, establishes updated guidance for Barrett's esophagus patients.
May 17th, 2024 — Source

Novel genetic mechanisms may serve as therapeutic target against glioma
A study from the laboratory of Shi-Yuan Cheng, Ph.D., professor in the Ken and Ruth Davee Department of Neurology's Division of Neuro-oncology, has identified novel mechanisms underlying RNA splicing events within glioma tumor cells, mechanisms which may serve as novel therapeutic targets, according to findings published in the Journal of Clinical Investigation.
May 17th, 2024 — Source

Novel Nanobiocomposite: Agar-Tragacanth/Silk Fibroin Hydrogel Loaded with Zn-Based MOF
In a recent article published in the journal Scientific Reports, researchers present a novel nanobiocomposite (NBC) made of agar, tragacanth gum, silk fibroin, and metal--organic framework-5 (MOF-5) for potential biomedical applications. The hydrogel was investigated for its biological activity, including antimicrobial properties and potential for cancer therapy and wound healing.
May 17th, 2024 — Source

Polyglycerol Coatings: A Pathway to Eco-Friendly Nanoparticles
A research team headed by Assistant Professor Yajuan Zou and Research Professor Masazumi Fujiwara of Okayama University in Japan has created a polymer coating that can be applied to NPs to minimize ecotoxicity, according to a study published in the journal Chemosphere
May 17th, 2024 — Source

Proteins in the blood could warn people of cancer more than seven years before it is diagnosed
In a recent study published in Nature Communications, researchers from the United Kingdom (UK) investigated associations between 1,463 plasma proteins and 19 cancers, using observational and genetic approaches in participants of the UK Biobank. They found 618 protein-cancer associations and 317 cancer biomarkers, which included 107 cases detected over seven years before the diagnosis of cancer.
May 17th, 2024 — Source

Research finds the protein VISTA directly blocks T cells from functioning in immunotherapy
A Cleveland Clinic-led team of scientists and physicians have discovered that the immune checkpoint protein VISTA can directly turn off tumor-fighting T-cells during immunotherapy and resist treatment.
May 17th, 2024 — Source

Research team develops new AI tool to help classify brain tumors
A new AI tool to more quickly and accurately classify brain tumors has been developed by researchers at The Australian National University (ANU).
May 17th, 2024 — Source

Researchers make strides in microbiome-based cancer therapies via iron deprivation in the tumor microenvironment
A team from POSTECH and ImmunoBiome has made a potential breakthrough in the fight against cancer. Their research, published in the May issue of Nature Immunology, explores a dietary-derived bacterial strain, IMB001. This strain induces "nutritional immunity" to boost anti-tumor responses. This discovery sheds light on how microbial therapies work and opens doors for their use in clinical settings.
May 17th, 2024 — Source

Health — Cancer — May 14th, 2024

Adiposity in childhood affects the risk of breast cancer by changing breast tissue composition, study suggests
Breast cancer is the most common cancer in women worldwide. With rates continuing to rise, there is an urgent need to identify new modifiable breast cancer risk factors. New research led by the University of Bristol suggests that higher adiposity in childhood leads to less dense breast tissue forming, which results in a reduced breast cancer risk. However, further research is needed to understand the mechanism of the overall protective effect of childhood adiposity to identify new targets for intervention and prevention.
May 14th, 2024 — Source

Cowpea Mosaic Virus Nanoparticles Show Promise in Preventing Metastatic Cancers
An experimental treatment made from a plant virus is effective at protecting against a broad range of metastatic cancers in mice, shows a new study from the University of California San Diego.
May 14th, 2024 — Source

Exploring how intense ultrasound can release biological indicators of disease
Ultrasound imaging offers a valuable and noninvasive way to find and monitor cancerous tumors. However, much of the most crucial information about a cancer, such as specific cell types and mutations, cannot be learned from imaging and requires invasive and damaging biopsies. One research group developed a way to employ ultrasound to extract this genetic information in a gentler way.
May 14th, 2024 — Source

Medicaid 'Unwinding' Decried as Biased Against Disabled People
Jacqueline Saa has a genetic condition that leaves her unable to stand and walk on her own or hold a job. Every weekday for four years, Saa, 43, has relied on a home health aide to help her cook, bathe and dress, go to the doctor, pick up medications, and accomplish other daily tasks.
May 14th, 2024 — Source

New research identifies a larger pool of genes involved in age-related blood cell mutations than previously thought
Scientists have discovered 17 additional genes that drive the abnormal overgrowth of mutated blood cells as we age. The findings, published 14 May in Nature Genetics, provide a more complete view of the genetic factors behind clonal hematopoiesis—a process associated with aging and linked to increased risks of blood cancers.
May 14th, 2024 — Source

Nursing Homes Wield Pandemic Immunity Laws To Duck Wrongful Death Suits
In early 2020, with reports of covid-19 outbreaks making dire headlines, Trever Schapers worried about her father's safety in a nursing home in Queens.
May 14th, 2024 — Source

Petroleum and chlorine mix in water could yield harmful byproducts, says new study
A new study from the University of Hawaiʻi at Mānoa shows that chlorine mixed with petroleum in water can potentially produce inadvertent byproducts harmful to human health. The research is published in the journal Chemosphere.
May 14th, 2024 — Source

Prostate cancer study: More health benefits from plant-based diet
Men with prostate cancer could significantly reduce the chances of the disease worsening by eating more fruits, vegetables, nuts, and olive oil, according to new research.
May 14th, 2024 — Source

Stem cells provide new insight into genetic pathway of childhood cancer
Scientists have discovered a new insight into the genetic pathway of childhood cancer, offering new hope for tailored treatments.
May 14th, 2024 — Source

Health — Cancer — May 13th, 2024

A blood test to help detect lung cancer? New test offered at 18 locations
Julie Harris had never been tested for lung cancer. A low-dose CT scan, the only recommended screening for adults at risk of developing lung cancer, was not something she'd ever found time to do.
May 13th, 2024 — Source

Cancer and COVID drove patient to double-lung transplant
Chicago resident Arthur "Art" Gillespie fell ill in early March 2020 with COVID, after he and his father went to visit an uncle in a nursing facility.
May 13th, 2024 — Source

How obesity and metabolic syndrome affects women's risks of breast cancer and cancer-related death
In the Women's Health Initiative (WHI) randomized trial, a low-fat diet reduced breast cancer mortality, especially in women with more metabolic syndrome (MetS) components (obesity, high blood pressure, elevated blood sugar, and abnormal cholesterol). An analysis of WHI findings indicates that MetS and obesity each have different associations with breast cancer subtypes and mortality risk. The findings are published in the journal Cancer.
May 13th, 2024 — Source

Intense ultrasound extracts genetic info for less invasive cancer biopsies
Ultrasound imaging offers a valuable and noninvasive way to find and monitor cancerous tumors. However, much of the most crucial information about a cancer, such as specific cell types and mutations, cannot be learned from imaging and requires invasive and damaging biopsies. One research group developed a way to employ ultrasound to extract this genetic information in a gentler way.
May 13th, 2024 — Source

Nanoparticle plant virus treatment shows promise in fighting metastatic cancers in mice
An experimental treatment made from a plant virus is effective at protecting against a broad range of metastatic cancers in mice, according to a new study from the University of California San Diego.
May 13th, 2024 — Source

New insights into Chaga mushroom's mechanisms for fighting oral cancer NewsGuard 100/100 Score
In a recent study published in Scientific Reports, researchers investigated the mechanisms behind the anti-tumor activity of Chaga mushroom extracts in HSC-4 human oral cancer cells.
May 13th, 2024 — Source

New method unravels the mystery of slow electrons
Slow electrons are used in cancer therapy as well as in microelectronics. It is very hard to observe how they behave in solids. But scientists at TU Wien have made this possible.
May 13th, 2024 — Source

Plant virus based nanoparticles show promise against metastatic cancer in mice
An experimental treatment made from a plant virus is effective at protecting against a broad range of metastatic cancers in mice, shows a new study from the University of California San Diego.
May 13th, 2024 — Source or Source

Study reveals latest cancer trends in Canada
The number of cancer cases and deaths in Canada is expected to increase because of a growing and aging population, but the overall rates of people being diagnosed with and dying from cancer will continue to decline, according to the latest cancer trends research in CMAJ (Canadian Medical Association Journal)
May 13th, 2024 — Source

Therapeutic opportunities for hypermutated urothelial carcinomas beyond immunotherapy
In an editorial, in Oncoscience titled "Therapeutic opportunities for hypermutated urothelial carcinomas beyond immunotherapy," researcher Ioannis A. Voutsadakis from Sault Area Hospital and Northern Ontario School of Medicine discuss tumor mutation burden (TMB)—a novel clinical biomarker for prediction of checkpoint inhibitor immunotherapy response across cancers.
May 13th, 2024 — Source

Variations in 'ancient' immune cells linked to patients' survival in cancer
Researchers from the Cancer Science Institute of Singapore (CSI) at the National University of Singapore (NUS), have achieved breakthroughs in understanding relapse after chemotherapy for a type of cancer known as diffuse large B-cell lymphoma (DLBCL).
May 13th, 2024 — Source

Health — Cancer — May 11th, 2024

Mainz Biomed to unveil breakthrough early cancer detection study results at DDW 2024
Mainz Biomed N.V., a molecular genetics diagnostic company specializing in the early detection of cancer, will present an analysis from its eAArly DETECT study at Digestive Disease Week (DDW) 2024 in Washington D.C. from May 18th to May 21st. DDW is recognized as a premier forum for the latest advancements in gastroenterology, hepatology, endoscopy, and gastrointestinal surgery.
May 11th, 2024 — Source

Health — Cancer — May 10th, 2024

Cancer patients often face medical debt, even with insurance
When cancer strikes, you could easily go into debt, even with health insurance in place, according to a new survey from the American Cancer Society.
May 8th, 2024 — Source

Combination of breast cancer and chemotherapy may speed up physical decline in older adults
A UCLA-led study suggests that women who are 65 years old or older with high-risk breast cancer and are treated with chemotherapy are more likely to develop a substantial decline in physical function.
May 8th, 2024 — Source

ERR-gamma 'trains' stomach stem cells to become acid-producing cells
Researchers have identified molecular and genetic pathways that direct the generation and maturation of parietal cells, the only cells in the body that produce acid, from stem cells. The findings can lead to new strategies to regulate parietal cell function in different diseases involving these cells, including autoimmune gastritis and stomach and esophageal cancers.
May 8th, 2024 — Source

FDA-approved TIVDAK®: Targeting tissue factor in cervical cancer
On April 29th, 2024, the U.S. FDA granted full approval for Seagen Inc.'s TIVDAK® (tisotumab vedotin) targeting tissue factor (TF) for the treatment of patients with recurrent or metastatic cervical cancer who have progressed on or after chemotherapy. This marks a significant advancement in the therapeutic landscape for cervical cancer, highlighting the potential of antibody-drug conjugates (ADCs) in oncology.
May 8th, 2024 — Source

Frequent salt addition at the table increases gastric cancer risk by 41%
In a recent study published in Gastric Cancer, researchers investigated how frequently people in the United Kingdom add salt to their food at the table and how this relates to their risk of developing stomach cancer.
May 8th, 2024 — Source

Outdoor workers face skin cancer danger
Steve Murray, 68, has spent a lot of time out in the sun, at work and at play.
May 8th, 2024 — Source

Melanoma in darker skin tones
Melanoma, an aggressive form of skin cancer that accounts for 75% of all skin-cancer-related deaths, is often detected later in people with darker skin complexions -- and the consequences can be devastating, a new study reveals.
May 8th, 2024 — Source or Source

Racial, ethnic differences seen in breast cancer treatment declination
For patients with breast cancer, there are racial and ethnic differences in treatment declination, according to a study published online May 9 in JAMA Network Open.
May 8th, 2024 — Source

Scientists make progress on new charged particle therapy for cancer
ANSTO researchers have made significant progress on a new approach to cancer treatment Neutron Capture Enhanced Particle Therapy (NCEPT), which has the potential to improve outcomes for patients with deeply situated, diffuse tumors.
May 8th, 2024 — Source

Study points to personalized treatment opportunities for glioblastoma
A study appearing in Cancer Cell uncovers the evolutionary dynamics of glioblastoma recurrence through proteogenomic analysis, offering potential therapeutic avenues.
May 8th, 2024 — Source or Source

Treating breast cancer through surgery
Globally, 2.3 million women are diagnosed with breast cancer every year, according to the World Health Organization. Advances in treating breast cancer are improving care and quality of life.
May 8th, 2024 — Source

Using MRI, engineers have found a way to detect light deep in the brain
Scientists often label cells with proteins that glow, allowing them to track the growth of a tumor, or measure changes in gene expression that occur as cells differentiate.
May 8th, 2024 — Source

Health — Cancer — May 8th, 2024

Geology Finds a Role in Cancer Research
Normally used to study Earth's history, hydrogen isotopes—and the techniques used to spot them—are now cluing scientists in to early signs of cancer.
May 8th, 2024 — Source

Researchers discover new target for potential leukemia therapy
A team of Dana-Farber Cancer Institute investigators discovered that a subset of myeloid and lymphoid leukemias depend on a molecular complex called PI3Kgamma for survival. The study provides both mechanistic and preclinical evidence supporting the rapid initiation of clinical trials for patients with acute myeloid leukemia (AML) to test an existing medicine that inhibits the complex, called eganelisib, both alone and in combination with the most used AML chemotherapy, cytarabine.
May 8th, 2024 — Source

Scientists unravel how psychedelic drugs interact with serotonin receptors to potentially produce therapeutic benefits
Researchers at the Icahn School of Medicine at Mount Sinai have shed valuable light on the complex mechanisms by which a class of psychedelic drugs binds to and activates serotonin receptors to produce potential therapeutic effects in patients with neuropsychiatric disorders such as depression and anxiety.
May 8th, 2024 — Source

Health — Cancer — May 7th, 2024

AI predicts tumor-killing cells with high accuracy, study shows
Using artificial intelligence, Ludwig Cancer Research scientists have developed a powerful predictive model for identifying the most potent cancer-killing immune cells for use in cancer immunotherapies.
May 7th, 2024 — Source

Amgen plows ahead with costly, highly toxic cancer dosing despite FDA challenge
When doctors began using the drug sotorasib in 2021 with high expectations for its innovative approach to attacking lung cancer, retired medical technician Don Crosslin was an early beneficiary. Crosslin started the drug that July. His tumors shrank, then stabilized.
May 7th, 2024 — Source

Breakthrough Nanoparticle Targets Breast Cancer and Brain Tumors
In a recent study published in Proceedings of the National Academy of Sciences, scientists at the University of Miami Miller School of Medicine's Sylvester Comprehensive Cancer Center developed a nanoparticle that can deliver drugs to both breast tumors and brain metastases by crossing the blood-brain barrier.
May 7th, 2024 — Source

Dogma-challenging telomere findings may offer new insights for cancer treatments
A new study led by University of Pittsburgh and UPMC Hillman Cancer Center researchers shows that an enzyme called PARP1 is involved in repair of telomeres, the lengths of DNA that protect the tips of chromosomes, and that impairing this process can lead to telomere shortening and genomic instability that can cause cancer.
May 7th, 2024 — Source

Future research on bladder cancer should focus on mechanical changes in tissue, suggest study
In collaboration with University Hospital Basel, researchers from ETH are investigating the early stages of bladder cancer. Their findings show that future research should also focus on mechanical changes in tumor tissue.
May 7th, 2024 — Source

How the drug abemaciclib treats breast cancer
The anti-cancer drug abemaciclib (also known as Vernezio) has been added to the Australian Pharmaceutical Benefits Scheme (PBS) to treat certain types of breast cancer.
May 7th, 2024 — Source

How TP53 gene loss drives gastric cancer evolution
Gastric cancer (GC) ranks as the fifth-most common and fourth-deadliest cancer worldwide, presenting significant health challenges, particularly in China, where it is most prevalent and accounts for nearly half of newly diagnosed and death cases. In addition to somatic mutations, the complex pathology of GC is also determined by exposure to external factors like dietary and microorganisms such as Helicobacter pylori, Streptococcus anginosus, and Candida albicans.
May 7th, 2024 — Source

New PET agent provides same-day imaging for clear cell renal cell carcinoma patients
A novel investigational PET imaging agent can rapidly and accurately visualize lesions in clear cell renal cell cancer (ccRCC) patients according to new research published in the May issue of The Journal of Nuclear Medicine.
May 7th, 2024 — Source

Laboratory and natural strains of intestinal bacterium turn out to have similar mutational profiles
Understanding mutational processes in a cell offers clues to the evolution of a genome. Most actively, mutation processes are studied in human cancer cells, while other genomes are often neglected.
May 7th, 2024 — Source

Mouse study shows intermittent fasting protects against liver inflammation and liver cancer
Fatty liver disease often leads to chronic liver inflammation and can even result in liver cancer. Scientists from the German Cancer Research Center (DKFZ) and the University of Tübingen have now shown in mice that intermittent fasting on a 5:2 schedule can halt this development.
May 7th, 2024 — Source

Research shows altered regulation of genes linked to prostate cancer among firefighters
Firefighters may have an increased risk of prostate cancer due to on-the-job chemical exposures, according to new research from the University of Arizona Mel and Enid Zuckerman College of Public Health and University of Michigan in collaboration with fire service partners and researchers around the country through the Fire Fighter Cancer Cohort Study.
May 7th, 2024 — Source

Researchers study the intricacies of homologous recombination and abnormal chromosome bridges
Keeping the genetic information stored in genomic DNA intact during the cell division cycle is crucial for almost all lifeforms. Extensive DNA damage invariably causes various adverse genomic rearrangements, which can lead to cell death in the best cases and to the occurrence of diseases like cancer in the worst cases.
May 7th, 2024 — Source

Researchers use foundation models to discover new cancer imaging biomarkers
Researchers have harnessed the technology behind foundation models, which power tools like ChatGPT, to discover new cancer imaging biomarkers that could transform how patterns are identified from radiological images. Improved identification of such patterns can greatly impact the early detection and treatment of cancer.
May 7th, 2024 — Source or Source

Study sheds light on cancer cell 'tug-of-war'
Understanding how cancerous cells spread from a primary tumor is important for any number of reasons, including determining the aggressiveness of the disease itself. The movement of cells into the extracellular matrix (ECM) of neighboring tissue is an essential step in cancer progression that directly correlates to the onset of metastasis.
May 7th, 2024 — Source

Telehealth program created to improve access to specialty care found to reduce reliance on opioids in pain management
More Americans suffer from chronic pain than diabetes, heart disease, and cancer combined. Yet, a shortage of pain medicine specialists persists, causing many pain sufferers to seek care in primary care settings.
May 7th, 2024 — Source

Transfected SARS-CoV-2 spike DNA suppresses cancer cell response to chemotherapy
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and COVID-19 infection has led to worsened outcomes for patients with cancer. SARS-CoV-2 spike protein mediates host cell infection and cell-cell fusion that causes stabilization of tumor suppressor p53 protein. In-silico analysis previously suggested that SARS-CoV-2 spike interacts with p53 directly but this putative interaction has not been demonstrated in cells.
May 7th, 2024 — Source

US geographic region results in vastly different anal cancer risk for people with HIV
A new study that followed a cohort of more than 110,000 people establishes significant disparities in the risk of anal cancer for people with HIV and for men who have sex with men with HIV, depending on the region of the country they live in.
May 7th, 2024 — Source

Years after his death, late scientist's work could yield new cancer treatments
Some of the final work of a late University of Virginia School of Medicine scientist has opened the door for life-saving new treatments for solid cancer tumors, including breast cancer, lung cancer and melanoma.
May 7th, 2024 — Source

Health — Cancer — May 3rd, 2024

Combined therapy makes headway for liver cancer
A drug that targets a protein known as phosphatidylserine boosted the response rate for hepatocellular carcinoma (HCC) patients receiving immunotherapy without compromising their safety, according to results of a phase two clinical trial conducted by UT Southwestern Medical Center.
May 3rd, 2024 — Source

Drug targeting RNA modifications shows promise for treating neuroblastoma
Neuroblastoma is a common pediatric cancer that originates in developing nerve cells outside the brain. While increasingly intensive treatments have improved the survival of patients with high-risk neuroblastoma, currently more than 40% of patients do not survive.
May 3rd, 2024 — Source

Gene expression and bioinformatics tools to optimize cancer therapy
In the field of biomedical research and genomics, the advancement of bioinformatics technologies and tools is opening new frontiers in the understanding of diseases and their diagnosis and treatment. In particular, differential gene expression analysis (DGE) is emerging as a crucial technique to investigate the molecular mechanisms underlying diseases.
May 3rd, 2024 — Source

How cancer cells harness energy to drive disease progression
Researchers have revealed crucial insights into how the Warburg effect causes the dedifferentiation of cancer cells through epigenetic reprogramming. This discovery potentially opens up new avenues for cancer treatments that target cellular metabolism.
May 3rd, 2024 — Source

Lymphocytes recruit the immune system to fight most aggressive breast cancer, study confirms
Researchers at the UAB and the Hospital del Mar Research Institute have confirmed that patients with the presence of NK lymphocytes around tumors have a better response to treatment. This confirms the feasibility of using cytokines secreted by NK cells as markers of response to treatment with a simple blood test and supports the use of these lymphocytes to reinforce treatment in patients with metastatic HER2-positive breast cancer.
May 3rd, 2024 — Source

New approach for developing cancer vaccines could make immunotherapies more effective in acute myeloid leukemia
Acute myeloid leukemia (AML) is a type of blood cancer that forms in the soft marrow of the bones, typically attacking cells that would otherwise form the key component of the body's immunodefense system, white blood cells.
May 3rd, 2024 — Source

New immunosuppressive mechanism found in brain cancer
Scientists have discovered how glioblastoma evades the immune system by inducing pro-tumor macrophages via a glucose based epigenetic modification.
May 3rd, 2024 — Source

Newly discovered mechanism of T-cell control can interfere with cancer immunotherapies
Activated T cells that carry a certain marker protein on their surface are controlled by natural killer (NK) cells, another cell type of the immune system. In this way, the body presumably curbs destructive immune reactions.
May 3rd, 2024 — Source

Pan-cancer analysis uncovers a new class of promising CAR T-cell immunotherapy targets
St. Jude found 156 potential targets for chimeric antigen receptor (CAR) T--cell immunotherapy. Explore the discovery's promise to improve cancer therapies.
May 3rd, 2024 — Source

Pan-cancer analysis uncovers a new class of promising CAR T--cell immunotherapy targets
Targeting anti-cancer therapy to affect cancer cells but not healthy cells is challenging. For chimeric antigen receptor (CAR) T--cell immunotherapy, where a patient's own immune cells are re-engineered to attack cancer cells, many solid and brain cancers lack an effective target.
May 3rd, 2024 — Source

Scientists discover new immunosuppressive mechanism in brain cancer
The Wistar Institute assistant professor Filippo Veglia, Ph.D., and team, have discovered a key mechanism of how glioblastoma—a serious and often fatal brain cancer—suppresses the immune system so that the tumor can grow unimpeded by the body's defenses.
May 3rd, 2024 — Source

Study shows extending interval between colonoscopies feasible after negative result
For individuals without a family history of colorectal cancer (CRC), increasing the interval between colonoscopies for those with a first colonoscopy with negative findings seems safe and can avoid unnecessary colonoscopies, according to a study published online May 2 in JAMA Oncology.
May 3rd, 2024 — Source

The key role of Galectin-3 in brain tumor development
A research group at the Department of Biochemistry and Molecular Biology of the University of Seville has made a significant advance by discovering the crucial role of the protein Galectin-3 in the progression of various types of brain tumors.
May 3rd, 2024 — Source

Health — Cancer — May 1st, 2024

New mRNA cancer vaccine triggers fierce immune response to fight malignant brain tumor
In a first-ever human clinical trial of four adult patients, an mRNA cancer vaccine developed at the University of Florida quickly reprogrammed the immune system to attack glioblastoma, the most aggressive and lethal brain tumor.
May 1st, 2024 — Source

Researchers find difference in pancreatic cancer cells, offering new hope for immunotherapy effectiveness
A new study has found that pancreatic cancer cells are different based on their location in the pancreas, providing new information about tumors that could lead to better targeted treatments.
May 1st, 2024 — Source

Two-punch treatment delivers blood cancer knockout: Study shows drug combo eradicates cancer cells in lab-based tests
A novel combination of two cancer drugs has shown great potential as a future treatment for patients with acute myeloid leukemia (AML), one of the most common types of blood cancers. A new study by WEHI researchers has revealed the combination of two existing drugs eradicated AML cancer cells in lab-based tests.
May 1st, 2024 — Source

Health — Cancer — April 30th, 2024

Listening to mindfulness audios during radiation found to improve physical, emotional side effects
Men with prostate cancer who are treated with radiation therapy experience significant side effects such as fatigue, sleep problems, anxiety and depressive symptoms. But listening to mindfulness audio recordings significantly eased those symptoms, a new Northwestern Medicine study has found.
April 30th, 2024 — Source

Microbiome researchers challenge the state of the art in colon cancer biomarker discovery
For the first time, researchers from VIB-KU Leuven, UZ Leuven, Janssen Pharmaceutica and multiple international collaborators have introduced quantitative methods and extensive confounder control to discover microbiome biomarkers in colorectal cancer development.
April 30th, 2024 — Source

Patients diagnosed with cancer in prison more likely to die from the disease, research shows
Cancer patients diagnosed in English prisons do not receive the same level of curative treatment as those in the general population, meaning they are at increased risk of death.
April 30th, 2024 — Source

Scientists find cancer-like features in atherosclerosis, spurring opportunity for new treatment approaches
Researchers have discovered that the smooth muscle cells that line the arteries of people with atherosclerosis can change into new cell types and develop traits similar to cancer that worsen the disease. The study has been published in Circulation.
April 30th, 2024 — Source

Smoking and alcohol leading cause of surge in cancer deaths and cases in Asia, global study finds
A large new global study published in The Lancet Regional Health—Southeast Asia reveals that cancer-related deaths rose to 5.6 million in 2019 from 2.8 million in 1999 in Asia, attributing the surge mainly to smoking and alcohol.
April 30th, 2024 — Source

Targeting protein interactions may boost antitumor immunity in breast cancer
A multi-institutional team of investigators has discovered that targeting a specific protein interaction within immunosuppressive breast cancer cells may increase antitumor immune responses in otherwise difficult to treat solid tumors, according to recent findings published in the Journal of Clinical Investigation.
April 30th, 2024 — Source

The Neglected U.S. Victims of Agent Orange
The Department of Veterans Affairs has long given Vietnam veterans disability compensation for illness connected to Agent Orange, widely used to defoliate Southeast Asian battlefields during the U.S. war.
April 30th, 2024 — Source

Health — Cancer — April 29th, 2024

Component of keto diet plus immunotherapy may reduce prostate cancer
Adding a pre-ketone supplement -- a component of a high-fat, low-carb ketogenic diet -- to a type of cancer therapy in a laboratory setting was highly effective for treating prostate cancer, researchers found.
April 29th, 2024 — Source

French startup bags €2M to make cancer clinical trials more accessible
Clinical trials are key to life-saving treatments, but participation is low
April 29th, 2024 — Source

Fruit fly helps unlock clues about how organs, tissue and cancer grow
The fruit fly, Drosophila, has been used by scientists for more than 100 years to unravel key features of life on Earth, such as how animals respond to the sun and how the bodies of animals are patterned from head to tail.
April 29th, 2024 — Source

Exposed to agent orange at US bases, veterans face cancer without VA compensation
As a young GI at Fort Ord in Monterey County, California, Dean Osborn spent much of his time in the oceanside woodlands, training on soil and guzzling water from streams and aquifers now known to be contaminated with cancer-causing pollutants.
April 29th, 2024 — Source

Kaposi sarcoma discovery and mouse model could facilitate drug development
Researchers at UNC Lineberger Comprehensive Cancer Center, after decades of research efforts, have developed a mouse model of Kaposi sarcoma that could be key to the development of new drugs to treat the disease. Kaposi sarcoma is a cancer that is the most common cancer in people living with HIV.
April 29th, 2024 — Source

Research shows link between pollution and heart risks in residents of the city of São Paulo, Brazil
The relationship between living in a polluted city like São Paulo (Brazil) and lung disease or cancer is well known. But the problems go further. Unprecedented research shows that long-term exposure to air pollution is directly linked to increased heart risks in residents of the capital of the state of the same name. People with high blood pressure are at even greater risk.
April 29th, 2024 — Source

Researchers uncover molecular mechanism of natural killer cell dysfunction in Hodgkin lymphoma
A multidisciplinary research team comprising the Griffith Institute for Drug Discovery (GRIDD, Griffith University), Mater Research (based at the Translational Research Institute) and The University of Queensland's (UQ) Frazer Institute, have made a breakthrough discovery in the body's immune response to the blood cancer Hodgkin Lymphoma.
April 29th, 2024 — Source

Study finds major gaps in cancer screening use in Federally Qualified Health Centers
A national study led by researchers at The University of Texas MD Anderson Cancer Center and The University of New Mexico (UNM) Comprehensive Cancer Center found major gaps in breast, cervical and colorectal cancer screening use in Federally Qualified Health Centers (FQHCs) in the U.S., relative to overall screening rates in the country.
April 29th, 2024 — Source

Study reveals interaction mechanism between intestinal microbial environment and tumor immune microenvironment
Colorectal cancer stands as one of the leading malignancies in the digestive system, ranking third and second in terms of new cases among men and women worldwide, respectively. Given the high incidence of this disease and the low response rate to immunotherapy, it is imperative to identify the environmental impeding factors to devise more precise and effective therapeutic strategies.
April 29th, 2024 — Source

Health — Cancer — April 27th, 2024

Aspirin's immune-boosting effects in colorectal cancer revealed
Study reveals that aspirin helps the body's immune system detect and target cancer cells.
April 27th, 2024 — Source

Component of keto diet plus immunotherapy may reduce prostate cancer
Adding a pre-ketone supplement—a component of a high-fat, low-carb ketogenic diet—to a type of cancer therapy in a laboratory setting was highly effective for treating prostate cancer, researchers from the University of Notre Dame found.
April 27th, 2024 — Source

Health — Cancer — April 26th, 2024

Analysis identifies 50 new genomic regions associated with kidney cancer risk
In a new analysis of genetic susceptibility to kidney cancer, an international team of researchers has identified 50 new areas across the genome that are associated with the risk of developing kidney cancer. These insights could one day be used to advance our understanding of the molecular basis of kidney cancer, inform screening efforts for those at highest risk, and identify new drug targets.
April 26th, 2024 — Source or Source

Biomarkers identified for successful treatment of bone marrow tumors
CAR T cell therapy has proven effective in treating various hematological cancers. However, not all patients respond equally well to treatment. In a clinical study, researchers from the University of Leipzig Medical Center and the Fraunhofer Institute for Cell Therapy and Immunology identified several biomarkers that are associated with the response to CAR T cell therapy in multiple myeloma, a malignant tumor disease in the bone marrow.
April 26th, 2024 — Source

Breast cancer rates rising among Canadian women in their 20s, 30s and 40s
Rates of breast cancer in women under the age of 50 are rising in Canada according to a study which showed an increase in breast cancer diagnoses among females in their Twenties, Thirties, and Forties.
April 26th, 2024 — Source

First UK real-world study shows promise for sacituzumab govitecan in metastatic breast cancer
A recent British Journal of Cancer evaluated the real-world safety and efficacy of sacituzumab govitecan (SG) against metastatic triple-negative breast cancer (mTNBC).
April 26th, 2024 — Source

Scientists discover a new signaling pathway and design a novel drug for liver fibrosis
A healthy liver filters all the blood in your body, breaks down toxins and digests fats. It produces collagen to repair damaged cells when the liver is injured. However, a liver can produce too much collagen when an excess accumulation of fat causes chronic inflammation, a condition called metabolic dysfunction-associated steatohepatitis (MASH).
April 26th, 2024 — Source

Study identifies driver of liver cancer that could be target for treatment
Metabolic diseases like obesity can increase the risk of developing liver cancer, research has shown. But how one disease predisposes to the other is unclear. In a new study, Yale researchers uncovered a key role played by a molecule called fatty acid binding protein 5 (FABP5) and found that inhibiting it blocked tumor progression in many cases.
April 26th, 2024 — Source

Health — Cancer — April 24th, 2024

Dermatologist explains light therapy for skin
Dermatologists advise their patients to avoid harmful ultraviolet light, which can cause skin damage, photo-aging and skin cancer. But they also may prescribe light therapy to treat certain skin conditions. Light therapy is a treatment that uses different wavelengths of light to treat various skin conditions.
April 24th, 2024 — Source

Mini-colons advance colorectal cancer research
In a breakthrough for cancer research, scientists at EPFL have created lab-grown mini-colons that can accurately mimic the development of colorectal tumors, offering a powerful new tool for studying and testing treatments for the disease.
April 24th, 2024 — Source

New sustainable diagnostic approach offers precision cancer testing with minimal environmental impact
In a recent study in Nature Sustainability, researchers describe a diagnostic approach that combines dried sera spots (DSS) with nanoparticle-enhanced laser desorption and ionization mass spectrometric methods (NPELDI-MS) for accurate and cost-effective cancer detection.
April 24th, 2024 — Source

New Test Detects Cancer In Minutes Using Just 1 Drop of Dried Blood
Though the test is in its infancy, it could someday be used to spot three of cancer's deadliest forms.
April 24th, 2024 — Source

Newly discovered mechanism helps tumor cells evade the immune system early on
Tumors actively prevent the formation of immune responses by cytotoxic T cells, which are essential in combating cancer. Researchers at the Technical University of Munich (TUM) and the Ludwig-Maximilians-Universität München (LMU) Hospital have now uncovered for the first time how this exactly happens.
April 24th, 2024 — Source

Researchers map the spatio-temporal human brain dynamics of a visual image being recognized
For nearly a decade, a team of MIT Computer Science and Artificial Intelligence Laboratory (CSAIL) researchers have been seeking to uncover why certain images persist in people's minds, while many others fade. To do this, they set out to map the spatio-temporal brain dynamics involved in recognizing a visual image.
April 24th, 2024 — Source

Study unveils novel bladder cancer diagnostic model based on key mitochondrial genes
With millions of cases of bladder cancer (BC) around the world, the need for tools to ensure a timely diagnosis of this condition is a matter of concern. Scientists recently used mitochondrial-related genes (MRGs), known to be involved in the progression of the disease, to build a novel diagnostic model using machine learning (ML).
April 24th, 2024 — Source

Health — Cancer — April 22nd, 2024

Are 'Man Vans' Coming to a Parking Lot Near You Soon?
April 22, 2024 -- In Miami's Little Haiti neighborhood, a fleet of four RVs regularly pop up in parking lots at churches, libraries and other locations. Sometimes known as "man vans," these mobile screening units offer prostate cancer screenings and education as a way to reach patients who lack solid access to health care.
April 22th, 2024 — Source

Do neighborhood-level disparities in breast cancer--specific survival remain after accounting for individual, tumor, and treatment characteristics?
The screening, treatment, and survival in breast cancer cases have improved considerably, but differences in survival outcomes persist, especially in disadvantaged neighborhoods.
April 22th, 2024 — Source

Expert reviews the current state of retinoblastoma research
Retinoblastoma is a rare pediatric cancer, with approximately 250--300 new cases per year in the United States and 8,000 worldwide. The cancer grows within the retina, a thin layer of cells at the back of the eye, and is usually treatable when diagnosed early. However, if undiagnosed, retinoblastoma can metastasize and lead to death.
April 22th, 2024 — Source

Genetically engineering a treatment for incurable brain tumors
Purdue University researchers are developing and validating a patent-pending treatment for incurable glioblastoma brain tumors. Glioblastomas are almost always lethal with a median survival time of 14 months. Traditional methods used against other cancers, like chemotherapy and immunotherapy, are often ineffective on glioblastoma.
April 22th, 2024 — Source or Source

Hitchhiking of synthetic antigen stimulates antibody production against cancer cells
Researchers at the Indian Institute of Science (IISc) have designed a synthetic compound (antigen) that can latch on to a protein in blood and hitchhike a ride to the lymph node, where it can boost the production of antibodies against cancer cells.
April 22th, 2024 — Source

How does aspirin help prevent colorectal cancer development and progression?
Long-term daily use of aspirin can help to prevent the development and progression of colorectal cancer, but the mechanisms involved have been unclear. New research has revealed that aspirin may exert these protective effects by boosting certain aspects of the body's immune response against cancer cells.
April 22th, 2024 — Source

Insightful review explores alcohol-related liver cancer pathogenesis
While heavy drinking is a well-established risk factor for liver cancer, the specific mechanisms by which alcohol contributes to A-HCC remain unclear.
April 22th, 2024 — Source

Liver cells effectively serve as immune checkpoint regulating anti-cancer immunity
Liver inflammation, a common side-effect of cancers elsewhere in the body, has long been associated with worse cancer outcomes and more recently associated with poor response to immunotherapy. Now, a team led by researchers from the Abramson Cancer Center and Perelman School of Medicine at the University of Pennsylvania has found a big reason why.
April 22th, 2024 — Source

Neighborhood disadvantage tied to shorter breast cancer-specific survival
Neighborhood disadvantage is associated with shorter breast cancer-specific survival, according to a study published online April 18 in JAMA Network Open.
April 22th, 2024 — Source

Researchers find obese people and tall, centrally obese people are more likely to get colorectal cancer
A large international team of medical researchers has found that people with two types of body shape are more likely to develop colorectal cancer than people with other body types. In their study, published in the journal Science Advances, the group assessed body shape and genetic tendencies in thousands of people for risks of developing colorectal cancer.
April 22th, 2024 — Source

Study shows TP53INP2 protein could provide new way to combat muscle loss during aging
Sarcopenia is a common disorder in older people, characterized by progressive loss of muscle mass and function, a condition that can significantly affect quality of life and increase the risk of falls, injury and dependency. Research into this physiological process is essential to develop effective strategies to enable the population to age in a healthy way.
April 22th, 2024 — Source

UN labor agency report warns of rising threat of excess heat, climate change on world's workers
The U.N. labor organization warned Monday that over 70% of the world's workforce is likely to be exposed to excessive heat during their careers, citing increased concern about exposure to sunlight. It also warned of air pollution, pesticides and other hazards that could lead to health problems including cancer.
April 22th, 2024 — Source

Writing to wellness: New therapy helps cancer patients face biggest fears
Imagine your greatest fear. Now, write it down and tell it in first-person, as if it's happening right now. Vividly describe what it looks, sounds, smells, tastes and feels like. Don't hold back.
April 22th, 2024 — Source

Health — Cancer — April 19th, 2024

Cancer is a disease of aging, but studies of older adults sorely lacking, review suggests
A systemic review of the current body of research shows that investigators have inadequately addressed the intersection of aging, health disparities, and cancer outcomes among older adults.
April 19th, 2024 — Source

New AI tool 'TORCH' successfully identifies cancer origins in unknown primary cases
In a recent study published in Nature Medicine, researchers developed a deep-learning approach for tumor origin differentiation using cytological histology (TORCH), recognizing malignancy and predicting tumor origin in hydrothorax and ascites using cytological pictures from 57,220 patients.
April 19th, 2024 — Source

Researchers develop a new way to safely boost immune cells to fight cancer
Last year alone, more than 600,000 people in the United States died from cancer, according to the American Cancer Society. The relentless pursuit of understanding this complex disease has shaped medical progress in developing treatment procedures that are less invasive while still highly effective.
April 19th, 2024 — Source

Researchers explore causal machine learning, a new advancement for AI in health care
Artificial intelligence is making progress in the medical arena. When it comes to imaging techniques and the calculation of health risks, there is a plethora of AI methods in development and testing phases. Wherever it is a matter of recognizing patterns in large data volumes, it is expected that machines will bring great benefit to humanity. Following the classical model, the AI compares information against learned examples, draws conclusions, and makes extrapolations.
April 19th, 2024 — Source

Study of cancer-induced liver inflammation finds a promising therapeutic target
Liver inflammation, a common side-effect of cancers elsewhere in the body, has long been associated with worse cancer outcomes and more recently associated with poor response to immunotherapy. Now, a team led by researchers from the Abramson Cancer Center and Perelman School of Medicine at the University of Pennsylvania has found a big reason why.
April 19th, 2024 — Source

Tumor deposits in colorectal and gastric cancers
Tumor deposits (TDs), initially recognized in colorectal cancer, have been identified in various other cancer types, including gastric cancer. It is defined as aggregates of tumor cells found in adipose and fibrous tissues in the lymph node drainage area of a primary tumor.
April 19th, 2024 — Source

Health — Cancer — April 17th, 2024

Adding chemotherapy to hormone therapy helps control locally advanced prostate cancer, finds study
For patients with locally advanced prostate cancer, combined treatment with chemotherapy and hormonal therapy offers extended control of prostate-specific antigen (PSA) levels, compared to hormonal therapy alone, according to a study in the April issue of the Journal of Urology.
April 17th, 2024 — Source

Combined chemohormonal therapy for locally advanced prostate cancer offers extended control of PSA levels
For patients with locally advanced prostate cancer, combined treatment with chemotherapy and hormonal therapy offers extended control of prostate-specific antigen (PSA) levels, compared to hormonal therapy alone, reports a study in the April issue of The Journal of Urology®, an Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer.
April 17th, 2024 — Source

Harnessing B cells could fight cancer or autoimmune diseases by targeting mitochondrial metabolism
White cells called regulatory B cells could be harnessed to fight cancers and to treat autoimmune diseases by either increasing or decreasing their function, as indicated by a new research.
April 17th, 2024 — Source

New study calls into question prior study results that found tumor transmission slowing in Tasmanian devils
A trio of biologists and veterinarians with CRG Barcelona, the University of Cambridge and The Barcelona Institute of Science and Technology, respectively, has found evidence contradicting results found by a prior team of researchers who claimed that they had found that tumor transmission in Tasmanian devils was slowing.
April 17th, 2024 — Source

Shape-shifting cancer cell discovery reveals potential skin cancer drug targets
Cancer cells can change shape to travel around the body and spread (metastasize), but how they know when to do this has remained elusive.
April 17th, 2024 — Source

Targeted therapies outperform hundreds of other drugs in 'priming' lung cancer cells for destruction
Through millions of years of evolutionary refinement, the human body has developed a sophisticated surveillance mechanism—the immune system.
April 17th, 2024 — Source

Triple-negative breast cancer patients with high immune cell levels have lower relapse risk after surgery
Women with triple-negative breast cancer, and high levels of immune cells in the tumors, have a lower relapse risk after surgery, even without chemotherapy. This is shown by a study involving research at the University of Gothenburg.
April 17th, 2024 — Source

Health — Cancer — April 15th, 2024

Epilepsy drug prevents brain tumors in mice with neurofibromatosis type 1
A drug used to treat children with epilepsy prevents brain tumor formation and growth in two mouse models of neurofibromatosis type 1 (NF1), according to a study by researchers at Washington University School of Medicine in St. Louis. NF1 is a genetic condition that causes tumors to grow on nerves throughout the body, including the optic nerves, which connect the eyes to the brain.
April 15th, 2024 — Source

New cancer projections show increased prostate cases by 25% in 2050, despite prevention efforts NewsGuard 100/100 Score
New cancer cases have been increasing in the West. Those that top the list are breast, prostate, and lung cancer, with colorectal cancer (CRC).
April 15th, 2024 — Source

New way found to treat early relapse in leukemia
Researchers at Peter Mac have found a new way to treat a form of leukemia that stops the disease in its tracks to prolong remission.
April 15th, 2024 — Source

Study sheds light on the mechanisms underlying the development of malignant pediatric brain tumors
A study has revealed how aberrant epigenetic regulation contributes to the development of atypical teratoid/rhabdoid (AT/RT) tumors, which are aggressive brain tumors that mainly affect young children. There is an urgent need for more research in this area as current treatment options are ineffective against these highly malignant tumors.
April 15th, 2024 — Source

Targeted liver cancer treatment kills cancer cells and could cut chemo side effects
Drug-loaded 3D printed films could change cancer treatments forever as world first research from the University of South Australia shows that new films not only kill more than 80% of liver cancer cells but could also significantly reduce recurrence rates while minimizing systematic toxicities of traditional chemotherapy.
April 15th, 2024 — Source

Tiny DNA circles are key drivers of cancer formation, study suggests NewsGuard 100/100 Score
Tiny circles of DNA that defy the accepted laws of genetics are key drivers of cancer formation, according to an international study led by researchers at Stanford Medicine.
April 15th, 2024 — Source

World-first microscopic stiffness probe could advance early cancer diagnosis
Researchers at the University of Nottingham have created an endoscopic device that can 3D image the stiffness of individual biological cells and complex organisms, a discovery that could help doctors discover and treat cancer earlier.
April 15th, 2024 — Source

Health — Cancer — April 12th, 2024

Could U.S. Measles Cases Break a Record This Year? What to Know
When a mother in Atlanta, GA, noticed measles symptoms in her son earlier this year after returning from an international trip, she knew just bringing him straight into a local emergency room may put others at risk.
April 12th, 2024 — Source

Genomic deletions explain why some types of melanoma resist targeted therapies
Melanoma is the deadliest form of skin cancer. With global incidence rates rising, new, more effective treatments are necessary to alleviate the health burden of the disease. Important advances in recent years include doctors using genetic tests to look for specific mutations they can target for more personalized, effective treatment.
April 12th, 2024 — Source

Metformin may help the immune system better identify breast cancer cells
Metformin is a widely prescribed drug for managing type 2 diabetes. In recent years, indications of its potential anticancer properties have emerged in research. A study conducted at the University of Helsinki has found that metformin activates the body's immune cells. The effect was particularly observed in what are known as dendritic cells, which are the most effective in helping the immune system identify cancer cells as foreign entities.
April 12th, 2024 — Source

New genetic variants could raise a woman's risk of cervical cancer from HPV infections
Human papillomavirus (HPV) is the second most common cancer-causing virus, accounting for 690,000 cervical and other cancers each year worldwide. While the immune system usually clears HPV infections, those that persist can lead to cancer, and a new finding suggests that certain women may have a genetic susceptibility for persistent or frequent HPV infections.
April 12th, 2024 — Source

New treatment could be advance against cervical precancers
Women who undergo regular Pap smears are no doubt familiar with the possibility of "precancerous" cells being detected.
April 12th, 2024 — Source

Radon exposure associated with concerning rise in non-smoking lung cancer
Although lung cancer is traditionally thought of as a "smoker's disease," a surprising 15-20% of newly diagnosed lung cancers occur in people who have never smoked, many of whom are in their 40s or 50s.
April 12th, 2024 — Source

Researchers discover cell 'crosstalk' that triggers cancer cachexia
New research from the University of Oklahoma reveals a previously unknown chain of events sparking the development of cancer cachexia, a debilitating muscle-wasting condition that almost always occurs in people diagnosed with pancreatic cancer.
April 12th, 2024 — Source

Scientists uncover a missing link between poor diet and higher cancer risk
A research team from the National University of Singapore (NUS) has unearthed new findings that may help explain the connection between cancer risk and poor diet, as well as common diseases like diabetes, which arise from poor diet. The insights gained from this study hold promise for advancing cancer prevention strategies aimed at promoting healthy aging.
April 12th, 2024 — Source

Smart nanoprobe illuminates prostate cancer cells
(Nanowerk News) Biomedical imaging modalities such as magnetic resonance imaging (MRI) have revolutionized the ability to detect and track the progress of many cancer types. However, the difficulty of obtaining detailed images of cancer cells buried deep within normal tissues has slowed the usefulness of imaging technology for improved, personalized cancer care.
April 12th, 2024 — Source

Softer tumors fuel more aggressive spread of triple-negative breast cancer, research shows
Researchers have discovered how the mechanical properties of tumors can prime cancer cells to better survive their spread to other organs.
April 12th, 2024 — Source

Study shows AI improves accuracy of skin cancer diagnoses
A new study led by researchers at Stanford Medicine finds that computer algorithms powered by artificial intelligence based on deep learning can help health care practitioners to diagnose skin cancers more accurately. Even dermatologists benefit from AI guidance, although their improvement is less than that seen for non-dermatologists.
April 12th, 2024 — Source

Young women often delay looking into breast symptoms, research finds
Young women who find a lump or other potential signs of breast cancer often delay for weeks before finally seeing a doctor, a new study shows.
April 12th, 2024 — Source

Health — Cancer — April 11th, 2024

Exploring the role of artificial intelligence in early cancer detection
Two new review articles in AI in Precision Oncology explore the role of artificial intelligence (AI) in early cancer detection. A primer provides an overview of AI, and the second review examines the promising clinical applications of AI in early cancer detection.
April 11th, 2024 — Source

Family-focused interventions for African Americans with cancer
The moment you're told the dreaded words: "You have cancer," your life changes forever. A parent diagnosed with cancer goes through a rollercoaster of emotions from guilt and shame to resiliency.
April 11th, 2024 — Source

New treatment approach shows promise in hard-to-treat pediatric cancers
Researchers have developed a functional precision medicine approach that targets cancer by combining genetic testing with a new way to test individual drugs on tumor samples.
April 11th, 2024 — SourceThe results of the clinical study were published in Nature Medicine.

Personalized cancer treatments based on testing drugs quickly leads to faster treatment, better outcomes
Despite many efforts to find better, more effective ways to treat cancer, it remains a leading cause of death by disease among children in the U.S.
April 11th, 2024 — Source

PET/MRI found to accurately classify prostate cancer patients, offer potential to avoid unnecessary biopsies
PET/MRI can improve diagnostic accuracy for prostate cancer patients and help avoid unnecessary biopsies, according to new research published in the Journal of Nuclear Medicine. By applying the PRIMARY scoring system to PET/MRI results, researchers found that more than 80% of unnecessary biopsies could be avoided at the expense of missing one in eight clinically significant prostate cancer cases.
April 11th, 2024 — Source

Potential therapeutic target for small cell lung cancer discovered
Northwestern Medicine investigators have discovered that inhibiting a chromatin remodeling complex associated with a particular gene in small-cell lung cancer (SCLC) cells may decrease cancer cell differentiation and tumor growth, according to findings published in Nature Communications.
April 11th, 2024 — Source

Research team develops novel PTPN2/N1 inhibitor for cancer immunotherapy using generative AI
In recent years, cancer immunotherapy, exemplified by PD-1 and its ligand PD-L1 blockade, has made remarkable advances. But while immunotherapy drugs offer new treatment possibilities, only about 20% to 40% of patients respond to these treatments. The majority either don't respond or develop drug resistance. Researchers are now looking for ways to enhance the scope of tumor immunotherapy in order to benefit a wider range of patients.
April 11th, 2024 — Source

Researchers identify new genetic risk factors for persistent HPV infections
Human papillomavirus (HPV) is the second most common cancer-causing virus, accounting for 690,000 cervical and other cancers each year worldwide. While the immune system usually clears HPV infections, those that persist can lead to cancer, and a new finding suggests that certain women may have a genetic susceptibility for persistent or frequent HPV infections.
April 11th, 2024 — Source

Researchers review use of MRI to identify brain cancer biomarkers
Researchers from the School of Biomedical Engineering & Imaging Sciences (BMEIS) have published a systematic review in Neuro-Oncology Advances exploring the use of MRI imaging techniques to identify non-invasive biomarkers in brain cancer.
April 11th, 2024 — Source

Scientists find new ways to convert inhibitors into degraders, paving the way for future drug discoveries
Researchers have discovered ways to convert inhibitor-style targeted cancer drugs into small molecules known as degraders, which help destroy cancer-promoting proteins in cells.
April 11th, 2024 — Source

Scientists uncover key resistance mechanism to Wnt inhibitors in pancreatic and colorectal cancers
Scientists at Duke-NUS Medical School have uncovered why some pancreatic and colorectal cancers fail to respond to Wnt inhibitors, a promising new class of cancer drugs currently under development for these cancers. Their discovery, published in Science Advances, not only offers a new cancer therapy target but also a potential screening tool to identify those patients who will not benefit from this new therapy once it becomes available.
April 11th, 2024 — Source

Health — Cancer — April 10th, 2024

A new screening protocol can detect aggressive prostate cancers more selectively
Prostate cancer is the most common cancer in men. As a cause of men's cancer death, it ranks the second in Finland and the third in Europe.
April 10th, 2024 — Source or Source

AI-assisted breast-cancer screening may reduce unnecessary testing
Using AI to help doctors read mammograms reduces follow-up testing without missing cancer cases, simulation shows
April 10th, 2024 — Source

Deciphering cancer plasticity:Insights from MSK research
About 90% of deaths from cancer are a result of metastasis -; that is, from cancer's ability to spread from an initial primary tumor to seed new tumors throughout the body, often in the lungs, liver, and brain.
April 10th, 2024 — Source

Educational video boosts prostate cancer screening intentions in men
In findings shared today at the American Association for Cancer Research (AACR) Annual Meeting 2024 (Abstract LB371), the team showed that the video increased knowledge about prostate cancer and screening, and reduced uncertainty about obtaining prostate cancer screening in a diverse group of more than 600 men over age 40 who viewed the video during 14 different community health events in the Philadelphia region. Based on post-video surveys, 93 percent of men said they intended to undergo a prostate-specific antigen (PSA) screening blood test for prostate cancer, which the research team offered at the same time as part of the community events.
April 10th, 2024 — Source

EPA's PFAS rules: We'd prefer zero, but we'll accept 4 parts per trillion
For two chemicals, any presence in water supplies is too much.
April 10th, 2024 — Source

Study suggests liquid biopsy could detect and monitor aggressive small-cell lung cancer
A new lab assay developed by researchers at Fred Hutch Cancer Center could make diagnosis and treatment of small-cell lung cancer and non-small cell lung cancer easier. The work is published in the journal Science Advances.
April 10th, 2024 — Source

'Virtual biopsy' lets clinicians analyze skin noninvasively
The next time you have a suspicious-looking mole on your back, your dermatologist may be able to skip the scalpel and instead scan the spot with a noninvasive "virtual biopsy" to determine whether it contains any cancerous cells. Similarly, surgeons trying to determine whether they have removed all of a breast tumor may eventually rely on an image captured during surgery rather than wait for a pathologist to process the excised tissue.
April 10th, 2024 — Source

With cancer cases rising in young people, could earlier screenings help save lives?
Cancer cases are increasing among young people, with rising instances of colorectal cancer in people under age 55 and cervical cancer diagnoses ticking up for women ages 33 to 44, according to the American Cancer Society.
April 10th, 2024 — Source

Health — Cancer — April 6th, 2024

Statistics presented for global cancer incidence, deaths in 2022
In 2022, there were almost 20 million new cases of cancer as well as 9.7 million deaths from cancer, according to a study published online April 4 in CA: A Cancer Journal for Clinicians.
April 6th, 2024 — Source

Health — Cancer — April 5th, 2024

Advances in treating kidney cancer
Kidney cancer is one the most common cancers in the U.S., with over 81,000 new diagnoses in 2023 alone. Mayo Clinic sees a high volume of kidney cancer cases and is among the most experienced institutions in treating kidney tumors.
April 5th, 2024 — Source or Watch Video

Chemotherapy nausea and vomiting: Prevention is best defense
Not everyone has nausea and vomiting during chemotherapy. Learn if you're at risk and what you and your healthcare team can do to avoid these side effects.
April 5th, 2024 — Source

More than 25% of cancer survivors report significant levels of disability after cancer diagnosis, according to new study
A survey of nearly 50,000 cancer survivors has found that more than a quarter had a physical disability that impaired their mobility and almost 10% had a disability affecting self-care, Dana-Farber Cancer Institute researchers report in a new study, published in the Journal of Clinical Oncology. Both rates are sharply higher than those for adults who have not had cancer.
April 5th, 2024 — Source

Novel ADC and immunotherapy combo shows promise in endometrial cancer subtype
In a small, investigator-initiated Phase II study by Dana-Farber Cancer Institute investigators, a novel combination of an antibody-drug conjugate and an immune checkpoint inhibitor showed notable activity in pre-treated patients with a difficult-to-treat form of endometrial cancer.
April 5th, 2024 — Source

New micromaterial releases nanoparticles that selectively destroy cancer cells
Researchers have developed micromaterials made up only of proteins, capable of delivering over an extended period of time nanoparticles that attack specific cancer cells and destroy them. The micromaterials mimic natural secretory granules found in the endocrine system and were proven effective in mouse models of colorectal cancer.
April 5th, 2024 — Source or Source

Novel combination therapy shows promise in difficult-to-treat endometrial cancer, study finds
In a small, investigator-initiated phase 2 study by Dana-Farber Cancer Institute investigators, a novel combination of an antibody-drug conjugate and an immune checkpoint inhibitor showed notable activity in pre-treated patients with a difficult-to-treat form of endometrial cancer.
April 5th, 2024 — Source

Research team builds first tandem repeat expansions genetic reference maps
A research team led by the University of California, Irvine has built the first genetic reference maps for short lengths of DNA repeated multiple times which are known to cause more than 50 lethal human diseases, including amyotrophic lateral sclerosis, Huntington's disease and multiple cancers.
April 5th, 2024 — Source

Researchers present playbook of best practices for cancer team science in the modern era
The oncology community has a powerful opportunity to speed the creation of impactful new treatments by adopting a modern playbook for collaboration, according to scientists from Break Through Cancer and other team-oriented cancer organizations working together in a commentary in the journal Cancer Discovery.
April 5th, 2024 — Source

Study finds immunotherapy combination before surgery improves outcomes for patients with pancreatic cancer
A pilot study led by UCLA Health Jonsson Comprehensive Cancer Center investigators suggests that for people with borderline resectable pancreatic cancer, administrating an immunotherapy drug in combination with chemotherapy before surgery is safe and may improve long-term outcomes.
April 5th, 2024 — Source

Health — Cancer — April 4th, 2024

Research details adaptation tactics of pancreatic cancer
Like alien invaders in a sci-fi movie, pancreatic cancer cells quickly adapt to the weapons used against them and find ways to survive, even in the harshest of conditions.
April 4th, 2024 — Source

Study finds less invasive, safer option for removing benign pancreatic tumors
Insulinomas are abnormal tumors, usually benign, that grow in the beta cells of the pancreas. Insulinomas make extra insulin, more than the body can use. They can cause hypoglycemia or low blood sugar. Low blood sugar can cause confusion, sweating, weakness, confusion, and even coma. Surgery is the only treatment for patients with insulinoma. However, it is usually associated with a longer time to recover, and loss of healthy pancreatic tissue can lead to diabetes.
April 4th, 2024 — Source

US cancer center data breach exposes info of 827,000 patients
Cancer treatment and research center City of Hope is warning that a data breach exposed the sensitive information of over 820,000 patients.
April 4th, 2024 — Source

Health — Cancer — April 2nd, 2024

AI's ability to detect tumor cells could be key to more accurate bone cancer prognoses
Researchers at Kyushu University have developed and validated a machine-learning model that can accurately evaluate the density of surviving tumor cells after treatment in pathological images of osteosarcoma—the most prevalent malignant bone tumor. The model can assess how individual tumor cells respond to treatment and can predict overall patient prognosis more reliably than conventional methods.
April 2nd, 2024 — Source

Can generative AI truly transform healthcare into a more personalized experience?
In a recent article published in npj Digital Medicine, researchers explored the current literature on large language model (LLM)-based evaluation metrics for healthcare chatbots.
April 2nd, 2024 — Source

Existing drugs may hinder the development of bone metastasis in breast cancer patients
Researchers at Tel Aviv University developed a new therapeutic strategy based on existing medications to inhibit bone metastasis in breast cancer patients. Using both an animal model and tissue samples from patients in Israel and the US, they demonstrated that a combination of drugs already availabl
April 2nd, 2024 — Source

Investigators develop novel treatment for T-cell leukemias and lymphomas
A novel treatment for leukemias and lymphomas that arise from immune system T cells, developed by investigators at the Johns Hopkins Kimmel Cancer Center and its Ludwig Center and Lustgarten Laboratory, was found to be effective at killing these cancers in mice bearing human T-cell tumors.
April 2nd, 2024 — Source

Japan health supplements tied to 157 hospitalizations
Japanese dietary supplements at the center of an expanding health scare have now been linked to at least 157 hospitalizations, a health ministry official said Tuesday.
April 2nd, 2024 — Source

Minimally invasive procedure may spare patients from thyroid surgery
In a 10-center study, microwave ablation offered progression-free survival rates and fewer complications than surgery in the treatment of a form of thyroid cancer known as papillary thyroid carcinoma (PTC), according to research published in Radiology.
April 2nd, 2024 — Source

New insights into aggressive breast cancer and potential treatment options
Triple-negative breast cancer (TNBC) is difficult to treat due to its aggressive nature and resistance to chemotherapy. Exciting research published by the University of Southern Denmark sheds light on the mechanisms that drive this resistance and gives hope for better treatment for patients in the future.
April 2nd, 2024 — Source

New insights into how tumors on adrenal glands develop
Researchers from Kyushu University's Faculty of Medical Sciences report on new insights into the mechanisms of how adrenal gland tumors are formed. The team identified a new type of tumor cell population that they termed "steroids-producing nodules" or SPNs, which exhibits the unique characteristic of producing two different hormones.
April 2nd, 2024 — Source

New method for detecting and treating breast cancer subtypes
The most prevalent disease in women, breast cancer, poses a major risk to the health of women. Patients' clinical treatment and prognosis might differ significantly because of the high levels of intra- and intertumoral heterogeneity in breast cancer.
April 2nd, 2024 — Source

New study seeks hereditary causes of childhood cancer
Follow-up and treatment of children with cancer is significantly improved when inherited genetic causes are also investigated, according to a new Swedish study. The results of the research involving some 50 researchers and clinicians from across Sweden have been published in The Lancet Regional Health - Europe.
April 2nd, 2024 — Source

Researchers discover protective 'acid wall' formed by cancer cells
Cancer cells release a significantly more concentrated level of acid than previously known, forming an "acid wall" that could deter immune cells from attacking tumors, UT Southwestern Medical Center scientists show in a new study.
April 2nd, 2024 — Source

Silent cancers: Here's what you need to know when there are no obvious symptoms
The recent revelations about the Princess of Wales's cancer diagnosis highlight a crucial aspect of cancer detection—the disease's sometimes silent nature.
April 2nd, 2024 — Source

Soluble immune checkpoint factors in blood as potential biomarkers of therapeutic efficacy for ICI cancer immunotherapy
Cancer is a prevalent disorder where cells divide and grow uncontrollably and eventually spread to other regions or organs in the body. Non-small cell lung cancer (NSCLC) is a highly prevalent form of lung cancer. Current therapeutic strategies against NSCLC involve the administration of immune checkpoint inhibitors (ICIs) as they provide significant clinical benefits for patients with NSCLC.
April 2nd, 2024 — Source

Study finds triple-negative breast cancer tumors with increased immune cells have lower risk of recurrence after surgery
A new multicenter, international study suggests that people who have early-stage triple-negative breast cancer (TNBC) and high levels of immune cells within their tumors may have a lower risk of recurrence and better survival rates even when not treated with chemotherapy.
April 2nd, 2024 — Source

Study suggests lung cancer does not decrease in line with reduced smoking
Despite the fact that the number of people who smoke has decreased very sharply in Sweden, the number of cases of lung cancer in the population is not decreasing as much as expected. Among women, lung cancer has, in fact, increased.
April 2nd, 2024 — Source

'Zombie neurons' shed light on how the brain learns
Nestled at the back of your head, the cerebellum is a brain structure that plays a pivotal role in how we learn, adapting our actions based on past experiences. Yet the precise ways in which this learning happens are still being defined.
April 2nd, 2024 — Source

Health — Cancer — March 29th, 2024

Enhanced melanoma vaccine offers improved survival for men
A second-generation melanoma vaccine being developed at UVA Cancer Center improves long-term survival for melanoma patients compared with the first-generation vaccine, new research shows. Interestingly, the benefit of the second-generation vaccine was greater for male patients than for female patients.
March 29th, 2024 — Source

Heading off financial harms in cancer patients
A screening tool can quickly identify cancer patients at risk of financial toxicity, new findings from Columbia Nursing researchers show.
March 29th, 2024 — Source

New research highlights combining prostate MRI with a blood test to avoid unnecessary prostate biopsies
MRI of the prostate, combined with a blood test, can help determine if a prostate lesion is clinically significant cancer, new research suggests
March 29th, 2024 — Source

Private and secure generative AI tool supports operations and research in a cancer center
Dana-Farber Cancer Institute has implemented an artificial intelligence (AI) application intended for general use in a medical center or hospital. The system, called GPT4DFCI, is permitted for operations, administrative, and research uses but prohibited in direct clinical care.
March 29th, 2024 — Source

Researchers develop AI-based tool paving the way for personalized cancer treatments
In the ongoing fight against cancer, scientists around the globe are exploring innovative approaches to unlock the mysteries of the human immune system—the complex network of organs, cells and proteins that defends the body against disease.
March 29th, 2024 — Source

Unveiling gender differences in cancer: New insights into genomic instability
Recent research spearheaded by Chunmei Cui at the State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, China, casts a new light on the nuanced interplay between gender and cancer, uncovering significant sex-specific disparities in copy number alterations (CNA) across various cancer types.
March 29th, 2024 — Source

Health — Cancer — March 28th, 2024

Cancer-predisposition variants associated with adverse outcomes in rhabdomyosarcoma
Germline cancer-predisposition variants (CPVs) can be helpful in predicting risk in some pediatric cancers. However, CPV risk association in children with rhabdomyosarcoma has not been well studied. A new report led by researchers at Baylor College of Medicine evaluates the association of germline CPVs with rhabdomyosarcoma outcomes in a cohort of children enrolled in Children's Oncology Group studies. The findings are published in JAMA Network Open.
March 28th, 2024 — Source

Clinical trial: Some sarcoma patients improve with T cell immunotherapy
A clinical trial led by researchers at Washington University School of Medicine in St. Louis has shown that a T cell immunotherapy—in which the patients' own T cells are genetically modified to attack and kill cancer cells—is effective in treating some patients with rare cancers of the body's soft tissues.
March 28th, 2024 — Source

'Exhausted' immune cells in healthy women could be target for breast cancer prevention
Researchers at the University of Cambridge have created the world's largest catalogue of human breast cells, which has revealed early cell changes in healthy carriers of BRCA1 and BRCA2 gene mutations.
March 28th, 2024 — Source

Improving the world's most potent cancer drug
Fourteen mice scurried around in laboratory cages, eating, sniffing, and running peacefully. You would never guess that, several weeks earlier, half of them had received five times the lethal dose of a leading chemotherapy drug.
March 28th, 2024 — Source

Improving Cancer Immunotherapy Systemic Delivery
Purdue University researchers are creating and testing patent-pending poly (lactic-co-glycolic acid), or PLGA, nanoparticles modified with adenosine triphosphate, or ATP, to improve immunotherapy against malignant tumors.
March 28th, 2024 — Source

Longer durations of breastfeeding lowers the risk of childhood cancers
In a recent study published in JAMA Network Open, a Danish team of researchers investigated whether duration of breastfeeding was associated with a lower risk of childhood cancers such as acute lymphoblastic leukemia (ALL).
March 28th, 2024 — Source

Longer exclusive breastfeeding may lower risk for childhood hematologic cancers
Exclusive breastfeeding duration of at least three months may decrease the risk for childhood hematologic cancers, according to a study published online March 26 in JAMA Network Open.
March 28th, 2024 — Source

Memories of mitosis: Molecular mechanism that detects defects during cell division could aid cancer treatment
Every day, our cells are hard at work multiplying. Cell division is a precise process, but sometimes this process is impaired and diseases like cancer occur. Mitosis is one of the most important phases in the cell cycle. During this phase, a cell's DNA is split into two equal sets of chromosomes and it divides into two genetically identical daughter cells.
March 28th, 2024 — Source

New study shows association of historical housing discrimination and shortfalls in colon cancer treatment
A nationwide study of 196 cities shows that housing discrimination from 90 years ago still casts a historical shadow of inequities in colon cancer care today, S.M. Qasim Hussaini, M.D., of the University of Alabama at Birmingham and colleagues at the American Cancer Society and Johns Hopkins School of Public Health report in the journal JCO Oncology Practice.
March 28th, 2024 — Source

Predicting infection risk in childhood cancer
A statistical model can accurately predict the risk of bloodstream infections in a subset of children with cancer, according to a study published in the Journal of Clinical Oncology.
March 28th, 2024 — Source

Research from NY highlights pollution as a key factor in rising cancer rates among youth
In a recent study published in Scientific Reports, researchers investigated cancer incidence trends among adults in the New York State (NYS) and associations with common population-level exposures.
March 28th, 2024 — Source

Researchers discover molecule that promotes production of cancer cells in triple-negative breast cancer
A team of researchers from Hiroshima University has discovered a molecule that promotes the production of cancer cells. This molecule may prove to be a potential therapeutic target in the treatment of triple-negative breast cancer, an aggressive form of breast cancer.
March 28th, 2024 — Source

Researchers identify increased brain tumor risk with specific contraceptive use
In a recent study published in BMJ, researchers evaluated the intracranial meningioma risk associated with progestogen use.
March 28th, 2024 — Source

Scientists take a closer look at pulmonary fibrosis genetics
Regulators of gene expression are thought to play an outsized role in disorders from cancers to heart disease. But how exactly do variations in gene regulation translate into a disease's biology?
March 28th, 2024 — Source

Some cancer patients can find it hard to tell family and friends
Ever since Anthony Bridges found out he had prostate cancer six years ago, he hasn't stopped talking about it. He told his Facebook friends immediately.
March 28th, 2024 — Source

Study flips treatment paradigm in bilateral Wilms tumor, shows resistance to chemotherapy may be good
Resistance to chemotherapy is typically associated with poor outcomes for patients with cancer. However, St. Jude Children's Research Hospital scientists demonstrated that in bilateral Wilms tumor (cancer in both kidneys) chemotherapy resistance can point toward a more favorable histology and an ultimately good outcome.
March 28th, 2024 — Source

Study shows improved outcomes in hospitals accredited for rectal cancer surgery
Hospitals accredited by the American College of Surgeons (ACS) National Accreditation Program for Rectal Cancer (NAPRC) demonstrate significantly better outcomes for patients undergoing rectal cancer surgery compared to non-accredited hospitals, according to a new study published in the Journal of the American College of Surgeons.
March 28th, 2024 — Source

Study successfully mimics complex neuroblastoma vasculature on a chip to explore treatments
Neuroblastoma, one of the most common childhood cancers, is classified as a developmental cancer because it arises prenatally during the formation of organs and tissues. It originates from cancer cells that develop in neuroblasts, a type of immature nerve tissue, and primarily affects the adrenal glands.
March 28th, 2024 — Source

Health — Cancer — March 27th, 2024

Accelerating CAR T cell therapy: Lipid nanoparticles speed up manufacturing
Engineers have developed a novel method for manufacturing CAR T cells, one that takes just 24 hours and requires only one step, thanks to the use of lipid nanoparticles (LNPs), the potent delivery vehicles that played a critical role in the Moderna and Pfizer-BioNTech COVID-19 vaccines.
March 27th, 2024 — Source

An oncologist explains why some cancer patients receive both chemotherapy and surgery
When Kate Middleton, the princess of Wales, announced in March 2024 that she was receiving "preventive chemotherapy" following abdominal surgery, many wondered what that entails. Formally known as adjuvant therapy, administering chemotherapy or other treatments after surgery is a common approach to treating certain types of cancer and is not necessarily intended to prevent cancer.
March 27th, 2024 — Source

Beating by overheating: A new strategy to combat cancer
Many new drugs inhibit the processes that cancer cells need to divide rapidly. So as to inhibit the cancer as a whole. But cancer cells have all sorts of workarounds to get around that effect. As a result, the tumor becomes unresponsive to treatment.
March 27th, 2024 — Source

Biocompatible nanoparticles enhance systemic delivery of cancer immunotherapy
(Nanowerk News) Purdue University researchers are developing and validating patent-pending poly (lactic-co-glycolic acid), or PLGA, nanoparticles modified with adenosine triphosphate, or ATP, to enhance immunotherapy effects against malignant tumors.
March 27th, 2024 — Source

Biocompatible nanoparticles modified with ATP can enhance systemic delivery of cancer immunotherapy
Purdue University researchers are developing and validating patent-pending poly (lactic-co-glycolic acid), or PLGA, nanoparticles modified with adenosine triphosphate, or ATP, to enhance immunotherapy effects against malignant tumors.
March 27th, 2024 — Source

Combining epigenetic cancer medications may have benefit for colorectal cancers and other tumor types
A pair of medications that make malignant cells act as if they have a virus could hold new promise for treating colorectal cancers and other solid tumors, reports a study published in Science Advances.
March 27th, 2024 — Source

Durvalumab and Tremelimumab before surgery in patients with HR+/HER2-negative breast cancer
A new research paper was published in Oncotarget entitled, "Durvalumab and tremelimumab before surgery in patients with hormone receptor positive, HER2-negative stage II–III breast cancer."
March 27th, 2024 — Source

Exploring ferroptosis and its implications in lung cancer
An estimated 2.2 million people suffer from lung cancer worldwide, making it the second most common type of cancer. Though improvements in treatment have been made, the overall survival rate of lung cancer patients is low, and it remains a leading cause of death, accounting for 18% of total cancer-related deaths in 2022.
March 27th, 2024 — Source

Follow-up colonoscopy rate low within six months of abnormal stool test
Fewer than half of adults have a follow-up colonoscopy within six months following an abnormal stool-based screening test (SBT) for colorectal cancer (CRC), according to a study published online March 25 in JAMA Network Open.
March 27th, 2024 — Source

Investigating mechanisms of aggressive glioblastoma tumor growth
Northwestern Medicine investigators have identified a metabolism-related gene that may play a role in recruiting immune cells to support the growth of aggressive brain tumors, according to a study recently published in Nature Communications.
March 27th, 2024 — Source

Novel AI tools tackle soft tissue sarcomas, identify new treatment strategies
Using novel machine learning tools developed at Stanford Medicine, researchers have mapped three distinct cellular configurations that correspond to clinical outcomes for patients with a rare, difficult-to-treat cancer called soft tissue sarcoma.
March 27th, 2024 — Source

Princess Kate revelation shines light on under-50s cancer mystery
When Catherine, Princess of Wales, revealed she was being treated for cancer last week, part of the shock was that an otherwise healthy 42-year-old has a disease that mostly plagues older people.
March 27th, 2024 — Source

Researchers create new tool for assessing risk of kidney injury after chemotherapy
Using patient data from six major U.S. cancer centers, Brigham researchers and collaborators developed a risk prediction model for moderate-to-severe kidney injury after receiving the chemotherapy drug cisplatin in the largest, first generalizable study of its kind
March 27th, 2024 — Source

Researchers discover a mechanism that could improve platinum-based cancer therapy
Researchers have identified a protein that, when targeted, enables cisplatin-resistant cancer cells to become responsive to treatment. Cisplatin, and other similar platinum drugs, are incredibly effective at killing rapidly growing cancer cells, which is why they have been used in treating cancers for over 45 years.
March 27th, 2024 — Source

Researchers turn back the clock on cancer cells to offer new treatment paradigm
St. Jude Children's Research Hospital scientists reversed an aggressive cancer, reverting malignant cells towards a more normal state. Rhabdoid tumors are an aggressive cancer which is missing a key tumor suppressor protein. Findings showed that with the missing tumor suppressor, deleting or degrading the quality control protein DCAF5 reversed the cancer cell state.
March 27th, 2024 — Source

Revealing characteristics of circulating cell-free RNA in the blood of liver cancer patients
Recently, the research findings of the team led by CAS Academician Xiang Zhou from Wuhan University were published in the National Science Review. The team successfully developed an efficient technique for enriching trace amounts of circulating nucleic acids in blood.
March 27th, 2024 — Source

Treatment of advanced non-small cell lung cancer with driver mutations
Lung cancer is the leading cause of cancer-related death worldwide. Improved understanding of driver mutations of non-small cell lung cancer (NSCLC) has led to more biomarker-directed treatment for patients with advanced stages. The expanding number of drugs targeting these driver mutations offers more opportunity to improve patient's survival benefit.
March 27th, 2024 — Source

Health — Cancer — March 25th, 2024

ABT199/Venetoclax synergism with thiotepa in acute myeloid leukemia (AML) cells
A new research paper titled "ABT199/venetoclax synergism with thiotepa enhances the cytotoxicity of fludarabine, cladribine and busulfan in AML cells" has been published in Oncotarget.
March 25th, 2024 — Source

Cancer therapies show promise in combating tuberculosis
What could cancer teach us about tuberculosis? That's a question Meenal Datta has been chasing since she was a graduate student.
March 25th, 2024 — Source

Engineers develop novel method for manufacturing CAR T cells using lipid nanoparticles
For patients with certain types of cancer, CAR T cell therapy has been nothing short of life changing. Developed in part by Carl June, Richard W. Vague Professor at the Perelman School of Medicine, and approved by the Food and Drug Administration (FDA) in 2017, CAR T cell therapy mobilizes patients' own immune systems to fight lymphoma and leukemia, among other cancers.
March 25th, 2024 — Source

Incurable but not hopeless: How hope shapes patients' awareness of their advanced cancer prognosis
Hope is defined as the expectation of achieving a future good. Patients with cancer, whether it is curable or not, prioritize cure as their highest hope.
March 25th, 2024 — Source

New research identifies promising drug combination for multiple myeloma treatment
New research from the Royal College of Surgeons in Ireland has found that venetoclax, a medication currently approved for leukemia, provides benefits for patients with multiple myeloma when used in combination with another drug. This discovery offers a new avenue of treatment options for the currently incurable disease.
March 25th, 2024 — Source

Patient recovery after surgery for esophageal cancer isn't influenced by using standard or keyhole incisions
New research has found no evidence of a difference between recovery time and complications when comparing standard and keyhole surgical incisions for the treatment of oesophageal cancer (cancer of the gullet). The study, led by the University of Bristol Medical School and published in the British Journal of Surgery, showed surgeons treating patients with oesophageal cancer do not need to change their practice if they have a strong preference for either procedure type.
March 25th, 2024 — Source

Princess of Wales and King Charles: 1 in 2 people develop cancer during their lives
The Princess of Wales released a moving video message on March 22 to address speculation about her health. In it, the future queen disclosed that she'd been diagnosed with cancer following tests conducted after she underwent major abdominal surgery at a clinic in London in January.
March 25th, 2024 — Source

Health — Cancer — March 22nd, 2024

Eligibility for lung cancer screening up with 2021 USPSTF recommendations
Expanded U.S. Preventive Services Task Force (USPSTF) criteria for lung cancer screening (LCS) in 2021 have resulted in a 65.9 percent increase in the number of eligible individuals, according to a research letter published online March 21 in JAMA Network Open.
March 22nd, 2024 — Source

Lymph node-like biomaterial scaffold for augmenting CAR-T cell therapy
In a study published in the journal National Science Review, a research team aimed to enhance treatment efficacy of CAR-T cell therapy for solid tumors. The research was led by Dr. Zhen Gu and Dr. Hongjun Li from the College of Pharmaceutical Sciences at Zhejiang University, along with Dr. Jie Sun from the School of Medicine at Zhejiang University,
March 22nd, 2024 — Source

Navigating the maze of cancer: How precision medicine unravels the unknown
In our journey to unravel the obscurities of high-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs), we've embarked on a quest guided by personalized medicine principles. Imagine you're faced with a challenging puzzle—each piece representing a unique aspect of your illness.
March 22nd, 2024 — Source

New alveolar soft-part sarcoma chip can mimic the microenvironment during angiogenesis
Cancer, the second leading cause of death worldwide, is more likely to respond to effective treatment if identified early before metastasizing, resulting in a greater probability of surviving.
March 22nd, 2024 — Source

New research results explore the safety of short-term cultivated CAR T cells in cancer immunotherapy
Chimeric antigen receptor T cells—CAR T cells for short—are immune cells (T cells) that are taken from the body and genetically modified outside the body in the laboratory using transport vehicles for the genes to be transmitted (vectors). After being returned to the patient, these CAR T cells can specifically target and kill cells that contain defined antigens.
March 22nd, 2024 — Source

Rising survival rates for AML patients over 65 after allogeneic hematopoietic stem cell transplant
Bottom line: Among patients over 65 who received an allogeneic hematopoietic stem cell transplant (allo-HCT) for the treatment of acute myeloid leukemia (AML) between 2000 and 2021, leukemia-free and overall survival improved significantly over time.
March 22nd, 2024 — Source

Scientists consider fighting potentially lethal form of breast cancer with chemical produced by the disease
Triple negative breast cancer is the most aggressive subtype of the disease and is notorious for a poor prognosis, but scientists are working on a breakthrough method of converting these treatment-resistant tumors into a form that succumbs to therapy.
March 22nd, 2024 — Source

Scientists uncover four proteins that govern the identity of anaplastic large cell lymphoma
A collaboration between scientists from St. Jude Children's Research Hospital and Dana-Farber Cancer Institute uncovered four proteins that govern the identity of anaplastic large cell lymphoma (ALCL), an aggressive form of cancer. These proteins comprise a core regulatory circuit (CRC) that surprisingly incorporates a dysregulated signaling protein.
March 22nd, 2024 — Source

Study demonstrates safe reduction of lymph node removal in breast cancer patients
Patients with breast cancer that has started to spread to the lymph nodes in the armpit can safely avoid extensive removal of the lymph nodes if their treatment is tailored to their response to cancer-killing therapies such as chemotherapy before surgery.
March 22nd, 2024 — Source

Study finds outcomes after stem cell transplant in elderly patients with AML have improved since 2000
According to a study published in Clinical Cancer Research, among patients over 65 who received an allogeneic hematopoietic stem cell transplant (allo-HCT) for the treatment of acute myeloid leukemia (AML) between 2000 and 2021, leukemia-free and overall survival improved significantly over time.
March 22nd, 2024 — Source

What causes breast cancer?
There is a lot going on within the field of breast cancer research. A new AI tool is trying to fine-tune the screening program, another one is helping pathologists make diagnoses. New drugs are approved. This could save more lives. But there is still no answer to the trickiest question of all: What causes breast cancer?
March 22nd, 2024 — Source

Health — Cancer — March 20th, 2024

A computational model to simulate the biomechanical growth of breast tumors
Scientists from Universidad Carlos III de Madrid (UC3M) and Johns Hopkins University (JHU), in the U.S., have analyzed the growth of breast tumors from a biomechanical perspective and have created a computational model that simulates the invasion process of cancer cells, depending on the characteristics of the surrounding tissue and cell junctions, among other parameters.
March 20th, 2024 — Source

Advances and applications of nanoparticles in cancer therapy
The research team of Prof. Changyang Gong from the Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University has published a new review showing that rapid growth in nanoparticles as delivery systems hold vast promise to promote therapeutic approaches for cancer treatment. Dr. Xianzhou Huang served as team leader.
March 20th, 2024 — Source

AI-based mobile app can diagnose melanoma with very high precision
A mobile app that uses artificial intelligence, AI, to analyze images of suspected skin lesions can diagnose melanoma with very high precision. This is shown in a study led from Linköping University in Sweden where the app has been tested in primary care.
March 20th, 2024 — Source

Bacteria subtype linked to growth in up to 50% of human colorectal cancers, researchers report
Researchers at Fred Hutchinson Cancer Center have found that a specific subtype of a microbe commonly found in the mouth is able to travel to the gut and grow within colorectal cancer tumors. This microbe is also a culprit for driving cancer progression and leads to poorer patient outcomes after cancer treatment.
March 20th, 2024 — Source

Clinical trial shows rucaparib extends progression-free survival for uterine cancer patients
The results of a multisite clinical trial overseen by University of Colorado Cancer Center member Bradley Corr, MD, could offer new hope to patients with metastatic and recurrent uterine cancer, also known as endometrial cancer.
March 20th, 2024 — Source

Colon cancer is increasing in younger Coloradans even as death rate drops for people over 55
In 2020, the most recent year with data on cancer cases, 452 people under the age of 55 received a colorectal cancer diagnosis in Colorado, up from 367 a decade earlier—a 23% increase.
March 20th, 2024 — Source

Cryoablation could be a new treatment path for breast cancer patients with large tumors
A minimally invasive technique that uses ice to freeze and destroy small, cancerous tumors has now been proven effective for breast cancer patients with large tumors, providing a new treatment path for those who are not candidates for surgery, according to new research to be presented at the Society of Interventional Radiology Annual Scientific Meeting in Salt Lake City.
March 20th, 2024 — Source or Source

Delayed treatment effect predicting (DTEP) model found to enhance precision in immuno-oncology trial designs
Over the last decade, immunotherapies, particularly immune checkpoint inhibitors (ICIs), have emerged as promising treatments for various cancer types. However, a notable challenge in immuno-oncology trials is the frequent occurrence of delayed treatment effects (DTE), where the therapeutic benefits of ICIs may take months to manifest.
March 20th, 2024 — Source

Discovery sets stage for vaccine against gastric cancer, ulcers
H. pylori is one of the most common disease-causing bacteria. More than half of the world's population have the bacteria in their body; and while in Canada overall prevalence of H. pylori is between 20% and 30%, some groups—including Indigenous communities—have higher rates.
March 20th, 2024 — Source

Drug-pricing program improves prostate cancer treatment adherence, finds study
Prostate cancer patients receiving care at hospitals that are part of a special drug-pricing program were more likely to stick to their prescription drug therapy than patients at other hospitals, according to a study from researchers at the University of Michigan's Rogel Cancer Center and Institute for Healthcare Policy and Innovation.
March 20th, 2024 — Source

Enhanced screening could significantly decrease cervical cancer cases and deaths
Getting screened for cervical cancer isn't fun. And getting an alert that your initial exam showed a potential sign of trouble, and that you need to go back for a test or procedure to rule out cancer, is even less fun.
March 20th, 2024 — Source

Fitness Legend Richard Simmons Diagnosed with Skin Cancer
Another hill to climb.
March 20th, 2024 — Source

Genetic test can identify how patients with triple negative early-stage breast cancer will respond to immunotherapy
Researchers have developed a genetic test that can identify how patients with triple negative early-stage breast cancer will respond to immunotherapy drugs. This means that patients who are unlikely to respond to these drugs can avoid the adverse side effects associated with them and can be treated with other therapies.
March 20th, 2024 — Source

Immune cell protein identified as potential target for rare liver cancer treatment
Fibrolamellar carcinoma (FLC) is a rare liver cancer with a poor prognosis if not addressed early with surgery. The disease is caused by a single genetic mutation that creates a fusion protein. Scientists at St. Jude Children's Research Hospital and The University of Tennessee Health Science Center discovered an immune cell protein that can target and spark the destruction of FLC.
March 20th, 2024 — Source

Lu(a)minar flow odyssey—using the power of water and light in early leukemia diagnostics
Cancer is the scourge of the 21st century, and despite the rapid development in medical diagnostics and personalized treatments, most therapies remain insufficient to save a patient's life. Timely and accurate diagnosis is of paramount importance, but once a patient is diagnosed, the outcome of the battle to save a life still depends on many factors.
March 20th, 2024 — Source

Metalloimmunotherapy: Combination of cisplatin and STING agonist into one molecule boosts cancer immune response
Traditionally, therapies combining DNA-damaging agents and STING agonists have shown potential in treating cancer by enhancing immune response and reshaping the tumor microenvironment. However, until now, creating a single molecular entity housing both agents has remained elusive.
March 20th, 2024 — Source

New treatment option for prostate cancer shows successful outcomes
A minimally-invasive treatment using MRI and transurethral ultrasound instead of surgery or radiation is effective in treating prostate cancer, according to new research to be presented at the Society of Interventional Radiology Annual Scientific Meeting in Salt Lake City.
March 20th, 2024 — Source

News study shows cryoblation 'freeze' treatment works for large breast tumors
Killing off large tumors by freezing them could become an effective means of fighting difficult-to-treat breast cancer, a new study says.
March 20th, 2024 — Source

Pembrolizumab enhances breast cancer treatment regardless of age or menopausal status
New data from the KEYNOTE-756 phase 3 clinical trial show that adding the immunotherapy drug, pembrolizumab, to chemotherapy before and after surgery for breast cancer leads to better outcomes for patients regardless of their age or menopausal status.
March 20th, 2024 — Source

Researchers identify key regulators underlying regeneration in Drosophila
Some animals possess the remarkable ability to regenerate lost structures, exemplified by a lizard regrowing its tail. However, this regenerative process must be tightly regulated by the body to ensure proper tissue organization and to prevent abnormal growths, such as cancer. Yet, the precise mechanisms underlying this regulation are not well known.
March 20th, 2024 — Source

Second primary malignancies represent small proportion of adverse events after CAR T-cell therapy
Second primary malignancies (SPMs) represent a small proportion of adverse events (AEs) reported by patients receiving chimeric antigen receptor T-cell (CAR T-cell) therapy, according to a letter to the editor published online March 14 in Blood.
March 20th, 2024 — Source

Scientists find core regulatory circuit controlling identity of aggressive leukemia
A collaboration between scientists from St. Jude Children's Research Hospital and Dana-Farber Cancer Institute uncovered four proteins that govern the identity of anaplastic large cell lymphoma (ALCL), an aggressive form of cancer. These proteins comprise a core regulatory circuit (CRC) that surprisingly incorporates a dysregulated signaling protein.
March 20th, 2024 — Source

Study discusses liquid biopsy as a game changer for early lung cancer detection
In 2020, 1.8 million people succumbed to lung cancer. The late-stage discovery of lung cancer is one of the glaring challenges faced by the medical community. While surgical biopsies continue to remain the gold standard for cancer diagnosis, the invasive nature of the technique can lead to serious health complications.
March 20th, 2024 — Source

Team shows how an anticancer drug kills cancer cells and damages healthy cells, paves way for improved treatment
Some anti-cancer treatments not only target tumor cells but also healthy cells. If their effects on the latter are too strong, their use can become limiting.
March 20th, 2024 — Source

The search to discover why 'outliers' survive deadliest cancers
When Herve found out he had glioblastoma—the most aggressive form of brain cancer—at the age of 40, he made a deal with himself.
March 20th, 2024 — Source

U.S. could cut cervical cancer cases and deaths if more patients got follow-up after screening, study suggests
Getting screened for cervical cancer isn't fun. And getting an alert that your initial exam showed a potential sign of trouble, and that you need to go back for a test or procedure to rule out cancer, is even less fun.
March 20th, 2024 — Source

What breast cancer risk assessments can tell you
Actress Olivia Munn recently shared on social media that she had undergone a double mastectomy after being diagnosed with luminal B breast cancer. In an Instagram post, Munn explained how she had been diagnosed with the fast-growing cancer.
March 20th, 2024 — Source

Why do cancer patients lose weight? Study points to elevated lactate levels
Elevated levels of lactate may lead to the development of cachexia (disease-related weight loss) following the onset of cancer, according to a study including data from mice and humans published in Nature Metabolism.
March 20th, 2024 — Source

Health — Cancer — March 18th, 2024

Artificial mucus identifies link to tumor formation
During cold and flu season, excess mucus is a common, unpleasant symptom of illness, but the slippery substance is essential to human health. To better understand its many roles, researchers synthesized the major component of mucus, the sugar-coated proteins called mucins, and discovered that changing the mucins of healthy cells to resemble those of cancer cells made healthy cells act more cancer-like.
March 18th, 2024 — Source

Assessing breast cancer risk
The genetic risk of breast cancer has been in the news lately. Researchers at the Mayo Clinic Comprehensive Cancer Center are working toward pinpointing individuals' risk of developing breast cancer.
March 18th, 2024 — Source

Attacking metastatic prostate cancer early with combination treatment approach improves outcomes in preliminary study
A team of UCLA Health Jonsson Comprehensive Cancer Center investigators has shown the combination of a short course of powerful and intense hormonal therapy with targeted radiation is safe and effective in treating people with prostate cancer that has come back and has spread to other parts of the body.
March 18th, 2024 — Source

Arrayjet's ArrayPlex platform selected by Immunome for use in its discovery of targeted cancer therapies
Arrayjet, a leading provider of inkjet liquid-handling solutions, today announced that its ArrayPlex™ discovery platform has been selected by Immunome, Inc., a biotechnology company dedicated to developing first-in-class and best-in-class targeted cancer therapies, to expand its in-house high-throughput screening tools.
March 18th, 2024 — Source

Bacteria commonly found in the body contribute to stomach cancer, finds study
A new study has discovered that a type of bacteria commonly found in the body, which usually does not pose problems for healthy people, plays a significant role in causing stomach cancer, the fifth most common cancer in the world. The findings are published in the journal Cell.
March 18th, 2024 — Source

Breast Cancer Now funds researchers to investigate targeted radiotherapy for metastatic breast cancer in the brain
Researchers are trialing a new type of targeted radiotherapy to treat secondary breast cancer tumors in the brain, thanks to new funding from Breast Cancer Now.
March 18th, 2024 — Source

Clinical trial aims to provide a surgical solution for patients with 'inoperable' pancreatic tumors
A clinical trial from Keck Medicine of USC aims to provide a surgical solution for patients with a form of advanced pancreatic cancer previously considered inoperable.
March 18th, 2024 — Source

Hypofractioned post-prostatectomy radiotherapy new acceptable practice standard based on NRG Oncology trial findings
Results from the Phase III NRG Oncology NRG-GU003 clinical trial comparing hypofractioned post-prostatectomy radiotherapy (HYPORT) to conventionally fractioned post-prostatectomy radiotherapy (COPORT) determined that HYPORT was non-inferior to COPORT in terms of late gastrointestinal (GI) or genitourinary (GU) toxicity for patients primarily treated with prostatectomy for their prostate cancer.
March 18th, 2024 — Source

Newly discovered link between FBXW7 mutations and EGFR signaling in colorectal cancer
The Organoid group at the Hubrecht Institute has identified a new link between FBXW7 mutations and epidermal growth factor receptor (EGFR) signaling activity. The FBXW7 gene is commonly mutated in colorectal cancer and such mutations have been associated with worse treatment outcomes.
March 18th, 2024 — Source

Non-invasive blood test shows 83% sensitivity in detecting colorectal cancer, offering hope for early diagnosis NewsGuard 100/100 Score
In a recent study published in The New England Journal of Medicine, a team of scientists from the United States (U.S.) and Canada evaluated the performance of a blood-based testing method that uses cell-free deoxyribonucleic acid (DNA) to screen for colorectal cancer.
March 18th, 2024 — Source

Researchers pinpoint issue that could be hampering common chemotherapy drug
Researchers at the University of Toronto's Donnelly Centre for Cellular and Biomolecular Research have found two enzymes that work against the chemotherapy drug gemcitabine, preventing it from effectively treating pancreatic cancer.
March 18th, 2024 — Source

Role in mitochondrial metabolism paints more complete picture of MCL-1 function
The life and death of cells are governed by processes that—when disrupted—can lead to cancer. Apoptosis, the process of programmed cell death, is tightly regulated by the B-cell lymphoma-2 (BCL-2) family of proteins. This includes myeloid cell leukemia-1 (MCL-1), an anti-apoptotic protein that helps cells stay alive.
March 18th, 2024 — Source

Study: 20,000 men may have missed prostate cancer diagnosis due to the COVID-19 pandemic
Prostate cancer diagnoses in 20,000 men could have been missed due to the COVID-19 pandemic, finds a new study from the University of Surrey and the University of Oxford. Increased waiting times and changes in people's behavior in seeking medical attention during the pandemic could be responsible for missed diagnoses.
March 18th, 2024 — Source

This Mutation Likely Saved a Colon Cancer Patient's Life
When Ken Aaron, 51, woke up from his first-ever colonoscopy last February to his doctor mouthing the words “we found a tumor,” there was no one more surprised than he was. The married father of two had some very mild GI discomfort before he booked the scan, but, besides that, there was nothing significantly amiss with the writer, an avid hiker and skier who lives in the Adirondacks.
March 18th, 2024 — Source

Understanding what causes trastuzumab's cardiotoxicity
A new meta-analysis published in OMICS: A Journal of Integrative Biology helps shed light on how changes in mitochondria-related gene expression may cause the cardiotoxicity associated with the cancer therapy trastuzumab.
March 18th, 2024 — Source

US finalizes ban on last form of asbestos in use
President Joe Biden's administration on Monday finalized a rule banning the last remaining form of asbestos in the United States, half a century after the government first targeted the cancer-causing mineral.
March 18th, 2024 — Source

Health — Cancer — March 15th, 2024

Addressing higher colon cancer rates in rural areas
The technology needed to stop colorectal cancer before it turns deadly has never been better.
March 14th, 2024 — Source

Advances in multiple myeloma treatment
March is Myeloma Awareness Month. Multiple myeloma is a blood cancer that most often occurs in people over age 45. It's the second-most common blood cancer and the most common blood cancer in Black people.
March 14th, 2024 — Source

Dietitian suggests ways to prevent colorectal cancer
We may joke about the prep involved for a colonoscopy (an exam for abnormal changes in the large intestine). But cancers of the colon or rectum are no laughing matter. In fact, when you combine the cancer death rates of men and women, colorectal cancer is now the second deadliest cancer in the United States, according to the American Cancer Society.
March 14th, 2024 — Source

DNA origami-based vaccines toward safe and highly-effective precision cancer immunotherapy
(Nanowerk News) Therapeutic cancer vaccines are a form of immunotherapy in the making that could not only destroy cancer cells in patients, but keep a cancer from coming back and spreading. Multiple therapeutic cancer vaccines are being studied in clinical trials, but despite their promise, they are not routinely used yet by clinical oncologists to treat their patients.
March 14th, 2024 — Source or Source

Exploring olive oil compounds oleuropein and hydroxytyrosol as potential treatments for neuroblastoma NewsGuard 100/100 Score
In a recent review published in the Nutrients, a group of authors explored the therapeutic potential of oleuropein (OLE) and hydroxytyrosol (HT) from olive oil as novel antioxidants in the treatment of neuroblastoma (NB), addressing challenges such as recurrence and drug resistance.
March 14th, 2024 — Source

In vivo production of CAR-T cells using virus-mimetic fusogenic nanovesicles
Chimeric antigen receptors (CARs) are synthesized membrane proteins that enable lymphocytes to recognize and respond to the specific antigens of target cells. Despite the impressive efficacy of CAR-T cell therapy in treating B-cell lymphoma or leukemia, the expensive and complex manufacturing process has hindered its widespread clinical application.
March 14th, 2024 — Source

Innovative CAR T cell therapy targets two proteins to combat aggressive brain tumor growth NewsGuard 100/100 Score
In a recent report published in Nature Medicine, researchers presented the initial results of recurrent glioblastoma (rGBM) patients treated with intrathecally administered, autologous, bivalent chimeric antigen receptor (CAR) T cells targeting epidermal growth factor receptor (EGFR) and interleukin-13 receptor alpha 2 (IL13Rα2) in a phase 1 clinical trial.
March 14th, 2024 — Source

Large-scale study explores genetic link between colorectal cancer and meat intake
In one of the largest ever gene-environment interaction studies of red meat and colorectal cancer, which explored the impact of red meat consumption on a person's cancer risk based on their genotype, researchers have identified two genetic markers that may help explain the association between the two and explain why some people face a higher cancer risk.
March 14th, 2024 — Source

New technique opens up study of immune response to cancer based on DNA locked in old archive cancer samples
Scientists have developed an improved technique for reading the genetic material associated with the body's immune response to cancer, making it possible to study tissue samples that have been stored in archives for decades.
March 14th, 2024 — Source

Researchers discover a signaling molecule in neuroblastoma immunosuppression and aggressiveness
The MYCN oncoprotein (proteins related to the growth of cancer cells) plays a key role in starting, advancing and making it difficult to treat various human cancers. When MYCN is overactive, especially in high-risk neuroblastoma (childhood cancer often found in the adrenal glands), the tumors become less responsive to immunotherapy—a treatment that uses the body's immune system to fight cancer.
March 14th, 2024 — Source

Researchers gain insight into why T cells lose energy in solid tumors
T cells are often called "assassins" or "killers" because they can orchestrate and carry out missions to hunt down bacteria, viruses, and cancer cells throughout the body. Mighty as they may be, recent research has shown that once T cells infiltrate the environment of a solid tumor, they lose the energy needed to combat the cancer.
March 14th, 2024 — Source

The efficacy of the Mediterranean diet on health outcomes in adults with cancer
Cancer treatment is often associated with undue weight gain, mostly due to fat deposition. The Mediterranean diet (MED diet) may help support such patients during this period. A new study published in the European Journal of Clinical Nutrition explores the safety and benefits of this diet in adults with cancer, in addition to its feasibility in this population.
March 14th, 2024 — Source

Warning signs of colorectal cancer in younger adults
Colorectal cancer, the third-most common cancer in the U.S., has been rising among younger people for the past two decades. It is not one type of cancer but two cancers: colon cancer, which starts in the large intestine, and rectal cancer, which begins in the last part of the large intestine, known as the rectum.
March 14th, 2024 — Source

Health — Cancer — March 14th, 2024

A new strategy to attack aggressive brain cancer shrank tumors in two early tests
A new strategy to fight an extremely aggressive type of brain tumor showed promise in a pair of experiments with a handful of patients.
March 14th, 2024 — Source

A pioneering way to target the culprit behind a deadly liver cancer
Researchers have translated a cutting-edge tactic for treating genetic disorders into a fresh approach for potentially stymying cancer.
March 14th, 2024 — Source

Breast cancer diagnoses plummeted during first year of pandemic, finds study
Several studies have described the distinct ways the COVID-19 pandemic adversely impacted cancer care, but less is known about the specific ways the pandemic disrupted breast cancer, the most common non-skin cancer diagnosed in women.
March 14th, 2024 — Source

Cell division, DNA repair and cancer progression closely tied to CDK9 dysfunction
Researchers describe a newly observed role for the protein Cyclin Dependent Kinase 9 (CDK9) in regulating DNA repair during cellular division, where errors can become the origin of cancerous tumor growth. Through a process called phosphorylation, the experiment simulated the interaction of CDK9 with the other proteins and genes involved in cell division and cancerous tumor growth.
March 14th, 2024 — Source

EPA tightens limits on a chemical used to sterilize medical equipment, citing cancer risk
The Environmental Protection Agency is imposing stricter limits on a chemical used to sterilize medical equipment after finding a higher-than-expected cancer risk at facilities that use ethylene oxide to clean billions of devices including catheters and syringes.
March 14th, 2024 — Source

First-in-human trial finds new bladder cancer treatment safe
A first-in-human trial led by The University of Western Australia has found injecting an immunotherapy drug directly into the bladder wall to treat cancer is viable and safe.
March 14th, 2024 — Source

New AI model detects 90% of lymphatic cancer cases
Medical image analysis using AI has developed rapidly in recent years. Now, one of the largest studies to date has been carried out using AI-assisted image analysis of lymphoma, cancer of the lymphatic system. Researchers at Chalmers University of Technology in Sweden, have developed a computer model that can successfully find signs of lymph node cancer in 90% of cases.
March 14th, 2024 — Source

New analysis sheds light on cancer incidence and mortality trends in the UK NewsGuard 100/100 Score
In a recent study published in BMJ, researchers investigated trends in cancer incidence and deaths in the United Kingdom (UK) among individuals aged between 35 and 69 years.
March 14th, 2024 — Source

Next milestone in the treatment of liver tumors and acute and chronic liver diseases
The results of a Tübingen-led study raise hope that a newly developed drug could herald a new era in oncological liver surgery and liver transplantation. The drug could even have the potential to significantly improve the treatment of acute and chronic liver diseases.
March 14th, 2024 — Source

Olivia Munn's Breast Cancer: A Wake-Up Call for Women
Actress Olivia Munn's candid disclosures on Instagram about her aggressive breast cancer — a surprise discovery after a "clean" mammogram and negative genetic tests — were a poignant mix of details about her cancer journey and a cautionary tale for women.
March 14th, 2024 — Source

Protein discovery sparks treatment hope for aggressive cancer
Researchers have found a new way to potentially treat one of the most common forms of acute lymphoblastic leukemia.
March 14th, 2024 — Source or Source

Researchers develop dual anti-tumor vaccine
A research team at the LKS Faculty of Medicine, the University of Hong Kong (HKUMed), has discovered that exosomes derived from γδ-T cells not only have direct anti-tumor effects but also, when developed into a tumor vaccine, can effectively induce a tumor-specific immune response. The findings, which provide a new approach to cancer treatment, were published in the Journal of Extracellular Vesicles.
March 14th, 2024 — Source

Researchers find the key to genome-modifying drugs' sensitivity in malignant blood diseases
There are many anti-cancer genes that are no longer active in human tumors, preventing them from carrying out their protective function against cell transformation. One of the main mechanisms used by cancer cells to silence these 'good' genes is the addition of a chemical modification called methylation, which results in the loss of gene expression.
March 14th, 2024 — Source

Researchers target cancer's ability to survive at low oxygen levels
Researchers at the Francis Crick Institute have shed light on how cancer cells survive in the first few hours after being cut off from a supply of oxygen.
March 14th, 2024 — Source

Studying use of patients' own reprogrammed cells to attack cancer as alternative to more chemo
A process of taking patients' own cells and reprogramming them to fight cancer has been a last-ditch option for blood cancer patients when nothing else worked, but a new study underway in Aurora is trying to determine whether more patients could benefit from trying the procedure sooner.
March 14th, 2024 — Source

Targeting LTA4H improves the tumor immune microenvironment in ovarian cancer: Study
In ovarian cancer, the abnormal expression of various metabolic enzymes in the metabolism of polyunsaturated fatty acids (PUFA) is involved in the development of tumors and immune regulation. Most ovarian cancer patients are admitted with advanced disease due to its hidden symptoms and difficulty of detection at an early stage.
March 14th, 2024 — Source

Tissue samples show the deep genetic and cellular impacts of smoking
It's no secret that smoking is extremely detrimental to health. Tobacco smoke contains thousands of chemicals, including carcinogens, increasing the risk of cancer, cardiovascular and respiratory diseases.
March 14th, 2024 — Source

Using adavosertib-encapsulated MOFs for p53-mutated gallbladder cancer treatment via synthetic lethality
Since the revelation of poly(ADP-ribose) polymerase (PARP) inhibitors and their remarkable results in the treatment of BRCA1/2 mutant cancers, synthetic lethality (SL) in antitumor therapy has attracted increasing attention. SL is a phenomenon in which a single genetic event is insufficient to induce cell death, but multiple genetic events lead to cell death.
March 14th, 2024 — Source

Water droplet spun by sound screens for colon cancer
Mechanical engineers have devised a diagnostic platform that uses sound waves to spin an individual drop of water up to 6000 revolutions per minute. These speeds separate tiny biological particles within samples placed in a very light disc sitting on top of the spinning drop. The technique could allow new point-of-care applications ranging from precision bioassays to cancer diagnosis. The technique requires less time and sample volume while inflicting less damage to delicate exosomes.
March 14th, 2024 — Source

What is the breast cancer risk calculator recommended by Olivia Munn?
When Olivia Munn revealed this week that she was diagnosed with breast cancer and had a double mastectomy, she urged people to ask their doctors to figure out their score on a breast cancer risk calculator.
March 14th, 2024 — Source

Health — Cancer — March 11th, 2024

Better contact increases stem cell donors' availability, shows study
Every year, more than 20,000 people in Germany die of blood cancer. It is the most common type of cancer in children. Donations of stem cells from blood or bone marrow increase the chance of survival for people suffering from leukemia and other forms of blood cancer.
March 11th, 2024 — Source

Drug combo marks advance against bladder cancer
A cancer drug duo more than doubled the survival of people battling the most common form of advanced bladder cancer, trial results show.
March 11th, 2024 — Source

Online search data could be used to detect gynecological cancer cases earlier
Search engine data could be used to detect gynecological cancer cases earlier, potentially months ahead of GP referrals, according to new research.
March 11th, 2024 — Source

Protein 'brake' could help develop new cancer treatments
Some cancerous tumors hijack proteins that act as "brakes" on our immune system and use them to form a sort of shield against immune recognition. Immunotherapy treatments have been created that turn off these "brakes" and allow our body to attack foreign-looking cancer cells.
March 11th, 2024 — Source

Researchers use microscopy plus deep learning to advance prostate cancer diagnosis
Prostate cancer stands as a prevalent threat to men's health, ranking second in cancer-related deaths in the United States. Each year, approximately 250,000 men in the U.S. receive a prostate cancer diagnosis. While most cases have low morbidity and mortality rates, a subset of cases demands aggressive treatment.
March 11th, 2024 — Source

Revolutionizing prostate cancer diagnostics with 3D pathology and deep learning
Prostate cancer stands as a prevalent threat to men's health, ranking second in cancer-related deaths in the United States. Each year, approximately 250,000 men in the U.S. receive a prostate cancer diagnosis. While most cases have low morbidity and mortality rates, a subset of cases demands aggressive treatment.
March 11th, 2024 — Source

Scaling early detection of esophageal cancer with AI
Microsoft Research and Cyted have collaborated to build novel AI models to scale the early detection of esophageal cancer. The AI-supported methods demonstrated the same diagnostic performance as the existing manual workflow, potentially reducing the pathologist's workload by up to 63%.
March 11th, 2024 — Source

Study finds worsening metabolic syndrome increases the risk of developing cancer
New research indicates that individuals with persistent and worsening metabolic syndrome—which encompasses conditions such as high blood pressure, elevated blood sugar, excess abdominal fat, and abnormal cholesterol—face an elevated risk of developing various types of cancer.
March 11th, 2024 — Source

Study identifies successful methods to recruit South Asian women for breast cancer research
South Asian American women increasingly are diagnosed with breast cancer at younger ages and with more advanced disease compared with other groups, a fact made even more alarming because they are underrepresented in studies, said Jaya Satagopan, an associate dean for faculty affairs and professor at the School of Public Health and member of the Cancer Prevention and Control Program at Rutgers Cancer Institute of New Jersey.
March 11th, 2024 — Source

UCLA and UAMS teams secure $3.2 million NIH grant for melanoma research
A team of investigators from the UCLA Health Jonsson Comprehensive Cancer and the University of Arkansas for Medical Sciences (UAMS) Winthrop P. Rockefeller Cancer Institute was awarded a $3.2 million grant from the National Institutes of Health to identify new ways to prevent and overcome treatment resistance to targeted therapy in patients with all sub-types of cutaneous melanoma, an aggressive form of skin cancer.
March 11th, 2024 — Source

Health — Cancer — March 8th, 2024

Cancer causes: Popular myths about the causes of cancer
Misconceptions about cancer causes can lead to unnecessary worry about your health. Find out whether there's any truth to these common myths about the causes of cancer.
March 8th, 2024 — Source

'Double life' of key immune protein reveals new strategies for treating cancer and autoimmune diseases
Insights into the workings of an immune cell surface receptor, called PD-1, reveal how treatments that restrict its action can potentially be strengthened to improve their anticancer effect, a new study shows. The same findings also support experimental treatment strategies for autoimmune diseases, in which the immune system attacks the body, because stimulating the action of PD-1, as opposed to restricting it, can potentially block an overactive immune response.
March 8th, 2024 — Source

EHR developers adopt FHIR-based oncology standardization
The Biden Cancer Moonshot says that Epic, Oracle Health, Meditech, athenahealth, Flatiron, Ontada, ThymeCare and CVS Health have adopted the CMS Enhancing Oncology Model to increase interoperability, advance equity and improve cancer diagnosis outcomes.
March 8th, 2024 — Source

Mobile phone users who talk longer do not have a higher risk of brain tumors, international study finds
A large international research study, COSMOS, initiated by Karolinska Institutet, Stockholm and Imperial College London, has studied more than 250,000 mobile phone users to investigate whether those who use mobile phones extensively and over a long time-period have a higher risk of brain tumors than others.
March 8th, 2024 — Source

New study finds limited correlation between canine lymphoma and proximity to environmental toxins
As awareness of the health risks associated with radon and fracking exposure in connection to cancer continues to rise in human medicine, a recent study explored these ties with multicentric lymphoma, a prevalent canine cancer. Surprisingly, the study did not identify significant correlations between living near sources of environmental toxins, such as fracking by-products and radon, and dogs diagnosed with lymphoma.
March 8th, 2024 — Source

Study shows how estrogen protects against fatty liver
New research from Karolinska Institutet shows how estrogen protects against MASLD, a fatty liver disease that has increased dramatically during the current obesity epidemic. The study, published in Molecular Systems Biology, shows how a new drug under development could become a future treatment for fatty liver disease and liver cancer.
March 8th, 2024 — Source

Health — Cancer — March 6th, 2024

A noninvasive treatment may protect patients from memory impairment and cognitive effects of chemotherapy
Patients undergoing chemotherapy often experience cognitive effects such as memory impairment and difficulty concentrating—a condition commonly known as "chemo brain."
March 6th, 2024 — Source

A step towards clinic-ready patient-derived organoids for pancreatic cancer
Pancreatic cancer carries the highest mortality rate of all major cancers and is projected to become the second-leading cause of cancer-related deaths in the United States by 2030. It is especially difficult to treat because pancreatic tumors grow so quickly and are constantly evolving, making them prone to developing drug resistance.
March 6th, 2024 — Source

How fusion proteins hijack gene regulators to spur childhood cancer
Many childhood cancers start with a hijacking at the molecular level. A group of abnormal proteins known as fusion proteins aberrantly engages with a collection of proteins that switches genes on and off. As a result, genes that should be activated get repressed, and genes that should be repressed get activated, causing cancer.
March 6th, 2024 — Source

Lung cancer cells protected from cigarette smoke damage, researchers find
Lung cancer cells survive better and exhibit less cell damage when exposed to cigarette smoke in cell culture experiments compared to non-cancerous lung cells. New research by a team of undergraduate students led by a Penn State molecular biologist may have revealed how lung cancer cells can persist in smoke.
March 6th, 2024 — Source

Nanosurgical tool could be key to cancer breakthrough
The high-tech double-barrel nanopipette, developed by University of Leeds scientists, and applied to the global medical challenge of cancer, has - for the first time - enabled researchers to see how individual living cancer cells react to treatment and change over time -- providing vital understanding that could help doctors develop more effective cancer medication.
March 6th, 2024 — Source or Source

Radioguided surgery can detect, remove metastatic lymph nodes in newly diagnosed prostate cancer patients: Study
Radioguided surgery can detect and remove metastatic pelvic lymph nodes in patients newly diagnosed with prostate cancer, according to research published in the The Journal of Nuclear Medicine.
March 6th, 2024 — Source

Researchers develop test to ID aggressive ovarian cancers early
Researchers at the Johns Hopkins Kimmel Cancer Center and the Department of Gynecology and Obstetrics at the Johns Hopkins University School of Medicine have developed an algorithm to identify high-risk precancerous lesions on the fallopian tubes. Known as serous tubal intraepithelial carcinomas (STICs), these lesions are thought to be the main precursors of ovarian high-grade serous carcinoma (HGSC), the most common form of ovarian cancer in women.
March 6th, 2024 — Source

Researchers teach AI skin-cancer diagnosis tool to see color
McMaster oncology researchers are harnessing the power of artificial intelligence to improve health outcomes for people of color.
March 6th, 2024 — Source

Small version of a CERN detector could deliver more precise radiotherapy of head tumors
Particle detectors like the ones used by physicists at CERN can have wide applications beyond fundamental research. Scientists from the German National Center for Tumor Diseases (NCT), the German Cancer Research Center (DKFZ), and the Heidelberg Ion Beam Therapy Center (HIT) at Heidelberg University Hospital are now testing a new imaging device supplied by the Czech company ADVACAM on its first patients.
March 6th, 2024 — Source

Scientists unravel tumor neutrophil complexity, discover therapeutic subset
In a study published in Cell on March 5, Prof. Zhang Xiaoming at the Shanghai Institute of Immunity and Infection (SIII) of the Chinese Academy of Sciences and Profs. Gao Qiang, Fan Jia and Yang Li at Fudan University have uncovered an unexpected level of complexity hidden within neutrophils, which were previously thought to be a relatively uniform population of short-lived immune cells.
March 6th, 2024 — Source

Study: Protein helps prevent breast cancer metastasis
While better screening and improved treatments are leading to better outcomes for patients with breast cancer, 90% of breast cancer deaths are a result of metastasis, or the cancer growing and spreading to other parts of the body.
March 6th, 2024 — Source

Studying the relationships among cancer-promoting proteins
Researchers from the Bhogaraju Group at EMBL Grenoble have gained new insights into how a cancer-relevant family of proteins bind their targets. The results of the study, published in The EMBO Journal, could potentially help in the development of drugs against certain chemotherapy- and radiotherapy-resistant cancers.
March 6th, 2024 — Source

Using AI to predict the spread of lung cancer
For decades, scientists and pathologists have tried, without much success, to come up with a way to determine which individual lung cancer patients are at greatest risk of having their illness spread, or metastasize, to other parts of the body.
March 6th, 2024 — Source

Health — Cancer — March 4th, 2024

Advance in taxol biosynthesis could lead to large-scale production of anticancer drug
Paclitaxel is the world's best-selling plant-based anticancer drug and one of the most effective anticancer drugs over the past 30 years. It is widely used in the treatment of various types of cancer, including breast cancer, lung cancer, and ovarian cancer.
March 4th, 2024 — Source

Common immune response is found to be protective across many diseases
Combined, infection, autoimmunity and cancer account for 4 out of every 10 deaths worldwide, and represent major global health challenges.
March 4th, 2024 — Source

Gene-edited lymphocytes and the path toward 'off-the-shelf' therapy against cervical cancer
Cervical cancer is among the most common malignancies affecting women worldwide. In 2020 alone, approximately 600,000 women were diagnosed with this disease, and over 314,000 died from it. In 99% of the cases, cervical cancer cells harbor human papillomavirus (HPV), and thus, HPV vaccines are an effective way to mitigate the risk of developing this disease.
March 4th, 2024 — Source

Genetic germline variations influence expression of cancer cell genes, finds study
Researchers at Baylor College of Medicine's Dan L Duncan Comprehensive Cancer Center and Human Genome Sequencing Center investigated the extent to which forms of genetic variation called germline or inherited structural variation influence gene expression in human cancers.
March 4th, 2024 — Source

Genetic risk information enables tailored breast cancer screening
Recent results from researchers at the University of Helsinki indicate that genetic risk information can help tailor and target breast cancer screening more effectively to the women who would benefit the most.
March 4th, 2024 — Source

Improving access to early-stage lung cancer care in Europe
There are stark differences between European countries when it comes to both the reimbursement of, and access to, new treatments for patients with early-stage lung cancer. There are also differences in reimbursement times and indications between the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA).
March 4th, 2024 — Source

New analytical method provides first step toward early diagnosis of metastasis
Metastases are largely responsible for the death rate of patients with solid cancers; the prognosis of cancer patients reduces significantly if metastases are diagnosed. Until now there has been no procedure available to reliably predict the probability of future metastases.
March 4th, 2024 — Source

New drug shows promise for treating rare brain tumors
An experimental drug may provide a new treatment option for some patients with rare incurable brain tumors, according to an analysis published in the Journal of Clinical Oncology.
March 4th, 2024 — Source

Research team discovers new method to test for oral cancer
Oral cancers and precancerous mouth lesions are considered especially difficult to diagnose early and accurately.
March 4th, 2024 — Source

Researchers discover a noninvasive, low-cost test to detect oral cancer
Oral cancers and precancerous mouth lesions are considered especially difficult to diagnose early and accurately.
March 4th, 2024 — Source

Review explores therapeutic targets in tumor microenvironment
The tumor microenvironment (TME) is the ecosystem surrounding a tumor, which usually consists of non-tumoral cells and molecules they produce and release. The interplay between tumor cells and the TME significantly impacts tumor development, metastasis, as well as responses to therapeutic treatments.
March 4th, 2024 — Source

Scientists report positive immune response against mpox using a COVID-19 vaccine
Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States, show that a COVID-19 vaccine developed at the organization's Los Angeles campus also protects against mpox, according to research published in Communications Medicine.
March 4th, 2024 — Source

Study highlights disparities in lung cancer treatment access across Europe
There are stark differences between European countries when it comes to both the reimbursement of, and access to, new treatments for patients with early-stage lung cancer. There are also differences in reimbursement times and indications between the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA).
March 4th, 2024 — Source

Study: Impact of agricultural activities on PM2.5 in Lombardy is comparable to that of urbanization, industry
A research study from Politecnico di Milano in the journal Chemosphere has quantified the impact of agricultural activities on the spatial distribution of fine dust (PM 2.5) in Lombardy, showing that it is comparable to the impact of other well-known sources of pollution, such as urbanization, industry, and transportation.
March 4th, 2024 — Source

T follicular helper cells research makes new immune system discoveries
T follicular helper cells (Tfh) are essential for strong antibody-mediated reactions of our immune system during infections and vaccinations. However, if they get out of control, this can cause diseases such as autoimmunity, allergies or cancer.
March 4th, 2024 — Source

Thyroid disease is common in the US—learn more about signs, symptoms
There are 20 million people in the United States who suffer from thyroid disease. According to the National Cancer Institute, Kentucky has a higher rate of thyroid cancer than the rest of the country.
March 4th, 2024 — Source

Using sacituzumab govitecan plus platinum-based chemotherapy in breast, bladder, and lung carcinomas
A new research paper titled "Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas" has been published in Oncotarget.
March 4th, 2024 — Source

Health — Cancer — March 1st, 2024

Algorithm is 20 times quicker than humans at extracting critical medical chart data from imaging reports
A form of artificial intelligence called large language modeling (LLM), the same technology behind ChatGPT, could someday improve liver cancer care by extracting important data from medical charts much faster than humans, a recent UCSF study found.
March 1st, 2024 — Source

Blood shortage imperils US ability to treat patients who require blood on any given day
Our nation's ability to treat the patients who require blood on any given day—from victims of mass-casualty events to those undergoing treatment for cancer—is in serious peril, according to a new viewpoint paper, "The Bloody Transfusion Problem," published in the JAMA.
March 1st, 2024 — Source

Checking womb condition could curb cancer risk, study shows
Improved patient care is needed to reduce cancer risk among women with a condition that causes excessive thickening of the womb lining, research shows.
March 1st, 2024 — Source

Combining CAR-T cells and inhibitor drugs for high-risk neuroblastoma
Chimeric antigen receptor (CAR)-T cell therapy is a potent emerging weapon against cancer, altering patients' T cells so they can better find and destroy tumor cells. But CAR-T cell therapy doesn't work well in every cancer—including many cases of neuroblastoma, a cancer that begins in young children's nerve tissue and can metastasize to multiple areas of the body.
March 1st, 2024 — Source

European experts publish recommendations for treatment of acute lymphoblastic leukemia in adults
The treatment of acute lymphoblastic leukemia in adults is extremely complex, lengthy and very stressful for patients. Compared to other types of cancer in adults, ALL is relatively rare, as a result of which its treatment in Europe has been organized by multicenter study groups for decades.
March 1st, 2024 — Source

Less chemoradiation is possible for some cancer patients
According to a new study from experts at the University of Michigan Health Rogel Cancer Center, some oropharynx cancer patients may qualify for less radiation treatments. This could assist many patients in a quicker return to their normal lives.
March 1st, 2024 — Source

Magnetic resonance surveillance reduces mortality in women at high risk of BRCA1 breast cancer: Study
An international study, published in JAMA Oncology, in which the Clinical Oncology group of the Sant Pau Research Institute participated, has revealed that MRI monitoring in women with mutations in the BRCA1 genes significantly reduces breast cancer mortality without the need for preventive mastectomy.
March 1st, 2024 — Source

Researchers uncover how virus causes cancer, point to potential treatment
Cleveland Clinic researchers have discovered a key mechanism used by Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8), to induce cancer. The research points to effective new treatment options for KSHV-associated cancers, including Kaposi's sarcoma, primary effusion lymphoma, and HHV8-associated multicentric Castleman disease.
March 1st, 2024 — Source

Scientists discover a key mechanism used by human herpesvirus 8 to induce cancer
Cleveland Clinic researchers have discovered a key mechanism used by Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8), to induce cancer. The research points to effective new treatment options for KSHV-associated cancers, including Kaposi's sarcoma, primary effusion lymphoma, and HHV8-associated multicentric Castleman disease.
March 1st, 2024 — Source

Targeted drug shows promising ability in treating rare head and neck cancers
Experts at University of Michigan Health Rogel Cancer Center have conducted the first study evaluating the effectiveness of a targeted drug for patients with salivary gland cancers (SGC).
March 1st, 2024 — Source

The association between diet and colorectal cancer risk
In a nested case-control study published in JAMA Network Open, researchers from South Korea investigated the genetic variants that modify the association between diet and colorectal cancer (CRC) risk.
March 1st, 2024 — Source

The surprisingly complex inner workings of an endocrine tumor
There is strength in teamwork, and it turns out that this applies to tumors, too. Researchers from Japan have reported that different types of cells within a single benign tumor may work together to promote the tumor's growth.
March 1st, 2024 — Source

The trek to save many women from cervical cancer
Home-test kits and mobile labs for detecting a tumor in tissue near the uterus are improving health care in remote or marginalized communities.
March 1st, 2024 — Source