Health — Cancer — April 2nd, 2024

AI's ability to detect tumor cells could be key to more accurate bone cancer prognoses
Researchers at Kyushu University have developed and validated a machine-learning model that can accurately evaluate the density of surviving tumor cells after treatment in pathological images of osteosarcoma—the most prevalent malignant bone tumor. The model can assess how individual tumor cells respond to treatment and can predict overall patient prognosis more reliably than conventional methods.
April 2nd, 2024 — Source

Can generative AI truly transform healthcare into a more personalized experience?
In a recent article published in npj Digital Medicine, researchers explored the current literature on large language model (LLM)-based evaluation metrics for healthcare chatbots.
April 2nd, 2024 — Source

Existing drugs may hinder the development of bone metastasis in breast cancer patients
Researchers at Tel Aviv University developed a new therapeutic strategy based on existing medications to inhibit bone metastasis in breast cancer patients. Using both an animal model and tissue samples from patients in Israel and the US, they demonstrated that a combination of drugs already availabl
April 2nd, 2024 — Source

Investigators develop novel treatment for T-cell leukemias and lymphomas
A novel treatment for leukemias and lymphomas that arise from immune system T cells, developed by investigators at the Johns Hopkins Kimmel Cancer Center and its Ludwig Center and Lustgarten Laboratory, was found to be effective at killing these cancers in mice bearing human T-cell tumors.
April 2nd, 2024 — Source

Japan health supplements tied to 157 hospitalizations
Japanese dietary supplements at the center of an expanding health scare have now been linked to at least 157 hospitalizations, a health ministry official said Tuesday.
April 2nd, 2024 — Source

Minimally invasive procedure may spare patients from thyroid surgery
In a 10-center study, microwave ablation offered progression-free survival rates and fewer complications than surgery in the treatment of a form of thyroid cancer known as papillary thyroid carcinoma (PTC), according to research published in Radiology.
April 2nd, 2024 — Source

New insights into aggressive breast cancer and potential treatment options
Triple-negative breast cancer (TNBC) is difficult to treat due to its aggressive nature and resistance to chemotherapy. Exciting research published by the University of Southern Denmark sheds light on the mechanisms that drive this resistance and gives hope for better treatment for patients in the future.
April 2nd, 2024 — Source

New insights into how tumors on adrenal glands develop
Researchers from Kyushu University's Faculty of Medical Sciences report on new insights into the mechanisms of how adrenal gland tumors are formed. The team identified a new type of tumor cell population that they termed "steroids-producing nodules" or SPNs, which exhibits the unique characteristic of producing two different hormones.
April 2nd, 2024 — Source

New method for detecting and treating breast cancer subtypes
The most prevalent disease in women, breast cancer, poses a major risk to the health of women. Patients' clinical treatment and prognosis might differ significantly because of the high levels of intra- and intertumoral heterogeneity in breast cancer.
April 2nd, 2024 — Source

New study seeks hereditary causes of childhood cancer
Follow-up and treatment of children with cancer is significantly improved when inherited genetic causes are also investigated, according to a new Swedish study. The results of the research involving some 50 researchers and clinicians from across Sweden have been published in The Lancet Regional Health - Europe.
April 2nd, 2024 — Source

Researchers discover protective 'acid wall' formed by cancer cells
Cancer cells release a significantly more concentrated level of acid than previously known, forming an "acid wall" that could deter immune cells from attacking tumors, UT Southwestern Medical Center scientists show in a new study.
April 2nd, 2024 — Source

Silent cancers: Here's what you need to know when there are no obvious symptoms
The recent revelations about the Princess of Wales's cancer diagnosis highlight a crucial aspect of cancer detection—the disease's sometimes silent nature.
April 2nd, 2024 — Source

Soluble immune checkpoint factors in blood as potential biomarkers of therapeutic efficacy for ICI cancer immunotherapy
Cancer is a prevalent disorder where cells divide and grow uncontrollably and eventually spread to other regions or organs in the body. Non-small cell lung cancer (NSCLC) is a highly prevalent form of lung cancer. Current therapeutic strategies against NSCLC involve the administration of immune checkpoint inhibitors (ICIs) as they provide significant clinical benefits for patients with NSCLC.
April 2nd, 2024 — Source

Study finds triple-negative breast cancer tumors with increased immune cells have lower risk of recurrence after surgery
A new multicenter, international study suggests that people who have early-stage triple-negative breast cancer (TNBC) and high levels of immune cells within their tumors may have a lower risk of recurrence and better survival rates even when not treated with chemotherapy.
April 2nd, 2024 — Source

Study suggests lung cancer does not decrease in line with reduced smoking
Despite the fact that the number of people who smoke has decreased very sharply in Sweden, the number of cases of lung cancer in the population is not decreasing as much as expected. Among women, lung cancer has, in fact, increased.
April 2nd, 2024 — Source

'Zombie neurons' shed light on how the brain learns
Nestled at the back of your head, the cerebellum is a brain structure that plays a pivotal role in how we learn, adapting our actions based on past experiences. Yet the precise ways in which this learning happens are still being defined.
April 2nd, 2024 — Source

Health — Cancer — March 29th, 2024

Enhanced melanoma vaccine offers improved survival for men
A second-generation melanoma vaccine being developed at UVA Cancer Center improves long-term survival for melanoma patients compared with the first-generation vaccine, new research shows. Interestingly, the benefit of the second-generation vaccine was greater for male patients than for female patients.
March 29th, 2024 — Source

Heading off financial harms in cancer patients
A screening tool can quickly identify cancer patients at risk of financial toxicity, new findings from Columbia Nursing researchers show.
March 29th, 2024 — Source

New research highlights combining prostate MRI with a blood test to avoid unnecessary prostate biopsies
MRI of the prostate, combined with a blood test, can help determine if a prostate lesion is clinically significant cancer, new research suggests
March 29th, 2024 — Source

Private and secure generative AI tool supports operations and research in a cancer center
Dana-Farber Cancer Institute has implemented an artificial intelligence (AI) application intended for general use in a medical center or hospital. The system, called GPT4DFCI, is permitted for operations, administrative, and research uses but prohibited in direct clinical care.
March 29th, 2024 — Source

Researchers develop AI-based tool paving the way for personalized cancer treatments
In the ongoing fight against cancer, scientists around the globe are exploring innovative approaches to unlock the mysteries of the human immune system—the complex network of organs, cells and proteins that defends the body against disease.
March 29th, 2024 — Source

Unveiling gender differences in cancer: New insights into genomic instability
Recent research spearheaded by Chunmei Cui at the State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, China, casts a new light on the nuanced interplay between gender and cancer, uncovering significant sex-specific disparities in copy number alterations (CNA) across various cancer types.
March 29th, 2024 — Source

Health — Cancer — March 28th, 2024

Cancer-predisposition variants associated with adverse outcomes in rhabdomyosarcoma
Germline cancer-predisposition variants (CPVs) can be helpful in predicting risk in some pediatric cancers. However, CPV risk association in children with rhabdomyosarcoma has not been well studied. A new report led by researchers at Baylor College of Medicine evaluates the association of germline CPVs with rhabdomyosarcoma outcomes in a cohort of children enrolled in Children's Oncology Group studies. The findings are published in JAMA Network Open.
March 28th, 2024 — Source

Clinical trial: Some sarcoma patients improve with T cell immunotherapy
A clinical trial led by researchers at Washington University School of Medicine in St. Louis has shown that a T cell immunotherapy—in which the patients' own T cells are genetically modified to attack and kill cancer cells—is effective in treating some patients with rare cancers of the body's soft tissues.
March 28th, 2024 — Source

'Exhausted' immune cells in healthy women could be target for breast cancer prevention
Researchers at the University of Cambridge have created the world's largest catalogue of human breast cells, which has revealed early cell changes in healthy carriers of BRCA1 and BRCA2 gene mutations.
March 28th, 2024 — Source

Improving the world's most potent cancer drug
Fourteen mice scurried around in laboratory cages, eating, sniffing, and running peacefully. You would never guess that, several weeks earlier, half of them had received five times the lethal dose of a leading chemotherapy drug.
March 28th, 2024 — Source

Improving Cancer Immunotherapy Systemic Delivery
Purdue University researchers are creating and testing patent-pending poly (lactic-co-glycolic acid), or PLGA, nanoparticles modified with adenosine triphosphate, or ATP, to improve immunotherapy against malignant tumors.
March 28th, 2024 — Source

Longer durations of breastfeeding lowers the risk of childhood cancers
In a recent study published in JAMA Network Open, a Danish team of researchers investigated whether duration of breastfeeding was associated with a lower risk of childhood cancers such as acute lymphoblastic leukemia (ALL).
March 28th, 2024 — Source

Longer exclusive breastfeeding may lower risk for childhood hematologic cancers
Exclusive breastfeeding duration of at least three months may decrease the risk for childhood hematologic cancers, according to a study published online March 26 in JAMA Network Open.
March 28th, 2024 — Source

Memories of mitosis: Molecular mechanism that detects defects during cell division could aid cancer treatment
Every day, our cells are hard at work multiplying. Cell division is a precise process, but sometimes this process is impaired and diseases like cancer occur. Mitosis is one of the most important phases in the cell cycle. During this phase, a cell's DNA is split into two equal sets of chromosomes and it divides into two genetically identical daughter cells.
March 28th, 2024 — Source

New study shows association of historical housing discrimination and shortfalls in colon cancer treatment
A nationwide study of 196 cities shows that housing discrimination from 90 years ago still casts a historical shadow of inequities in colon cancer care today, S.M. Qasim Hussaini, M.D., of the University of Alabama at Birmingham and colleagues at the American Cancer Society and Johns Hopkins School of Public Health report in the journal JCO Oncology Practice.
March 28th, 2024 — Source

Predicting infection risk in childhood cancer
A statistical model can accurately predict the risk of bloodstream infections in a subset of children with cancer, according to a study published in the Journal of Clinical Oncology.
March 28th, 2024 — Source

Research from NY highlights pollution as a key factor in rising cancer rates among youth
In a recent study published in Scientific Reports, researchers investigated cancer incidence trends among adults in the New York State (NYS) and associations with common population-level exposures.
March 28th, 2024 — Source

Researchers discover molecule that promotes production of cancer cells in triple-negative breast cancer
A team of researchers from Hiroshima University has discovered a molecule that promotes the production of cancer cells. This molecule may prove to be a potential therapeutic target in the treatment of triple-negative breast cancer, an aggressive form of breast cancer.
March 28th, 2024 — Source

Researchers identify increased brain tumor risk with specific contraceptive use
In a recent study published in BMJ, researchers evaluated the intracranial meningioma risk associated with progestogen use.
March 28th, 2024 — Source

Scientists take a closer look at pulmonary fibrosis genetics
Regulators of gene expression are thought to play an outsized role in disorders from cancers to heart disease. But how exactly do variations in gene regulation translate into a disease's biology?
March 28th, 2024 — Source

Some cancer patients can find it hard to tell family and friends
Ever since Anthony Bridges found out he had prostate cancer six years ago, he hasn't stopped talking about it. He told his Facebook friends immediately.
March 28th, 2024 — Source

Study flips treatment paradigm in bilateral Wilms tumor, shows resistance to chemotherapy may be good
Resistance to chemotherapy is typically associated with poor outcomes for patients with cancer. However, St. Jude Children's Research Hospital scientists demonstrated that in bilateral Wilms tumor (cancer in both kidneys) chemotherapy resistance can point toward a more favorable histology and an ultimately good outcome.
March 28th, 2024 — Source

Study shows improved outcomes in hospitals accredited for rectal cancer surgery
Hospitals accredited by the American College of Surgeons (ACS) National Accreditation Program for Rectal Cancer (NAPRC) demonstrate significantly better outcomes for patients undergoing rectal cancer surgery compared to non-accredited hospitals, according to a new study published in the Journal of the American College of Surgeons.
March 28th, 2024 — Source

Study successfully mimics complex neuroblastoma vasculature on a chip to explore treatments
Neuroblastoma, one of the most common childhood cancers, is classified as a developmental cancer because it arises prenatally during the formation of organs and tissues. It originates from cancer cells that develop in neuroblasts, a type of immature nerve tissue, and primarily affects the adrenal glands.
March 28th, 2024 — Source

Health — Cancer — March 27th, 2024

Accelerating CAR T cell therapy: Lipid nanoparticles speed up manufacturing
Engineers have developed a novel method for manufacturing CAR T cells, one that takes just 24 hours and requires only one step, thanks to the use of lipid nanoparticles (LNPs), the potent delivery vehicles that played a critical role in the Moderna and Pfizer-BioNTech COVID-19 vaccines.
March 27th, 2024 — Source

An oncologist explains why some cancer patients receive both chemotherapy and surgery
When Kate Middleton, the princess of Wales, announced in March 2024 that she was receiving "preventive chemotherapy" following abdominal surgery, many wondered what that entails. Formally known as adjuvant therapy, administering chemotherapy or other treatments after surgery is a common approach to treating certain types of cancer and is not necessarily intended to prevent cancer.
March 27th, 2024 — Source

Beating by overheating: A new strategy to combat cancer
Many new drugs inhibit the processes that cancer cells need to divide rapidly. So as to inhibit the cancer as a whole. But cancer cells have all sorts of workarounds to get around that effect. As a result, the tumor becomes unresponsive to treatment.
March 27th, 2024 — Source

Biocompatible nanoparticles enhance systemic delivery of cancer immunotherapy
(Nanowerk News) Purdue University researchers are developing and validating patent-pending poly (lactic-co-glycolic acid), or PLGA, nanoparticles modified with adenosine triphosphate, or ATP, to enhance immunotherapy effects against malignant tumors.
March 27th, 2024 — Source

Biocompatible nanoparticles modified with ATP can enhance systemic delivery of cancer immunotherapy
Purdue University researchers are developing and validating patent-pending poly (lactic-co-glycolic acid), or PLGA, nanoparticles modified with adenosine triphosphate, or ATP, to enhance immunotherapy effects against malignant tumors.
March 27th, 2024 — Source

Combining epigenetic cancer medications may have benefit for colorectal cancers and other tumor types
A pair of medications that make malignant cells act as if they have a virus could hold new promise for treating colorectal cancers and other solid tumors, reports a study published in Science Advances.
March 27th, 2024 — Source

Durvalumab and Tremelimumab before surgery in patients with HR+/HER2-negative breast cancer
A new research paper was published in Oncotarget entitled, "Durvalumab and tremelimumab before surgery in patients with hormone receptor positive, HER2-negative stage II–III breast cancer."
March 27th, 2024 — Source

Exploring ferroptosis and its implications in lung cancer
An estimated 2.2 million people suffer from lung cancer worldwide, making it the second most common type of cancer. Though improvements in treatment have been made, the overall survival rate of lung cancer patients is low, and it remains a leading cause of death, accounting for 18% of total cancer-related deaths in 2022.
March 27th, 2024 — Source

Follow-up colonoscopy rate low within six months of abnormal stool test
Fewer than half of adults have a follow-up colonoscopy within six months following an abnormal stool-based screening test (SBT) for colorectal cancer (CRC), according to a study published online March 25 in JAMA Network Open.
March 27th, 2024 — Source

Investigating mechanisms of aggressive glioblastoma tumor growth
Northwestern Medicine investigators have identified a metabolism-related gene that may play a role in recruiting immune cells to support the growth of aggressive brain tumors, according to a study recently published in Nature Communications.
March 27th, 2024 — Source

Novel AI tools tackle soft tissue sarcomas, identify new treatment strategies
Using novel machine learning tools developed at Stanford Medicine, researchers have mapped three distinct cellular configurations that correspond to clinical outcomes for patients with a rare, difficult-to-treat cancer called soft tissue sarcoma.
March 27th, 2024 — Source

Princess Kate revelation shines light on under-50s cancer mystery
When Catherine, Princess of Wales, revealed she was being treated for cancer last week, part of the shock was that an otherwise healthy 42-year-old has a disease that mostly plagues older people.
March 27th, 2024 — Source

Researchers create new tool for assessing risk of kidney injury after chemotherapy
Using patient data from six major U.S. cancer centers, Brigham researchers and collaborators developed a risk prediction model for moderate-to-severe kidney injury after receiving the chemotherapy drug cisplatin in the largest, first generalizable study of its kind
March 27th, 2024 — Source

Researchers discover a mechanism that could improve platinum-based cancer therapy
Researchers have identified a protein that, when targeted, enables cisplatin-resistant cancer cells to become responsive to treatment. Cisplatin, and other similar platinum drugs, are incredibly effective at killing rapidly growing cancer cells, which is why they have been used in treating cancers for over 45 years.
March 27th, 2024 — Source

Researchers turn back the clock on cancer cells to offer new treatment paradigm
St. Jude Children's Research Hospital scientists reversed an aggressive cancer, reverting malignant cells towards a more normal state. Rhabdoid tumors are an aggressive cancer which is missing a key tumor suppressor protein. Findings showed that with the missing tumor suppressor, deleting or degrading the quality control protein DCAF5 reversed the cancer cell state.
March 27th, 2024 — Source

Revealing characteristics of circulating cell-free RNA in the blood of liver cancer patients
Recently, the research findings of the team led by CAS Academician Xiang Zhou from Wuhan University were published in the National Science Review. The team successfully developed an efficient technique for enriching trace amounts of circulating nucleic acids in blood.
March 27th, 2024 — Source

Treatment of advanced non-small cell lung cancer with driver mutations
Lung cancer is the leading cause of cancer-related death worldwide. Improved understanding of driver mutations of non-small cell lung cancer (NSCLC) has led to more biomarker-directed treatment for patients with advanced stages. The expanding number of drugs targeting these driver mutations offers more opportunity to improve patient's survival benefit.
March 27th, 2024 — Source

Health — Cancer — March 25th, 2024

ABT199/Venetoclax synergism with thiotepa in acute myeloid leukemia (AML) cells
A new research paper titled "ABT199/venetoclax synergism with thiotepa enhances the cytotoxicity of fludarabine, cladribine and busulfan in AML cells" has been published in Oncotarget.
March 25th, 2024 — Source

Cancer therapies show promise in combating tuberculosis
What could cancer teach us about tuberculosis? That's a question Meenal Datta has been chasing since she was a graduate student.
March 25th, 2024 — Source

Engineers develop novel method for manufacturing CAR T cells using lipid nanoparticles
For patients with certain types of cancer, CAR T cell therapy has been nothing short of life changing. Developed in part by Carl June, Richard W. Vague Professor at the Perelman School of Medicine, and approved by the Food and Drug Administration (FDA) in 2017, CAR T cell therapy mobilizes patients' own immune systems to fight lymphoma and leukemia, among other cancers.
March 25th, 2024 — Source

Incurable but not hopeless: How hope shapes patients' awareness of their advanced cancer prognosis
Hope is defined as the expectation of achieving a future good. Patients with cancer, whether it is curable or not, prioritize cure as their highest hope.
March 25th, 2024 — Source

New research identifies promising drug combination for multiple myeloma treatment
New research from the Royal College of Surgeons in Ireland has found that venetoclax, a medication currently approved for leukemia, provides benefits for patients with multiple myeloma when used in combination with another drug. This discovery offers a new avenue of treatment options for the currently incurable disease.
March 25th, 2024 — Source

Patient recovery after surgery for esophageal cancer isn't influenced by using standard or keyhole incisions
New research has found no evidence of a difference between recovery time and complications when comparing standard and keyhole surgical incisions for the treatment of oesophageal cancer (cancer of the gullet). The study, led by the University of Bristol Medical School and published in the British Journal of Surgery, showed surgeons treating patients with oesophageal cancer do not need to change their practice if they have a strong preference for either procedure type.
March 25th, 2024 — Source

Princess of Wales and King Charles: 1 in 2 people develop cancer during their lives
The Princess of Wales released a moving video message on March 22 to address speculation about her health. In it, the future queen disclosed that she'd been diagnosed with cancer following tests conducted after she underwent major abdominal surgery at a clinic in London in January.
March 25th, 2024 — Source

Health — Cancer — March 22nd, 2024

Eligibility for lung cancer screening up with 2021 USPSTF recommendations
Expanded U.S. Preventive Services Task Force (USPSTF) criteria for lung cancer screening (LCS) in 2021 have resulted in a 65.9 percent increase in the number of eligible individuals, according to a research letter published online March 21 in JAMA Network Open.
March 22nd, 2024 — Source

Lymph node-like biomaterial scaffold for augmenting CAR-T cell therapy
In a study published in the journal National Science Review, a research team aimed to enhance treatment efficacy of CAR-T cell therapy for solid tumors. The research was led by Dr. Zhen Gu and Dr. Hongjun Li from the College of Pharmaceutical Sciences at Zhejiang University, along with Dr. Jie Sun from the School of Medicine at Zhejiang University,
March 22nd, 2024 — Source

Navigating the maze of cancer: How precision medicine unravels the unknown
In our journey to unravel the obscurities of high-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs), we've embarked on a quest guided by personalized medicine principles. Imagine you're faced with a challenging puzzle—each piece representing a unique aspect of your illness.
March 22nd, 2024 — Source

New alveolar soft-part sarcoma chip can mimic the microenvironment during angiogenesis
Cancer, the second leading cause of death worldwide, is more likely to respond to effective treatment if identified early before metastasizing, resulting in a greater probability of surviving.
March 22nd, 2024 — Source

New research results explore the safety of short-term cultivated CAR T cells in cancer immunotherapy
Chimeric antigen receptor T cells—CAR T cells for short—are immune cells (T cells) that are taken from the body and genetically modified outside the body in the laboratory using transport vehicles for the genes to be transmitted (vectors). After being returned to the patient, these CAR T cells can specifically target and kill cells that contain defined antigens.
March 22nd, 2024 — Source

Rising survival rates for AML patients over 65 after allogeneic hematopoietic stem cell transplant
Bottom line: Among patients over 65 who received an allogeneic hematopoietic stem cell transplant (allo-HCT) for the treatment of acute myeloid leukemia (AML) between 2000 and 2021, leukemia-free and overall survival improved significantly over time.
March 22nd, 2024 — Source

Scientists consider fighting potentially lethal form of breast cancer with chemical produced by the disease
Triple negative breast cancer is the most aggressive subtype of the disease and is notorious for a poor prognosis, but scientists are working on a breakthrough method of converting these treatment-resistant tumors into a form that succumbs to therapy.
March 22nd, 2024 — Source

Scientists uncover four proteins that govern the identity of anaplastic large cell lymphoma
A collaboration between scientists from St. Jude Children's Research Hospital and Dana-Farber Cancer Institute uncovered four proteins that govern the identity of anaplastic large cell lymphoma (ALCL), an aggressive form of cancer. These proteins comprise a core regulatory circuit (CRC) that surprisingly incorporates a dysregulated signaling protein.
March 22nd, 2024 — Source

Study demonstrates safe reduction of lymph node removal in breast cancer patients
Patients with breast cancer that has started to spread to the lymph nodes in the armpit can safely avoid extensive removal of the lymph nodes if their treatment is tailored to their response to cancer-killing therapies such as chemotherapy before surgery.
March 22nd, 2024 — Source

Study finds outcomes after stem cell transplant in elderly patients with AML have improved since 2000
According to a study published in Clinical Cancer Research, among patients over 65 who received an allogeneic hematopoietic stem cell transplant (allo-HCT) for the treatment of acute myeloid leukemia (AML) between 2000 and 2021, leukemia-free and overall survival improved significantly over time.
March 22nd, 2024 — Source

What causes breast cancer?
There is a lot going on within the field of breast cancer research. A new AI tool is trying to fine-tune the screening program, another one is helping pathologists make diagnoses. New drugs are approved. This could save more lives. But there is still no answer to the trickiest question of all: What causes breast cancer?
March 22nd, 2024 — Source

Health — Cancer — March 20th, 2024

A computational model to simulate the biomechanical growth of breast tumors
Scientists from Universidad Carlos III de Madrid (UC3M) and Johns Hopkins University (JHU), in the U.S., have analyzed the growth of breast tumors from a biomechanical perspective and have created a computational model that simulates the invasion process of cancer cells, depending on the characteristics of the surrounding tissue and cell junctions, among other parameters.
March 20th, 2024 — Source

Advances and applications of nanoparticles in cancer therapy
The research team of Prof. Changyang Gong from the Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University has published a new review showing that rapid growth in nanoparticles as delivery systems hold vast promise to promote therapeutic approaches for cancer treatment. Dr. Xianzhou Huang served as team leader.
March 20th, 2024 — Source

AI-based mobile app can diagnose melanoma with very high precision
A mobile app that uses artificial intelligence, AI, to analyze images of suspected skin lesions can diagnose melanoma with very high precision. This is shown in a study led from Linköping University in Sweden where the app has been tested in primary care.
March 20th, 2024 — Source

Bacteria subtype linked to growth in up to 50% of human colorectal cancers, researchers report
Researchers at Fred Hutchinson Cancer Center have found that a specific subtype of a microbe commonly found in the mouth is able to travel to the gut and grow within colorectal cancer tumors. This microbe is also a culprit for driving cancer progression and leads to poorer patient outcomes after cancer treatment.
March 20th, 2024 — Source

Clinical trial shows rucaparib extends progression-free survival for uterine cancer patients
The results of a multisite clinical trial overseen by University of Colorado Cancer Center member Bradley Corr, MD, could offer new hope to patients with metastatic and recurrent uterine cancer, also known as endometrial cancer.
March 20th, 2024 — Source

Colon cancer is increasing in younger Coloradans even as death rate drops for people over 55
In 2020, the most recent year with data on cancer cases, 452 people under the age of 55 received a colorectal cancer diagnosis in Colorado, up from 367 a decade earlier—a 23% increase.
March 20th, 2024 — Source

Cryoablation could be a new treatment path for breast cancer patients with large tumors
A minimally invasive technique that uses ice to freeze and destroy small, cancerous tumors has now been proven effective for breast cancer patients with large tumors, providing a new treatment path for those who are not candidates for surgery, according to new research to be presented at the Society of Interventional Radiology Annual Scientific Meeting in Salt Lake City.
March 20th, 2024 — Source or Source

Delayed treatment effect predicting (DTEP) model found to enhance precision in immuno-oncology trial designs
Over the last decade, immunotherapies, particularly immune checkpoint inhibitors (ICIs), have emerged as promising treatments for various cancer types. However, a notable challenge in immuno-oncology trials is the frequent occurrence of delayed treatment effects (DTE), where the therapeutic benefits of ICIs may take months to manifest.
March 20th, 2024 — Source

Discovery sets stage for vaccine against gastric cancer, ulcers
H. pylori is one of the most common disease-causing bacteria. More than half of the world's population have the bacteria in their body; and while in Canada overall prevalence of H. pylori is between 20% and 30%, some groups—including Indigenous communities—have higher rates.
March 20th, 2024 — Source

Drug-pricing program improves prostate cancer treatment adherence, finds study
Prostate cancer patients receiving care at hospitals that are part of a special drug-pricing program were more likely to stick to their prescription drug therapy than patients at other hospitals, according to a study from researchers at the University of Michigan's Rogel Cancer Center and Institute for Healthcare Policy and Innovation.
March 20th, 2024 — Source

Enhanced screening could significantly decrease cervical cancer cases and deaths
Getting screened for cervical cancer isn't fun. And getting an alert that your initial exam showed a potential sign of trouble, and that you need to go back for a test or procedure to rule out cancer, is even less fun.
March 20th, 2024 — Source

Fitness Legend Richard Simmons Diagnosed with Skin Cancer
Another hill to climb.
March 20th, 2024 — Source

Genetic test can identify how patients with triple negative early-stage breast cancer will respond to immunotherapy
Researchers have developed a genetic test that can identify how patients with triple negative early-stage breast cancer will respond to immunotherapy drugs. This means that patients who are unlikely to respond to these drugs can avoid the adverse side effects associated with them and can be treated with other therapies.
March 20th, 2024 — Source

Immune cell protein identified as potential target for rare liver cancer treatment
Fibrolamellar carcinoma (FLC) is a rare liver cancer with a poor prognosis if not addressed early with surgery. The disease is caused by a single genetic mutation that creates a fusion protein. Scientists at St. Jude Children's Research Hospital and The University of Tennessee Health Science Center discovered an immune cell protein that can target and spark the destruction of FLC.
March 20th, 2024 — Source

Lu(a)minar flow odyssey—using the power of water and light in early leukemia diagnostics
Cancer is the scourge of the 21st century, and despite the rapid development in medical diagnostics and personalized treatments, most therapies remain insufficient to save a patient's life. Timely and accurate diagnosis is of paramount importance, but once a patient is diagnosed, the outcome of the battle to save a life still depends on many factors.
March 20th, 2024 — Source

Metalloimmunotherapy: Combination of cisplatin and STING agonist into one molecule boosts cancer immune response
Traditionally, therapies combining DNA-damaging agents and STING agonists have shown potential in treating cancer by enhancing immune response and reshaping the tumor microenvironment. However, until now, creating a single molecular entity housing both agents has remained elusive.
March 20th, 2024 — Source

New treatment option for prostate cancer shows successful outcomes
A minimally-invasive treatment using MRI and transurethral ultrasound instead of surgery or radiation is effective in treating prostate cancer, according to new research to be presented at the Society of Interventional Radiology Annual Scientific Meeting in Salt Lake City.
March 20th, 2024 — Source

News study shows cryoblation 'freeze' treatment works for large breast tumors
Killing off large tumors by freezing them could become an effective means of fighting difficult-to-treat breast cancer, a new study says.
March 20th, 2024 — Source

Pembrolizumab enhances breast cancer treatment regardless of age or menopausal status
New data from the KEYNOTE-756 phase 3 clinical trial show that adding the immunotherapy drug, pembrolizumab, to chemotherapy before and after surgery for breast cancer leads to better outcomes for patients regardless of their age or menopausal status.
March 20th, 2024 — Source

Researchers identify key regulators underlying regeneration in Drosophila
Some animals possess the remarkable ability to regenerate lost structures, exemplified by a lizard regrowing its tail. However, this regenerative process must be tightly regulated by the body to ensure proper tissue organization and to prevent abnormal growths, such as cancer. Yet, the precise mechanisms underlying this regulation are not well known.
March 20th, 2024 — Source

Second primary malignancies represent small proportion of adverse events after CAR T-cell therapy
Second primary malignancies (SPMs) represent a small proportion of adverse events (AEs) reported by patients receiving chimeric antigen receptor T-cell (CAR T-cell) therapy, according to a letter to the editor published online March 14 in Blood.
March 20th, 2024 — Source

Scientists find core regulatory circuit controlling identity of aggressive leukemia
A collaboration between scientists from St. Jude Children's Research Hospital and Dana-Farber Cancer Institute uncovered four proteins that govern the identity of anaplastic large cell lymphoma (ALCL), an aggressive form of cancer. These proteins comprise a core regulatory circuit (CRC) that surprisingly incorporates a dysregulated signaling protein.
March 20th, 2024 — Source

Study discusses liquid biopsy as a game changer for early lung cancer detection
In 2020, 1.8 million people succumbed to lung cancer. The late-stage discovery of lung cancer is one of the glaring challenges faced by the medical community. While surgical biopsies continue to remain the gold standard for cancer diagnosis, the invasive nature of the technique can lead to serious health complications.
March 20th, 2024 — Source

Team shows how an anticancer drug kills cancer cells and damages healthy cells, paves way for improved treatment
Some anti-cancer treatments not only target tumor cells but also healthy cells. If their effects on the latter are too strong, their use can become limiting.
March 20th, 2024 — Source

The search to discover why 'outliers' survive deadliest cancers
When Herve found out he had glioblastoma—the most aggressive form of brain cancer—at the age of 40, he made a deal with himself.
March 20th, 2024 — Source

U.S. could cut cervical cancer cases and deaths if more patients got follow-up after screening, study suggests
Getting screened for cervical cancer isn't fun. And getting an alert that your initial exam showed a potential sign of trouble, and that you need to go back for a test or procedure to rule out cancer, is even less fun.
March 20th, 2024 — Source

What breast cancer risk assessments can tell you
Actress Olivia Munn recently shared on social media that she had undergone a double mastectomy after being diagnosed with luminal B breast cancer. In an Instagram post, Munn explained how she had been diagnosed with the fast-growing cancer.
March 20th, 2024 — Source

Why do cancer patients lose weight? Study points to elevated lactate levels
Elevated levels of lactate may lead to the development of cachexia (disease-related weight loss) following the onset of cancer, according to a study including data from mice and humans published in Nature Metabolism.
March 20th, 2024 — Source

Health — Cancer — March 18th, 2024

Artificial mucus identifies link to tumor formation
During cold and flu season, excess mucus is a common, unpleasant symptom of illness, but the slippery substance is essential to human health. To better understand its many roles, researchers synthesized the major component of mucus, the sugar-coated proteins called mucins, and discovered that changing the mucins of healthy cells to resemble those of cancer cells made healthy cells act more cancer-like.
March 18th, 2024 — Source

Assessing breast cancer risk
The genetic risk of breast cancer has been in the news lately. Researchers at the Mayo Clinic Comprehensive Cancer Center are working toward pinpointing individuals' risk of developing breast cancer.
March 18th, 2024 — Source

Attacking metastatic prostate cancer early with combination treatment approach improves outcomes in preliminary study
A team of UCLA Health Jonsson Comprehensive Cancer Center investigators has shown the combination of a short course of powerful and intense hormonal therapy with targeted radiation is safe and effective in treating people with prostate cancer that has come back and has spread to other parts of the body.
March 18th, 2024 — Source

Arrayjet’s ArrayPlex platform selected by Immunome for use in its discovery of targeted cancer therapies
Arrayjet, a leading provider of inkjet liquid-handling solutions, today announced that its ArrayPlex™ discovery platform has been selected by Immunome, Inc., a biotechnology company dedicated to developing first-in-class and best-in-class targeted cancer therapies, to expand its in-house high-throughput screening tools.
March 18th, 2024 — Source

Bacteria commonly found in the body contribute to stomach cancer, finds study
A new study has discovered that a type of bacteria commonly found in the body, which usually does not pose problems for healthy people, plays a significant role in causing stomach cancer, the fifth most common cancer in the world. The findings are published in the journal Cell.
March 18th, 2024 — Source

Breast Cancer Now funds researchers to investigate targeted radiotherapy for metastatic breast cancer in the brain
Researchers are trialing a new type of targeted radiotherapy to treat secondary breast cancer tumors in the brain, thanks to new funding from Breast Cancer Now.
March 18th, 2024 — Source

Clinical trial aims to provide a surgical solution for patients with 'inoperable' pancreatic tumors
A clinical trial from Keck Medicine of USC aims to provide a surgical solution for patients with a form of advanced pancreatic cancer previously considered inoperable.
March 18th, 2024 — Source

Hypofractioned post-prostatectomy radiotherapy new acceptable practice standard based on NRG Oncology trial findings
Results from the Phase III NRG Oncology NRG-GU003 clinical trial comparing hypofractioned post-prostatectomy radiotherapy (HYPORT) to conventionally fractioned post-prostatectomy radiotherapy (COPORT) determined that HYPORT was non-inferior to COPORT in terms of late gastrointestinal (GI) or genitourinary (GU) toxicity for patients primarily treated with prostatectomy for their prostate cancer.
March 18th, 2024 — Source

Newly discovered link between FBXW7 mutations and EGFR signaling in colorectal cancer
The Organoid group at the Hubrecht Institute has identified a new link between FBXW7 mutations and epidermal growth factor receptor (EGFR) signaling activity. The FBXW7 gene is commonly mutated in colorectal cancer and such mutations have been associated with worse treatment outcomes.
March 18th, 2024 — Source

Non-invasive blood test shows 83% sensitivity in detecting colorectal cancer, offering hope for early diagnosis NewsGuard 100/100 Score
In a recent study published in The New England Journal of Medicine, a team of scientists from the United States (U.S.) and Canada evaluated the performance of a blood-based testing method that uses cell-free deoxyribonucleic acid (DNA) to screen for colorectal cancer.
March 18th, 2024 — Source

Researchers pinpoint issue that could be hampering common chemotherapy drug
Researchers at the University of Toronto's Donnelly Centre for Cellular and Biomolecular Research have found two enzymes that work against the chemotherapy drug gemcitabine, preventing it from effectively treating pancreatic cancer.
March 18th, 2024 — Source

Role in mitochondrial metabolism paints more complete picture of MCL-1 function
The life and death of cells are governed by processes that—when disrupted—can lead to cancer. Apoptosis, the process of programmed cell death, is tightly regulated by the B-cell lymphoma-2 (BCL-2) family of proteins. This includes myeloid cell leukemia-1 (MCL-1), an anti-apoptotic protein that helps cells stay alive.
March 18th, 2024 — Source

Study: 20,000 men may have missed prostate cancer diagnosis due to the COVID-19 pandemic
Prostate cancer diagnoses in 20,000 men could have been missed due to the COVID-19 pandemic, finds a new study from the University of Surrey and the University of Oxford. Increased waiting times and changes in people's behavior in seeking medical attention during the pandemic could be responsible for missed diagnoses.
March 18th, 2024 — Source

This Mutation Likely Saved a Colon Cancer Patient's Life
When Ken Aaron, 51, woke up from his first-ever colonoscopy last February to his doctor mouthing the words “we found a tumor,” there was no one more surprised than he was. The married father of two had some very mild GI discomfort before he booked the scan, but, besides that, there was nothing significantly amiss with the writer, an avid hiker and skier who lives in the Adirondacks.
March 18th, 2024 — Source

Understanding what causes trastuzumab's cardiotoxicity
A new meta-analysis published in OMICS: A Journal of Integrative Biology helps shed light on how changes in mitochondria-related gene expression may cause the cardiotoxicity associated with the cancer therapy trastuzumab.
March 18th, 2024 — Source

US finalizes ban on last form of asbestos in use
President Joe Biden's administration on Monday finalized a rule banning the last remaining form of asbestos in the United States, half a century after the government first targeted the cancer-causing mineral.
March 18th, 2024 — Source

Health — Cancer — March 15th, 2024

Addressing higher colon cancer rates in rural areas
The technology needed to stop colorectal cancer before it turns deadly has never been better.
March 14th, 2024 — Source

Advances in multiple myeloma treatment
March is Myeloma Awareness Month. Multiple myeloma is a blood cancer that most often occurs in people over age 45. It's the second-most common blood cancer and the most common blood cancer in Black people.
March 14th, 2024 — Source

Dietitian suggests ways to prevent colorectal cancer
We may joke about the prep involved for a colonoscopy (an exam for abnormal changes in the large intestine). But cancers of the colon or rectum are no laughing matter. In fact, when you combine the cancer death rates of men and women, colorectal cancer is now the second deadliest cancer in the United States, according to the American Cancer Society.
March 14th, 2024 — Source

DNA origami-based vaccines toward safe and highly-effective precision cancer immunotherapy
(Nanowerk News) Therapeutic cancer vaccines are a form of immunotherapy in the making that could not only destroy cancer cells in patients, but keep a cancer from coming back and spreading. Multiple therapeutic cancer vaccines are being studied in clinical trials, but despite their promise, they are not routinely used yet by clinical oncologists to treat their patients.
March 14th, 2024 — Source or Source

Exploring olive oil compounds oleuropein and hydroxytyrosol as potential treatments for neuroblastoma NewsGuard 100/100 Score
In a recent review published in the Nutrients, a group of authors explored the therapeutic potential of oleuropein (OLE) and hydroxytyrosol (HT) from olive oil as novel antioxidants in the treatment of neuroblastoma (NB), addressing challenges such as recurrence and drug resistance.
March 14th, 2024 — Source

In vivo production of CAR-T cells using virus-mimetic fusogenic nanovesicles
Chimeric antigen receptors (CARs) are synthesized membrane proteins that enable lymphocytes to recognize and respond to the specific antigens of target cells. Despite the impressive efficacy of CAR-T cell therapy in treating B-cell lymphoma or leukemia, the expensive and complex manufacturing process has hindered its widespread clinical application.
March 14th, 2024 — Source

Innovative CAR T cell therapy targets two proteins to combat aggressive brain tumor growth NewsGuard 100/100 Score
In a recent report published in Nature Medicine, researchers presented the initial results of recurrent glioblastoma (rGBM) patients treated with intrathecally administered, autologous, bivalent chimeric antigen receptor (CAR) T cells targeting epidermal growth factor receptor (EGFR) and interleukin-13 receptor alpha 2 (IL13Rα2) in a phase 1 clinical trial.
March 14th, 2024 — Source

Large-scale study explores genetic link between colorectal cancer and meat intake
In one of the largest ever gene-environment interaction studies of red meat and colorectal cancer, which explored the impact of red meat consumption on a person's cancer risk based on their genotype, researchers have identified two genetic markers that may help explain the association between the two and explain why some people face a higher cancer risk.
March 14th, 2024 — Source

New technique opens up study of immune response to cancer based on DNA locked in old archive cancer samples
Scientists have developed an improved technique for reading the genetic material associated with the body's immune response to cancer, making it possible to study tissue samples that have been stored in archives for decades.
March 14th, 2024 — Source

Researchers discover a signaling molecule in neuroblastoma immunosuppression and aggressiveness
The MYCN oncoprotein (proteins related to the growth of cancer cells) plays a key role in starting, advancing and making it difficult to treat various human cancers. When MYCN is overactive, especially in high-risk neuroblastoma (childhood cancer often found in the adrenal glands), the tumors become less responsive to immunotherapy—a treatment that uses the body's immune system to fight cancer.
March 14th, 2024 — Source

Researchers gain insight into why T cells lose energy in solid tumors
T cells are often called "assassins" or "killers" because they can orchestrate and carry out missions to hunt down bacteria, viruses, and cancer cells throughout the body. Mighty as they may be, recent research has shown that once T cells infiltrate the environment of a solid tumor, they lose the energy needed to combat the cancer.
March 14th, 2024 — Source

The efficacy of the Mediterranean diet on health outcomes in adults with cancer
Cancer treatment is often associated with undue weight gain, mostly due to fat deposition. The Mediterranean diet (MED diet) may help support such patients during this period. A new study published in the European Journal of Clinical Nutrition explores the safety and benefits of this diet in adults with cancer, in addition to its feasibility in this population.
March 14th, 2024 — Source

Warning signs of colorectal cancer in younger adults
Colorectal cancer, the third-most common cancer in the U.S., has been rising among younger people for the past two decades. It is not one type of cancer but two cancers: colon cancer, which starts in the large intestine, and rectal cancer, which begins in the last part of the large intestine, known as the rectum.
March 14th, 2024 — Source

Health — Cancer — March 14th, 2024

A new strategy to attack aggressive brain cancer shrank tumors in two early tests
A new strategy to fight an extremely aggressive type of brain tumor showed promise in a pair of experiments with a handful of patients.
March 14th, 2024 — Source

A pioneering way to target the culprit behind a deadly liver cancer
Researchers have translated a cutting-edge tactic for treating genetic disorders into a fresh approach for potentially stymying cancer.
March 14th, 2024 — Source

Breast cancer diagnoses plummeted during first year of pandemic, finds study
Several studies have described the distinct ways the COVID-19 pandemic adversely impacted cancer care, but less is known about the specific ways the pandemic disrupted breast cancer, the most common non-skin cancer diagnosed in women.
March 14th, 2024 — Source

Cell division, DNA repair and cancer progression closely tied to CDK9 dysfunction
Researchers describe a newly observed role for the protein Cyclin Dependent Kinase 9 (CDK9) in regulating DNA repair during cellular division, where errors can become the origin of cancerous tumor growth. Through a process called phosphorylation, the experiment simulated the interaction of CDK9 with the other proteins and genes involved in cell division and cancerous tumor growth.
March 14th, 2024 — Source

EPA tightens limits on a chemical used to sterilize medical equipment, citing cancer risk
The Environmental Protection Agency is imposing stricter limits on a chemical used to sterilize medical equipment after finding a higher-than-expected cancer risk at facilities that use ethylene oxide to clean billions of devices including catheters and syringes.
March 14th, 2024 — Source

First-in-human trial finds new bladder cancer treatment safe
A first-in-human trial led by The University of Western Australia has found injecting an immunotherapy drug directly into the bladder wall to treat cancer is viable and safe.
March 14th, 2024 — Source

New AI model detects 90% of lymphatic cancer cases
Medical image analysis using AI has developed rapidly in recent years. Now, one of the largest studies to date has been carried out using AI-assisted image analysis of lymphoma, cancer of the lymphatic system. Researchers at Chalmers University of Technology in Sweden, have developed a computer model that can successfully find signs of lymph node cancer in 90% of cases.
March 14th, 2024 — Source

New analysis sheds light on cancer incidence and mortality trends in the UK NewsGuard 100/100 Score
In a recent study published in BMJ, researchers investigated trends in cancer incidence and deaths in the United Kingdom (UK) among individuals aged between 35 and 69 years.
March 14th, 2024 — Source

Next milestone in the treatment of liver tumors and acute and chronic liver diseases
The results of a Tübingen-led study raise hope that a newly developed drug could herald a new era in oncological liver surgery and liver transplantation. The drug could even have the potential to significantly improve the treatment of acute and chronic liver diseases.
March 14th, 2024 — Source

Olivia Munn's Breast Cancer: A Wake-Up Call for Women
Actress Olivia Munn's candid disclosures on Instagram about her aggressive breast cancer — a surprise discovery after a "clean" mammogram and negative genetic tests — were a poignant mix of details about her cancer journey and a cautionary tale for women.
March 14th, 2024 — Source

Protein discovery sparks treatment hope for aggressive cancer
Researchers have found a new way to potentially treat one of the most common forms of acute lymphoblastic leukemia.
March 14th, 2024 — Source or Source

Researchers develop dual anti-tumor vaccine
A research team at the LKS Faculty of Medicine, the University of Hong Kong (HKUMed), has discovered that exosomes derived from γδ-T cells not only have direct anti-tumor effects but also, when developed into a tumor vaccine, can effectively induce a tumor-specific immune response. The findings, which provide a new approach to cancer treatment, were published in the Journal of Extracellular Vesicles.
March 14th, 2024 — Source

Researchers find the key to genome-modifying drugs' sensitivity in malignant blood diseases
There are many anti-cancer genes that are no longer active in human tumors, preventing them from carrying out their protective function against cell transformation. One of the main mechanisms used by cancer cells to silence these 'good' genes is the addition of a chemical modification called methylation, which results in the loss of gene expression.
March 14th, 2024 — Source

Researchers target cancer's ability to survive at low oxygen levels
Researchers at the Francis Crick Institute have shed light on how cancer cells survive in the first few hours after being cut off from a supply of oxygen.
March 14th, 2024 — Source

Studying use of patients' own reprogrammed cells to attack cancer as alternative to more chemo
A process of taking patients' own cells and reprogramming them to fight cancer has been a last-ditch option for blood cancer patients when nothing else worked, but a new study underway in Aurora is trying to determine whether more patients could benefit from trying the procedure sooner.
March 14th, 2024 — Source

Targeting LTA4H improves the tumor immune microenvironment in ovarian cancer: Study
In ovarian cancer, the abnormal expression of various metabolic enzymes in the metabolism of polyunsaturated fatty acids (PUFA) is involved in the development of tumors and immune regulation. Most ovarian cancer patients are admitted with advanced disease due to its hidden symptoms and difficulty of detection at an early stage.
March 14th, 2024 — Source

Tissue samples show the deep genetic and cellular impacts of smoking
It's no secret that smoking is extremely detrimental to health. Tobacco smoke contains thousands of chemicals, including carcinogens, increasing the risk of cancer, cardiovascular and respiratory diseases.
March 14th, 2024 — Source

Using adavosertib-encapsulated MOFs for p53-mutated gallbladder cancer treatment via synthetic lethality
Since the revelation of poly(ADP-ribose) polymerase (PARP) inhibitors and their remarkable results in the treatment of BRCA1/2 mutant cancers, synthetic lethality (SL) in antitumor therapy has attracted increasing attention. SL is a phenomenon in which a single genetic event is insufficient to induce cell death, but multiple genetic events lead to cell death.
March 14th, 2024 — Source

Water droplet spun by sound screens for colon cancer
Mechanical engineers have devised a diagnostic platform that uses sound waves to spin an individual drop of water up to 6000 revolutions per minute. These speeds separate tiny biological particles within samples placed in a very light disc sitting on top of the spinning drop. The technique could allow new point-of-care applications ranging from precision bioassays to cancer diagnosis. The technique requires less time and sample volume while inflicting less damage to delicate exosomes.
March 14th, 2024 — Source

What is the breast cancer risk calculator recommended by Olivia Munn?
When Olivia Munn revealed this week that she was diagnosed with breast cancer and had a double mastectomy, she urged people to ask their doctors to figure out their score on a breast cancer risk calculator.
March 14th, 2024 — Source

Health — Cancer — March 11th, 2024

Better contact increases stem cell donors' availability, shows study
Every year, more than 20,000 people in Germany die of blood cancer. It is the most common type of cancer in children. Donations of stem cells from blood or bone marrow increase the chance of survival for people suffering from leukemia and other forms of blood cancer.
March 11th, 2024 — Source

Drug combo marks advance against bladder cancer
A cancer drug duo more than doubled the survival of people battling the most common form of advanced bladder cancer, trial results show.
March 11th, 2024 — Source

Online search data could be used to detect gynecological cancer cases earlier
Search engine data could be used to detect gynecological cancer cases earlier, potentially months ahead of GP referrals, according to new research.
March 11th, 2024 — Source

Protein 'brake' could help develop new cancer treatments
Some cancerous tumors hijack proteins that act as "brakes" on our immune system and use them to form a sort of shield against immune recognition. Immunotherapy treatments have been created that turn off these "brakes" and allow our body to attack foreign-looking cancer cells.
March 11th, 2024 — Source

Researchers use microscopy plus deep learning to advance prostate cancer diagnosis
Prostate cancer stands as a prevalent threat to men's health, ranking second in cancer-related deaths in the United States. Each year, approximately 250,000 men in the U.S. receive a prostate cancer diagnosis. While most cases have low morbidity and mortality rates, a subset of cases demands aggressive treatment.
March 11th, 2024 — Source

Revolutionizing prostate cancer diagnostics with 3D pathology and deep learning
Prostate cancer stands as a prevalent threat to men's health, ranking second in cancer-related deaths in the United States. Each year, approximately 250,000 men in the U.S. receive a prostate cancer diagnosis. While most cases have low morbidity and mortality rates, a subset of cases demands aggressive treatment.
March 11th, 2024 — Source

Scaling early detection of esophageal cancer with AI
Microsoft Research and Cyted have collaborated to build novel AI models to scale the early detection of esophageal cancer. The AI-supported methods demonstrated the same diagnostic performance as the existing manual workflow, potentially reducing the pathologist's workload by up to 63%.
March 11th, 2024 — Source

Study finds worsening metabolic syndrome increases the risk of developing cancer
New research indicates that individuals with persistent and worsening metabolic syndrome—which encompasses conditions such as high blood pressure, elevated blood sugar, excess abdominal fat, and abnormal cholesterol—face an elevated risk of developing various types of cancer.
March 11th, 2024 — Source

Study identifies successful methods to recruit South Asian women for breast cancer research
South Asian American women increasingly are diagnosed with breast cancer at younger ages and with more advanced disease compared with other groups, a fact made even more alarming because they are underrepresented in studies, said Jaya Satagopan, an associate dean for faculty affairs and professor at the School of Public Health and member of the Cancer Prevention and Control Program at Rutgers Cancer Institute of New Jersey.
March 11th, 2024 — Source

UCLA and UAMS teams secure $3.2 million NIH grant for melanoma research
A team of investigators from the UCLA Health Jonsson Comprehensive Cancer and the University of Arkansas for Medical Sciences (UAMS) Winthrop P. Rockefeller Cancer Institute was awarded a $3.2 million grant from the National Institutes of Health to identify new ways to prevent and overcome treatment resistance to targeted therapy in patients with all sub-types of cutaneous melanoma, an aggressive form of skin cancer.
March 11th, 2024 — Source

Health — Cancer — March 8th, 2024

Cancer causes: Popular myths about the causes of cancer
Misconceptions about cancer causes can lead to unnecessary worry about your health. Find out whether there's any truth to these common myths about the causes of cancer.
March 8th, 2024 — Source

'Double life' of key immune protein reveals new strategies for treating cancer and autoimmune diseases
Insights into the workings of an immune cell surface receptor, called PD-1, reveal how treatments that restrict its action can potentially be strengthened to improve their anticancer effect, a new study shows. The same findings also support experimental treatment strategies for autoimmune diseases, in which the immune system attacks the body, because stimulating the action of PD-1, as opposed to restricting it, can potentially block an overactive immune response.
March 8th, 2024 — Source

EHR developers adopt FHIR-based oncology standardization
The Biden Cancer Moonshot says that Epic, Oracle Health, Meditech, athenahealth, Flatiron, Ontada, ThymeCare and CVS Health have adopted the CMS Enhancing Oncology Model to increase interoperability, advance equity and improve cancer diagnosis outcomes.
March 8th, 2024 — Source

Mobile phone users who talk longer do not have a higher risk of brain tumors, international study finds
A large international research study, COSMOS, initiated by Karolinska Institutet, Stockholm and Imperial College London, has studied more than 250,000 mobile phone users to investigate whether those who use mobile phones extensively and over a long time-period have a higher risk of brain tumors than others.
March 8th, 2024 — Source

New study finds limited correlation between canine lymphoma and proximity to environmental toxins
As awareness of the health risks associated with radon and fracking exposure in connection to cancer continues to rise in human medicine, a recent study explored these ties with multicentric lymphoma, a prevalent canine cancer. Surprisingly, the study did not identify significant correlations between living near sources of environmental toxins, such as fracking by-products and radon, and dogs diagnosed with lymphoma.
March 8th, 2024 — Source

Study shows how estrogen protects against fatty liver
New research from Karolinska Institutet shows how estrogen protects against MASLD, a fatty liver disease that has increased dramatically during the current obesity epidemic. The study, published in Molecular Systems Biology, shows how a new drug under development could become a future treatment for fatty liver disease and liver cancer.
March 8th, 2024 — Source

Health — Cancer — March 6th, 2024

A noninvasive treatment may protect patients from memory impairment and cognitive effects of chemotherapy
Patients undergoing chemotherapy often experience cognitive effects such as memory impairment and difficulty concentrating—a condition commonly known as "chemo brain."
March 6th, 2024 — Source

A step towards clinic-ready patient-derived organoids for pancreatic cancer
Pancreatic cancer carries the highest mortality rate of all major cancers and is projected to become the second-leading cause of cancer-related deaths in the United States by 2030. It is especially difficult to treat because pancreatic tumors grow so quickly and are constantly evolving, making them prone to developing drug resistance.
March 6th, 2024 — Source

How fusion proteins hijack gene regulators to spur childhood cancer
Many childhood cancers start with a hijacking at the molecular level. A group of abnormal proteins known as fusion proteins aberrantly engages with a collection of proteins that switches genes on and off. As a result, genes that should be activated get repressed, and genes that should be repressed get activated, causing cancer.
March 6th, 2024 — Source

Lung cancer cells protected from cigarette smoke damage, researchers find
Lung cancer cells survive better and exhibit less cell damage when exposed to cigarette smoke in cell culture experiments compared to non-cancerous lung cells. New research by a team of undergraduate students led by a Penn State molecular biologist may have revealed how lung cancer cells can persist in smoke.
March 6th, 2024 — Source

Nanosurgical tool could be key to cancer breakthrough
The high-tech double-barrel nanopipette, developed by University of Leeds scientists, and applied to the global medical challenge of cancer, has - for the first time - enabled researchers to see how individual living cancer cells react to treatment and change over time -- providing vital understanding that could help doctors develop more effective cancer medication.
March 6th, 2024 — Source or Source

Radioguided surgery can detect, remove metastatic lymph nodes in newly diagnosed prostate cancer patients: Study
Radioguided surgery can detect and remove metastatic pelvic lymph nodes in patients newly diagnosed with prostate cancer, according to research published in the The Journal of Nuclear Medicine.
March 6th, 2024 — Source

Researchers develop test to ID aggressive ovarian cancers early
Researchers at the Johns Hopkins Kimmel Cancer Center and the Department of Gynecology and Obstetrics at the Johns Hopkins University School of Medicine have developed an algorithm to identify high-risk precancerous lesions on the fallopian tubes. Known as serous tubal intraepithelial carcinomas (STICs), these lesions are thought to be the main precursors of ovarian high-grade serous carcinoma (HGSC), the most common form of ovarian cancer in women.
March 6th, 2024 — Source

Researchers teach AI skin-cancer diagnosis tool to see color
McMaster oncology researchers are harnessing the power of artificial intelligence to improve health outcomes for people of color.
March 6th, 2024 — Source

Small version of a CERN detector could deliver more precise radiotherapy of head tumors
Particle detectors like the ones used by physicists at CERN can have wide applications beyond fundamental research. Scientists from the German National Center for Tumor Diseases (NCT), the German Cancer Research Center (DKFZ), and the Heidelberg Ion Beam Therapy Center (HIT) at Heidelberg University Hospital are now testing a new imaging device supplied by the Czech company ADVACAM on its first patients.
March 6th, 2024 — Source

Scientists unravel tumor neutrophil complexity, discover therapeutic subset
In a study published in Cell on March 5, Prof. Zhang Xiaoming at the Shanghai Institute of Immunity and Infection (SIII) of the Chinese Academy of Sciences and Profs. Gao Qiang, Fan Jia and Yang Li at Fudan University have uncovered an unexpected level of complexity hidden within neutrophils, which were previously thought to be a relatively uniform population of short-lived immune cells.
March 6th, 2024 — Source

Study: Protein helps prevent breast cancer metastasis
While better screening and improved treatments are leading to better outcomes for patients with breast cancer, 90% of breast cancer deaths are a result of metastasis, or the cancer growing and spreading to other parts of the body.
March 6th, 2024 — Source

Studying the relationships among cancer-promoting proteins
Researchers from the Bhogaraju Group at EMBL Grenoble have gained new insights into how a cancer-relevant family of proteins bind their targets. The results of the study, published in The EMBO Journal, could potentially help in the development of drugs against certain chemotherapy- and radiotherapy-resistant cancers.
March 6th, 2024 — Source

Using AI to predict the spread of lung cancer
For decades, scientists and pathologists have tried, without much success, to come up with a way to determine which individual lung cancer patients are at greatest risk of having their illness spread, or metastasize, to other parts of the body.
March 6th, 2024 — Source

Health — Cancer — March 4th, 2024

Advance in taxol biosynthesis could lead to large-scale production of anticancer drug
Paclitaxel is the world's best-selling plant-based anticancer drug and one of the most effective anticancer drugs over the past 30 years. It is widely used in the treatment of various types of cancer, including breast cancer, lung cancer, and ovarian cancer.
March 4th, 2024 — Source

Common immune response is found to be protective across many diseases
Combined, infection, autoimmunity and cancer account for 4 out of every 10 deaths worldwide, and represent major global health challenges.
March 4th, 2024 — Source

Gene-edited lymphocytes and the path toward 'off-the-shelf' therapy against cervical cancer
Cervical cancer is among the most common malignancies affecting women worldwide. In 2020 alone, approximately 600,000 women were diagnosed with this disease, and over 314,000 died from it. In 99% of the cases, cervical cancer cells harbor human papillomavirus (HPV), and thus, HPV vaccines are an effective way to mitigate the risk of developing this disease.
March 4th, 2024 — Source

Genetic germline variations influence expression of cancer cell genes, finds study
Researchers at Baylor College of Medicine's Dan L Duncan Comprehensive Cancer Center and Human Genome Sequencing Center investigated the extent to which forms of genetic variation called germline or inherited structural variation influence gene expression in human cancers.
March 4th, 2024 — Source

Genetic risk information enables tailored breast cancer screening
Recent results from researchers at the University of Helsinki indicate that genetic risk information can help tailor and target breast cancer screening more effectively to the women who would benefit the most.
March 4th, 2024 — Source

Improving access to early-stage lung cancer care in Europe
There are stark differences between European countries when it comes to both the reimbursement of, and access to, new treatments for patients with early-stage lung cancer. There are also differences in reimbursement times and indications between the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA).
March 4th, 2024 — Source

New analytical method provides first step toward early diagnosis of metastasis
Metastases are largely responsible for the death rate of patients with solid cancers; the prognosis of cancer patients reduces significantly if metastases are diagnosed. Until now there has been no procedure available to reliably predict the probability of future metastases.
March 4th, 2024 — Source

New drug shows promise for treating rare brain tumors
An experimental drug may provide a new treatment option for some patients with rare incurable brain tumors, according to an analysis published in the Journal of Clinical Oncology.
March 4th, 2024 — Source

Research team discovers new method to test for oral cancer
Oral cancers and precancerous mouth lesions are considered especially difficult to diagnose early and accurately.
March 4th, 2024 — Source

Researchers discover a noninvasive, low-cost test to detect oral cancer
Oral cancers and precancerous mouth lesions are considered especially difficult to diagnose early and accurately.
March 4th, 2024 — Source

Review explores therapeutic targets in tumor microenvironment
The tumor microenvironment (TME) is the ecosystem surrounding a tumor, which usually consists of non-tumoral cells and molecules they produce and release. The interplay between tumor cells and the TME significantly impacts tumor development, metastasis, as well as responses to therapeutic treatments.
March 4th, 2024 — Source

Scientists report positive immune response against mpox using a COVID-19 vaccine
Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States, show that a COVID-19 vaccine developed at the organization's Los Angeles campus also protects against mpox, according to research published in Communications Medicine.
March 4th, 2024 — Source

Study highlights disparities in lung cancer treatment access across Europe
There are stark differences between European countries when it comes to both the reimbursement of, and access to, new treatments for patients with early-stage lung cancer. There are also differences in reimbursement times and indications between the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA).
March 4th, 2024 — Source

Study: Impact of agricultural activities on PM2.5 in Lombardy is comparable to that of urbanization, industry
A research study from Politecnico di Milano in the journal Chemosphere has quantified the impact of agricultural activities on the spatial distribution of fine dust (PM 2.5) in Lombardy, showing that it is comparable to the impact of other well-known sources of pollution, such as urbanization, industry, and transportation.
March 4th, 2024 — Source

T follicular helper cells research makes new immune system discoveries
T follicular helper cells (Tfh) are essential for strong antibody-mediated reactions of our immune system during infections and vaccinations. However, if they get out of control, this can cause diseases such as autoimmunity, allergies or cancer.
March 4th, 2024 — Source

Thyroid disease is common in the US—learn more about signs, symptoms
There are 20 million people in the United States who suffer from thyroid disease. According to the National Cancer Institute, Kentucky has a higher rate of thyroid cancer than the rest of the country.
March 4th, 2024 — Source

Using sacituzumab govitecan plus platinum-based chemotherapy in breast, bladder, and lung carcinomas
A new research paper titled "Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas" has been published in Oncotarget.
March 4th, 2024 — Source

Health — Cancer — March 1st, 2024

Algorithm is 20 times quicker than humans at extracting critical medical chart data from imaging reports
A form of artificial intelligence called large language modeling (LLM), the same technology behind ChatGPT, could someday improve liver cancer care by extracting important data from medical charts much faster than humans, a recent UCSF study found.
March 1st, 2024 — Source

Blood shortage imperils US ability to treat patients who require blood on any given day
Our nation's ability to treat the patients who require blood on any given day—from victims of mass-casualty events to those undergoing treatment for cancer—is in serious peril, according to a new viewpoint paper, "The Bloody Transfusion Problem," published in the JAMA.
March 1st, 2024 — Source

Checking womb condition could curb cancer risk, study shows
Improved patient care is needed to reduce cancer risk among women with a condition that causes excessive thickening of the womb lining, research shows.
March 1st, 2024 — Source

Combining CAR-T cells and inhibitor drugs for high-risk neuroblastoma
Chimeric antigen receptor (CAR)-T cell therapy is a potent emerging weapon against cancer, altering patients' T cells so they can better find and destroy tumor cells. But CAR-T cell therapy doesn't work well in every cancer—including many cases of neuroblastoma, a cancer that begins in young children's nerve tissue and can metastasize to multiple areas of the body.
March 1st, 2024 — Source

European experts publish recommendations for treatment of acute lymphoblastic leukemia in adults
The treatment of acute lymphoblastic leukemia in adults is extremely complex, lengthy and very stressful for patients. Compared to other types of cancer in adults, ALL is relatively rare, as a result of which its treatment in Europe has been organized by multicenter study groups for decades.
March 1st, 2024 — Source

Less chemoradiation is possible for some cancer patients
According to a new study from experts at the University of Michigan Health Rogel Cancer Center, some oropharynx cancer patients may qualify for less radiation treatments. This could assist many patients in a quicker return to their normal lives.
March 1st, 2024 — Source

Magnetic resonance surveillance reduces mortality in women at high risk of BRCA1 breast cancer: Study
An international study, published in JAMA Oncology, in which the Clinical Oncology group of the Sant Pau Research Institute participated, has revealed that MRI monitoring in women with mutations in the BRCA1 genes significantly reduces breast cancer mortality without the need for preventive mastectomy.
March 1st, 2024 — Source

Researchers uncover how virus causes cancer, point to potential treatment
Cleveland Clinic researchers have discovered a key mechanism used by Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8), to induce cancer. The research points to effective new treatment options for KSHV-associated cancers, including Kaposi's sarcoma, primary effusion lymphoma, and HHV8-associated multicentric Castleman disease.
March 1st, 2024 — Source

Scientists discover a key mechanism used by human herpesvirus 8 to induce cancer
Cleveland Clinic researchers have discovered a key mechanism used by Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8), to induce cancer. The research points to effective new treatment options for KSHV-associated cancers, including Kaposi's sarcoma, primary effusion lymphoma, and HHV8-associated multicentric Castleman disease.
March 1st, 2024 — Source

Targeted drug shows promising ability in treating rare head and neck cancers
Experts at University of Michigan Health Rogel Cancer Center have conducted the first study evaluating the effectiveness of a targeted drug for patients with salivary gland cancers (SGC).
March 1st, 2024 — Source

The association between diet and colorectal cancer risk
In a nested case-control study published in JAMA Network Open, researchers from South Korea investigated the genetic variants that modify the association between diet and colorectal cancer (CRC) risk.
March 1st, 2024 — Source

The surprisingly complex inner workings of an endocrine tumor
There is strength in teamwork, and it turns out that this applies to tumors, too. Researchers from Japan have reported that different types of cells within a single benign tumor may work together to promote the tumor's growth.
March 1st, 2024 — Source

The trek to save many women from cervical cancer
Home-test kits and mobile labs for detecting a tumor in tissue near the uterus are improving health care in remote or marginalized communities.
March 1st, 2024 — Source

Health — Cancer — February 28th, 2024

Bioinformatics approach offers a step toward personalized immunotherapy for all
Most cancers are thought to evade the immune system. These cancers don't carry very many mutations, and they aren't infiltrated by cancer-fighting immune cells. Scientists call these cancers immunologically "cold."
February 28th, 2024 — Source

Data-processing tool could enable better early stage cancer detection
Cancers begin with abnormal changes in individual cells, and the ability to track the accumulation of mutations at the single-cell level can shed new light on the early stages of the disease. Such knowledge could enable more effective early detection and treatment options for patients as well as more accurate predictions of disease progression.
February 28th, 2024 — Source

How early-stage cancer cells hide from the immune system
One of the immune system's primary roles is to detect and kill cells that have acquired cancerous mutations. However, some early-stage cancer cells manage to evade this surveillance and develop into more advanced tumors.
February 28th, 2024 — Source

New lung cell atlas unveils pathways to lung adenocarcinoma development
Researchers at The University of Texas MD Anderson Cancer Center built a new atlas of lung cells, uncovering new cellular pathways and precursors in the development of lung adenocarcinoma, the most common type of lung cancer. These findings, published today in Nature, open the door for development of new strategies to detect or intercept the disease in its earliest stages.
February 28th, 2024 — Source

New method discovered to halt active cancer cells
Scientists have discovered a way to stop active cancer cells in their tracks—meaning they can then be eliminated by new drug treatments.
February 28th, 2024 — Source

New pediatric cancer marker: Hope for a treatment target
Researchers have newly identified a universal, essential biomarker for the childhood cancer neuroblastoma—and a potential new target for treatment.
February 28th, 2024 — Source

Novel drug combination shows promise for treating advanced skin cancers in kidney transplant recipients
People who have had a kidney transplant are at high risk for developing skin cancers. New research directed by investigators from the Johns Hopkins Kimmel Cancer Center is exploring the best combination of treatments to target skin cancers while preserving the transplanted organs.
February 28th, 2024 — Source

Regression approach outperforms ML algorithms in predicting optimal surgical method in submucosal tumor patient
Submucosal tumors (SMTs) are usually found in the stomach and esophagus during an upper endoscopy. Submucosal tunneling endoscopic resection (STER) and non-tunneling endoscopic resection (NTER) are the two most commonly used techniques in the treatment of gastric and esophageal SMTs.
February 28th, 2024 — Source

Sensory nerves appear to drive head and neck cancer growth
Researchers at the University of Colorado Anschutz Medical Campus studying interactions between nerves and tumor microenvironments have found that commonly used drugs like botox may stop or slow the progression of certain head and neck cancers.
February 28th, 2024 — Source

Study proposes streamlined approach to developing cancer drugs
Drug discovery can be a frustrating process of trial and error. Scientists using fragment-based drug discovery link fragments of different molecules together to create a more potent drug but may not know whether a compound works until millions of dollars in research and development have already been spent.
February 28th, 2024 — Source

Study unravels the earliest cellular genesis of lung adenocarcinoma
Researchers at The University of Texas MD Anderson Cancer Center built a new atlas of lung cells, uncovering new cellular pathways and precursors in the development of lung adenocarcinoma, the most common type of lung cancer. These findings, published in Nature, open the door for development of new strategies to detect or intercept the disease in its earliest stages.
February 28th, 2024 — Source

Uncovering the role of mucus in pancreatic cancer transformation
Knowing exactly what's inside a tumor can maximize our ability to fight cancer. But that knowledge doesn't come easy. Tumors are clusters of constantly changing cancer cells. Some become common cancer variants. Others morph into deadlier, drug-resistant varieties. No one truly understands what governs this chaotic behavior.
February 28th, 2024 — Source

Health — Cancer — February 27th, 2024

Enzyme checkpoint identified in tumor-associated macrophages
A study by a scientific team from the University of Vienna and the MedUni Vienna, recently published in Cellular & Molecular Immunology, shows that the enzyme phosphoglycerate dehydrogenase (PHGDH) acts as a metabolic checkpoint in the function of tumor-associated macrophages (TAMs) and thus affects tumor growth.
February 27th, 2024 — Source

Health — Cancer — February 26th, 2024

5G-enabled robotic surgery: A new era in gastric cancer treatment
Globally, gastric cancer is the fifth most common malignancy and the fourth leading cause of cancer-related death, with China bearing nearly half of these cases. These figures underscore an urgent need for innovative solutions in the field, particularly given the huge disparities in access to diagnostic and treatment resources in remote and underserved areas.
February 26th, 2024 — Source

A very long, winding road: Developing novel therapeutics for metastatic tumors
In a new editorial paper published in Oncoscience titled, "A very long and winding road: developing novel therapeutics for metastatic tumors," researcher Paul Dent from the Department of Biochemistry and Molecular Biology at Virginia Commonwealth University writes that tumors that have metastasized to distant locations, such as the brain, are most often impossible to treat and cure, although immunotherapeutic approaches have had recent successes in some tumor types such as non-small cell lung cancer (NSCLC) and cutaneous melanoma.
February 26th, 2024 — Source

AGA Research Foundation secures $1.4 million endowment grant for pancreatic cancer research
The AGA Research Foundation has announced a $1.4 million endowment grant from The Bern Schwartz Family Foundation. The AGA Institute will provide matching support, resulting in a $2.8 million endowment dedicated to advancing basic research in pancreatic cancer, the third leading cause of cancer deaths in the U.S.
February 26th, 2024 — Source

Clinical trial tests combination antibody therapy in adults with advanced cancer
In an early-phase clinical trial, a combination of antibody-based medications targeting the immune system generated promising safety data and anti-tumor activity in individuals with various types of advanced cancer. The findings are published in Cancer.
February 26th, 2024 — Source

How does cancer impact cognitive decay?
In a recent study published in Scientific Reports, researchers used the Australian Imaging Biomarkers and Lifestyle (AIBL) study data to investigate the risk of mild cognitive impairment (MCI) and Alzheimer's disease (AD) among cancer patients.
February 26th, 2024 — Source

Medicare approves genetic test for solid tumors
A genetic test that identifies cancer mutations in solid tumors and that was developed by researchers at Washington University School of Medicine in St. Louis has been approved for reimbursement by the Centers for Medicare & Medicaid Services (CMS).
February 26th, 2024 — Source

New screening tool to explore mechanisms behind cancer, autoimmunity and neurodegeneration
Scientists have developed a new screening tool to uncover how genetic changes affect gene activity and can lead to diseases such as cancer, autoimmunity, neurodegeneration and cardiovascular disease. This new tool enables the investigation of thousands of DNA mutations identified by genetic studies in one experiment, guiding the development of advanced diagnostics and treatments.
February 26th, 2024 — Source

Poor diet and lack of exercise: Survey reveals Americans unaware of colon cancer risk factors
In a time of inactive workdays and rising obesity rates in America, most people don't know that what they eat, drink and how much they move can impact their risk for colorectal cancer, a highly preventable form of cancer that is affecting a growing number of people in their 30s, 40s and 50s.
February 26th, 2024 — Source

Predicting immunotherapy success via biomarkers
Researchers at the Technion's Ruth and Bruce Rappaport Faculty of Medicine and the Rappaport Family Institute for Research in the Medical Sciences have discovered a subset of blood cells that predict the success of immunotherapy treatment.
February 26th, 2024 — Source

Research suggests natural compound could be promising new alternative treatment for colon cancer
A new study has discovered a naturally occurring compound found in fruit has the potential to be an effective alternative treatment for colon cancer. The disease, which affects the large intestine, remains a significant global health concern, ranking as the third most common cancer worldwide.
February 26th, 2024 — Source

Scientists devise novel strategy to seek and destroy leukemia stem cells
Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States, have devised an innovative approach to target and destroy hard-to-kill leukemia stem cells. The journal Blood has published the preclinical findings.
February 26th, 2024 — Source

Study reveals typical growth patterns for children with Fanconi anemia
Published in the American Journal of Medical Genetics, a University of Minnesota Medical School study found that it is normal for children with Fanconi anemia to be shorter and thinner than other children. Fanconi anemia is a rare genetic condition affecting DNA repair that may lead to bone marrow failure, leukemia and other cancers.
February 26th, 2024 — Source

Study shows expanded cancer gene testing feasible, beneficial for patients
A new University of Kentucky Markey Cancer Center study published in JCO Precision Oncology demonstrates a feasible way to expand germline genetic testing for patients with cancer.
February 26th, 2024 — Source

Study: Antibody combination shows safety and anti-tumor activity in advanced cancer patients
In an early phase clinical trial, a combination of antibody-based medications targeting the immune system generated promising safety data and anti-tumor activity in individuals with various types of advanced cancer. The findings are published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society.
February 26th, 2024 — Source

Tumor biology may underlie racial differences in certain breast cancer outcomes
Regardless of socioeconomic factors and tumor variables, Black women with triple negative breast cancer have a significantly poorer response to chemotherapy than white women, researchers at Duke Cancer Institute report.
February 26th, 2024 — Source

We need to minimize morbidity to really save the lives of children with brain cancer, researchers say
We have long known that not all childhood cancers are created equal, but the differences are becoming increasingly apparent. While advances in diagnosis and treatment mean that survival has increased significantly for some forms of cancer, it has changed very little for cancer types that are harder to understand and treat.
February 26th, 2024 — Source

Health — Cancer — February 25th, 2024

Colon cancer under 50: know your risks and how to prevent it
Colon cancer rates are on the rise among young Americans and Americans of color, so much so that the disease is now the leading cause of cancer death for men under 50 and the second most deadly cancer for women under 50.
February 25th, 2024 — Source

Health — Cancer — February 23rd, 2024

An Innovative Method Beats Chemo-Resistant Ovarian Cancer
Northwestern Medicine researchers have uncovered the Achilles heel of chemotherapy-resistant ovarian cancer -- its need for cholesterol — and how to utilize it to get rid of it.
February 23rd, 2024 — Source

Chemotherapy method uses patient's own cells as trojan horse to direct cancer-killing drugs to tumors
Lung cancer is not the most common form of cancer, but it is by far among the deadliest. Despite treatments such as surgery, radiation therapy, and chemotherapy, only about a quarter of all people with the disease will live more than five years after diagnosis, and lung cancer kills more than 1.8 million people worldwide each year, according to the World Health Organization.
February 23rd, 2024 — Source

Genetic signature may predict response to immunotherapy for non-small cell lung cancer
A new study identified a set of 140 genes that may help predict enhanced disease-free survival in patients with non-small cell lung cancer (NSCLC) treated with a combination of immunotherapy and low-dose radiation. The results, published in Cell Reports Medicine, suggested that this "gene signature" could be used to identify a subclass of lung tumors that is more likely to be eradicated by immunotherapies.
February 23rd, 2024 — Source

Intravesical gemcitabine/docetaxel as an alternative therapy for patients with non-muscle-invasive bladder cancer
Bladder cancer is one of the more common cancers worldwide. It is considered a major health care problem with a high financial burden. Of these cases, 75% are non-muscle-invasive, which characterizes dangerous diseases with a high risk of recurrence (up to 70% within five years of diagnosis) and progression (up to 40% within five years of diagnosis).
February 23rd, 2024 — Source

Neutrophil reprogramming promotes tumor growth in certain cancers
A new research study led by A*STAR.Singapore Immunology Network (A*STAR.SIgN) has found that neutrophils-;one of the most abundant white blood cells in our body-;change drastically in certain cancers, adopting a new function whereby they promote tumor growth. By carefully studying neutrophils as soon as they enter the tumor, scientists from A*STAR.SIgN also uncovered ways to accurately differentiate tumor-promoting neutrophils from normal neutrophils present in the rest of the body
February 23rd, 2024 — Source

New brain stimulation technique shows promise for treating brain disorders
The human brain's adaptability to internal and external changes, known as neural plasticity, forms the foundation for understanding cognitive functions like memory and learning, as well as various neurological disorders.
February 23rd, 2024 — Source

Research reveals how cancer hijacks immune cells to promote tumor growth
A new research study led by A*STAR.Singapore Immunology Network (A*STAR.SIgN) has found that neutrophils—one of the most abundant white blood cells in our body—change drastically in certain cancers, adopting a new function whereby they promote tumor growth.
February 23rd, 2024 — Source

Researcher makes promising discoveries on role of vitamin B6 in pancreatic cancer
Vitamin B6 is beneficial in many ways, notably for its role in maintaining a strong immune system. However, when pancreatic cancer develops, its cells also need vitamin B6 to replicate. During the ensuing tug-of-war over a limited supply of vitamin B6, pancreatic cancer almost always emerges as the victor.
February 23rd, 2024 — Source

Patient mindset training helps care teams
A new study from Stanford University, published Jan. 19 in Patient Education and Counseling, evaluates the effectiveness of patient mindset training on provider learning and behavior.
February 23rd, 2024 — Source

Study reveals over 134,000 missed cancer diagnoses in the U.S. during COVID-19 pandemic
Over 134,000 cancer cases went undiagnosed in the U.S. during the first 10 months of the COVID-19 pandemic, according to a new University of Kentucky Markey Cancer Center study.
February 23rd, 2024 — Source

Health — Cancer — February 21st, 2024

Breakthrough research on glioma progression wins BIAL Award in Biomedicine
A team of researchers from Germany, the USA, the UK, and Norway won the third edition of the BIAL Award in Biomedicine, a 300,000 Euro prize promoted by the BIAL Foundation, which seeks to recognize a work in biomedicine of exceptional quality and scientific relevance published in the last ten years.
February 21st, 2024 — Source

Deciphering cell-to-cell conversations: AI predicts anti-cancer immunotherapy response
A recent study introduces a novel approach to cancer treatment using artificial intelligence (AI) trained on cell-to-cell communication networks.
February 21st, 2024 — Source

Hepatocellular carcinoma incidence and mortality in the US by sex, age, and race
Over the past two decades, there has been a significant increase in the incidence of primary liver cancer in the U.S., with higher rates observed in men. Its burden increases with age and disproportionately affects men, with mortality rates three times higher in men than in women. The higher incidence in men can be partially attributed to a greater prevalence of risk factors such as alcohol abuse and chronic HBV and HCV infections.
February 21st, 2024 — Source

Intramolecular bivalent glues: A promising avenue for protein degradation
Living cells resemble highly organized small towns - in addition to energy production, transportation systems, and construction, cells also require efficient waste disposal. Most proteins, which shape and sustain cellular function, have only a limited half-life and must eventually be disposed of, along with defective and unwanted proteins.
February 21st, 2024 — Source

New class of 'intramolecular bivalent glue' could transform cancer drug discovery
A breakthrough class of molecular glue identified at the University of Dundee could pave the way for a new generation of drugs to target cancers and neurodegenerative diseases.
February 21st, 2024 — Source

Novel combination therapy offers promising results for treatment-refractory hepatoblastoma
Hepatoblastoma (HB) is the most common liver cancer in children. Researchers and physicians in the field are concerned because in the last decade HB has been rising rapidly worldwide and has seen the most rapid increase among all pediatric solid tumors.
February 21st, 2024 — Source

Outcomes similar for therapy-related, de novo MDS after haplo-HSCT
Patients with therapy-related myelodysplastic syndrome (t-MDS) and de novo MDS have comparable outcomes after haploidentical hematopoietic stem cell transplantation (haplo-HSCT), according to a study published online Feb. 8 in Clinical and Experimental Medicine.
February 21st, 2024 — Source

Outsmarting chemo-resistant ovarian cancer with nanoparticle treatment
Women diagnosed with ovarian cancer may initially respond well to chemotherapy, but the majority of them will develop resistance to treatment and die from the disease. Now Northwestern Medicine scientists have discovered the Achilles heel of chemotherapy-resistant ovarian cancer—its hunger for cholesterol—and how to sneakily use that to destroy it.
February 21st, 2024 — Source

Rising incidence and mortality rate of hepatocellular carcinoma in the USA: A comprehensive analysis
Over the past two decades, there has been a significant increase in the incidence of primary liver cancer in the USA, with higher rates observed in men. Its burden increases with age and disproportionately affects men, with mortality rates three times higher in men than in women.
February 21st, 2024 — Source

Study shows early success of a novel drug in treating a rare and chronic blood cancer
A novel treatment for polycythemia vera, a potentially fatal blood cancer, demonstrated the ability to control overproduction of red blood cells, the hallmark of this malignancy and many of its debilitating symptoms in a multi-center clinical trial led by the Icahn School of Medicine at Mount Sinai.
February 21st, 2024 — Source

TB vaccine shrinks liver cancer tumors in mice
A UC Davis Health study found that a single dose of Bacillus Calmette-Guerin (BCG), the vaccine for tuberculosis (TB), reduced liver tumor burden and extended the survival of mice with liver cancer. The study, published in Advanced Science, is the first to show the promising effects of the vaccine in treating liver cancer.
February 21st, 2024 — Source

Team develops accurate and inexpensive approach for optical biopsy
Detecting cancer during its early stages, that is, before it spreads to other parts of the body, almost always leads to better treatment outcomes and lower mortality rates. However, for people without good access to health care, such as those with low resources or who live in rural areas, timely diagnosis is rare. This is in great part due to the lack of simple, quick, and cost-effective diagnostic techniques for many types of cancer.
February 21st, 2024 — Source

'Virtual biopsy' uses AI to help doctors assess lung cancer
Imperial researchers have used artificial intelligence (AI) to extract information about the chemical makeup of lung tumors from medical scans. For the first time, they have demonstrated how combining medical imaging with AI can be used to provide a 'virtual biopsy' for cancer patients.
February 21st, 2024 — Source

Health — Cancer — February 19th, 2024

Asbestos in mulch? Here's the risk if you've been exposed
Mulch containing asbestos has now been found at 41 locations in New South Wales, including Sydney parks, schools, hospitals, a supermarket and at least one regional site. Tests are under way at other sites.
February 19th, 2024 — Source

Associations between food additive emulsifiers and cancer risk
In a recent study published in PLoS Medicine, researchers assessed associations between food emulsifier intake and cancer risk among NutriNet-Santé study participants.
February 19th, 2024 — Source

Liver metastasis, metabolism, and a therapeutic conundrum
A new study led by researchers at the Herbert Irving Comprehensive Cancer Center (HICCC) has identified a crucial factor that can drive tumor cells to spread to the liver. The work, which is published in the current issue of Nature Cancer, points toward strategies that could help treat these often recalcitrant tumors.
February 19th, 2024 — Source

Novel monoclonal antibody shows promise in targeting HER2-positive breast cancer cells
In a step forward for breast cancer treatment, researchers at Tohoku University have developed a novel monoclonal antibody which specifically targets a certain type of breast cancer cell. Their findings, published in the International Journal of Molecular Sciences, offer a new tool for treating this disease.
February 19th, 2024 — Source

Research finds brain cancer risk increase after moderate/severe, penetrating TBI
Moderate/severe and penetrating traumatic brain injury (TBI) are associated with an increased risk for subsequent development of brain cancer, according to a study published online Feb. 15 in JAMA Network Open.
February 19th, 2024 — Source

What factors are associated with recent prostate-specific antigen screening in transgender women?
A new report in JAMA Network Open reports on factors associated with prostate cancer screening among transgender women.
February 19th, 2024 — Source

What reactivates dormant cancer cells?
Researchers at Columbia University have found a molecule that is responsible for arousing dormant cells from breast cancer and nudging them to create metastases. Silencing this molecule, called Malat1, in mice with breast cancer reduced metastases and improved survival, suggesting that a similar treatment could benefit patients.
February 19th, 2024 — Source

Health — Cancer — February 16th, 2024

Coffee consumption associated with reduced mortality in people with colorectal cancer
There appears to be a significant link between the coffee intake of people with intestinal cancer and mortality, as well as the likelihood of the disease returning after remission. A team in which WUR researchers participated have reached this conclusion.
February 16th, 2024 — Source

FDA approval of 4-drug combination for front-line treatment of metastatic pancreatic cancer
A four-drug chemotherapy regimen of irinotecan liposome (Onivyde) in combination with oxaliplatin, leucovorin, and fluorouracil—together referred to as NALIRIFOX—has been approved by the U.S. Food and Drug Administration (FDA) for the first-line treatment of metastatic pancreatic adenocarcinoma.
February 16th, 2024 — Source

Hitchhiking cancer vaccine makes progress in the clinic
Therapeutic cancer vaccines are an appealing strategy for treating malignancies. In theory, when a patient is injected with peptide antigens—protein fragments from mutant proteins only expressed by tumor cells—T cells learn to recognize and attack cancer cells expressing the corresponding protein.
February 16th, 2024 — Source

Lockdown skin cancer diagnosis delays linked to deaths and £6bn costs in Europe
Delays in diagnosing melanoma due to COVID-19 lockdown may have contributed to over 100,000 years of life lost across Europe and over £6bn in costs, mainly indirectly due to loss of productivity, finds a new study led by UCL and University Hospital of Basel researchers.
February 16th, 2024 — Source

Nanobubbles Revolutionize Lung Cancer Therapy by Inhaling IL-12 mRNA Cargo
Lung cancer is one of the most common cancers and has one of the lowest survival rates in the world. Cytokines, which are small signaling proteins, such as interleukin-12 (IL-12), have demonstrated considerable potential as robust tumor suppressors. However, their applications are limited due to a multitude of severe side effects.
February 16th, 2024 — Source

Promising target for CAR T-cell therapy leads to potent antitumor responses against cutaneous and rare melanomas
Scientists at the UCLA Health Jonsson Comprehensive Cancer Center have built and demonstrated the potential efficacy of a new chimeric antigen receptor (CAR) T-cell-based immunotherapy specifically designed to treat patients with cutaneous and rare subtypes of melanoma.
February 16th, 2024 — Source

Study finds neoadjuvant chemotherapy significantly improves outcomes for penile squamous cell carcinoma patients
Penile squamous cell carcinoma is a rare malignancy with limited treatment options and poor prognosis, especially in advanced stages. Because of its rarity, few studies focus on better understanding and managing this disease.
February 16th, 2024 — Source

Transforming Cancer Care: Aventa Genomics and the Future of Genomic Testing
In this interview, Chris Roberts of Aventa Genomics highlights the groundbreaking Aventa FusionPlus test, detailing its superior ability to detect gene fusions in cancer diagnostics and its pivotal role in advancing personalized oncology treatments.
February 16th, 2024 — Source

Health — Cancer — February 14th, 2024

Advanced melanoma survival rates improve significantly from 2013 to 2019, Dutch study finds
In a recent study published in EClinicalMedicine, a group of researchers assessed the change in overall survival (OS) among advanced melanoma patients diagnosed between 2013 and 2021.
February 14th, 2024 — Source

Discovery of new plant protein fold may be seed for anti-cancer drugs
University of Michigan researchers are celebrating their discovery of a new plant biochemistry and its unusual ability to form cyclic peptides—molecules that hold promise in pharmaceuticals as they can bind to challenging drug targets.
February 14th, 2024 — Source

Genome sequencing unveils mutational impacts of radiation on mammalian cells
The recent release of the wastewater from Japan's Fukushima nuclear disaster stirred apprehension regarding the health implications of radiation exposure. Classified as a Group 1 carcinogen, ionizing radiation has long been associated with various cancers and genetic disorders, as evidenced by survivors and descendants of atomic bombings and the Chernobyl disaster.
February 14th, 2024 — Source

Liver cancer: A promising avenue for more effective immunotherapies
A research team of Canadian and French scientists, led by INRS professor Maya Saleh, has been investigating immunotherapy resistance in certain patients with hepatocellular carcinoma (HCC) associated with steatotic liver disease. The findings are published in the journal Cell Reports.
February 14th, 2024 — Source

Magnetic resonance-guided adaptive radiation therapy may improve survival in pancreatic cancer patients
A study co-led by researchers at Miami Cancer Institute, part of Baptist Health South Florida, has found that ablative stereotactic magnetic resonance (MR)-guided adaptive radiation therapy may improve local control (LC) and overall survival (OS) in patients with borderline resectable (BRPC) and locally advanced pancreas cancer (LAPC). Long-term outcomes from the Phase 2 SMART trial demonstrate encouraging OS and limited toxicity as published recently in Radiotherapy and Oncology.
February 14th, 2024 — Source

Nanoparticles 'hitchhike' on immune cells to catch cancer metastasis early
(Nanowerk News) Our lymph nodes are the canaries in the coal mine of our immune system – firing into gear at the first indication of illness, then sending immune cells where they’re needed in the body to fight infection and disease.
February 14th, 2024 — Source or Source

New breakthrough in pancreatic cancer research could help slow the disease's deadly spread
Scientists at Cold Spring Harbor Laboratory (CSHL) and the University of California, Davis have reached a new breakthrough in pancreatic cancer research-;eight years in the making. It could help slow the disease's deadly spread.
February 14th, 2024 — Source

New immunotherapy for multiple myeloma proves to be more effective in the lab than CAR-T treatment already in use
Immunotherapy is already improving treatment options for many cancer types, but research groups keep exploring ways to boost the body's immune response against the tumor.
February 14th, 2024 — Source

Novel drug combination shows promise for advanced HER2-negative breast cancer
A novel three-drug combination achieved notable responses in patients with advanced HER2-negative breast cancer, according to new research directed by investigators from the Johns Hopkins Kimmel Cancer Center.
February 14th, 2024 — Source

Pancreatic cancer hijacks a brain-building protein
Scientists have discovered that pancreatic ductal adenocarcinoma (PDAC) hijacks a protein called EN-1 to evade cancer-fighting genes during metastasis. Future drugs targeting EN-1 or related proteins in cancer cells could lead to better, more personalized treatments.
February 14th, 2024 — Source

Phosphoproteomic profiling reveals the complex interplay of immune cells in tumors
Researchers from the Icahn School of Medicine at Mount Sinai, in collaboration with the Clinical Proteomic Tumor Analysis Consortium of the National Institutes of Health, The University of Texas MD Anderson Cancer Center, Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, and others, have unveiled a detailed understanding of immune responses in cancer, marking a significant development in the field.
February 14th, 2024 — Source

Promising new therapeutic approach for treating metastatic pancreatic cancer
A research paper published in Nature Cancer details new insights into the role of efferocytosis—the burying of dead cells—in pancreatic cancer that spreads to the liver.
February 14th, 2024 — Source

Research reveals new insights into the role of efferocytosis in pancreatic cancer liver metastasis
A research paper published today (14 February 2024) in Nature Cancer details new insights into the role of efferocytosis – the burying of dead cells – in pancreatic cancer that spreads to the liver.
February 14th, 2024 — Source

Researchers characterize the immune landscape in cancer
Findings could pave the way for the development of new therapeutic strategies
February 14th, 2024 — Source

Researchers edge closer to delivering personalized medicine to cancer patients
For the first time, Purdue researchers prove that measuring mechanical motions in living cancer tissues is a viable and promising approach for predicting chemoresistance
February 14th, 2024 — Source

Scientists uncover technique to cut off cancer's fuel supply
Scientists at The University of Texas at Austin have discovered how an aggressive and deadly form of leukemia fuels its growth. In an experimental study, they were able to curb the cancer's growth without harming healthy cells. The finding provides clues for future drug developers about how to increase the effectiveness of one type of chemotherapy.
February 14th, 2024 — Source

The roles of USP1 in Ewing sarcoma
Ewing sarcoma is a cancer of bone and soft tissue in children and young adults that is driven by the EWS-ETS fusion transcription factor, most commonly EWS-FLI1.
February 14th, 2024 — Source

Treating liver cancer with microrobots
(Nanowerk News) The idea of injecting microscopic robots into the bloodstream to heal the human body is not new. It's also not science fiction.
February 14th, 2024 — Source or Source

Health — Cancer — February 12th, 2024

An augmentation to standard treatment of pancreatic ductal adenocarcinoma using five repurposed drugs
In a new paper, researcher Richard E. Kast from IIAIGC Study Center presents the data and rationale for adding five generic non-oncology drugs from general medical practice to gemcitabine, nab-paclitaxel, a current standard cytotoxic chemotherapy of pancreatic ductal adenocarcinoma.
February 12th, 2024 — Source

Androgen receptor signaling found to upregulate gene driving melanoma severity in men
In a recent study published by Nature Communications, researchers uncovered a previously unknown method by which androgen-activated androgen receptors (ARs) increase fucosyltransferase 4 (FUT4) expression, which promotes melanoma invasiveness by interfering with adherens junctions (AJs).
February 12th, 2024 — Source

Differential expression of Mad2 gene in human esophageal cancer
A new research paper titled "Differential expression of Mad2 gene is consequential to the patterns of histone H3 post-translational modifications in its promoter region in human esophageal cancer samples" has been published in Oncotarget.
February 12th, 2024 — Source

Dutch insurers demand nudes from breast cancer patients despite ban
No photos? No, second operation
February 12th, 2024 — Source

King Charles, the prostate, and your health
King Charles III does not have prostate cancer. That is about the only thing we know about the royal cancer patient's condition right now.
February 12th, 2024 — Source

Mechanistically-based blood proteomic markers may be able to stratify risk for hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the third leading cause of death from cancer worldwide but is often diagnosed at an advanced incurable stage. Yet, despite the urgent need for blood-based biomarkers for early detection, few studies capture ongoing biology to identify risk-stratifying biomarkers.
February 12th, 2024 — Source

New approach combines oncolytic virotherapy and adoptive T cell therapy for cancer treatment
A multi-institutional team of Chinese microbiologists and pharmacologists has developed a novel way to fight cancerous tumors. Called ONCOTECH, it combines oncolytic virotherapy and adoptive T cell therapy for treatment of patients with cancerous tumors. The study is published in the journal Nature Biotechnology.
February 12th, 2024 — Source

New method traces primed resistance in cancer via sister cells
In many cancers, such as ovarian cancer, each round of chemotherapy kills the majority of cancer cells, while a small population of them survives through treatment. These cells are typically more resistant for the next cycle of therapy and can thus regrow to a deadly, treatment-resistant tumor.
February 12th, 2024 — Source

New research shows promise for urine-based test to detect ovarian cancer
New research by Joseph Reiner and colleagues at Virginia Commonwealth University shows promise for a urine-based test for ovarian cancer. Reiner will present their research at the 68th Biophysical Society Annual Meeting, to be held February 10 - 14, 2024 in Philadelphia, Pennsylvania.
February 12th, 2024 — Source

Novel Tumor Therapies by Targeting Extracellular Hydroxyapatite
Disrupting the acidic “microenvironment” of a tumor without causing injury to normal tissue is a novel method of tumor elimination discovered by a diverse research team at Vanderbilt University and Vanderbilt University Medical Center.
February 12th, 2024 — Source

Physical activity may help alleviate pain intensity for cancer survivors
Study shows that higher levels of physical activity are linked with less pain, and to a similar extent in adults with and without a history of cancer.
February 12th, 2024 — Source

Researchers design gel from wood pulp to heal damaged heart tissue, improve cancer treatments
You can mend a broken heart this Valentine's Day now that researchers have invented a new hydrogel that can be used to heal damaged heart tissue and improve cancer treatments.
February 12th, 2024 — Source

Sister cells uncover pre-existing resistant states in cancer
In many cancers, such as ovarian cancer, each round of chemotherapy kills the majority of cancer cells, while a small population of them survives through treatment. These cells are typically more resistant for the next cycle of therapy and can thus regrow to a deadly, treatment resistant tumor.
February 12th, 2024 — Source

Smoking linked to melanoma-associated death in early-stage melanoma
Katherine M. Jackson, M.D., from the Saint John's Cancer Institute at Providence Saint John's Health Center in Santa Monica, California, and colleagues examined the association of smoking with survival in patients with early-stage primary cutaneous melanoma in a post-hoc analysis of data from the randomized, multinational first and second Multicenter Selective Lymphadenectomy Trials.
February 12th, 2024 — Source

Study could pave the way to non-invasive techniques to detect skin cancer
A study conducted by Aston University researchers has demonstrated that the appearance of aging skin looks noticeably different compared to younger skin, when examined under polarized laser light.
February 12th, 2024 — Source

Study paves way for solutions to boost pediatric clinical trial enrollment
Every year in the U.S., about 15,000 children and teens under 20 are diagnosed with cancer. Yet, most don't get a chance to participate in clinical trials, which offer the newest, most promising treatments and improve patient outcomes.
February 12th, 2024 — Source

Study reveals a crucial survival tactic employed by cancer cells
A study led by the group of Didier Trono at EPFL has revealed a crucial survival tactic employed by cancer cells. The scientists have identified a group of proteins, known as "KRAB zinc finger proteins" (KZFPs), that help cancer cells maintain genetic stability and avoid immune system detection.
February 12th, 2024 — Source or Source

Health — Cancer — February 9th, 2024

An anticancer drug opens a new path for the treatment of Parkinson's
Once they enter the body, drugs, apart from carrying out their therapeutic function, are biochemically transformed by the action of the metabolic machinery, a process that facilitates their expulsion. This biotransformation results in a gradual disappearance of the drug, which is converted into its metabolites.
February 9th, 2024 — Source

Data show significant prevalence of sleep apnea among cardio-oncology patients
Sleep apnea is prevalent among cardio-oncology patients who are at higher risk for congestive heart failure from cancer therapy, according to a new study being presented at the American College of Cardiology Advancing the Cardiovascular Care of the Oncology Patient course.
February 9th, 2024 — Source

Fatty acids rewire energy supply chain in stomach cancer development, study shows
New research has revealed how metabolic changes spurred by fatty acids contribute to the transformation of cells into abnormal versions of themselves that are the precursors to stomach cancer.
February 9th, 2024 — Source

First individualized predictive model for multiple myeloma treatment
Multiple myeloma remains challenging to treat. New therapeutic advances have improved outcomes, but selecting the right treatment for a patient can be complex because the disease can vary drastically from person to person. In a new article published in the Journal of Clinical Oncology, Moffitt Cancer Center researchers in collaboration with Sylvester Comprehensive Cancer Center and groups around the world share results from a novel model that can provide tailored predictions of how individual patients respond to different therapies.
February 9th, 2024 — Source

Hazard training for mobility scooter users virtually non-existent despite facing regular risks
Despite being vulnerable road users, motorized mobility scooter users receive virtually no training about the types of hazards they face that might put them at risk—from designs of road crossings they find difficult to navigate, to obstacles on roads and pavements.
February 9th, 2024 — Source

New strategy for safer CAR T cell therapy in lymphomas
In treating aggressive lymphomas and blood cancer (leukemia), chimeric antigen receptor T cells (CAR T cells) are increasingly being used. For this therapy, immune cells are taken from patients and programmed by means of genetic engineering to detect proteins in the malignant tumor cells.
February 9th, 2024 — Source

New tumor spatial mapping tool to assess cancer aggressiveness and personalize treatment
Scientists have developed a new AI tool that maps the function of proteins in a cancerous tumor, enabling clinicians to decide how to target treatment in a more precise way.
February 9th, 2024 — Source

Novel cancer nanodrug targets tumor acidity without harming healthy tissue
A multidisciplinary research team at Vanderbilt University and Vanderbilt University Medical Center has discovered a new way to kill a tumor by disrupting its acidic "microenvironment" without harming normal tissue.
February 9th, 2024 — Source

Novel hydroxyapatite-targeting nanodrug may be a paradigm shift for cancer treatment
A multidisciplinary research team at Vanderbilt University and Vanderbilt University Medical Center has discovered a new way to kill a tumor by disrupting its acidic "microenvironment" without harming normal tissue.
February 9th, 2024 — Source

Novel technique has potential to transform breast cancer detection
An innovative breast imaging technique provides high sensitivity for detecting cancer while significantly reducing the likelihood of false positive results, according to a study published in Radiology: Imaging Cancer. Researchers said the technique has the potential to offer more reliable breast cancer screening for a broader range of patients.
February 9th, 2024 — Source

Research reveals a process tumors use to induce immune suppressor cells and evade immunotherapy
Cleveland Clinic researchers recently published a study in Cell Reports that shines new light on a next-generation target of immunotherapy—the immune checkpoint protein VISTA.
February 9th, 2024 — Source

The path of escape: How breast tumor cells avoid common cancer therapy
An interdisciplinary team of UNC-Chapel Hill researchers from computational medicine, genetics, biostatistics, and surgery investigated how cell cycle flexibility allows tumor cells to escape the effect of anti-cancer drugs that target cell division. UNC Lineberger members Jeremy Purvis, Ph.D., professor of genetics, and Phillip Spanheimer, MD, assistant professor of surgery, led this study.
February 9th, 2024 — Source

Health — Cancer — February 7th, 2024

Can ChatGPT outperform an expert in answering questions about colorectal cancer?
A recent Scientific Reports study investigated the proficiency of ChatGPT in answering questions related to colorectal cancer (CRC).
February 7th, 2024 — Source

Cancer survival rate: What it means for your prognosis
Find out what a survival rate can tell you and what it can't. This information can help you put survival statistics in perspective.
February 7th, 2024 — Source

Children of care leavers risk inheriting parents' emotional scars
The trauma associated with care experience casts a long shadow on mothers' mental health and that of their children, finds new UCL research.
February 7th, 2024 — Source

Chronic jet lag leads to human liver cancer in a mouse model
When asked about what could cause cancer, people most likely think of chemicals like tobacco or radiation such as UV light in sunshine, but chronic jet lag probably does not come to mind. Human epidemiological studies have linked chronic jet lag, also known as chronic circadian dysfunction, to increased liver cancer risk. However, direct evidence that it leads to liver cancer has been lacking.
February 7th, 2024 — Source

Doctors may not be giving young cancer patients what they need
The rate of cancer deaths in the U.S. has steadily declined for several decades. But there's a caveat: We've recently seen a small but worrisome increase in the rate of certain cancers—particularly colon cancers—among adults under 50. These patients have a set of needs that the health care system, accustomed to an older patient population, is not always meeting.
February 7th, 2024 — Source

Evaluation of ruxolitinib, a JAK inhibitor, in multiple myeloma
A new research perspective titled "Preclinical and clinical evaluation of the Janus Kinase inhibitor ruxolitinib in multiple myeloma" has been published in Oncotarget.
February 7th, 2024 — Source or Watch Video

Exploring the unexpected long-term consequences of female fertility
The constant remodeling of the organs of the female reproductive tract during the reproductive cycle leads to fibrosis and chronic inflammation over the years. Scientists from the German Cancer Research Center (DKFZ) have now uncovered these unexpected long-term consequences of female reproductive function in mice.
February 7th, 2024 — Source

First MYC inhibitor to demonstrate safety and anti-tumor activity in a phase I first-in-human clinical trial
Directed by Laura Soucek, an ICREA Research Professor, Director of VHIO's Experimental Therapeutics Program and head of our Models of Cancer Therapies Group, two decades of research aimed at combating resistance to therapy and cancer regression through inhibiting the MYC oncogene—found deregulated in most, if not all tumor types—has led to the in-house development of the Omomyc (OMO-103) therapeutic mini-protein by the VHIO and Catalan Institute of Research and Advanced Studies' (ICREA) spin-off company Peptomyc S.L., which Soucek co-founded in 2014 alongside Marie-Eve Beaulieu, Peptomyc's Chief Scientific Officer.
February 7th, 2024 — Source

How lung cancer hijacks immune cell metabolism to fuel its own growth
Lung adenocarcinoma is the most common lung cancer and the cause of most cancer-related deaths in the United States. There are several ways lung adenocarcinoma can arise, one of which is a mutation in a protein called EGFR (epidermal growth factor receptor).
February 7th, 2024 — Source

How play can help break the cycle of violence
In Canada, only 1 in 5 children who need mental health services receive them. Clinical and psychiatric programs, while effective, can involve long wait times and prohibitive costs. A new study involving McGill University researchers points to a solution to fill the gap: a low-cost, community-based program that has seen inspiring results.
February 7th, 2024 — Source

Immune cell networks key to success of personalized cancer treatment
Through an analysis of tumor samples collected over time from patients with advanced melanoma, a Ludwig Cancer Research study has identified a set of preexisting conditions in tumors that predict whether such patients are likely to respond to a personalized immunotherapy known as adoptive T cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL).
February 7th, 2024 — Source

New technique could make human T cells 100 times more potent at killing cancer cells
Scientists at the UC San Francisco (UCSF) and Northwestern Medicine may have found a way around the limitations of engineered T cells by borrowing a few tricks from cancer itself.
February 7th, 2024 — Source

Parenting by lying linked to more lie-telling in children
While instrumental lies—a type of parental lie told to encourage behavioral changes—may lead to behavioral compliance, a new study by Nanyang Technological University, Singapore (NTU Singapore) suggests that children told such lies are more likely to lie to their parents.
February 7th, 2024 — Source

Predicting neurodevelopmental disease in children from parents' traits
Predicting the trajectory of neurodevelopmental and psychiatric disorders like autism or schizophrenia is difficult because they can be influenced by many different genetic and environmental factors.
February 7th, 2024 — Source

Proton beam therapy: A modern treatment for cancer, but not in Canada (yet)
Radiation is a targeted form of cancer treatment used for up to half of all patients with cancer. Most radiation treatments are delivered using focused X-rays. Because X-rays travel through tissues, this can lead to extra exposure to radiation for healthy organs and tissue.
February 7th, 2024 — Source

PROX1/α-SMA correlated with colorectal cancer progression, poor outcomes and therapeutic resistance
A new research paper titled "PROX1 interaction with α-SMA-rich cancer-associated fibroblasts facilitates colorectal cancer progression and correlates with poor clinical outcomes and therapeutic resistance" has been published in Aging.
February 7th, 2024 — Source

Q&A: Cancer keeps coming for the young. Why?
A report released last month by the American Cancer Society reflects significant progress in recent decades in early detection and treatment of the disease.
February 7th, 2024 — Source

Researchers discover that blocking ephrin B2 signaling can stop multiple myeloma growth
Cedars-Sinai Cancer investigators have discovered a protein expressed on multiple myeloma cancer cells that drives disease growth and development. The new study found that blocking part of the protein's unique signaling pathway stops myeloma growth in culture and in laboratory mice.
February 7th, 2024 — Source

Scientists discover how some advanced breast cancers become resistant to hormone therapy
Researchers have identified why some advanced estrogen receptor (ER) positive breast cancers become resistant to hormone therapy, and have identified drugs currently in development that could keep disease stable for longer for these patients.
February 7th, 2024 — Source

Scientists discover that a protein associated with neurodegenerative diseases is also linked to childhood brain cancer
A protein that has been widely studied owing to its association with neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) is also linked to medulloblastoma, a type of central nervous system cancer. Medulloblastoma is one of the most common and aggressive brain tumors in children, arising from undifferentiated cells during early neural development.
February 7th, 2024 — Source

Study demonstrates antitumor action of substance present in Brazilian green propolis
Propolis has long been used in traditional medicine and has won attention from the scientific community following proof of its health benefits, which include antioxidant, anti-inflammatory, antimicrobial, antitumor, and immunomodulatory properties. Its composition varies according to origin, geographic location, and the bee species that produces it.
February 7th, 2024 — Source

Study suggests the possibility of combination therapy of SORA and FGF21 in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a common human disease and one of the main causes of cancer-related death. The angiogenesis inhibitor Sorafenib (SORA) is commonly used in the treatment of advanced HCC as a first-line drug.
February 7th, 2024 — Source

Towards a better understanding of endothelial cell transformation in cancer progression
Endothelial-mesenchymal transition (EndoMT, also termed as EndMT), a biological process resulting in the formation of mesenchymal (or lineage-committed) phenotypes from endothelial cells (lining blood vessels), plays a crucial role in tumor progression. Despite the important role of EndoMT, the underlying mechanism and characteristics of cells in intermediate/partial EndoMT remain largely unexplored.
February 7th, 2024 — Source

Treating stomach cancer
More than 26,000 people in the U.S. will be diagnosed with stomach cancer this year, and nearly 11,000 people will die of the disease, according to the American Cancer Society. Stomach cancer accounts for about 1.5% of all new cancers diagnosed in the U.S. each year.
February 7th, 2024 — Source

Woman Got Cremation Ads in the Mail After Getting Chemotherapy
"This matter has brought to light the close interplay between data brokers and data analytics firms in the digital marketing landscape."
February 7th, 2024 — Source

Health — Cancer — February 5th, 2024

Boosting fitness levels linked to lower prostate cancer risk
In a recent study published in the British Journal of Sports Medicine, researchers investigate the relationship between changes in adult cardiorespiratory fitness (CRF) and the incidence and mortality of prostate cancer.
February 5th, 2024 — Source

Data show more Millennials and Gen Zers get colon cancer: Is obesity why?
Fresh data from the American Cancer Society show colon cancer is now the leading cause of cancer deaths in men under the age of 50. Among women under age 50, colon cancer is second only to breast cancer. Not so long ago, colon cancer ranked fourth in that age group.
February 5th, 2024 — Source

Decoding cancer's spread: Epigenetic switch controls metastasis formation
Scientists from the German Cancer Research Center (DKFZ) and Heidelberg University investigated in mice how spreading tumor cells behave at the site of metastasis: Some tumor cells immediately start to form metastases. Others leave the blood vessel and may then enter a long period of dormancy. What determines which path the cancer cells take is their epigenetic status.
February 5th, 2024 — Source

Drug candidate granted FDA orphan drug status for pancreatic cancer
The U.S. Food and Drug Administration (FDA) has awarded Orphan Drug Designation to Canget BioTekpharma LLC for FL118, a drug candidate developed at Roswell Park Comprehensive Cancer Center, as a possible treatment for pancreatic cancer.
February 5th, 2024 — Source

Innovative modeling may help breast cancer patients who don't respond to treatment
Monash University-led research is using math to predict how new combination therapies can help patients with breast cancer who no longer respond to conventional therapies.
February 5th, 2024 — Source

New drug halts growth of aggressive breast cancer in pre-clinical study
A promising drug could lead to a new treatment for the most aggressive form of breast cancer, which affects thousands of women each year. A pre-clinical study led by the University of Adelaide found the new drug successfully inhibits the growth of triple negative breast cancer without any toxic side effects.
February 5th, 2024 — Source

New prostate cancer resource keeps treatment options simple to understand
Every week, more than 400 men are diagnosed with prostate cancer. With treatment, survival rates for prostate cancer are high, but understanding the treatment options and side effects can be confusing.
February 5th, 2024 — Source

PI3K/AKT and MEK/ERK pathways targeted in new therapy for docetaxel-resistant prostate cancer
A team of researchers from the Badalona Applied Research Group in Oncology (B·ARGO) and the Urologic Tumours Unit of the Institut Català d'Oncologia (ICO) and the Germans Trias i Pujol Research Institute (IGTP) have found a new therapeutic strategy for patients with a specific subtype of metastatic prostate cancer resistant to standard chemotherapy treatment with docetaxel.
February 5th, 2024 — Source

Preclinical study uncovers two proteins' crucial role in causing cancer cell growth
Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States, have discovered a new cellular mechanism that plays an important role in cancer cells' ability to cause disease. The study is published in Nature Structural & Molecular Biology.
February 5th, 2024 — Source

Protein may hold key to restoring treatment response in drug-resistant neuroendocrine prostate cancer
It may be possible to restore drug-resistant neuroendocrine prostate cancer to a state that responds to treatment by depletion of a certain protein in cancer cells. A recent study by the University of Eastern Finland found that this protein, DPYSL5, is expressed in neuroendocrine prostate cancer.
February 5th, 2024 — Source

Researchers develop computer program to assist in early breast cancer detection
A group of researchers, led by Nanyang Technological University, Singapore (NTU Singapore), has developed a computer program to identify potential tumors in the human breast, making use of the observation that malignant breast tumors distribute heat differently to healthy breast tissue.
February 5th, 2024 — Source

Simple blood protein tests predict which lymphoma patients are most likely to have poor CAR T outcomes
As new cancer treatments become available, some of the most important ongoing research must look at ways to optimize those new approaches so that more patients can benefit from groundbreaking therapies.
February 5th, 2024 — Source

Strategies to shield breast cancer patients from lymphedema
In a global effort to improve the lives of breast cancer survivors, new health research has looked at strategies that can help prevent lymphedema for millions of cancer survivors as a result of damage or removal of their lymph nodes during cancer treatment.
February 5th, 2024 — Source

Study defines mechanisms underlying promising precision therapy for pancreatic cancer
A research study led by a multidisciplinary team of scientists at Roswell Park Comprehensive Cancer Center details evidence on the therapeutic efficacy of a compound that targets a key genetic feature of pancreatic cancer. The work, published in Cancer Research, illustrates potential clinical applications for the novel anticancer agent MRTX1133 and outlines its effect on both the tumor and the surrounding environment.
February 5th, 2024 — Source

Health — Cancer — February 2nd, 2024

A one-molecule immune evasion system: New discovery could land one-two punch against cancer
A multinational team of researchers led by Columbia University has discovered that tumors can repurpose a single cellular protein to hide themselves from the immune system in two distinct ways. Drugs targeting that protein could strike a double blow against many cancers, and make immunotherapy, one of the newest types of tumor therapies even more effective.
February 2nd, 2024 — Source

Biomarkers discovered for difficult-to-diagnose breast tumor
The epigenetic 'signature' of a rare, hard-to-diagnose breast tumor has been found by scientists at the Garvan Institute of Medical Research. The discovery could lead to improved treatment guidelines and better outcomes for patients with this rare disease.
February 2nd, 2024 — Source

'Heart-on-a-chip' to test chemotherapies and other cancer drugs for heart toxicity
Chemotherapy can be toxic to heart cells. To help protect the hearts of cancer patients, Cedars-Sinai investigators have created a three-dimensional "heart-on-a-chip" to evaluate drug safety.
February 2nd, 2024 — Source

Immune cells lose 'killer instinct' in cancerous tumors, but functionality can be re-awakened
Some immune cells in our bodies see their "killer instinct" restricted after entering solid tumors, according to new research.
February 2nd, 2024 — Source

Lab-grown tumors predict treatment outcomes in landmark study
Researchers have grown tumors in the lab to accurately predict which drugs will work for people with bowel cancer—before they begin treatment.
February 2nd, 2024 — Source

Neuroendocrine prostate cancer could be restored to a state that responds to treatment
It may be possible to restore drug-resistant neuroendocrine prostate cancer to a state that responds to treatment by depletion of a certain protein in cancer cells. A recent study published in Communications Biology by the University of Eastern Finland found that this protein, DPYSL5, is expressed in neuroendocrine prostate cancer.
February 2nd, 2024 — Source

Proteins suggest a path to reduce drug resistance in a form of cancer
Doctors have nearly a dozen new targeted drugs to treat patients with acute myeloid leukemia, or AML, yet three of four patients still die within five years. Some patients succumb within just a month or two, despite the battery of drugs used to treat the aggressive blood disease, where blood cells don't develop properly.
February 2nd, 2024 — Source

Rate of venous thromboembolism increases with cancer surgery, study finds
Patients who underwent major surgery for cancer of the bladder, breast, colon or rectum, gynecologic organs, kidney and upper urothelial tract, lung, prostate, or gastroesophageal tract were matched with cancer-free members of the general population in a 1:10 ratio (432,218 patients with cancer and 4,009,343 cancer-free comparators).
February 2nd, 2024 — Source

Researchers discover epigenetic status determines metastasis
Scientists from the German Cancer Research Center (DKFZ) and Heidelberg University have investigated in mice how spreading tumor cells behave at the site of metastasis. Some tumor cells immediately start to form metastases. Others leave the blood vessel and may then enter a long period of dormancy.
February 2nd, 2024 — Source

Scientists uncover a crucial link between cholesterol synthesis and cancer progression
Scientists led by a team at Duke-NUS Medical School have made a breakthrough in understanding the mechanisms that influence cancer cell growth and development. Publishing in the Journal of Clinical Investigation, the researchers illuminate the previously hidden role of a novel enzyme, called fatty acid hydroxylase domain containing 2 (FAXDC2), revealing its pivotal role in cholesterol synthesis and cancer progression.
February 2nd, 2024 — Source

Why a dangerous subtype of Wilms tumor is so resistant to chemotherapy
An international team, led by researchers at Nagoya University in Japan, may have determined why the diffuse anaplasia (DA) subtype of Wilms tumor (WT) resists chemotherapy. This subtype grows even when it has a high burden of DNA damage and increases the mutation rate of tumor protein 53 (TP53), a gene that plays a critical role in the regulation of cell growth and division.
February 2nd, 2024 — Source

Health — Cancer — February 1st, 2024

A nanotechnology‐based CRISPR/Cas9 delivery system for genome editing in cancer treatment
In a study published in MedComm—Biomaterials and Applications Professor Changyang Gong and his Ph.D. student Shiyao Zhou elaborate on the mechanism of CRISPR/Cas9 system. The CRISPR/Cas9 system consists of Cas9 protein and single stranded directing RNA (sgRNA).
February 1st, 2024 — Source

How does cancer spread to other parts of the body?
All cancers begin in a single organ or tissue, such as the lungs or skin. When these cancers are confined in their original organ or tissue, they are generally more treatable.
February 1st, 2024 — Source

More cancers linked to contaminated water at camp Lejeune
A much anticipated government study finds that military personnel stationed at Camp Lejeune in North Carolina between 1975 and 1985 face at least a 20% higher risk for certain cancers than those stationed elsewhere.
February 1st, 2024 — Source

Nanoscale imaging method reveals new cells and structures in human brain tissue
(Nanowerk News) Using a novel microscopy technique, MIT and Brigham and Women’s Hospital/Harvard Medical School researchers have imaged human brain tissue in greater detail than ever before, revealing cells and structures that were not previously visible.
February 1st, 2024 — Source

Health — Cancer — January 31st, 2024

AI can predict brain cancer patients' survival
New research shows that artificial intelligence (AI) can predict whether adult patients with brain cancer will survive more than eight months after receiving radiotherapy treatment. The use of the AI to successfully predict patient outcomes would allow clinicians to be better informed for planning the next stage of treatment and refer patients to potentially life-saving treatment quicker.
January 31, 2024 — Source

AI-based applications for personalized cancer medicine and related regulatory challenges: An overview
Personalized therapies could improve the treatment of many diseases in the future. Cancer medicine in particular has made significant progress in recent years. Applications of artificial intelligence (AI) will allow to adapt personalized therapies in an even more targeted manner.
January 31, 2024 — Source

Are younger women experiencing a higher incidence of breast cancer?
In a recent study published in the journal JAMA Network Open, researchers evaluated the incidence of breast cancer among young women between the ages of 20 and 49 years. They assessed the incidence according to age at diagnosis, tumor stage, estrogen and progesterone hormone receptor status, and race and ethnicity.
January 31, 2024 — Source

BCAS1 defines a heterogeneous cell population in diffuse glioma patients
Oligodendrocyte precursor markers have become of great interest to identify new diagnostic and therapeutic targets for diffuse gliomas, since state-of-the-art studies point towards immature oligodendrocytes as a possible source of gliomagenesis. Brain-enriched myelin-associated protein 1 (BCAS1) is a novel marker of immature oligodendrocytes and was proposed to contribute to tumorigenesis in non-central nervous system tumors.
January 31, 2024 — Source

Brain protein's virus-like structure may help explain cancer-induced memory loss
In a rare but serious complication of cancer, the body's own immune system can start attacking the brain, causing rapid-onset memory loss and cognitive deficits. What triggers this sudden biological civil war was largely unknown.
January 31, 2024 — Source

Combination drug therapy shows promise for a treatment-resistant cancer
A combination of two cancer drugs could be effective against malignant peripheral nerve sheath tumors (MPNSTs)—soft tissue tumors that are stubbornly resistant to chemotherapy and radiation—according to a laboratory study led by researchers at the Johns Hopkins Kimmel Cancer Center.
January 31, 2024 — Source

Combination of photonic sensors and microfluidics could detect cancer markers within 20 minutes
Russian scientists have proposed a new promising rapid way to diagnose breast cancer. It will spot the disease based on a blood test that takes between 15 and 20 minutes. The solution can be adapted to spot other diseases, too. Once that is accomplished, it could even enable simultaneous screening for multiple diseases.
January 31, 2024 — Source

Do deep learning tools outperform humans in diagnosing breast cancer via ultrasound imaging?
In a recent study published in the journal npj Precision Oncology, researchers conducted a systematic review to examine the accuracy of deep learning (DL) in diagnosing breast cancer using ultrasound (US) compared to human readers in clinical settings.
January 31, 2024 — Source

New compounds target and kill brain cancer cells after being energized by low X-ray dose
Researchers led by Nanyang Technological University, Singapore (NTU Singapore) have developed a new and precise way to treat the most common type of brain cancer using a substantially lower dose of X-rays than existing radiation treatments.
January 31, 2024 — Source

New research finds oral leukemia therapy to work as well as intravenous decitabine
Researchers at Hackensack Meridian's John Theurer Cancer Center (JTCC), are part of a published Phase 3 study reporting on the equivalent safety and effectiveness in the oral treatment of blood cancers--such as myelodysplastic syndrome and/or chronic myelomonocytic leukemia--to its previously inpatient, intravenous treatment counterparts.
January 31, 2024 — Source

Research shows effectiveness of new technique to detect ovarian cancer marker peptides
A new study led by researchers at Virginia Commonwealth University found that a novel technique is effective at detecting specific biomarkers that are present in the urine of ovarian cancer patients. The research could one day play a role in helping doctors more accurately diagnose ovarian cancer.
January 31, 2024 — Source

Study finds incidence of cervical cancer in certain racial/ethnic groups has increased in recent years
The incidence and mortality of cervical cancer increased in specific racial/ethnic groups during recent years, according to a study published online Jan. 17 in the International Journal of Cancer.
January 31, 2024 — Source

Team creates framework to provide optimal personalized treatment options for esophageal cancer patients
A multidisciplinary team of researchers that included 14 graduate students from The University of Texas at Arlington has created a new framework to provide optimal personalized treatment options for individuals with esophageal cancer.
January 31, 2024 — Source

Treatment of aggressive breast cancer: Discovery of a new protein involved in the development of metastases
A protein found abundantly in breast cancers that are refractory to conventional treatments is thought to cause the development of metastasis. Targeting it would prevent metastatic spread and therefore increase patients' survival.
January 31, 2024 — Source

Health — Cancer — January 29th, 2024

Addition of durvalumab, bevacizumab to TACE beneficial in liver cancer
For patients with embolization-eligible unresectable hepatocellular carcinoma (uHCC), the addition of durvalumab (D) and bevacizumab (B) to transarterial chemoembolization (TACE) improves progression-free survival (PFS), according to a study presented at the American Society of Clinical Oncology annual Gastrointestinal Cancers Symposium, held from Jan. 18 to 20 in San Francisco.
January 29, 2024 — Source

Breast cancer test may make bad chemotherapy recommendations for Black patients
A common test used to decide whether breast cancer patients should receive chemotherapy may be making bad recommendations for some Black women, leading them to forgo chemotherapy when it might have helped, according to new research from the University of Illinois Chicago.
January 29, 2024 — Source

Cancer in rural Upstate New York: Study reveals obstacles, opportunities for care
People struggling with cancer who live in rural areas outside Rochester confront transportation issues and unique challenges related to farm life, a Wilmot Cancer Institute study shows.
January 29, 2024 — Source

Combination drug activates calcium channels to trigger deadly influx of calcium ions inside tumor cells
Calcium ions are essential for cells, but can be toxic in higher concentrations. A team of researchers has now designed and prepared a combination drug that kills tumor cells by modulating the calcium influx into the cell. An external calcium source is not necessary because only the calcium ions already present in the tumor tissue are used, according to the study, published in the journal Angewandte Chemie International Edition.
January 29, 2024 — Source

Common biomarker test could be misguiding treatment for some Black women with breast cancer
A common test used to decide whether breast cancer patients should get chemotherapy may be making bad recommendations for some Black women, leading them to forgo chemotherapy when it might have helped, according to new research from the University of Illinois Chicago.
January 29, 2024 — Source

Destroying tumor cells with calcium
Activating calcium channels leads to a deadly influx of calcium ions into tumor cells
January 29, 2024 — Source

Dr. Chao Ma: Pioneering 'Leukemia-on-a-Chip' for CAR T Cell Therapy at SLAS 2024
In this interview, NewsMedical speaks with Innovation Award nominee Chao Ma, Ph.D., a Research Assistant Professor at New York University Tandon School of Engineering. We first spoke to Dr. Ma at SLAS 2022; this conversation aims to delve into how this important research has evolved and where it is heading.
January 29, 2024 — Source

European scientists target high-risk childhood cancer with liquid biopsy
Neuroblastoma mainly affects toddlers and young children - in the EU region there are 1500 new cases per year. Neuroblastoma is a malignant tumor of the peripheral nervous system and around 50% of patients are high-risk cases. Recurrences occur frequently, and conventional therapies are no longer effective for these children.
January 29, 2024 — Source

How precise diagnosis of lymphoma offers patients best treatment options
Dr. Lisa Rimsza is a pathologist, director of the Mayo Clinic Molecular Diagnostic Laboratory and researcher with the Mayo Clinic Comprehensive Cancer Center. Her research specializes in lymphoma, with a focus on developing tests for accurate patient diagnoses and assessing disease aggressiveness.
January 29, 2024 — Source or Watch Video

Is lung cancer treatment working? This chip can tell from a blood draw
Using a chip to process blood samples, doctors can monitor the amount of cancer cells in a patient's blood to determine how well a treatment is working by the fourth week, according to a new University of Michigan study.
January 29, 2024 — Source

Method that rapidly predicts breast cancer survival rates clinically validated
Digistain, a company with its roots at Imperial, has proven the worth of its breast cancer assessment method in a significant clinical trial.
January 29, 2024 — Source

Myeloid mutations associated with high-risk adult acute lymphoblastic leukemia
Scientists previously thought mutations in myeloid genes could only cause myeloid cancers such as myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML)—hence the name given to these genes. However, a recent study led by researchers at the University of Chicago Medicine reveals that myeloid mutations can also cause high-risk acute lymphoblastic leukemia (ALL) and that ALL patients with these mutations require non-standard treatment.
January 29, 2024 — Source

New technology makes cancer easier for immune system to find and destroy
A new technology to increase visibility of cancer cells to the immune system using CRISPR has been developed, and could lead to a new way to treat cancer.
January 29, 2024 — Source

OU research focuses on innovative combination of imaging techniques to detect pancreatic cancer
Researchers at OU Health Stephenson Cancer Center at the University of Oklahoma Health Sciences have embarked on a revolutionary new research study that could improve the detection of a deadly disease -; pancreatic cancer -; and give patients a chance to live longer, healthier lives.
January 29, 2024 — Source

Overweight and obesity linked to rising death rates from bowel cancer among young adults
Overweight and obesity are contributing to rising death rates from bowel cancer among people aged 25-49 years in the European Union (EU) and the UK, although death rates from this type of cancer are decreasing overall across Europe.
January 29, 2024 — Source

Protein identified as a potential biomarker and therapeutic target for aggressive neuroendocrine carcinomas
Investigators from the UCLA Health Jonsson Comprehensive Cancer Center have identified a protein called UCHL1 in highly aggressive neuroendocrine carcinomas and neuroblastoma that could potentially be used as a molecular biomarker for diagnosing these cancers and predicting and monitoring responses to therapy.
January 29, 2024 — Source

Q&A: How exercise can boost cancer treatment and recovery
A team of UBC researchers wants to help people living with cancer incorporate exercise as an important part of their treatment and recovery.
January 29, 2024 — Source

Research identifies predictors of venous thromboembolism after pulmonary resection for lung cancer
A new study presented at The Society of Thoracic Surgeons' 2024 Annual Meeting in San Antonio, Texas, examines the ongoing controversy surrounding the choice between multi-arterial grafting (MAG) and single arterial grafting (SAG) in coronary artery bypass grafting (CABG) for multivessel coronary revascularization.
January 29, 2024 — Source

Research identifies predictors of venous thromboembolism after pulmonary resection for lung cancer
In patients who undergo pulmonary resection for lung cancer, a major potential postoperative complication is venous thromboembolism (VTE)—a condition that develops when a blood clot forms in a vein—which can lead to part of the clot breaking off and lodging in the lung, resulting in a pulmonary embolism (PE).
January 29, 2024 — Source

Researchers leverage AI to develop early diagnostic test for ovarian cancer
For more than three decades, a highly accurate early diagnostic test for ovarian cancer has eluded physicians. Now, scientists in the Georgia Tech Integrated Cancer Research Center (ICRC) have combined machine learning with information on blood metabolites to develop a new test able to detect ovarian cancer with 93% accuracy among samples from the team's study group.
January 29, 2024 — Source

RNA sequencing analysis feasible for diagnosis of molecular subtypes in pediatric B-ALL
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, representing more than 30% of all pediatric cases. A pilot study in The Journal of Molecular Diagnostics, published by Elsevier, confirms the feasibility of implementing an RNA sequencing analysis (RNA-Seq) workflow for clinical diagnosis of molecular subtypes in pediatric B-acute lymphoblastic leukemia (B-ALL).
January 29, 2024 — Source

Scientists discover cancer treatment two-and-a-half times more effective when tumors have defective mitochondria
Scientists have made an unusual discovery that could help to identify patients who are up to two-and-a-half times more likely to respond to currently available cancer drugs.
January 29, 2024 — Source

Scientists reveal direct link between mitochondrial DNA mutations and cancer treatment response
Cancer Research UK-funded scientists have made an unusual discovery that could help to identify patients who are up to two and a half times more likely to respond to currently available cancer drugs.
January 29, 2024 — Source

Specific plant foods reduce premature aging in childhood cancer survivors
For childhood cancer survivors, specific plant foods are associated with a lower risk for premature aging, according to a study published online Jan. 23 in the Journal of Clinical Oncology.
January 29, 2024 — Source

Study identifies risk factors for deadly blood clots after lung cancer surgery
In patients who undergo pulmonary resection for lung cancer, a major potential postoperative complication is venous thromboembolism (VTE)-;a condition that develops when a blood clot forms in a vein-;which can lead to part of the clot breaking off and lodging in the lung, resulting in a pulmonary embolism (PE).
January 29, 2024 — Source

Study shows breast cancer rates increasing among younger women
Diagnoses of breast cancer have increased steadily in women under age 50 over the past two decades, with steeper increases in more recent years, according to a study led by researchers at Washington University School of Medicine in St. Louis. The surge is driven largely by increases in the number of women diagnosed with estrogen-receptor positive tumors, cancerous growths fueled by estrogen.
January 29, 2024 — Source

Subcutaneous nivolumab as effective as IV for renal cell carcinoma, with much faster treatment time: Clinical trial
Subcutaneous injection of the immunotherapy nivolumab (brand name Opdivo) is noninferior to intravenous delivery and dramatically reduces treatment time in patients with renal cell carcinoma, as seen in the results of a large phase 3 clinical trial reported today at the 2024 American Society of Clinical Oncology (ASCO) Genitourinary Cancers Symposium in San Francisco, California.
January 29, 2024 — Source

Health — Cancer — January 26th, 2024

Blood test could diagnose patients with deadly brain tumors, including glioblastoma
A simple blood test could help diagnose patients with the deadliest form of brain cancer, sparing them from undergoing invasive, highly-risky surgery.
January 26, 2024 — Source

'Cancer-cooling' protein puts bowel cancer on ice
A protein in the immune system can be manipulated to help overcome bowel cancer, according to new research from The Australian National University (ANU). The research is published in Science Advances.
January 26, 2024 — Source

Oncology trial shows positive results for patients with muscle-invasive urothelial carcinoma
Patients with muscle-invasive urothelial cancer and a high risk of recurrence after surgery may have a new treatment option. The Alliance for Clinical Trials in Oncology has announced positive results from the Phase III AMBASSADOR (A031501) trial for the adjuvant treatment of patients with localized muscle-invasive urothelial carcinoma (MIUC) and locally advanced urothelial carcinoma.
January 26, 2024 — Source

Puffed-up MOFs for improved drug delivery
The spongelike structure of metal organic frameworks (MOFs) allows these polymers to possibly carry and deliver a range of therapeutic compounds. Now, researchers reporting in ACS Applied Bio Materials ("Performance of MIL-101(Cr) and MIL-101(Cr)-Pore Expanded as Drug Carriers for Ibuprofen and 5‑Fluorouracil Delivery") treated a chromium-containing MOF with a dose of acetic acid, more concentrated than in vinegar, to expand its pore size and surface area.
January 26, 2024 — Source

Researchers develop puffed-up MOFs for improved drug delivery
The spongelike structure of metal-organic frameworks (MOFs) allows these polymers to possibly carry and deliver a range of therapeutic compounds. Now, researchers reporting in ACS Applied Bio Materials have treated a chromium-containing MOF with a dose of acetic acid, more concentrated than in vinegar, to expand its pore size and surface area.
January 26, 2024 — Source

Researchers discover inherited genetic mutations can predict interval breast cancer
An investigation conducted by researchers at Karolinska Institutet has led to a discovery in breast cancer diagnostics and treatments that could reshape screening programs and clinical approaches. The study, published in JAMA Oncology, unravels the impact of rare genetic variants on interval breast cancers, providing new insights into tailored screening strategies.
January 26, 2024 — Source

Researchers discover why one type of chemotherapy works best in bladder cancer
Tisch Cancer Institute researchers have discovered that a certain type of chemotherapy improves the immune system's ability to fight off bladder cancer, particularly when combined with immunotherapy.
January 26, 2024 — Source

The impact of electric cooking on reducing nitrogen dioxide--related diseases in urban China
In a study published in the journal Eco-Environment & Health, researchers from Tsinghua University used modeled NO2 exposure concentrations, exposure-response relationships with lung cancer, chronic obstructive pulmonary disease, and diabetes mellitus, and baseline disability-adjusted life years (DALYs) to estimate the
January 26, 2024 — Source

Toolkit for reducing cervical cancer risk
Cervical cancer is the fourth most common cancer in women globally, particularly in low- and middle-income countries. In the U.S., cervical cancer is no longer a common cause of cancer death because of the use of a screening test called a Pap smear, which detects changes in cervical cells.
January 26, 2024 — Source

Treatment can do more harm than good for prostate cancer. Why active surveillance may be better
Although about 1 in 8 men in the U.S. will be diagnosed with prostate cancer during their lifetime, only about 1 in 44 will die from it. Most men diagnosed with prostate cancer die from other causes, especially those with a low-risk prostate cancer that usually grows so slowly it isn't life-threatening.
January 26, 2024 — Source

What are the symptoms of an enlarged prostate and how is it treated?
The announcement that King Charles III was admitted to a private hospital Friday to undergo a procedure for an enlarged prostate has sparked interest in what is an extremely common condition among older men.
January 26, 2024 — Source

Health — Cancer — January 24th, 2024

Chemotherapy becomes more efficient when senescent cells are eliminated by immunotherapy, shows study
Cancer treatments, including chemotherapy, in addition to killing a large number of tumor cells, also result in the generation of senescent tumor cells (also called "zombie cells"). While senescent cells do not reproduce, they do, unfortunately, generate a favorable environment for the expansion of tumor cells that may have escaped the effects of the chemotherapy and eventually result in tumor regrowth.
January 24, 2024 — Source

Detecting bowel cancer without a stool test
An international team of researchers from Adelaide and the United States has opened the door to non-stool-based bowel cancer detection by showing that a probiotic bacteria already being used to treat gut disorders can be engineered to reveal the presence of early tumors.
January 24, 2024 — Source

FDA warns of rare secondary cancer risk with CAR-T therapies
The U.S. Food and Drug Administration has told drugmakers to add a boxed warning to a type of cancer treatment called CAR-T therapy, saying the treatment itself may sometimes cause a secondary cancer.
January 24, 2024 — Source

Finding the optimal combination of anticancer drug administration for the conditioning of cord blood transplantation
Allogeneic hematopoietic stem-cell transplantation (allo-HSCT) can cure hematopoietic diseases, such as acute myeloid leukemia. Cord blood transplantation (CBT), which accounts for more than one-third of allo-HSCTs in Japan, uses hematopoietic stem cells contained in the blood in the umbilical cord and placenta. Moreover, it is a valuable option for patients lacking suitable HLA-matched donors.
January 24, 2024 — Source

Harnessing skin cancer genes to heal hearts
Biomedical engineers at Duke University have demonstrated that one of the most dangerous mutations found in skin cancers might moonlight as a pathway to mending a broken heart.
January 24, 2024 — Source

How a timekeeping gene affects tumor growth depends entirely on context
A new study has found that the circadian clock—which synchronizes physiological and cellular activities with the day-night cycle and is generally thought to be tumor suppressive—in fact has a contextually variable role in cancer.
January 24, 2024 — Source

Imaging after one week on pembrolizumab may predict treatment response in advanced melanoma
Imaging the tumors of patients with advanced melanoma receiving pembrolizumab (Keytruda) after only one week—rather than the standard of around three months—identified metabolic changes that corresponded with treatment response and progression-free survival (PFS).
January 24, 2024 — Source

mRNA therapeutic successfully combats ovarian cancer in mice
Each year, several thousand women in Germany die from ovarian cancer. In many cases, the disease is only detected when it is very advanced and metastases have already formed—usually in the intestines, abdomen or lymph nodes. At such a late stage, only 20% to 30% of all those affected survive the next five years.
January 24, 2024 — Source

mRNA therapy revives p53 to combat ovarian tumors
Ovarian cancer is often very aggressive and responds poorly to the therapies currently available. A recent study by Goethe University Frankfurt and University Hospital Frankfurt offers hope that this could change in the medium term. The researchers used an mRNA as a therapeutic.
January 24, 2024 — Source

New study links biomarkers and chemotherapy-related gastrointestinal symptoms
A study led by University of California, Irvine researchers has revealed a connection between blood levels of omega-3 and the inflammatory biomarker interleukin-8 and greater chemotherapy-related gastrointestinal symptoms in breast cancer patients.
January 24, 2024 — Source

Prostate cancer treatment guided by new tool
According to the Centers for Disease Control and Prevention, cancer is a leading cause of death in the United States. Unfortunately for American men, prostate cancer remains one of the deadliest cancers.
January 24, 2024 — Source

Research explains why protein-poor diet during pregnancy increases risk of prostate cancer in offspring
Experiments with rats conducted by researchers at São Paulo State University (UNESP) in Brazil increase our understanding of why descendants of women who were malnourished during pregnancy tend to face a higher risk of prostate cancer in adulthood.
January 24, 2024 — Source

Researchers develop machine-learning tool to detect cancer earlier via liquid biopsy
Researchers at City of Hope and Translational Genomics Research Institute (TGen) have developed and tested an innovative machine-learning approach that could one day enable the earlier detection of cancer in patients by using smaller blood draws. The study is published in the journal Science Translational Medicine.
January 24, 2024 — Source

Rice scientists identify promising new immunological pathway to treat breast cancer bone metastases
Rice University researchers in the lab of chemist Han Xiao have identified a promising new immunological pathway to treat stubborn bone tumors, one of most prevalent forms of metastases in breast cancer patients.
January 24, 2024 — Source

Study identifies promising target for treating inflammatory bowel disease and colitis-induced colorectal cancers
Inflammation in the gut can trigger a doom loop of sorts. The condition messes with the sensitive relationships between food, digestive acids, microbes and the immune system in ways that can promote further inflammation and, sometimes, the eventual growth of tumors.
January 24, 2024 — Source

Study investigates perceived barriers to cancer care in rural South Dakota
Cancer rates across the United States are falling, but in South Dakota, cancer remains the leading cause of death. What unique challenges does South Dakota have when it comes to cancer care that is causing the state to fall behind the rest of the country?
January 24, 2024 — Source

Targeting FSP1 regulates iron homeostasis in drug-tolerant persister head and neck cancer cells
A new research paper titled "Targeting of FSP1 regulates iron homeostasis in drug-tolerant persister head and neck cancer cells via lipid-metabolism-driven ferroptosis" has been published in Aging.
January 24, 2024 — Source

Turning senescent tumor cells into targets for better cancer treatment
Cancer treatments, including chemotherapy, in addition to killing a large number of tumor cells, also result in the generation of senescent tumor cells (also called "zombi cells"). While senescent cells do not reproduce, they do, unfortunately, generate a favorable environment for the expansion of tumor cells that may have escaped the effects of the chemotherapy and eventually result in tumor regrowth.
January 24, 2024 — Source

Health — Cancer — January 22nd, 2024

Awesome Games Done Quick 2024 raises $2.5 million for cancer research
Highlights included a talented gamer dog beating Gyromite.
January 22, 2024 — Source

Bone marrow adipocytes provide early sign of progression from MGUS to multiple myeloma
A new research perspective titled "Bone marrow adipocytes provide early sign for progression from mgus to multiple myeloma" has been published in Oncotarget.
January 22, 2024 — Source

Cancer grade probing system method evaluates model tumor malignancy
An important part of choosing the most suitable cancer therapy is understanding the malignancy of the tumor; however, current methods for evaluating brain tumor malignancy are invasive and have a high risk of complications.
January 22, 2024 — Source

Cholangiocarcinoma: New organ-on-chip aims at accelerating research and personalized medicine
It is only a few centimeters in size and can be held between two fingers, but hidden in the micro-channels carved inside it is a three-dimensional and highly faithful model of a biliary tract cancer called cholangiocarcinoma, complete with its tumor microenvironment. This 3D model is built starting from a sample of patient's cancer cells and thus it represents a patient-specific "organ-on-chip": a technology made possible only through a multidisciplinary approach that merges biomedicine, physics and engineering.
January 22, 2024 — Source

Melanoma overdiagnosis soars among white Americans, study finds
More than half of all melanoma diagnoses among white Americans may be overdiagnosed, according to a new study led by a researcher at Dell Medical School at the University of Texas at Austin.
January 22, 2024 — Source

Mutational signatures of cancer: Can passengers set a direction for prognosis?
An editorial paper was published in Oncoscience by researcher Peeter Karihtala from the University of Helsinki and University Hospital Comprehensive Cancer Center, titled, "The mutational signatures of cancer: can passengers set a direction for prognosis?"
January 22, 2024 — Source

New approach to robotic mastectomy can preserve full breast and nipple sensation
When I was a child, my grandma was diagnosed with breast cancer. She had a radical mastectomy at 55, which back then meant removing all her muscle, skin, and breast tissue—a disfiguring surgery that resulted in lingering pain, swelling, and complete loss of sensation in her chest.
January 22, 2024 — Source

New approaches to treating diverse bile duct cancers prevalent in southeast Asia
An international study has effectively targeted three distinct groups in cholangiocarcinoma (CCA)—or cancer of the bile duct—with drug inhibitors. These findings, published in the journal Gut, deepen our understanding of the mechanisms that cause CCA to develop and propose new therapeutic targets for this lethal disease. This research is of particular relevance to the Southeast Asian region, where bile duct cancer is endemic.
January 22, 2024 — Source

New strategy to boost prostate cancer treatment efficacy
Rutgers researchers can predict which patients will benefit from a popular prostate cancer drug—and they have devised a strategy that may make the treatment work longer.
January 22, 2024 — Source

Protein discovery could help solve prostate cancer drug resistance
Researchers have identified a receptor protein known as CHRM1 as a key player in prostate cancer cells' resistance to docetaxel, a commonly-used chemotherapy drug to treat advanced cancer that has spread beyond the prostate.
January 22, 2024 — Source

Receptor protein found to be a key player in prostate cancer cells' drug resistance
Researchers have identified a receptor protein known as CHRM1 as a key player in prostate cancer cells' resistance to docetaxel, a commonly used chemotherapy drug to treat advanced cancer that has spread beyond the prostate. The discovery opens the door to new treatment strategies that could overcome this resistance. This could ultimately help extend the lives of those with prostate cancer, one of the leading causes of cancer deaths among men.
January 22, 2024 — Source

Research team develops new tools to improve pancreatic cancer patient care
Cedars-Sinai Cancer investigators have used a unique precision medicine and artificial intelligence (AI) tool called the Molecular Twin Precision Oncology Platform to identify biomarkers that outperform the standard test for predicting pancreatic cancer survival. Their study, published in Nature Cancer, demonstrates the viability of a tool that could one day guide and improve treatment for all cancer patients.
January 22, 2024 — Source

Researcher details his personal battle with cancer
On January 3, 2024, Mikhail V. Blagosklonny M.D., Ph.D., from Roswell Park Comprehensive Cancer Center published a new brief report in Oncoscience titled "My battle with cancer. Part 1."
January 22, 2024 — Source

Researchers develop first ever guideline for cancer screening in rare muscle disease
Researchers from the National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Center (BRC) and University of Manchester have been instrumental in developing the first guideline for cancer screening in an inflammatory muscle disease called "myositis," which has an increased cancer risk.
January 22, 2024 — Source

Researching a new treatment option for severe blood disorders of the bone marrow
When people develop myelodysplastic neoplasms (MDS), the healthy maturation of blood cells is impaired. Severe forms, known as higher-risk MDS, are characterized by rapid progression, severe symptoms and often a transition to acute leukemia. Patients for whom potentially curative or intensive treatments, such as stem cell transplantation or high-dose chemotherapy, are not suitable, have very few alternative treatment options.
January 22, 2024 — Source

Rutgers researchers devise strategy to boost prostate cancer treatment efficacy
Rutgers researchers can predict which patients will benefit from a popular prostate cancer drug -- and have devised a strategy that may make the treatment work longer.
January 22, 2024 — Source

Scientists Will Test a Cancer-Hunting mRNA Treatment
Strand Therapeutics has figured out a way to turn the molecule on and off in certain tissues to more precisely treat tumors.
January 22, 2024 — Source

Study of gigantism in whales provides clues to genomic mechanism involved in tumor suppression
The functioning of certain regions of a few genes in cetaceans (whales, porpoises and dolphins) may explain why the Blue whale (Balaenoptera musculus) can reach lengths of up to 30 meters—almost 10 m more than a bus—while the Bottlenose dolphin (Tursiops truncatus) is 4 m long at most. It can also help toward the development of new cancer treatments.
January 22, 2024 — Source

Top Harvard cancer researchers accused of scientific fraud; 37 studies affected
Researchers accused of manipulating data images with copy-and-paste.
January 22, 2024 — Source

What factors affect patients' decisions regarding active surveillance for low-risk prostate cancer?
Because low-risk prostate cancer is unlikely to spread or impact survival, experts and guidelines recommend active surveillance, which involves regular monitoring and thus avoids or delays treatment like surgery or radiation therapy and their life-changing complications.
January 22, 2024 — Source

Health — Cancer — January 19th, 2024

3D bioprinting sheds light on why blood vessel curvature may foster brain cancer metastasis
Recent research suggests that the winding paths of blood vessels might trigger the development of metastatic cancers, a topic gaining considerable attention in academia. A collaborative team utilized 3D bioprinting technology to reproduce intricate brain blood vessel structures in the laboratory.
January 19, 2024 — Source

Analyzing tissue-agnostic therapies for the treatment of primary brain tumors
Researchers from Miami Cancer Institute, part of Baptist Health South Florida, have published a study in Trends in Cancer that analyzes the use of tissue-agnostic therapeutics in patients with primary brain tumors (PBTs). The article describes the current and potential impact of tissue-agnostic therapies on the management of PBTs.
January 19, 2024 — Source

Can yoga improve your prostate health?
In a recent perspective published in Prostate Cancer and Prostate Diseases, researchers presented the potential benefits of yoga in improving prostate health.
January 19, 2024 — Source

CT-based radiomics deep learning to predict lymph node metastasis in tumors
Researchers at University of Tsukuba have developed an imaging model to predict preoperative lymph node metastasis in nonfunctional pancreatic neuroendocrine tumors by combining radiomics (data analysis based on radiological images) and deep learning; this model has been developed as a new method for noninvasively determining preoperative lymph node metastasis.
January 19, 2024 — Source

Evaluating the effectiveness and safety of single-port robot-assisted technique in nipple-sparing mastectomy procedures
In a recent study published in JAMA Surgery, a group of researchers evaluated the safety and feasibility of a single-port (SP) robotic-assisted approach for performing nipple-sparing mastectomies (NSM).
January 19, 2024 — Source

Gotta go fast: all the awesome stuff at AGDQ 2024
Awesome Games Done Quick (AGDQ) 2024 wraps up this weekend and The Verge is on-site in the positively balmy Pittsburgh, Pennsylvania to bring you the final two days of speedrunning goodness.
January 19, 2024 — Source

Groundbreaking study identifies FAM3C as a key regulator of breast cancer progression
A groundbreaking study conducted by Professor Jiyoung Park and her research team in the Department of Biological Sciences at UNIST has identified FAM3C, a metabolism-regulating signaling molecule produced by cancer-associated adipocytes (CAAs), as a key regulator of breast cancer progression within the tumor microenvironment (TME). The findings, published in the prestigious academic journal Cancer Research, shed light on the potential for targeted therapies in the treatment of breast cancer.
January 19, 2024 — Source

Molecular jackhammers drill pathway to killing cancer cells  
Just as jackhammers can penetrate concrete, molecular jackhammers (MJH) are nanoscopic machines capable of creating blows so strong that they can crack or rupture the cell membrane, decompensating and killing the cell. The MJHs are turned on by near-infrared (NIR) light that stimulates synchronized delocalized vibrations throughout the cell—a mechanical action that can be exploited to rapidly kill cancer cells.
January 19, 2024 — Source

Multiple myeloma cured after hepatitis treatment reveals that this cancer can be caused by viruses
A few years ago, a patient was cured of multiple myeloma after being treated for hepatitis C, astounding researchers from the group led by Joaquín Martínez, from the H12O-CNIO Hematological Tumours Clinical Research Unit, a collaboration between the Hospital 12 de Octubre (H12O) and the National Cancer Research Centre (CNIO). Multiple myeloma is one of the most common cancers of the blood.
January 19, 2024 — Source

New 3D spatial approach reveals interactive view of glioblastoma and therapeutic targets
A multidisciplinary team of investigators has developed a first-of-its-kind interactive 3D spatial approach that reveals new therapeutic targets and provides users with a comprehensive three-dimensional view of glioblastoma tumors, detailed in a recent study published in Cell.
January 19, 2024 — Source

New study challenges role of rectal exam in prostate cancer screening
A study by the Comprehensive Cancer Center Vienna of MedUni Vienna and Vienna General Hospital has taken a closer look at the effectiveness of common examination methods for the early detection of prostate cancer. It was found that rectal examination has no advantages over the PSA blood test for detecting prostate cancer.
January 19, 2024 — Source

Novel strategy for ultrahigh density copper single atom enzymes developed for tumor therapies
A research group led by Prof. Wang Hui and Prof. Zhang Xin from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences introduced a new strategy to prepare ultrahigh density copper single-atom enzymes for tumor self-cascade catalytic therapy.
January 19, 2024 — Source

Researchers improve blood tests' ability to detect and monitor cancer
A new way to recover significantly more circulating tumor DNA in a blood sample could improve the sensitivity of liquid biopsies used to detect, monitor, and guide treatment of tumors.
January 19, 2024 — Source

Study analyzes the use of tissue-agnostic therapeutics in patients with primary brain tumors
Researchers from Miami Cancer Institute, part of Baptist Health South Florida, today published a study in Trends in Cancer that analyzes the use of tissue-agnostic therapeutics in patients with primary brain tumors (PBTs). The publication describes the current and potential impact of tissue-agnostic therapies on the management of PBTs. As part of the publication, the researchers discuss data from clinical trials of tissue-agnostic targets for PBTs in the context of challenges in managing these tumors.
January 19, 2024 — Source

Study shows risk for cancer increases for relatives of patients with leukemia
Relatives of patients with myelodysplastic neoplasia (MDS), acute myeloid leukemia (AML), or acute lymphoblastic leukemia (ALL) have an increased risk for cancer, according to a study published in the February issue of Cancer Epidemiology.
January 19, 2024 — Source

Study: Rectal examination has no advantage over PSA blood test for prostate cancer screening
A study by the Comprehensive Cancer Center Vienna of MedUni Vienna and Vienna General Hospital has taken a closer look at the effectiveness of common examination methods for the early detection of prostate cancer. It was found that rectal examination has no advantages over the PSA blood test for detecting prostate cancer.
January 19, 2024 — Source

Targeting annexin-A1 can halt cancer cell growth, study finds
A new study published in Oncogene highlights the effectiveness of MDX-124, the first therapeutic drug to target annexin-A1, a protein that is overexpressed in several cancer types and promotes tumor progression.
January 19, 2024 — Source

The secret life of CD4+ T cells: From helpers to melanoma fighters
A study led by the Peter Doherty Institute for Infection and Immunity (Doherty Institute) has found that CD4+ T cells, traditionally called 'helper T cells' for their role in aiding the activation of other immune cells, are remarkably effective in controlling melanoma.
January 19, 2024 — Source

Using generative AI to identify potent and selective MYT1 inhibitors for the treatment of cancer
Recent research has identified MYT1 as a promising new therapeutic target for breast and gynecological cancer and discovered a series of novel, potent, and highly selective inhibitors specifically targeting MYT1.
January 19, 2024 — Source

Vascular changes persist after multisystem inflammatory syndrome in children, research finds
Multisystem inflammatory syndrome in children (MIS-C) may be associated with an increased risk for future cardiovascular complications due to significant persistent vascular alterations, according to a research letter published online Jan. 16 in JAMA Pediatrics.
January 19, 2024 — Source

Health — Cancer — January 16th, 2024

Advancing pancreatic cancer treatment with total robotic Whipple surgery
New technologies are improving pancreatic cancer treatment, offering hope to patients facing one of the least survivable forms of cancer. The Whipple procedure, a complex surgery for localized pancreatic cancer, can now be done robotically.
January 16, 2024 — Source

Chemists find potential new drug for photodynamic cancer therapy
A modern alternative to chemotherapy and radiotherapy is photodynamic therapy. It is used to treat cancer, skin diseases, and infectious diseases. The essence of the method is that light-sensitive substances are introduced into the blood, which accumulate in the affected tissues. They are then irradiated with light of the desired wavelength and intensity.
January 16, 2024 — Source

Aging cells may boost ovarian cancer spread, say scientists
Ovarian cancer is dangerous because it often goes undetected until it has spread beyond the ovaries, and the symptoms can also be attributed to other conditions.
January 16, 2024 — Source

Cancer-related mutations appear in stem cell derivatives used in regenerative medicine, shows study
Human pluripotent stem cells are cells that have two very important traits—a seemingly endless proliferative capability and the amazing ability to give rise to any cell in our body. These characteristics make these cells a great tool for research of early human development as well as disease modeling and drug discovery, and most importantly, as a cell source for regenerative medicine.
January 16, 2024 — Source

Combination treatment improves lung cancer outcomes, finds study
A new study has found that patients with non-small cell lung cancer (NSCLC) treated with a combination of low-dose radiation and immunotherapy had higher progression-free survival compared to patients who received immunotherapy alone two years after treatment.
January 16, 2024 — Source

Combining health data with whole genome sequence data in cancer patients can help doctors provide more tailored care
In a recent study published in Nature Medicine, a group of researchers evaluated the impact of integrating whole-genome sequencing data with clinical outcomes across 13,880 tumors from 33 cancer types, assessing precision care potentials within the United Kingdom (UK) National Healthcare System (NHS) through the 100,000 Genomes Cancer Programme.
January 16, 2024 — Source

Energy-starved breast cancer cells consume their surroundings for fuel, research suggests
Breast cancer cells ingest and consume the matrix surrounding them to overcome starvation, according to a new study published January 16 in the open access journal PLOS Biology, by Elena Rainero of the University of Sheffield, UK, and colleagues.
January 16, 2024 — Source

Evolutionary conservation of CD4 and LAG-3 and their cytoplasmic tail motifs with opposing immune functions
T cell surface markers CD4 and LAG-3 are related proteins that promote and inhibit cell activity, respectively. However, although LAG-3 has started to gain appreciation as an immune checkpoint molecule that can be targeted in cancer immunotherapy, only CD4 is well understood.
January 16, 2024 — Source

Light-driven molecular jackhammers destroy cancer cells
Scientists have long explored using light to precisely control molecular-scale machines inside living cells for applications like targeted drug delivery. However, progress in this promising field has been incremental.
January 16, 2024 — Source

Mathematical model mimics vascular tumor growth in breast cancer and its response to treatment
Choosing the right cancer treatment is a massive undertaking involving multiple stages, high experimental complexity and significant costs. Currently, two main methods are used to find the best possible treatment solutions: in vitro testing and clinical trials. However, predicting the drug effects on each individual patient remains the Holy Grail of personalized medicine.
January 16, 2024 — Source

Mathematicians build 'attentive' neural network that recognizes breast cancer with 99.6% accuracy
Mathematicians from RUDN University have built a neural network that recognizes breast cancer on histological samples with almost 100% accuracy. This was achieved with the help of a module, which "sharpened the attention" of the model.
January 16, 2024 — Source

Medicaid expansion associated with reduction in early mortality after lung cancer surgery
In a new, national, hospital-based study, researchers at the American Cancer Society (ACS) found that Medicaid expansion was associated with a statistically significant reduction in early mortality following surgical resection of stage I-III non-small cell lung cancer (NSCLC). The study results indicate that access to health insurance coverage via Medicaid expansion in the United States during a crucial period -- in this case, during recovery from major surgery -- is associated with improved survival.
January 16, 2024 — Source

Molecular 'super-glue' shows promise of cancer drug discovery platform
St. Jude Children's Research Hospital scientists have published their work on SJ3149, a compound with broad activity against many cancer types, particularly acute myeloid leukemia (AML). SJ3149 sticks to the cancer-related protein casein kinase 1 alpha (CK1α), leading to its destruction.
January 16, 2024 — Source

Nanorobots Facilitate a 90% Decrease in Bladder Tumor Size
A recent study published in Nature Nanotechnology describes how urea-powered nanorobots helped a research team shrink the growth of bladder tumors in mice by 90%.
January 16, 2024 — Source

New drug candidate may prevent metastasis
A UCF College of Medicine researcher is developing a new treatment that could slow or even stop cancer cells from spreading.
January 16, 2024 — Source

New frontier in glioblastoma theragnosis: Visualizing the tumor microenvironment
Recently, a team of South Korean researchers led by nuclear medicine physician and Professor Yun Mijin from Severance Hospital in collaboration with Director C. Justin Lee of the Center for Cognition and Sociality within the Institute for Basic Science (IBS) made a new discovery that could revolutionize both the diagnosis and treatment of glioblastoma.
January 16, 2024 — Source

New method improves detection of potential therapeutic tumor targets in human biopsies
Many cancers, including some types of breast cancer, are driven by alterations in the activity of cellular enzymes called kinases. Therapies that directly inhibit these cancer-promoting activities have proven to be effective for patients in which individual driving kinases can be diagnosed.
January 16, 2024 — Source

Photodynamic study shows selective destruction of cancer cells via autophagy mechanism
In Japan, cancer has been the leading cause of death since 1981. At present, surgery, chemotherapy, and radiotherapy are the main treatment options. However, these treatments considerably reduce postoperative quality of life; hence, the development of new treatment methods is highly desired.
January 16, 2024 — Source

Special RNA shown to suppress the formation of breast cancer cells
Breast cancer is the most common cancer in women. The development of breast cancer often originates from epithelial cells in the mammary gland—the very cells that specialize in milk production during and after pregnancy.
January 16, 2024 — Source

Study finds S. aureus can offset the effect of cancer therapy for Sezáry syndrome
"Consequently, an efficient treatment must address both the bacteria and the cancer itself," says the head of the research team, Niels Ødum, Professor at the Department of Immunology and Microbiology, University of Copenhagen.
January 16, 2024 — Source

Study pinpoints breast cancer 'cells-of-origin' in high-risk women
Women who inherit and carry a faulty BRCA2 gene have a substantially increased risk of developing breast cancer—approximately 70% of carriers will develop the disease over their lifetime.
January 16, 2024 — Source

Study shows parents more likely to attempt suicide in first years after child's cancer diagnosis, compared to later on
Receiving a cancer diagnosis for a child is an incredibly stressful and distressing experience for parents. These parents, especially mothers, face an increased risk of psychiatric disorders, but little is known about the risk of suicide.
January 16, 2024 — Source

The lesser-known health benefit of Dry January: Cancer prevention
As we begin 2024, resolutions to eat healthier and exercise more are likely on many minds. This year, you may consider adding another: Reducing alcohol or taking a break altogether. Many people have also started to participate in "Dry January"—a month-long vow to go alcohol-free.
January 16, 2024 — Source

Urea-powered nanorobots reduce bladder tumors by 90% in mice
The research, which was conducted on mice, demonstrates how these tiny nanomachines are propelled by urea present in urine and precisely target the tumor, attacking it with a radioisotope carried on their surface. Led by the IBEC and CIC biomaGUNE, the study opens the door to new, more efficient treatments for bladder cancer.
January 16, 2024 — Source

Health — Cancer — January 15th, 2024

A single dose of urea-powered nanorobots reduces bladder tumors by 90% in mouse study
Bladder cancer has one of the highest incidence rates in the world and ranks as the fourth most common tumor in men. Despite its relatively low mortality rate, nearly half of bladder tumors resurface within 5 years, requiring ongoing patient monitoring. Frequent hospital visits and the need for repeat treatments contribute to making this type of cancer one of the most expensive to cure.
January 15, 2024 — Source or Source

Bladder tumors reduced by 90% using nanorobots
Bladder cancer has one of the highest incidence rates in the world and ranks as the fourth most common tumour in men. Despite its relatively low mortality rate, nearly half of bladder tumours resurface within 5 years, requiring ongoing patient monitoring. Frequent hospital visits and the need for repeat treatments contribute to making this type of cancer one of the most expensive to cure.
January 15, 2024 — Source

Activity of pazopanib in EWSR1-NFATC2 translocation-associated bone sarcoma
In this case report researchers discuss the case of a patient with a EWSR1-NFATC2 fusion positive bone sarcoma who had exceptional tumor control through using pazopanib and surgery for an overall duration exceeding five years. The report also reviews the literature on EWSR1-NFATC2 translocation-associated sarcomas and use of pazopanib in bone sarcomas.
January 15, 2024 — Source

Decrease in head and neck cancer incidence seen during pandemic
During the first year of the COVID-19 pandemic, the incidence of head and neck cancer (HNC) decreased, according to a study published online Jan. 11 in JAMA Otolaryngology-Head & Neck Surgery.
January 15, 2024 — Source

MIT experts develop AI models that can detect pancreatic cancer early
Two machine learning models dubbed the "PRISM" neural network were created using five million patient health records.
January 15, 2024 — Source

Neoadjuvant chemotherapy may help some breast cancer patients skip regional nodal irradiation
For patients whose breast cancer converted from lymph node-positive to lymph node-negative disease after neoadjuvant chemotherapy, skipping adjuvant regional nodal irradiation (RNI) did not increase the risk of disease recurrence or death five years after surgery, according to results from the NRG Oncology/NSABP B-51/RTOG 1304 clinical trial presented at the San Antonio Breast Cancer Symposium, held December 5--9, 2023.
January 15, 2024 — Source

New mechanism with potential to boost checkpoint-blocking cancer immunotherapies identified
Researchers at the University of Aberdeen working on a partnership study that looks at how the immune system could help improve cancer treatment have found a potential new way to aid and develop better cancer therapies.
January 15, 2024 — Source

Novel regulator of immune evasion in cancer identified
Northwestern Medicine investigators have identified a previously unknown regulator of tumor immune evasion, which may help improve the efficacy of current and future anti-tumor immunotherapies, according to recent findings published in the Journal of Clinical Investigation.
January 15, 2024 — Source

Substance use disorders on the rise for survivors of specific cancers
The prevalence of substance use disorder (SUD) seems to be elevated among survivors of certain types of cancer, according to a study published online Jan. 11 in JAMA Oncology.
January 15, 2024 — Source

Sharp pain in your feet? Researchers test promising therapy for cancer patients' neuropathy
A wearable, app-controlled wireless device that stimulates nerves in the legs and feet may help individuals with cancer who suffer from burning and shooting pain and cramping in their lower limbs brought on by chemotherapy, a new study showed.
January 15, 2024 — Source

UTI: This common infection can be serious
"Simple urinary tract infections can be managed by your primary care provider, but when they become complex leading to other issues or problems, you should seek the care of a specialist," says Dr. Mitchell Humphreys, a urologist at Mayo Clinic.
January 15, 2024 — Source

Health — Cancer — January 13th, 2024

New analysis of cancer cells identifies 370 targets for smarter, personalized treatments
A new, systematic analysis of cancer cells identifies 370 candidate priority drug targets across 27 cancer types, including breast, lung and ovarian cancers.
January 13, 2024 — Source

Health — Cancer — January 12th, 2024

A novel approach for lymph node metastasis treatment
Researchers at Tohoku University have discovered a new approach for treating lymph node metastasis. Anticancer drugs are administered directly into the LNs under ultrasound guidance (lymphatic drug delivery system or LDDS) to target sentinel lymph nodes (LNs) and generate antitumor effects locally, preventing distant metastasis.
January 12, 2024 — Source

'Big data' analysis reveals new targets for treating ovarian cancer
A recent study used a big data multi-omics analysis to examine changes in gene expression as cells from human fallopian tubes become cancerous.
January 12, 2024 — Source

Cancer Drugs Find New Role as Insulin Regenerators
Both drugs are already approved by the FDA—they just need to be tested and re-approved as diabetes treatments.
January 12, 2024 — Source

Clinical breast exam rarely detects second breast cancer after DCIS
For patients undergoing surveillance following diagnosis and treatment of ductal carcinoma in situ (DCIS), very few second breast cancers are detected by clinical breast examination by a physician, according to a study published online Dec. 28 in the Journal of the National Comprehensive Cancer Network.
January 12, 2024 — Source

Drinkable, carbon monoxide-infused foam enhances effectiveness of experimental cancer therapy
Did smokers do better than non-smokers in a clinical trial for an experimental cancer treatment? That was the intriguing question that led University of Iowa researchers and their colleagues to develop a drinkable, carbon monoxide-infused foam that boosted the effectiveness of the therapy, known as autophagy inhibition, in mice and human cells.
January 12, 2024 — Source

HIMSSCast: How Karmanos Cancer Institute uses AI to find high-risk breast cancer
"Finding out the patient is high-risk after they are diagnosed with cancer is too late," says Dr. Eric Brown, surgical oncologist and breast multidisciplinary team co-lead.
January 12, 2024 — Source

HOXA9 tracking reveals RBM5 dual function and therapeutic potential for acute myeloid leukemia
The protein HOXA9 is overexpressed in most acute myeloid leukemia (AML) cases and is associated with poor patient outcomes. However, HOXA9 is a difficult protein to target therapeutically, so researchers at St. Jude Children's Research Hospital looked for ways to extinguish it indirectly.
January 12, 2024 — Source

Long-term expansion and self-organization of human fetal brain organoids
In a recent study published in Cell, researchers established fetal brain organoids (FeBOs) as a versatile platform for brain cancer modeling.
January 12, 2024 — Source

MIT experts develop AI models that can detect pancreatic cancer early
Two machine learning models dubbed the “PRISM” neural network were created using five million patient health records.
January 12, 2024 — Source

Obesity linked to detection of blood cancer precursor
Individuals with obesity are more likely to have monoclonal gammopathy of undetermined significance (MGUS), a benign blood condition that often precedes multiple myeloma, according to new research published in Blood Advances.
January 12, 2024 — Source

Passive smoking associated with significant increases in the risk of nine health outcomes including lung and breast cancer
In a recent study published in Nature Medicine, researchers assess and quantify the adverse health effects of second-hand smoke (SHS) exposure.
January 12, 2024 — Source

Research reveals an immune cell that can attack cancer
According to preclinical research published in Cell researchers at City of Hope have discovered that a type of immune cell in the human body known to be important for allergy and other immune responses can also attack cancer.
January 12, 2024 — Source

Researchers discover compound that fights leukemia and lymphoma
Researchers at The University of Texas at El Paso have identified a novel pharmaceutical compound that successfully kills leukemia and lymphoma cancer cells, potentially paving the way for new forms of therapy.
January 12, 2024 — Source

Health — Cancer — January 11th, 2024

A call for improved CDC communication on adult immunization
In an editorial in the Annals of Internal Medicine, CUNY SPH Distinguished Lecturer Scott Ratzan, Senior Scholar Ken Rabin, and colleagues call for the Centers for Disease Control and Prevention (CDC) to "raise its persuasive communications game" on adult immunization to clinicians and the public.
January 11, 2024 — Source

Cervical cancer screening recommendations
January is Cervical Cancer Awareness Month. Each year, more than 11,000 new cases of cervical cancer are diagnosed in the U.S., according to the Centers for Disease Control and Prevention.
January 11, 2024 — Source

Cracking the code: How what you eat might affect your cancer risk
There is an unresolved debate about the extent to which the environment contributes to cancer risk. Although epidemiological studies suggest that environmental factors such as diet can certainly contribute, especially for colon cancer, how dietary factors could tip the scale in favor of cancer is not known.
January 11, 2024 — Source

Delicate Labor-Industry Deal in Flux as Newsom Revisits $25 Minimum Health Wage
Gov. Gavin Newsom is revisiting California's phase-in of a nation-leading $25 minimum wage for health workers in the face of a projected $38 billion deficit, less than three months after he approved the measure. But renegotiating wages could threaten a delicate compromise between unions and the health industry.
January 11, 2024 — Source

Graphene Quantum Dots for Chemodynamic Cancer Therapy
A metal-free nanozyme based on graphene quantum dots (GQDs) for extremely effective tumor chemodynamic treatment (CDT) has been developed by a research team headed by Prof. Hui Wang from the Hefei Institutes of Physical Science (HFIPS) of the Chinese Academy of Sciences and reported in Matter.
January 11, 2024 — Source

High-dose radiotherapy with chemotherapy found to be effective in treating people with non-small cell lung cancer
A new study led by researchers from the UCLA Health Jonsson Comprehensive Cancer Center shows that using high doses of radiation while integrating an ablative radiotherapy technique called stereotactic ablative radiotherapy (SABR) concurrently with chemotherapy is safe and effective in treating people with locally advanced non-small cell lung cancer that is not suitable for surgery.
January 11, 2024 — Source

In a Fractious Rerun, GOP Rivals Haley and DeSantis Debate Health Care. Trump Sits It Out.
The race to win the quickly approaching Iowa caucuses was the theme running through Wednesday night's Republican presidential debate hosted by CNN at Drake University in Des Moines, Iowa. Front-runner Donald Trump was again absent and only two other candidates made the cut: Florida Gov. Ron DeSantis and former South Carolina Gov. Nikki Haley.
January 11, 2024 — Source

Legal barriers to Medicaid remain upon release for many justice-involved individuals
New data released today by the Center for Public Health Law Research (CPHLR) at Temple University Beasley School of Law point to continued legal barriers for justice-involved seeking continuity of care through Medicaid coverage upon their release from incarceration, a population much more likely to face risk of overdose or death from opioid use disorder.
January 11, 2024 — Source

More transparency needed in human-robot interactions in nursing care, researchers say
It is essential in nursing care to have a transparent mapping of the entire human-robot interaction. That is the finding of the interdisciplinary research project Responsible Robotics, which researchers from TUM and the University of Graz completed in 2023. A data recorder helps to capture all events that occur when using a nursing care robot and make them visible and understandable for everyone involved.
January 11, 2024 — Source

Novel PET tracer enhances lesion detection in medullary thyroid cancer, offers potential for targeted therapy
A newly developed PET imaging agent has been found to be effective in identifying medullary thyroid cancer (MTC) in preclinical and clinical studies, according to new research. The results of the studies indicate that the PET imaging agent may be a promising theranostic candidate for clinical use.
January 11, 2024 — Source

Research shows deadly brain cancer can mimic healthy neurons
Certain cancers are more difficult to treat because they contain cells that are highly skilled at evading drugs or our immune systems by disguising themselves as healthy cells.
January 11, 2024 — Source

Researchers find Boswellia, an extract of frankincense, shows anti-cancer activity in small trial
Extracts of a plant used in traditional medicine for centuries have shown anti-proliferative effects against breast cancer in a small early-stage clinical trial.
January 11, 2024 — Source

Researchers profile two elusive proteins critical for healthy cell division
The cells in our bodies constantly divide and renew themselves. But if division goes wrong, cancer or other diseases can result. Now, University of Connecticut researchers have profiled two elusive proteins critical for healthy cell division.
January 11, 2024 — Source

Study challenges traditional views on how the brain processes movement and sensation
Our body movements profoundly impact how our brain processes sensory information. Historically, it was believed that the brain's primary motor cortex played a key role in modulating sensory experiences during movement. However, a new study led by researchers from Fujita Health University has challenged this view.
January 11, 2024 — Source

Study finds loss of RBFOX2 protein promotes pancreatic cancer metastasis through effects on cytoskeletal remodeling
Pancreatic cancer presents a challenging prognosis, marked by a five-year overall survival rate of merely 12.5%. Diagnosis frequently occurs at an advanced stage, characterized by metastasis to distant sites.
January 11, 2024 — Source

Study: US health costs related to chemicals in plastics reached $250 billion in 2018
Endocrine-disrupting chemicals (EDCs) in plastics pose a serious threat to public health and cost the U.S. an estimated $250 billion in increased health care costs in 2018, according to new research published in the Journal of the Endocrine Society. The paper is titled "Chemicals Used in Plastic Materials: An Estimate of the Attributable Disease Burden and Costs in the US."
January 11, 2024 — Source

Systematic cancer cell analysis uncovers hundreds of overlooked drug targets
A new, systematic analysis of cancer cells identifies 370 candidate priority drug targets across 27 cancer types, including breast, lung and ovarian cancers.
January 11, 2024 — Source

The key to early-onset bowel cancer may be gut bacteria
Three weeks after her 40th birthday, Julie McDonald had a colonoscopy. When she walked into the doctor's office afterwards, there were photos lined up on the desk.
January 11, 2024 — Source

Touching a nerve in the fight against chronic pain and diseases
The human body's longest cranial nerve has the potential to improve health on numerous fronts, according to researchers.
January 11, 2024 — Source

Updated genomic landscape for pediatric acute myeloid leukemia enables new treatment possibilities
Compared to adult cancers, pediatric cancers often have distinctive genetic causes. This means there is an opportunity to develop pediatric-focused diagnostic strategies and treatments. Research by St. Jude Children's Research Hospital published today (Jan. 11) in Nature Genetics clarifies the genomic landscape of pediatric acute myeloid leukemia (pAML).
January 11, 2024 — Source

Health — Cancer — January 10th, 2024

Blood test distinguishes neuroendocrine subtype of advanced prostate cancer
Like a criminal entering a witness protection program, cancer cells can shed their past and take on a new identity. Detecting such an identity switch is particularly challenging when metastatic castration-resistant prostate cancer (CRPC) advances from adenocarcinoma to neuroendocrine prostate cancer (NEPC), a very difficult cancer to treat.
January 10, 2024 — Source

Mammography AI Can Cost Patients Extra. Is It Worth It?
As I checked in at a Manhattan radiology clinic for my annual mammogram in November, the front desk staffer reviewing my paperwork asked an unexpected question: Would I like to spend $40 for an artificial intelligence analysis of my mammogram? It's not covered by insurance, she added.
January 10, 2024 — Source or Source

Metal-free graphene quantum dots show promise for highly efficient tumor therapy
A research group led by Prof. WANG Hui from the Hefei Institutes of Physical Science (HFIPS) of the Chinese Academy of Sciences has introduced a metal-free nanozyme based on graphene quantum dots (GQDs) for highly efficient tumor chemodynamic therapy (CDT).
January 10, 2024 — Source or Source

Natural compounds derived from soy and other plants found to reduce breast cancer recurrence and improve survival
Soy compounds called isoflavones are among the plant-derived compounds that may significantly reduce the risk of breast cancer recurrence or death, according to a new meta-analysis co-directed by investigators from the Johns Hopkins Kimmel Cancer Center.
January 10, 2024 — Source

New trial of 'pill-on-a-thread' brings screening for esophageal cancer closer
A man from Cambridge is the first to join the surveillance part of a clinical trial that could see routine screening for esophageal cancer introduced into the NHS, potentially halving deaths from this cancer every year.
January 10, 2024 — Source

One more step toward treatment of PARP inhibitor-resistant ovarian cancers
A new editorial paper titled "One more step toward treatment of PARP inhibitor-resistant ovarian cancers" has been published in Oncotarget.
January 10, 2024 — Source

Photocrosslinked Nanoparticles For More Stable Anticancer Therapy
Amino acids, such as tyrosine and tryptophan, are the essential building blocks of proteins. Since these biomolecules have distinct chemical groups on each end and side chain, they have the inherent potential to form a chain by creating an amide (peptide) bond.
January 10, 2024 — Source

Rock on: He played guitar while getting his brain tumor removed
Professional guitarist Christian Nolen took his stage show to an operating room last month, strumming out Deftones tunes for surgeons as they worked to remove a tumor from his brain.
January 10, 2024 — Source

Scientists find 'key' to potential breast cancer prevention and treatment
Every time a cancer cell divides, it sustains damage to its own DNA molecules. Researchers, including Gaorav Gupta, MD, Ph.D., associate professor in the Department of Radiation Oncology at the UNC School of Medicine, have long wondered how cancers are able to evade detection by the body's own defenses, despite the immune system being on constant watch for cells displaying DNA damage.
January 10, 2024 — Source

Scientists uncover 13 distinct patterns in DNA mutation risks with implications for cancer evolution
Mutations, which occur continuously in every cell of our bodies, are a key contributor to cancer, aging, and neurodegeneration. While exposure to mutagenic chemicals, or mistakes in cellular processes during DNA replication contribute to these mutations, the exact distribution and patterns of these changes across human chromosomes have remained a mystery until now.
January 10, 2024 — Source

Study links patient characteristics with the likelihood of bypassing the nearest surgical center for breast cancer treatment
In a recent study published in Cancer, researchers investigated hospital quality and patient factors associated with treatment location for breast cancer surgery.
January 10, 2024 — Source

The Nano Machines Made to Fight Antibiotic-Resistance and Cancer
Antibiotic-resistant bacteria were responsible for nearly 5 million deaths globally in 2019, as detailed in The Lancet. The rise and fall of antibiotics is a topic that is deeply personal to Dr. Ana Santos, who led the EU-funded project REBELLION.
January 10, 2024 — Source

Health — Cancer — January 9th, 2024

Children with neuroblastomas may benefit from new drug cocktail
Children who develop neuroblastomas, a rare form of cancer which develops in nerve cells, may benefit from receiving certain anti-tumor drugs as well as chemotherapy, a new trial has found.
January 9, 2024 — Source or Source

Clinical trial: New dual therapy could revolutionize treatment of urothelial and bladder cancers
An international clinical trial of a treatment for advanced urothelial cancer has found a new dual therapy can nearly double patients' life expectancy.
January 9, 2024 — Source

Closing the gap: PATROL's approach to overcoming lung cancer diagnostic inequality
Deaths from lung cancer have been declining in developed countries due to early detection, enabling timely curative treatments. However, lung cancer still results in high mortality rates in low and middle-income countries (LMICs), where there is a need for new diagnostic tools.
January 9, 2024 — Source

COVID-19 affected Canadians with noncommunicable diseases more than those without, study finds
Researchers at the Montreal Behavioural Medicine Centre (MBMC) say people with noncommunicable diseases (NCDs) such as heart disease, cancer, diabetes, or chronic lung ailments were disproportionately impacted by the COVID-19 pandemic.
January 9, 2024 — Source

Epigenetic therapy shows promise for endocrine-resistant breast cancer
Researchers have revealed a reason why endocrine resistance develops in breast cancers and how to potentially treat it in patients.
January 9, 2024 — Source or Source

How this startup uses AI to give speech-impaired people their voice back
Having just secured fresh funding, Whispp was named a CES 2024 Innovation Award honouree
January 9, 2024 — Source

Leukemia: Artificial intelligence provides support in diagnostics
IT specialists and physicians develop new method for recognizing genetic aberrations
January 9, 2024 — Source

New insights into the roles of cell mechanics in tumor malignancy
Cancer, as a life-threatening disease, has been a major research focus. Understanding the mechanisms of tumor progression has been a significant challenge. In recent years, increasing evidence has indicated a correlation between the mechanical properties of tumor cells and tumor progression and malignancy.
January 9, 2024 — Source

Newly developed inhibitor shows potential for prostate cancer
More than 65,000 men fall ill with prostate cancer each year in Germany. Of these, 12,000 develop a treatment-resistant form that eventually ends in death. Now, a team of researchers from the Medical Faculty at the University of Freiburg has developed an active substance that might represent a future treatment option.
January 9, 2024 — Source

Research better characterizes a rare form of leukemia on the molecular level
Leukemia is a common term used to refer to a form of blood cancer. However, there are different types of leukemia depending on the cell type involved. One unique form is myeloid/natural killer (NK) cell precursor acute leukemia (MNKPL). Because of its rarity, no consensus exists on the specific clinical characteristics needed to identify this disease.
January 9, 2024 — Source

Research group unveils the first individual risk prediction model for multiple myeloma
A multicenter collaboration has produced the first computational model for newly diagnosed multiple myeloma that predicts an individual's personalized prognosis based on their tumor genomics and treatments. The collaboration was led by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine
January 9, 2024 — Source

Researchers characterize the tumor suppressor activity of the PTEN protein in melanoma
Cutaneous melanoma is considered the deadliest form of skin cancer because it's aggressive and tends to spread quickly through the body. While scientists have made significant progress in understanding the molecular mechanisms leading to melanoma development, it is still unclear how the PTEN protein regulates melanoma progression.
January 9, 2024 — Source

Study shows there are disparities in cancer research and advocacy funding
A new Cleveland Clinic study shows there are disparities in cancer research and advocacy funding and that less funding strongly correlates with fewer clinical trials in a particular disease.
January 9, 2024 — Source

Study unveils machine learning-aided non-invasive imaging for rapid liver fat visualization
Steatotic liver disease (SLD), previously known as non-alcoholic fatty liver disease, which includes a range of conditions caused by fat build-up in the liver due to abnormal lipid metabolism, affects about 25% of the population worldwide, making it the most common liver disorder. Often referred to as "silent liver disease," SLD progresses without noticeable symptoms and can lead to more severe conditions like cirrhosis (liver scarring) and liver cancer.
January 9, 2024 — Source

The role of fibronectin in BRAF-mutant thyroid cancer treatment
New research overseen by University of Colorado Cancer Center member Rebecca Schweppe, Ph.D., could lead to improved treatment for people with thyroid cancer characterized by a mutation in the BRAF gene—a mutation also responsible for some types of melanoma, colorectal cancer, leukemia, lymphoma, and ovarian cancer.
January 9, 2024 — Source

Turning basic research into new treatment for the most aggressive forms of breast cancer
Thirty years ago, Gail Sonenshein was studying cancer in immune cells when she read an article in the New York Times that would shape the rest of her career. The article described a new residency program in women's health, part of an effort to improve treatment and outcomes for women at a time when most medical knowledge came from exclusively studying men.
January 9, 2024 — Source

Vaccine demonstrates potential in delaying relapse of KRAS-mutated pancreatic and colorectal cancers
A vaccine has shown potential to prevent relapse of KRAS-mutated pancreatic and colorectal cancers for patients who had previously undergone surgery, according to a Phase I trial led by researchers at The University of Texas MD Anderson Cancer Center.
January 9, 2024 — Source

Health — Cancer — January 8th, 2024

AI reveals hidden rules of cell neighborhoods in cancer
Researchers from Children's Hospital of Philadelphia (CHOP) have developed a new AI-powered algorithm to help understand how different cells organize themselves into particular tissues and communicate with one another. This new tool was tested on two types of cancer tissues to reveal how these "neighborhoods" of cells interact with one another to evade therapy, and more studies could reveal more information about the function of these cells in the tumor microenvironment.
January 8, 2024 — Source

Does where patients choose to have breast cancer surgery drive health care inequality?
Including patients as partners for making decisions about their medical treatments is an important aspect of patient-centered care. A new study from England examined choices that patients with breast cancer make when considering where to have surgery for their condition and assessed how policies that offer such choices might affect inequalities in the health care system. The findings are published in the journal Cancer.
January 8, 2024 — Source

Growing tiny tumors in the lab for personalized lung cancer treatment
Lung cancer accounts for nearly 20% of annual cancer-related deaths worldwide. According to 2022 statistics from the Swiss Cancer League, nearly 5,000 new cases of lung cancer are reported in Switzerland each year. Over the five years following diagnosis, only one person in five survives.
January 8, 2024 — Source or Source

Investigators profile three treatment response trajectories to close in on triple-negative breast cancer
Cedars-Sinai Cancer investigators have analyzed the cells within triple-negative breast cancer tumors before and after radiation therapy with immunotherapy, identifying three patient groups with different responses to the treatment. Their study, published in Cancer Cell, found that for some patients with this difficult-to-treat cancer, radiation therapy plus immunotherapy could yield the best tumor-fighting immune response prior to surgery.
January 8, 2024 — Source

New peptide library paves the way for targeting elusive cancer factor MYC
In a recent study published in the Journal of the American Chemical Society, researchers present the second-generation NTB bicyclic stereodiversified peptide library.
January 8, 2024 — Source

Novel tissue-derived brain organoids could revolutionize brain research
Scientists have developed 3D mini-organs from human fetal brain tissue that self-organize in vitro. These lab-grown organoids open up a brand-new way of studying how the brain develops. They also offer a valuable means to study the development and treatment of diseases related to brain development, including brain tumors.
January 8, 2024 — Source

Protein structures signal fresh targets for anticancer drugs
Cell replication in our bodies is triggered by a cascade of molecular signals transmitted between proteins. Compounds that block these signals when they run amok show potential as cancer drugs.
January 8, 2024 — Source

Researchers target double-stranded DNA for cancer therapy
A team of UConn School of Pharmacy researchers have published their work in Cell Reports Medicine, highlighting groundbreaking advancements in treating cancer.
January 8, 2024 — Source

Revolutionary study reveals Lactobacillus acidophilus could ward off liver cancer linked to fatty liver disease
In a recent study published in eBioMedicine, researchers investigated whether probiotic supplementation with Lactobacillus acidophilus could help prevent non-alcoholic fatty liver disease-associated hepatocellular carcinoma (NAFLD-HCC) development using tumourigenesis mouse models.
January 8, 2024 — Source

Studying cells to improve treatment for an aggressive childhood cancer
New research is shedding light and potentially expanding options for patients living with medulloblastoma, an aggressive childhood cancer. The work is published in Molecular Cell.
January 8, 2024 — Source

Study reveals critical role of FAM3C in breast cancer progression
A study conducted by Professor Jiyoung Park and her research team in the Department of Biological Sciences at UNIST has identified FAM3C, a metabolism-regulating signaling molecule produced by cancer-associated adipocytes (CAAs), as a key regulator of breast cancer progression within the tumor microenvironment (TME).
January 8, 2024 — Source

Targeted MRI detects chronic liver disease
Fibrosis—the thickening and scarring of connective tissue—plays a major role in these liver diseases but detection of fibrosis is limited to biopsy, which suffers from limitations including the risk of complications, sampling only a tiny fraction of the liver, and an inability to serially monitor disease progression due to its invasive nature.
January 8, 2024 — Source

The 'mosquito effect': How tumor cells outwit the body's immune system
In a first-of-its-kind research breakthrough, a team of scientists at the University of Massachusetts Amherst has analyzed and described what they call the "mosquito effect," which sheds light on how specific pathogens, such as cancerous tumor cells, can outwit the body's immune system.
January 8, 2024 — Source

The Process Behind Cancer Immunotherapy Triggered Intestinal Inflammation
A recent study shows a key mechanism by which anti-CTLA-4 antibodies create inflammatory toxicities during anticancer immune checkpoint inhibitor therapies: microbiota-reactive T cells cause colitis in mice harboring the microbiota of wild-caught mice after CTLA-4 blockade. The results might help create CTLA-4 inhibitors of the next generation that stimulate anticancer immune responses without causing gastrointestinal disorders.
January 8, 2024 — Source

Tumor microenvironment-activated nanostructure enables precise multi-modal therapy
Recently, a research team led by Prof. Wu Zhengyan from Hefei Institutes of Physical Science, Chinese Academy of Sciences, in collaboration Binzhou Medical University, successfully designed a nanostructure that improves the detection and treatment of tumors.
January 8, 2024 — Source

Health — Cancer — January 7th, 2024

Researchers identify why cancer immunotherapy can cause colitis
Researchers at the University of Michigan Health Rogel Cancer Center have identified a mechanism that causes severe gastrointestinal problems with immune-based cancer treatment.
January 7, 2024 — Source

When bad cells go good: Harnessing cellular cannibalism for cancer treatment
Scientists have solved a cellular murder mystery nearly 25 years after the case went cold. Following a trail of evidence from fruit flies to mice to humans revealed that cannibalistic cells likely cause a rare human immunodeficiency. Now the discovery shows promise for enhancing an up-and-coming cancer treatment.
January 7, 2024 — Source

Health — Cancer — January 5th, 2024

Alternative cancer treatments: 11 options to consider
Alternative cancer treatments can't cure your cancer, but they may provide some relief from signs and symptoms.
January 5, 2024 — Source

Cancer risk: What the numbers mean
Take the time to understand what cancer risk is and how it's measured. This can help you put your own cancer risk into perspective.
January 5, 2024 — Source

Fruit fly research solves human disease and fuels new cancer immunotherapy approach
Scientists have solved a cellular murder mystery nearly 25 years after the case went cold. Following a trail of evidence from fruit flies to mice to humans revealed that cannibalistic cells likely cause a rare human immunodeficiency. Now the discovery shows promise for enhancing an up-and-coming cancer treatment.
January 5, 2024 — Source

Getting a better look at tumors
MRI-based method detects water exchange in tumor cells to measure their malignancy
January 5, 2024 — Source

Inhalable sensors could enable early lung cancer detection
Using a new technology developed at MIT, diagnosing lung cancer could become as easy as inhaling nanoparticle sensors and then taking a urine test that reveals whether a tumor is present.
January 5, 2024 — Source or Source or Source

New guidelines for imaging estrogen receptor in breast cancer patients using FES PET
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) and the European Association of Nuclear Medicine (EANM) have issued a new procedure standard/practice guideline for estrogen receptor imaging of breast cancer patients using FES PET. The standard/guideline, published ahead of print in The Journal of Nuclear Medicine, is intended to assist physicians in recommending, performing, interpreting, and reporting the results of 18F-FES PET studies for patients with breast cancer.
January 5, 2024 — Source

New study reveals crucial 'housekeeping' genetic elements and their potent role to fight cancer
A recent study in genetic control elements revealed around 11,000 gene regulators active in every cell type, also known as housekeeping cis-regulatory elements (HK-CREs). These elements are vital in maintaining cellular stability beyond conventional gene regulation, influencing diverse cellular functions across healthy cell types. Moreover, a subset of these housekeeping elements, particularly those related to zinc finger genes, was found to have reduced activity in diverse cancers, suggesting their role as potential housekeeping tumor suppressors.
January 5, 2024 — Source

Researchers identify mechanism that causes gastrointestinal problems with cancer immunotherapy
Researchers at the University of Michigan Health Rogel Cancer Center have identified a mechanism that causes severe gastrointestinal problems with immune-based cancer treatment.
January 5, 2024 — Source

Researchers identify why cancer immunotherapy can cause colitis
Researchers have identified a mechanism that causes severe gastrointestinal problems with immune-based cancer treatment, also finding a way to deliver immunotherapy's cancer-killing impact without the unwelcome side effect.
January 5, 2024 — Source

Health — Cancer — December 29th, 2023

Breast cancer cells' self-sacrificial behavior uncovered as potential cause of relapse
For patients with early-stage breast cancer, there is a 7% to 11% chance of relapse within five years after receiving initial treatment, and this rate can be higher for patients with more advanced stages of the cancer. While chemotherapy aims to eliminate all cancer cells, some of them may evade treatment and survive, resulting in the recurrence of the cancer.
December 29, 2023 — Source

Revolutionary nanodrones enable targeted cancer treatment
A study led by Professor Sebyung Kang and Professor Sung Ho Park in the Department of Biological Sciences at UNIST has unveiled a remarkable breakthrough in cancer treatment. The research team has successfully developed unprecedented "NK cell-engaging nanodrones" capable of selectively targeting and eliminating cancer cells, offering a potential solution for intractable types of cancers.
December 29, 2023 — Source

Potent and highly selective CDK9 inhibitor for treatment of hematologic malignancies
To evade cell cycle controls, malignant cells rely upon rapid expression of select proteins to mitigate pro-apoptotic signals resulting from damage caused by both cancer treatments and unchecked over-proliferation. Cyclin-dependent kinase 9 (CDK9)-dependent signaling induces transcription of downstream oncogenes promoting tumor growth, especially in hyperproliferative "oncogene-addicted" cancers, such as human hematological malignancies (HHMs).
December 29, 2023 — Source

Robotics to aid early lung cancer detection at Englewood Health
Robotic-assisted bronchoscopy enables doctors to perform minimally invasive biopsies in distant areas of the lungs, including small nodules in the peripheral regions.
December 29, 2023 — Source

Health — Cancer — December 28th, 2023

New form of immunotherapy under investigation for cancer that resists conventional T cell therapies
Medical investigators are theorizing that a combination of two treatments that activate myeloid cells may effectively treat a recalcitrant form of pancreatic cancer that thwarts conventional immunotherapy.
December 28, 2023 — Source

New Nanostructure for Tumor-Specific Multimodal Theranostics
A nanostructure enhancing tumor detection and treatment has been developed by a research team led by Prof. Zhengyan Wu at the Hefei Institutes of Physical Science, Chinese Academy of Sciences, in collaboration with Binzhou Medical University.
December 28, 2023 — Source

Radiation therapy for cancer pain relief
Patients with cancer have another tool in their toolbox for managing pain. Palliative radiation therapy is an effective option for relieving body aches associated with cancer.
December 28, 2023 — Source

Researchers find that regret is rarer than believed among patients who undergo gender affirming surgery
In a Viewpoint article published in JAMA Surgery, three Johns Hopkins researchers urge the medical community to dismiss a widely held, but scientifically unsupported belief that many people who are transgender and gender diverse (TGD), and undergo gender affirming surgery (GAS), later regret their decision to undergo such procedures.
December 28, 2023 — Source

Study suggests Hispanic, Indigenous Americans undercaptured in National Cancer Database
Hispanic and American Indian or Alaska Native (AI/AN) individuals diagnosed with breast, colorectal, lung, and prostate cancer have been undercaptured in the National Cancer Database (NCDB), but their representation is improving, according to a study published online Dec. 27 in JAMA Network Open.
December 28, 2023 — Source

Health — Cancer — December 27th, 2023

A short history of sunscreen, from basting like a chook to preventing skin cancer
Australians have used commercial creams, lotions or gels to manage our skin's sun exposure for nearly a century.
December 27, 2023 — Source

Anthrax lethal toxin and tumor necrosis factor-α synergize to induce mouse death
Bacillus anthracis lethal toxin (LT) is a determinant of lethal anthrax. Its function in myeloid cells is required for bacterial dissemination, and LT itself can directly trigger dysfunction of the cardiovascular system. The interplay between LT and the host responses is important in the pathogenesis, but our knowledge of this interplay remains limited.
December 27, 2023 — Source

Scientists use organoid model to identify potential new pancreatic cancer treatment
A drug screening system that models cancers using lab-grown tissues called organoids has helped uncover a promising target for future pancreatic cancer treatments, according to a new study from researchers at Weill Cornell Medicine.
December 27, 2023 — Source

Squamous cell carcinoma of the oral cavity: Treatment and distant metastatic behavior
A research perspective was recently published in Oncoscience, titled "Squamous cell carcinoma of the oral cavity—follow up treatment and distant metastatic behavior."
December 27, 2023 — Source

Successful RPM needs leading edge tech, thoughtful implementations
Done right, more widespread adoption of remote patient monitoring will offer breakthrough innovations where healthcare delivery can be improved, clinician workloads can be right-sized and better patient outcomes can be achieved, an expert says.
December 27, 2023 — Source

The big potential of MOFs in tackling fundamental problems
(Nanowerk News) Metal organic frameworks (MOFs) are advanced porous materials with multifunctional tunable properties. Discovered approximately 20 years ago, these sponge-like molecule structures are being improved today by scientists determinately to make positive change in the world.
December 27, 2023 — Source

Unraveling the mystery of hereditary diffuse gastric cancer
Gastric cancer, a significant global health burden, claims more than 7% of cancer-related deaths annually. Although only 1%–3% of cases have a genetic basis, understanding these genetic drivers is crucial for developing preventative strategies.
December 27, 2023 — Source

What's in Australia's 10-year digital health blueprint?
It is doubling down on data access to enable personalised care and connected health over the next decade.
December 27, 2023 — Source

Health — Cancer — December 26th, 2023, 2023

Understanding the genetic basis of hereditary diffuse gastric cancer
Gastric cancer, a significant global health burden, claims over 7% of cancer-related deaths annually. Although only 1-3% of cases have a genetic basis, understanding these genetic drivers is crucial for developing preventative strategies.
December 26, 2023 — Source

Health — Cancer — December 24th, 2023

Patient error makes 1 in 10 home colon cancer tests unusable
At-home tests for colon cancer make this important screening readily available to folks who can't afford or would rather not go through a colonoscopy.
December 24, 2023 — Source

Health — Cancer — December 22nd, 2023

Cancer Patients Face Frightening Delays in Treatment Approvals
Marine Corps veteran Ron Winters clearly recalls his doctor’s sobering assessment of his bladder cancer diagnosis in August 2022.
December 22, 2023 — Source

Investigating disparities in breast reconstruction rates after mastectomies
Yale Cancer Center researchers at Yale School of Medicine found significant disparities in the use of post-mastectomy immediate breast reconstruction (PMIBR) among elderly women, especially in the United States and also in South Korea.
December 22, 2023 — Source

Mailed orders found to double liver cancer screening rates
Liver cancer screening among patients with cirrhosis almost doubled when they were mailed a signed order from their specialist, according to a new study from the Perelman School of Medicine at the University of Pennsylvania. However, when researchers added an incentive of $20 to the mailed orders, it made no difference in whether patients completed their screenings. The work was published this week in Hepatology Communications.
December 22, 2023 — Source

Unimolecular self-assembled hemicyanine-oleic acid conjugate acts to eliminate cancer stem cells: Study
Cancer stem cells (CSCs) are a rare population of cells in tumor tissues that drive tumorigenesis, recurrence, and metastasis. Therefore, the development of anti-tumor therapies that can eliminate CSCs has significant implications for cancer treatment. Photodynamic therapy (PDT) is a therapeutic modality that uses a specific laser wavelength to activate photosensitizers, generating large amounts of reactive oxygen species (ROS) to selectively inhibit tumor growth.
December 22, 2023 — Source

Health — Cancer — December 21st, 2023

Predicting lymphoma patients' treatment outcomes
Cedars-Sinai Cancer investigators have discovered a new way to predict whether a cancer of the immune system will recur in patients treated with a bone marrow transplant. Their study, published in the Journal of Clinical Oncology, is the first to use a novel technique called spatial profiling to predict patient outcomes, and could lead to more precisely targeted treatment.
December 21, 2023 — Source

Researchers find cancer-causing metals in a Chesapeake Bay tributary adjacent to a coal ash landfill
A recent study in Environmental Pollution unveils alarming discoveries: Researchers have identified cancer-causing contaminants in sediments and fish in a Chesapeake Bay tributary near a coal ash landfill.
December 21, 2023 — Source

Health — Cancer — December 19th, 2023

A microfluidic magnetic detection system for tumor-derived exosome analysis
In a study published on 7 November 2023 in the journal Microsystems & Nanoengineering, researchers from the Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, and Shanghai Tech University, have developed an innovative microfluidic magnetic detection system (μFMS) for analyzing tumor-derived exosomes (TDEs), potential biomarkers for cancer diagnosis.
December 19, 2023 — Source

Advanced microfluidic system for early cancer detection
In a groundbreaking study published in the journal Microsystems & Nanoengineering ("Microfluidic magnetic detection system combined with a DNA framework-mediated immune-sandwich assay for rapid and sensitive detection of tumor-derived exosomes"), Researchers from the Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, and Shanghai Tech University, have developed an innovative microfluidic magnetic detection system (μFMS) for analyzing tumor-derived exosomes (TDEs), potential biomarkers for cancer diagnosis. This novel system could greatly enhance the early detection and treatment of cancer.
December 19, 2023 — Source

Bendamustine prior to CAR T-cell therapy in patients with refractory large B-cell lymphoma: Poorer treatment outcomes
Treatment with bendamustine prior to CAR T-cell therapy in patients with refractory large B-cell lymphoma associates with poorer treatment outcomes, finds a recent study.
December 19, 2023 — Source

Study reveals hidden inactive form of p38a protein
p38a protein, a key enzyme in the regulation of various cellular functions, plays a crucial role in some diseases, including cancer, chronic inflammation, and neurodegenerative conditions. Since the discovery of p38a, various pharmaceutical companies and numerous research groups have dedicated considerable efforts to develop inhibitors of this protein. However, the results have not met the expectations foreseen to be able to design drugs.
December 19, 2023 — Source

Using Nanotechnology to Study Tumor Physiology
Pablo S. Valera, a pre-Ph.D. researcher, completed a study just published in PNAS. The study highlights the potential of Surface-Enhanced Raman spectroscopy (SERS) in investigating metabolites released by cancer cells.
December 19, 2023 — Source

Viral enhancement of nanomaterial cancer sensor improves early detection
Researchers from SUTD have developed an advanced system of breast cancer cell detection with improved speed and sensitivity, using a viral mechanism to enhance the tool's sensing accuracy.
December 19, 2023 — Source

Health — Cancer — December 18th, 2023

Discovery unveils promising anticancer drug targeting KRAS protein
Through a highly collaborative research effort led by the laboratory of Saïd Sebti, Ph.D, at the VCU Massey Comprehensive Cancer Center, a team of scientists has successfully developed a targeted therapy that hones in on the KRAS protein that drives some of the deadliest human cancers, including pancreatic, lung and colon tumors.
December 18, 2023 — Source

Harnessing nanotechnology to understand tumor behavior
A new study conducted by pre-Ph.D. researcher Pablo S. Valera demonstrates the potential of surface-enhanced Raman spectroscopy (SERS) to explore metabolites secreted by cancer cells in cancer research.
December 18, 2023 — Source or Source

Melatonin and carcinogenesis in mice: The 50th anniversary of relationships
Fifty years ago, in 1973, Vladimir N. Anisimov and co-authors demonstrated for the first time an inhibitory effect of the pineal gland hormone melatonin on cancer in vivo, namely on transplantable mammary tumors in mice. Subsequently, it was shown in a number of studies that melatonin administration with drinking water at night inhibits chemically induced mammary carcinogenesis in mice and rats.
December 18, 2023 — Source

New $3.2 million grant fuels collaborative fight against cancers
Researchers from disparate disciplines located at USC, Cedars-Sinai Medical Center, Children's Hospital Los Angeles and Stanford University gather to find solutions to cancer through the newly formed Convergent Science Cancer Consortium.
December 18, 2023 — Source

New Chemosensor Rapidly Detects Lethal Pulmonary Disease
Patients who suffer from certain long-term diseases might have to wait years to receive an accurate diagnosis. For instance, numerous pulmonary and cardiovascular problems can present with symptoms similar to shortness of breath. As a result, patients could receive therapy for a disease that is misdiagnosed and far from being appropriately treated.
December 18, 2023 — Source

Patients with metastatic colorectal cancer may continue benefiting from immunotherapy after treatment discontinuation
The majority of patients with metastatic colorectal cancer whose cancer did not progress during initial treatment with immune checkpoint inhibitors (ICIs) had no disease progression two years after discontinuing treatment, reports a new study.
December 18, 2023 — Source

Psilocybin may benefit individuals with cancer and major depression
Results from a phase II clinical trial indicate that psilocybin, a hallucinogenic chemical found in certain mushrooms of the genus Psiloybe, may benefit individuals with cancer and major depression. Trial participants treated with psilocybin not only experienced a lessening of depressive symptoms but also spoke highly of the therapy when interviewed at the end of the trial. The findings are published by Wiley in two articles appearing online in CANCER, a peer-reviewed journal of the American Cancer Society
December 18, 2023 — Source

Study points to the possibility of using cholesterol-lowering drugs to treat aggressive colorectal tumors
Hard-to-detect colorectal pre-cancerous lesions known as serrated polyps, and the aggressive tumors that develop from them, depend heavily on the ramped-up production of cholesterol, according to a preclinical study from researchers at Weill Cornell Medicine. The finding points to the possibility of using cholesterol-lowering drugs to prevent or treat such tumors.
December 18, 2023 — Source

Health — Cancer — December 15th, 2023

Acetaldehyde dehydrogenases in liver zonation and liver cancer
A study, published in the journal Gene Expression and led by Brady Jin-Smith from the Department of Pathology at Tulane University, focuses on ALDHs, a group of key enzymes that catalyze the irreversible oxidation of various aliphatic and aromatic aldehydes to the corresponding carboxylic acids. Understanding their distribution and function within the liver is key to addressing liver diseases, including cancer.
December 15, 2023 — Source

Nanoparticles Could Help Boost Body's Ability to Fight Cancer
Researchers at Johns Hopkins have discovered small particles that enhance therapeutic cancer vaccinations, which train the immune system to fight cancerous growths. These novel fat-based nanoparticles not only trigger a dual immune system response that strengthens the body’s defenses against cancer, but they also improve the tumor-targeting efficacy of vaccinations.
December 15, 2023 — Source

Novel therapeutic target overcomes resistance to radiation therapy
A new study finds that radiation therapy (RT) suppresses a key protein called bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) and activates immune suppressive cells. These effects dampen the capacity of cancer-fighting immune cells and decrease the effectiveness of radiation, inducing therapy resistance in cancer patients, according to a paper published December 15, 2023 in the Journal of Clinical Investigation.
December 15, 2023 — Source

Researchers develop new electrochemical chemosensor for fast, effective diagnosis of a lethal pulmonary disease
Patients struggling with some chronic diseases often must wait years for a proper diagnosis. For example, symptoms such as shortness of breath can be attributed to many pulmonary as well as cardiovascular disorders, so patients may be treated for a misdiagnosed disease that is far from accurate diagnosis and treatment.
December 15, 2023 — Source

Wnt pathway dysfunction influences colorectal cancer response to immunotherapy, finds study
Colorectal cancer (CRC) presents with varying clinical characteristics due to tumor heterogeneity. Microsatellite instability (MSI), present in 10–15% of CRC cases, indicates a different clinical trajectory than microsatellite stable (MSS) patients. Notably, MSI patients tend to have better outcomes and respond well to immunotherapy, but not to chemotherapy. The reason behind this disparity and the mechanisms governing MSI remained largely unknown.
December 15, 2023 — Source

Health — Cancer — December 14th, 2023

Nanoparticle-Based Drug Delivery System for Inflammation
Dr. Yu Zheng, together with her graduate student Qin Qin (from the Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University), developed and wrote the review.
December 14, 2023 — Source

Nanoparticles amplify potential cancer vaccine power
Johns Hopkins researchers have identified minuscule particles that supercharge therapeutic cancer vaccines, which train the immune system to attack tumors. These new lipid nanoparticles—tiny structures made of fat—not only stimulate a two-pronged immune system response that enhances the body's ability to fight cancer but also make vaccines more effective in targeting tumors.
December 14, 2023 — Source

Novel insights into HBV-hepatocellular carcinoma at single-cell sequencing
HBV-related HCC poses a significant global health challenge, characterized by its cellular diversity and complex tumor immune microenvironment. The increasing unmet need in HBV-HCC treatment highlights the need for a deeper understanding of the role of the intricate immune microenvironment, tumor cell plasticity, and dynamics of tumor evolution in HBV-associated hepatic carcinogenesis.
December 14, 2023 — Source

Optimizing cervical cancer screening: New study evaluates best approaches for HIV-positive women
In a recent study published in Nature Medicine, a group of researchers evaluated the effectiveness and outcomes of various cervical cancer screening strategies for women living with Human Immunodeficiency Virus (HIV) in Tanzania, supporting World Health Organisation's (WHO's) 2021 guidelines for reducing cervical cancer mortality in this high-risk group.
December 14, 2023 — Source

Pfizer completes purchase of cancer-focused Seagen
Pfizer said Thursday it completed a $43 billion takeover of cancer-focused biotech company Seagen that the pharma giant said would enable it to double its oncology platform.
December 14, 2023 — Source

Study models advantages, harms, and affordability of WHO proposed cervical cancer screening strategies for women in LMICs
In a recent article published in Nature Medicine, researchers assessed the harms, benefits, and affordability of seven primary screening algorithms for human papillomavirus (HPV) in the general population of women across 78 lower-middle-income countries (LMICs) using the Policy1-Cervix platform.
December 14, 2023 — Source

Trends in mortality from leading cancers from 2002 to 2019 for the 314 districts in England
In a recent study published in The Lancet Oncology, a group of researchers assessed mortality trends in the leading cancers from 2002 to 2019 across 314 districts in England using high-resolution spatiotemporal analysis.
December 14, 2023 — Source

Ultrafast laser technology could offer improved cancer treatment
Ultrafast laser technology continues to surprise. While research in this field may seem rather abstract at first glance, it very often leads to concrete applications. This is particularly true in health care, where the technology can be used to treat certain cancers.
December 14, 2023 — Source

Health — Cancer — December 12th, 2023

A nanoprobe with a barcode: Sensors detect active proteases
Protein-splitting enzymes play an important role in many physiological processes. Such proteases are generally present in an inactive state, only becoming activated under certain conditions. Some are linked to diseases like infections or cancer, making it important to have methods that can selectively detect active proteases.
December 12, 2023 — Source

AI-based risk model for breast cancer screening
A recent Lancet Regional HealthLancet Regional Health study assesses the performance of an artificial intelligence (AI)-based risk model for breast cancer screening in Europe.
December 12, 2023 — Source

Liquid biopsy predicts immunotherapy response and toxicity in patients with advanced lung cancer
By monitoring changes in circulating tumor DNA (ctDNA) among 30 patients treated with immunotherapies for metastatic non-small cell lung cancers, researchers were able to determine molecular response -- the clearance of tumor genetic material in the bloodstream.
December 12, 2023 — Source

Research paves the way for predicting disease progression for incurable cancer
Researchers have come one step closer to answering why, in some patients, a type of lymphoma changes from indolent to aggressive, and in particular, they are closer to identifying which patients are at high risk of this change happening.
December 12, 2023 — Source

Research proposes new MRI technology for non-invasive assessment of interstitial fluid flow
Interstitial fluid flow is closely related to drug delivery and distribution, playing a crucial role in their therapeutic effects on tumors. However, few non-invasive measurement methods are available for measuring low-velocity biological fluid flow.
December 12, 2023 — Source

Study exposes opportunities for strengthening cancer drugs trials in China
More than one-eighth of the randomized trials of cancer drugs seeking regulatory approval in China in recent years used inappropriate controls to test the effectiveness and safety of the drugs, according to a new study published December 12 in the open access journal PLOS Medicine by Professor Xiaodong Guan of Peking University, China, and colleagues.
December 12, 2023 — Source

Understudied cell in the brain could be key to treating glioblastoma
Glioblastoma is one of the most treatment-resistant cancers, with those diagnosed surviving for less than two years. In a new study, researchers have found that a largely understudied cell could offer new insight into how the aggressive, primary brain cancer is able to resist immunotherapy.
December 12, 2023 — Source

Mammogram rates increase when patients schedule themselves
By making mammograms easy to schedule through personal online patient portals, researchers saw a significant increase in screenings for breast cancer.
December 12, 2023 — Source

Mammograms found to increase when patients self-schedule
Having the ability to self-schedule mammograms was associated with a 15 percentage point increase following through with getting the screening, according to research from the Perelman School of Medicine at the University of Pennsylvania. The paper was published today in the American Journal of Preventive Medicine.
December 12, 2023 — Source

Health — Cancer — December 11th, 2023

AI accurately predicts cancer outcomes from tissue samples
Researchers at UT Southwestern Medical Center have developed a novel artificial intelligence (AI) model that analyzes the spatial arrangement of cells in tissue samples. This innovative approach, detailed in Nature Communications, has accurately predicted outcomes for cancer patients, marking a significant advancement in utilizing AI for cancer prognosis and personalized treatment strategies.
December 11, 2023 — Source

Bile duct function and disease highlighted in new study
Research from the Gupta Lab provides important insights into the extrahepatic bile ducts. These bile ducts outside of the liver are a critical but poorly understood component of the human digestive system. The study, led by Serrena Singh and supervised by Vikas Gupta, MD, Ph.D., assistant professor of medicine (digestive diseases), and published in the journal Development Cell, marks a significant step forward in understanding diseases affecting these ducts, such as primary sclerosing cholangitis and cholangiocarcinoma.
December 11, 2023 — Source

Breaking Barriers to Colorectal Cancer Care for Black Patients
Colorectal cancer disproportionately affects Black Americans, and access to care for the highly preventable disease is thought to be behind why this group is 20% more likely to receive a colorectal cancer diagnosis than any other racial or ethnic group.
December 11, 2023 — Source

CAR-T cell therapy remains viable for patients in lymphoma remission, study finds
A study led by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine suggests that CAR-T immunotherapy remains a viable option for patients who have lymphoma that goes into remission before the cell therapy begins.
December 11, 2023 — Source

Combination of dasatinib and blinatumomab offers effective treatment for older Ph+ ALL patients
Older patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) who were not good candidates for the standard treatment of intensive chemotherapy had a median overall survival (OS) of 6.5 years on an alternate regimen of dasatinib and blinatumomab.
December 11, 2023 — Source

Early diagnosis of high-grade serous ovarian cancer feasible
Early diagnosis of high-grade serous ovarian cancer (HGSOC) seems feasible through analysis of genomic alterations in DNA from Papanicolaou (Pap) test smears, according to a study published online Dec. 6 in Science Translational Medicine.
December 11, 2023 — Source

First-in-human clinical trial of CAR T cell therapy with new binding mechanism shows promising early responses
Early results from a Phase I clinical trial of AT101, a new CAR T cell therapy that uses a distinct binding mechanism to target CD19, show a 100% complete response (CR) rate at the higher dose levels studied in the trial, according to researchers from the University of Pennsylvania Perelman School of Medicine and Penn Medicine's Abramson Cancer Center.
December 11, 2023 — Source

Gut-derived exosomes as a novel mediator of hepatic lipid metabolism
Non-alcoholic fatty liver disease (NAFLD), characterized by excessive hepatic lipid accumulation, poses a high prevalence and can progress to cirrhosis and liver cancer. To enhance preventive and therapeutic efforts, an in-depth exploration of the regulatory mechanisms of NAFLD is imperative.
December 11, 2023 — Source

Hodgkin lymphoma prognosis, biology tracked with circulating tumor DNA
Circulating tumor DNA predicts recurrence and splits disease into two subgroups of Hodgkin lymphoma. New drug targets or changes in treatments may reduce toxicity.
December 11, 2023 — Source

Landscape for acute myeloid leukemia patients evolving rapidly as research discoveries advance new treatments
The treatment landscape for acute myeloid leukemia (AML) is evolving rapidly, as research discoveries at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and other academic cancer centers advance new, more effective therapies for this aggressive blood cancer.
December 11, 2023 — Source

Long-term results show combination treatment that skips chemotherapy is effective for older patients with Ph+ ALL
Older patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) who were not good candidates for the standard treatment of intensive chemotherapy had a median overall survival (OS) of 6.5 years on an alternate regimen of dasatinib and blinatumomab.
December 11, 2023 — Source

MD Anderson researchers report early success of novel menin-targeted therapies in leukemia
Two clinical trials led by researchers from The University of Texas MD Anderson Cancer Center demonstrated early positive results from novel therapies targeting menin for the treatment of relapsed or refractory acute leukemias with specific genetic alterations. Results from the studies were shared today in oral presentations at the 2023 American Society of Hematology (ASH) Annual Meeting. More information on all ASH Annual Meeting content from MD Anderson can be found at MDAnderson.org/ASH
December 11, 2023 — Source

New combinations and targeted therapies for acute myeloid leukemia on the horizon
The treatment landscape for acute myeloid leukemia (AML) is evolving rapidly, as research discoveries at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and other academic cancer centers advance new, more effective therapies for this aggressive blood cancer.
December 11, 2023 — Source

New drug combination doubles effectiveness in shrinking enlarged spleens in myelofibrosis patients
Combining the JAK inhibitor ruxolitinib with the BCL-xL inhibitor navitoclax was twice as effective in reducing enlarged spleens -- a major indicator of clinical improvement -- compared with standard-of-care ruxolitinib monotherapy for adult patients with intermediate or high-risk myelofibrosis, a rare bone marrow cancer, according to results of the Phase III TRANSFORM-1 trial reported by researchers from The University of Texas MD Anderson Cancer Center.
December 11, 2023 — Source

New drug combo shows promise in targeting RAS-mutant multiple myeloma
The combination of a drug and a protein fragment prevents the growth of blood cancer cells, a new study in mice shows.
December 11, 2023 — Source

New hybrid treatment forces cancer cells to starve
The combination of a drug and a protein fragment prevents the growth of blood cancer cells, a new study in mice shows.
December 11, 2023 — Source

Non-invasive technology for the high-throughput characterization of cancer cells
The electrical properties of cancer cells can provide information on their cancer type, state, and drug resistance. However, conventional platforms to measure these properties are complex and can only analyze a few cells. Researchers have successfully developed a high-throughput device that measures the electrical properties of cancer cells through continuous flow electrorotation. The new platform offers a high degree of automation and can simultaneously analyze several cells.
December 11, 2023 — Source

Novel combination therapy found to significantly reduce spleen volume in patients with myelofibrosis
Combining the JAK inhibitor ruxolitinib with the BCL-xL inhibitor navitoclax was twice as effective in reducing enlarged spleens—a major indicator of clinical improvement—compared with standard-of-care ruxolitinib monotherapy for adult patients with intermediate or high-risk myelofibrosis, a rare bone marrow cancer, according to results of the Phase III TRANSFORM-1 trial reported by researchers from The University of Texas MD Anderson Cancer Center.
December 11, 2023 — Source

Novel menin inhibitors show promise for patients with advanced acute myeloid leukemias
Two clinical trials led by researchers from The University of Texas MD Anderson Cancer Center demonstrated early positive results from novel therapies targeting menin for the treatment of relapsed or refractory acute leukemias with specific genetic alterations.
December 11, 2023 — Source

Phase I clinical trial of new CAR T cell therapy AT101 shows promising early responses
Early results from a Phase I clinical trial of AT101, a new CAR T cell therapy that uses a distinct binding mechanism to target CD19, show a 100 percent complete response (CR) rate at the higher dose levels studied in the trial, according to researchers from the University of Pennsylvania Perelman School of Medicine and Penn Medicine's Abramson Cancer Center. The findings were published today in Molecular Cancer and presented at the 65th American Society of Hematology (ASH) Annual Meeting and Exposition (Abstract 2096).
December 11, 2023 — Source

Potential new treatment for pulmonary neuroendocrine tumors
Medical researchers found a way to grow samples of different types of neuroendocrine tumors (NETs) in the lab. While generating their new model, the researchers discovered that some pulmonary NETs need the protein EGF to be able to grow. These types of tumors may therefore be treatable using inhibitors of the EGF receptor.
December 11, 2023 — Source

Real-world data show impact of immunotherapy in populations underrepresented in clinical trials
New research in the December 2023 issue of Journal of the National Comprehensive Cancer Network finds that patients treated with first-line immunotherapy for advanced non-small cell lung cancer (NSCLC) showed similar results in terms of survival, progression-free survival, and treatment duration, regardless of race or ethnicity, even with differences in income and insurance.
December 11, 2023 — Source

Revolutionizing probiotic therapy: The emergence of CRISPR-Cas engineered strains
Probiotics, defined as live microorganisms beneficial to health, have shown promise in areas like anti-inflammatory activity and brain function, etc. However, challenges remain due to variability in tolerance and colonization among species and strains. Recent advances in genome engineering, including CRISPR-Cas, have facilitated the creation of novel probiotic strains, offering potential treatments for metabolic disorders, inflammation, infections, and cancer.
December 11, 2023 — Source

Risk factors for long-term arm morbidities following breast cancer treatments
In this review, researchers Ifat Klein, Michael Friger, Merav Ben David, and Danit Shahar from Assuta Medical Center and Ben-Gurion University of the Negev in Israel aimed to examine the risk factors for arm morbidity following breast cancer treatments. The team took a broad view of all types of physical morbidity, including prolonged pain, lymphedema, decreased range of motion, and functional limitations.
December 11, 2023 — Source

Study could pave the way for synergistic therapeutic combinations to better treat SF3B1-mutant MDS
A new study from researchers with Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and collaborating organizations provides insight into the underlying mechanisms of gene mutations commonly seen in patients with myelodysplastic syndromes (MDS) and other myeloid neoplasms.
December 11, 2023 — Source

Study reports progress in long-term protection against ovarian cancer tumors
Investigators from the C.S. Mott Center for Human Growth and Development at the Wayne State University School of Medicine reported today in Cancer Immunology Research the characterization of a novel therapeutic approach capable of restoring immune surveillance and providing long-term protection against ovarian cancer tumors.
December 11, 2023 — Source

Targeted oral therapy reduces disease burden and improves symptoms for patients with rare blood disorder in trial
The targeted therapy bezuclastinib was safe and rapidly reduced markers of disease burden while also improving symptoms for patients with a rare blood disorder called nonadvanced system mastocytosis, according to results of the Phase II SUMMIT trial reported by researchers at The University of Texas MD Anderson Cancer Center.
December 11, 2023 — Source

Targeted therapy reduces markers of disease burden, improves symptoms for patients with nonadvanced system mastocytosis
The targeted therapy bezuclastinib was safe and rapidly reduced markers of disease burden while also improving symptoms for patients with a rare blood disorder called nonadvanced system mastocytosis, according to results of the Phase II SUMMIT trial reported by researchers at The University of Texas MD Anderson Cancer Center.
December 11, 2023 — Source

Third-generation anti-CD19 CAR T-cells show efficacy without neurotoxicity in B-cell lymphoma phase 1 clinical trial
The Malaghan Institute of Medical Research, in collaboration with Wellington Zhaotai Therapies Limited, today announced results of its phase 1 dose escalation trial of a new third generation anti-CD19 chimeric antigen receptor (CAR) T-cell therapy to be presented at the American Society of Hematology (ASH) Annual Meeting in San Diego on 11 December. The research is also published in the journal Blood.
December 11, 2023 — Source

Health — Cancer — December 8th, 2023

Catalyst makes drugs inside the body to minimize side effects
A highly active catalyst capable of synthesizing drug molecules within the body has been developed by RIKEN chemists. In mice, an anticancer drug assembled near tumors using the injected catalyst suppressed tumor growth.
December 8, 2023 — Source

Even small amounts of physical activity could be valuable in late-stage lung cancer
Lung cancer kills more people globally each year than any other type of cancer, however new Curtin University-led research has found less than five minutes of daily physical activity could be linked with prolonged life in people living with inoperable forms of the disease.
December 08, 2023 — Source

Evolving insights in blood-based liquid biopsies for prostate cancer interrogation
During the last decade, blood sampling of cancer patients aimed at analyzing the presence of cells, membrane-bound vesicles, or molecules released by primary tumors or metastatic growths emerged as an alternative to traditional tissue biopsies.
December 08, 2023 — Source

Potentially targetable fusion RNAs may be more common in metastatic breast cancer than previously realized
Comprehensive profiling of fusion RNAs present in a large cohort of metastatic breast tumors revealed unique fusion mutations that may be therapeutically targetable, according to results presented at the San Antonio Breast Cancer Symposium, held December 5--9, 2023.
December 08, 2023 — Source

Q&A: How serious is FDA warning about revolutionary blood-cancer treatment?
The Food and Drug Administration announced last week that it's investigating reports of secondary cancers in patients who received CAR T-cell therapy, one of a suite of immunotherapies that have revolutionized cancer care over the past decade. The treatment reprograms a patient's T cells, a key part of the immune system, to recognize and attack cancer cells.
December 08, 2023 — Source

Reassessing what we can expect from peptides in disease detection
Based on blood tests, it is possible to detect rare genetic diseases, recognize cancer, or determine the inflammation level in the body. Moreover, due to the rapid development of medical diagnostics based on biofluid analysis, many efforts are being made worldwide to adapt medical approaches, making personalized medicine the paradigm of future health care.
December 08, 2023 — Source

Researchers discover new lipid nanoparticle that shows muscle-specific mRNA delivery, reduces off-target effects.
A team of researchers based at the University of Toronto's (U of T) Leslie Dan Faculty of Pharmacy has discovered a novel ionizable lipid nanoparticle that enables muscle-focused mRNA delivery while minimizing off-target delivery to other tissues. The team also showed that mRNA delivered by the lipid nanoparticles investigated in their study triggered potent cellular-level immune responses as a proof-of-concept melanoma cancer vaccine.
December 08, 2023 — Source

Skipping adjuvant radiotherapy may not impact risk of recurrence or progression in patients with low-risk DCIS
Patients with low-risk ductal carcinoma in situ (DCIS) who skipped adjuvant radiotherapy after breast-conserving surgery had comparable five-year outcomes to those with high-risk DCIS who received adjuvant radiotherapy, according to results from the E4112 clinical trial presented at the San Antonio Breast Cancer Symposium, held December 5--9, 2023.
December 08, 2023 — Source

Some breast cancer survivors may safely de-escalate mammography three years after surgery
Women 50 or older who de-escalated to less-frequent mammography three years after curative surgery for early-stage breast cancer had similar outcomes to women who received annual mammography, according to results from the Mammo-50 trial presented at the San Antonio Breast Cancer Symposium, held December 5--9, 2023.
December 08, 2023 — Source

The first CRISPR therapy approved in the U.S. will treat sickle cell disease
The gene-editing treatment aims to help people with recurring pain crises
December 08, 2023 — Source

Health — Cancer — December 6th, 2023

Blood hormone levels key to identifying which post-menopausal women will benefit most from taking anastrozole to prevent breast cancer
Queen Mary University of London has found that hormone levels, measured through blood tests, are an important indicator of whether women will benefit from recently licensed medication for the prevention of breast cancer.
December 6, 2023 — Source

Fungus-fighting protein could help overcome severe autoimmune disease and cancer
A protein in the immune system programmed to protect the body from fungal infections is also responsible for exacerbating the severity of certain autoimmune diseases such as irritable bowel disease (IBS), type 1 diabetes, eczema and other chronic disorders, new research from The Australian National University (ANU) has found.
December 6, 2023 — Source

HDAC inhibitors may offer new strategy for reversing fibrotic wall around pancreatic tumors
Pancreatic cancer is one of the deadliest cancers-;only about one in eight patients survives five years after diagnosis. Those dismal statistics are in part due to the thick, nearly impenetrable wall of fibrosis, or scar tissue, that surrounds most pancreatic tumors and makes it hard for drugs to access and destroy the cancer cells.
December 6, 2023 — Source

How drugs can target the thick 'scar tissue' of pancreatic cancer
Researchers discovered how anti-cancer drugs called HDAC inhibitors help treat pancreatic cancer by altering scar tissue (fibroblast) development. The findings suggest HDAC inhibitors could be powerful tools in fighting pancreatic cancer -- alone and in combination with other therapies.
December 6, 2023 — Source

Neoadjuvant chemotherapy can eliminate need for regional nodal irradiation in breast cancer
For patients whose breast cancer converted from lymph node-positive to lymph node-negative disease after neoadjuvant chemotherapy, skipping adjuvant regional nodal irradiation (RNI) did not increase the risk of disease recurrence or death five years after surgery, according to results from the NRG Oncology/NSABP B-51/RTOG 1304 clinical trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.
December 6, 2023 — Source or Source

Studies suggest novel targeted therapies may benefit patients with metastatic HR+/ HER2- breast cancer
Two studies led by researchers at The University of Texas MD Anderson Cancer Center demonstrated clinical benefit from novel targeted therapies, which may offer new treatment options for patients with metastatic hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancer.
December 6, 2023 — Source

Health — Cancer — December 5th, 2023

From resistance to resilience: Reprogramming drug resistance signals with an artificial gene circuit device
In clinical practice, drug resistance poses a significant challenge in cancer treatment. The process of developing resistance is regulated by complex decision-making pathways and genetic signal networks. The cross-redundancy and compensatory mechanisms between different pathways limit the effectiveness of interventions against drug resistance.
December 5, 2023 — Source

Knocking out part of the innate immune system to improve cancer therapy
Researchers at Shanghai Jiao Tong University School of Medicine, China, have discovered that shutting down part of the innate immune system increases anti-tumor activity.
December 5, 2023 — Source

Method for containing toxins from mine waste could protect drinking water, prevent cancer
Imagine an abandoned mine site, surrounded by dead trees and dotted with dark, red ponds with no signs of aquatic life. This is the result of mine waste left in the environment that gets weathered by water and air. With exposure to the elements over time, the waste produces toxic substances such as arsenic and lead.
December 5, 2023 — Source

Protein implicated in tumor growth found to be heavily associated with pancreatic cancer
When Nancy Klauber-DeMore, M.D., began studying secreted frizzled-related protein 2, or SFRP2, it was as a breast cancer researcher and surgeon. Since she first showed in 2008 that the protein is involved in tumor growth and angiogenesis—the growth of new blood vessels to feed the tumor—she's expanded her research to include osteosarcoma, a bone cancer that mostly affects children and young adults.
December 5, 2023 — Source

Study uses game theory to show low tumor heterogeneity leads to higher aggression
A study by the University of the Basque Country (UPV/EHU) uses game theory to establish that tumors with less cellular heterogeneity are more aggressive.
December 5, 2023 — Source

Study exploits biomolecular condensates to inhibit androgen receptor in prostate cancer
Transcription factors play essential roles in turning the genetic information encoded in genes into proteins in all cells and organisms. These regulatory proteins bind DNA, turn genes on or off, and control the rate at which DNA is transcribed into mRNA, which is needed for protein synthesis. Because of their central role in transcriptional control, many diseases can be traced back to dysregulated transcription factors. Inhibiting their activity, especially in cancer, offers therapeutic potential, but many transcription factors have a trick up their sleeve.
December 5, 2023 — Source

Tiny Capsules With Big Potential: Self-Folding Polymers Boost MRI Imaging and Cancer Treatment
Self-folding polymers containing gadolinium forming nanosized complexes could be the key to enhanced magnetic resonance imaging and next-generation drug delivery, as demonstrated by scientists at Tokyo Tech. Thanks to their small size, low toxicity, and good tumor accumulation and penetration, these complexes represent a leap forward in contrast agents for cancer diagnosis, as well as neutron capture radiotherapy.
December 5, 2023 — Source

Health — Cancer — December 4th, 2023

Aspirin may benefit cancer treatments
Aspirin is an inexpensive and readily available medication that could benefit cancer treatments, preventing metastatic cancer spread and reducing vascular complications, finds a new meta-analysis study.
December 4, 2023 — Source

Fred Hutch Cancer Center clinical network breached
The organization reported that it detected intrusion over the Thanksgiving holiday. All clinics and the MyChart patient portal are operating.
December 4, 2023 — Source

Discovery points to new approach to treating liver cancer
A breakthrough in the understanding of the relationship between a naturally occurring enzyme and the liver cancer drug sorafenib could improve the effectiveness of the drug, which currently prolongs the life of liver cancer patients for only two to three months. A study of the relationship between the enzyme DDX5, liver cancer sorafenib, published in the journal Cell Death & Disease, points to the potential for a more effective therapy that combines existing anti-cancer drugs with treatments that spur production of this enzyme.
December 4, 2023 — Source

Hard to drug: Protein droplets reveal new ways to inhibit transcription factors in an aggressive form of prostate cancer
Transcription factors play essential roles in turning the genetic information encoded in genes into proteins in all cells and organisms. These regulatory proteins bind DNA, turn genes on or off, and control the rate at which DNA is transcribed into mRNA, which is needed for protein synthesis.
December 4, 2023 — Source

Identifying new potential in cancer-killing T cells
When Joanina Gicobi began her Ph.D. degree five years ago at Mayo Clinic Graduate School of Biomedical Sciences, she was interested in thinking creatively about ways to improve cancer treatment. In particular, she was curious about the body's natural ability to fight tumors: Could that process be improved? In the laboratory of Haidong Dong, M.D., Ph.D., she joined efforts to learn more about the T cells that are part of an inherent cancer-killing immune response.
December 4, 2023 — Source

Immunotherapy in first-line standard therapy significantly improves survival in metastatic or recurrent cervical cancer
Published in The Lancet, results of the randomized phase III BEATcc academic trial show that adding immune checkpoint inhibitor atezolizumab to standard of care with bevacizumab and chemotherapy significantly improves progression-free survival and overall survival in patients with metastatic or recurrent cervical cancer who are not candidates for curative-intent surgery and/or radiotherapy.
December 4, 2023 — Source

Mathematics supporting fresh theoretical approach in oncology
A study by the University of the Basque Country (UPV/EHU) uses game theory to establish that tumors with less cellular heterogeneity are more aggressive
December 4, 2023 — Source

MicroRNA holds clues to why some mammals are cancer-prone
Researchers at the College of Veterinary Medicine (CVM) have identified an important pathway that reveals why some mammals, like humans, dogs, and cats, regularly develop mammary cancer while others, such as horses, pigs, and cows, rarely do.
December 4, 2023 — Source

Osteopontin induces mitochondrial biogenesis in deadherent cancer cells: Study
A new research paper was published in Oncotarget is titled, "Osteopontin induces mitochondrial biogenesis in deadherent cancer cells."
December 4, 2023 — Source

Personalizing treatment for colorectal cancer patients by combining tissue-based biomarkers and ctDNA
Combining artificial intelligence-generated digital pathology tools, conventional histopathological assessment and circulating tumor DNA (ctDNA) analysis can improve treatment stratification of patients with colorectal cancer after surgery. David Kerr and colleagues outline this novel paradigm for personalized adjuvant treatment of colorectal cancer in a study in Nature Reviews Clinical Oncology.
December 4, 2023 — Source

Potential pitfalls when using the Cre-LoxP system in cancer research
A new editorial paper has been published in Oncoscience, titled, "Be mindful of potential pitfalls when using the Cre-LoxP system in cancer research."
December 4, 2023 — Source

Scientists uncover new mechanism by which leukemia cells exploit cellular recycling process
In a recent study, scientists led by Professor Stefan Müller from Goethe University's Institute of Biochemistry II investigated a specific form of blood cancer known as acute myeloid leukemia, or AML. The disease mainly occurs in adulthood and often ends up being fatal for older patients. In about a third of AML patients, the cancer cells' genetic material has a characteristic mutation that affects the so-called NPM1 gene, which contains the building instructions for a protein of the same name.
December 4, 2023 — Source or Source

Study finds 'shared care' is preferred by patients, is cheaper and just as effective
A new study led by researchers at Peter Mac has found sharing follow-up care between a GP and hospital-based specialists was preferred by bowel cancer patients, was cheaper for the health care system and was just as effective as standard hospital-based care.
December 4, 2023 — Source

The paradoxical role of white blood cells in the spread of breast cancer
A new study from Karolinska Institutet, published in Cell Reports, shows that tumor-associated macrophages, which are white blood cells that are found in breast tumors, can both help and hinder the spread of cancer cells to other organs. The researchers found that macrophages that produce a substance called VEGF-C reduce the spread of breast cancer to the lungs but increase the spread to the lymph nodes. This may have implications for the prognosis and treatment of breast cancer.
December 4, 2023 — Source

Training the immune system to prevent cancer—researchers discover paradigm-shifting approach
As one of the most insidious diseases in the world, cancer has few treatments that work to eradicate it completely. Now, a new approach pioneered by two researchers working at the University of Missouri's Roy Blunt NextGen Precision Health building shows promising results in preventing lung cancer caused by a carcinogen in cigarettes—a discovery that immunologists Haval Shirwan and Esma Yolcu rank among the most significant of their careers.
December 4, 2023 — Source

Unraveling the age-related cellular changes in osteosarcoma progression
In a study published in the journal Genes & Diseases, scientists from Union Hospital, Tongji Medical College, and Huazhong University of Science and Technology delve into the molecular intricacies of osteosarcoma in the elderly. The team investigated senescent cells, cells that no longer divide or grow, and their influence on tumor progression.
December 4, 2023 — Source

YTHDF2's role in promoting acute myeloid leukemia: The key lies in microRNA processing
In a study published in the journal Genes & Diseases, researchers from Beckman Research Institute of City of Hope, explored the impact of m6A modification on the maturation process of precursor microRNAs (pre-miRNAs) and its potential role in tumorigenesis. They have uncovered a novel mechanism behind the progression of acute myeloid leukemia (AML), a life-threatening blood cancer characterized by rapid expansion of abnormally differentiated hematopoietic cells.
December 4, 2023 — Source

Health — Cancer — December 1st, 2023

Black men with advanced prostate cancer less likely to receive crucial treatment, study finds
A new study led by investigators at the UCLA Health Jonsson Comprehensive Cancer Center found Black men diagnosed with more advanced stages of prostate cancer are significantly less likely to be prescribed novel hormone therapy than other racial and ethnic groups--including white or Latino men--despite the therapy being proven to effectively control the growth of prostate tumors and extend the lives of men with the disease.
December 1, 2023 — Source

New report highlights essential role of collaborating with patients to improve cancer care
A new report released today by the Asia Pacific Oncology Alliance (APOA), a network of stakeholders from across the cancer continuum who are committed to improving cancer care in Asia Pacific, highlights the importance of the patient voice in improving cancer experiences and outcomes across the region.
December 1, 2023 — Source

Researchers discover deep structural biology connections that help improve CAR therapy
Chimeric antigen receptors (CARs) have opened up an exciting new field of therapeutic advancements for rare and difficult-to-treat cancers, as they have the ability to deliver targeted therapies that can kill tumor cells.
December 1, 2023 — Source

Study finds racial disparity in the utilization of crucial prostate cancer therapy
A new study led by investigators at the UCLA Health Jonsson Comprehensive Cancer Center found Black men diagnosed with more advanced stages of prostate cancer are significantly less likely to be prescribed novel hormone therapy than other racial and ethnic groups — including white or Latino men — despite the therapy being proven to effectively control the growth of prostate tumors and extend the lives of men with the disease.
December 1, 2023 — Source

Ten years on, Lung-MAP success demonstrates potential of public-private partnerships in clinical research
The unique public-private partnership that for almost a decade has undergirded the first National Cancer Institute (NCI)-sponsored precision medicine clinical trial in lung cancer can serve as a model for future clinical research that is more rapid, innovative, and inclusive.
December 1, 2023 — Source

Health — Cancer — November 30th, 2023

A novel targeted molecular therapy for drug-resistant biliary tract cancer
Biliary tract cancers (BTCs) including cholangiocarcinoma (CCA) and gallbladder cancer (GBC) are becoming more prevalent globally. An effective chemotherapeutic agent for the treatment of BTCs is gemcitabine. Other novel molecular-targeted drugs have also been developed; however, they are only effective at treating a few cases of BTCs.
November 30, 2023 — Source

Largest study of its kind shows leafy greens may decrease bowel cancer risk
Increasing the amount of folate through our diet or taking supplements could help to reduce bowel cancer risk.
November 30, 2023 — Source

Modular chimeric cytokine receptors improve CAR T-cell therapy for solid tumors
Immunotherapy using modified chimeric antigen receptor (CAR) T cells has greatly improved survival rates for pediatric patients with relapsed and recurrent leukemia. However, these therapies are not as effective in treating solid tumors and can have significant toxicity. Findings from St. Jude Children's Research Hospital showed that adding a modular chimeric cytokine receptor to CAR T cells increased their efficacy in multiple solid tumor models. The study was published today in Nature Biomedical Engineering.
November 30, 2023 — Source

Overcoming drug resistance with EAI-432, an allosteric EGFR inhibitor for non-small cell lung cancer
Researchers at Dana-Farber Cancer Institute have developed a promising new drug candidate, EAI-432, to treat non-small cell lung cancers (NSCLC)driven by mutations in the EGFR gene, particularly the L858R mutation which is present in about one-third of NSCLC patients.
November 30, 2023 — Source

Scientists find gene therapy reduces liver cancer in animal model
Researchers at UC Davis Comprehensive Cancer Center have shown that inhibiting a specific protein using gene therapy can shrink hepatocellular carcinoma (HCC) in mice. Silencing the galectin 1 (Gal1) protein, which is often over-expressed in HCC, also improved the anti-cancer immune response and increased the number of killer T cells inside tumors. The study was published in Acta Pharmaceutica Sinica B.
November 30, 2023 — Source

SLACOM and NCCN host the Latin American Regional Breast Cancer Summit
Today the Latin American and Caribbean Society of Medical Oncology (SLACOM) and National Comprehensive Cancer Network® (NCCN®) host the Latin American Regional Breast Cancer Summit: Advocating and Implementing Guideline-Concordant Cancer Care for Patients. Esteemed experts from Argentina, Brazil, Mexico, Columbia, Peru, and the United States will present challenges, barriers, and potential solutions for improving access to guideline-concordant breast cancer care in the Latin American region.
November 30, 2023 — Source

Structural racism in radiotherapy needs to be addressed to ensure equitable cancer care
Everyone should get quality care, no matter the color of their skin. However, implicit bias, micro-aggressions, and a lack of cultural understanding persist, leading to oppression and unequal treatment in healthcare. An insightful article in the new themed issue of the Journal of Medical Imaging and Radiation Sciences on specialized populations, published by Elsevier, highlights this serious problem, specifically addressing the assessment and treatment of radiation-induced skin reactions (RISR) in patients across the world undergoing external beam radiotherapy.
November 30, 2023 — Source

Team develops gene therapy to 'pre-treat' neuroblastoma tumors
University of Texas at Dallas researchers have developed a potential gene therapy to "pre-treat" neuroblastoma tumors in order to make chemotherapy more effective.
November 30, 2023 — Source

Using Nanodiamonds to Stop Melanoma Tumor Metastases
In a new study, scientist Rajiv K. Saxena and his team investigated the potential of nanodiamonds in combating tumor metastasis.
November 30, 2023 — Source

When cancer returns: How to cope with cancer recurrence
Use lessons from your initial treatment to give you confidence and strength when cancer comes back.
November 30, 2023 — Source

Health — Cancer — November 29th, 2023

Already-licensed drugs could be trialed to potentially treat secondary brain cancer, new research finds
The largest review of papers for brain cancer that has spread from the lungs has found abnormalities in the brain cancer for which licensed drugs could be clinically trialed to find out if they could treat the disease. The research led by the University of Bristol and published in Neuro-Oncology Advances also found genetic differences between smokers and non-smokers. The paper is titled "Genomic landscape and actionable mutations of brain metastases derived from non-small cell lung cancer: a systematic review."
November 29, 2023 — Source

DNA sequencing reveals clonal evolution of tumor in childhood leukemia
Researchers at the RUDN Laboratory of Biology of Single Cells have studied the possibilities of DNA sequencing at the level of individual cells in patients with a rare form of childhood leukemia. The study revealed the mechanisms of the clonal evolution of the tumor and its transformation into a more aggressive form of leukemia at the level of individual subclones. It has also been shown that this technology can also be used as a very accurate tool for assessing the response of the disease to the treatment.
November 29, 2023 — Source

Nanodiamonds can block tumor metastasis in mice, study shows
Nanodiamonds are 2--8 nm carbon nanoparticles, which can be easily functionalized with various chemical groups like carboxylic groups or drugs. Previous research has shown that actively dividing cells are more likely to absorb nanodiamonds and that epithelial cells treated with carboxylic nanodiamonds lose the ability to migrate across cell-permeable cellulose membranes.
November 29, 2023 — Source

Pancreatic cancer triggers immune response, but disease-fighting T cells may not easily infiltrate PDAC tumors: Study
Recent findings at Cold Spring Harbor Laboratory (CSHL) shine a new light on pancreatic cancer.
November 29, 2023 — Source

Research highlights need for education to combat cancer in Appalachia
University of Kentucky Markey Cancer Center research underscores the need for interventions to increase educational attainment and knowledge of cancer in Appalachian Kentucky.
November 29, 2023 — Source

Researchers detail how prostate cancers grow more aggressively to evade treatment
As cancers grow and spread in the human body, they tend to become more aggressive over time, and this can accelerate during treatment as they develop resistance to drugs. In prostate cancers, some evolve into a rare, treatment-resistant tumor known as a small cell neuroendocrine, or SCN, cancer.
November 29, 2023 — Source

Researchers identify cell signaling pathways controlling melanoma cell metastasis to the brain
Melanoma is the deadliest form of skin cancer because of its ability to quickly grow and spread throughout the body. More than half of those with advanced melanoma will see the disease spread to the brain, where it rapidly progresses, often leading to death in only three to four months. Researchers in Moffitt Cancer Center's Donald A. Adam Melanoma and Skin Cancer Center of Excellence have been working to better understand what drives melanoma brain metastasis.
November 29, 2023 — Source

Thyroid cancer prevalent among transgender female veterans
There is a high prevalence of thyroid cancer among transgender female veterans, according to a study presented at the annual meeting of the American Thyroid Association, held from Sept. 27 to Oct. 1 in Washington, D.C.
November 29, 2023 — Source

Health — Cancer — November 28th, 2023

Country of birth is a key factor in assessing risk for conditions favorable to stomach cancer development
Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have found that country of birth--not just geographic region--is a key risk factor for gastric intestinal metaplasia, a precursor lesion of stomach cancer.
November 28, 2023 — Source

Cracking the code: Researchers unravel how mutant protein drives cancer growth
The p53 protein is a tumor suppressor that plays a crucial role in preventing the formation of cancerous cells. But when it mutates and becomes defective in cells, the protein can significantly boost a person's risk of cancer development.
November 28, 2023 — Source

Growing microtumors in a dish helps rapidly identify genes that drive tumor growth
Researchers have identified a new way to screen genes that cause several different types of cancers to grow, identifying particularly promising targets for precision oncology in oral and esophageal squamous cancers.
November 28, 2023 — Source

Morphology-based gross classification system for hepatocellular carcinoma stratification
A new study published in the journal Gut has found that different gross subtypes of hepatocellular carcinoma (HCC) have significantly different prognoses and molecular characteristics. The study, led by researchers at The First Hospital of Jilin University, suggests that gross classification may be valuable for developing individualized diagnosis and treatment strategies for HCC.
November 28, 2023 — Source

New therapy target to shut down multiple myeloma's ability to survive and thrive
Multiple myeloma (MM) is one of the most formidable and deadly cancers known to man, with only 50% of patients surviving for more than five years after diagnosis.
November 28, 2023 — Source

Recent decline in risk for colorectal cancer recurrence seen in stage I to III disease
From 2004 to 2019, the risk for recurrence of colorectal cancer (CRC) decreased in patients with stages I to III disease, according to a study published online Nov. 16 in JAMA Oncology to coincide with the annual meeting of the Danish Surgical Society, held from Nov. 16 to 17 in Copenhagen.
November 28, 2023 — Source

Patients coping with mesothelioma experienced higher levels of toxicity on CheckMate743 regimen than reported in trials
Based on results from the CheckMate743 trial, the dual regimen of ipilimumab and nivolumab is the standard of care for the treatment of unresectable pleural mesothelioma. However, research published today in the Journal of Thoracic Oncology (JTO) showed that a group of Australian patients treated with that immunotherapy combination experienced higher levels of toxicity than were reported in the clinical trial results.
November 28, 2023 — Source

Scientists uncover new therapeutic targets for high-risk pediatric leukemia
Scientists at St. Jude Children's Research Hospital comprehensively identified genes directly regulated by a protein associated with high-risk pediatric leukemias. High-risk leukemias, particularly MLL-rearranged (MLL-r) leukemia, often overexpress the homeodomain transcription factor HOXA9 protein, which cannot currently be targeted with drugs. This study provides a foundation for revealing the HOXA9 regulation network and finding novel drug targets downstream of HOXA9 that can form the basis of new treatments.
November 28, 2023 — Source

Study reveals hidden immune defense against cancer
Researchers at the UCLA Jonsson Comprehensive Cancer Center have found certain immune cells can still fight cancer even when the cancer cells lack an important protein that the immune system relies on to help track down cancer cells.
November 28, 2023 — Source

You May Be Increasing Your Skin Cancer Risk Without Knowing It
The "sunscreen paradox" has confounded doctors of late: As more and more people use sunscreen, rates of melanoma and other skin cancers are going up.
November 28, 2023 — Source

Health — Cancer — November 27th, 2023

CRISPR-powered 'cancer shredding' technique opens new possibility for treating most common and deadly brain cancer
The gene-editing technology CRISPR shows early promise as a therapeutic strategy for the aggressive and difficult-to-treat brain cancer known as primary glioblastoma, according to findings of a new study from Gladstone Institutes.
November 27, 2023 — Source

Decline in excess mortality seen in first decade after quitting smoking
Former smokers avoid more than half of the excess cardiovascular, cancer, and respiratory mortality associated with current smoking within the first decade after quitting, according to a research letter published online Nov. 27 in JAMA Internal Medicine.
November 27, 2023 — Source

Fighting leukemia with therapeutic RNA
Each year, about 13,000 people in Germany are diagnosed with leukemia, an umbrella term that encompasses various forms of blood cancer. Among those affected are also many children and adolescents under 15 years of age. A common and very aggressive form of leukemia in adults is acute myeloid leukemia (AML).
November 27, 2023 — Source

How to check your mouth for cancer when getting to see a dentist is hard
Regular dental checkups and oral hygiene visits are important for identifying the early stage of mouth cancer. However, the shortage of dentists in the UK has led to a rise in mouth cancers that are spotted too late, according to the charity Oral Health Foundation. Ninety percent of NHS dentists surveyed by the BBC last year were not accepting new adult patients for NHS treatment.
November 27, 2023 — Source

Mortality is higher for Black patients receiving neoadjuvant chemo for breast cancer: Study
For patients with early-stage breast cancer treated with neoadjuvant chemotherapy (NACT), Blacks have higher mortality risk than Whites, according to a study published online Nov. 22 in JAMA Network Open.
November 27, 2023 — Source

New CRISPR approach shows promise for treating glioblastoma
The gene-editing technology CRISPR shows early promise as a therapeutic strategy for the aggressive and difficult-to-treat brain cancer known as primary glioblastoma, according to findings of a new study from Gladstone Institutes.
November 27, 2023 — Source

One protein is key to the spread of lung cancer: New study finds a way to stop it
A new study by Tulane University has uncovered a previously unknown molecular pathway that could be instrumental to halting lung cancer in its tracks.
November 27, 2023 — Source

Scientists devise new technique that can pinpoint the causes and treatments of autoimmune diseases
An international team of researchers has developed a method that combines advanced high-throughput microfluidics and gene editing technology to source new treatments that could potentially help people with autoimmune conditions and cancer. In validating the new technique, they discovered a molecule they believe could inhibit interferon gamma production in the gut which — if proven in clinical trials — could represent an ideal means to control inflammatory bowel disease (IBD).
November 27, 2023 — Source

Secrecy at Canada's pest management agency must end, say researchers
Health Canada increased maximum residue limits for glyphosate in some crops, such as oats and beans, in 2021 despite concerns about the health impact of glyphosate-based herbicides (GBHs). The World Health Organization's (WHO) International Agency for Research on Cancer regards these pesticides as genotoxic, meaning they can damage DNA and are likely carcinogenic.
November 27, 2023 — Source

Seeing cancer's spread through a computational window
Biomedical engineers at Duke University have significantly enhanced the capabilities of a computational model that simulates the movement of individual cancer cells across long distances within the entire human body.
November 27, 2023 — Source

Study finds breast density discussions with clinicians varies significantly by race/ethnicity and literacy level
Breast density information aims to increase awareness of breast density and its risks and inform future breast screening decisions. Breast density notifications (BDN) advise women to discuss breast density with their clinicians, but prior research shows less than half of women in the general population have those conversations and little is known about the content of conversations that do occur.
November 27, 2023 — Source

Targeting ras with protein engineering
A review paper titled "Targeting Ras with protein engineering" has been published in Oncotarget.
November 27, 2023 — Source

Health — Cancer — November 24th, 2023

A comprehensive approach to ensuring the well-being of cancer health care workers is essential, says study
Three years into the pandemic and as Australia's case numbers rise, health care providers are still working tirelessly to safeguard vulnerable patients, often at a personal cost.
November 24, 2023 — Source

Advancing neuropathology with AI-driven classification of diffuse gliomas
Diffuse gliomas, which account for the majority of malignant brain tumors in adults, comprise astrocytoma, oligodendroglioma, and glioblastoma. Current diagnosis of glioma types requires combining both histological features and molecular characteristics.
November 24, 2023 — Source

Backlash to affirmative action hits pioneering maternal health program for Black women
For Briana Jones, a young Black mother in San Francisco, a city program called the Abundant Birth Project has been a godsend.
November 24, 2023 — Source

Incidence of local-stage cancers decreased from 2019 to 2022: Study
From 2019 to 2020, the incidence of local-stage disease decreased significantly for 19 of 22 cancer types compared with stable year-over-year changes pre-COVID-19, according to a study published online Nov. 16 in the International Journal of Cancer.
November 24, 2023 — Source

New ingestible sensor for non-intrusive sleep disorder monitoring developed by MIT and collaborators
A recent Source study reported the effectiveness of an ingestible vitals-monitoring pill (VM pill) to monitor vital signs, including heart and respiratory rate based on a human trial.
November 24, 2023 — Source

Report suggests compensation is key to fixing primary care shortage
The United States faces a serious shortage of primary care physicians for many reasons, but one, in particular, is inescapable: compensation.
November 24, 2023 — Source

Researchers identify biomarkers for checkpoint inhibitor-induced hyperprogression of melanoma cells
Duke Cancer Institute researchers have identified potential biomarkers that predict the likelihood for checkpoint inhibitor drugs to backfire, driving hyper-progression of melanoma cells instead of unleashing the immune system to fight them.
November 24, 2023 — Source

Scar tissue holds hints about pancreatic cancer outcome, research finds
Scar tissue that forms around a growing pancreatic tumor called a pancreatic ductal adenocarcinoma harbors valuable clues as to how long people with these cancers are likely to live, according to a new study led by researchers at Stanford Medicine.
November 24, 2023 — Source

Scientists discover potent and selective inhibitors for ovarian cancer treatment
To identify potential therapeutic targets and preclinical drug candidates for the treatment of ovarian cancer, researchers led by Tan Li from the Shanghai Institute of Organic Chemistry of the Chinese Academy of Sciences have developed novel small molecule inhibitors of CPSF3, a key module of the cleavage and polyadenylation specificity factor (CPSF) complex that catalyzes pre-mRNA splicing and regulates transcription termination.
November 24, 2023 — Source

Study links ultra-processed food consumption to increased risk of head and neck cancers
A recent European Journal of Nutrition study explored the risk of oesophageal adenocarcinoma (OAC) and head and neck cancer (HNC) posed by the consumption of ultra-processed foods (UPFs). This analysis was carried out in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
November 24, 2023 — Source

Study suggests dental professionals can play a crucial role in identifying signs of chronic disease
Dental professionals can make a marked and positive difference to public health by being trained to spot some of the key markers of chronic disease, according to new research.
November 24, 2023 — Source

Study: Prostate cancer focal therapy is cost-effective and may improve patient outcomes
Minimally invasive focal therapies for prostate cancer are associated with a lower overall cost and improved quality of life for patients.
November 24, 2023 — Source

Trial results support 'new gold standard' for head and neck cancer radiotherapy
Phase III trial results on a precision radiotherapy technique support a "new gold standard" for treating head and neck cancer patients. The research suggests the new approach can reduce the risk of swallowing problems after radiotherapy, without impacting the success of treatment.
November 24, 2023 — Source

What would a Desantis presidency look like for health care?
On the presidential campaign trail, Republican Ron DeSantis touts himself as a champion of medical freedom, outlawing vaccine mandates and protecting doctors who refuse to provide certain medical treatments on moral grounds.
November 24, 2023 — Source

Where DNA copying into RNA starts could determine whether cancer cells are receptive to treatment
In research published in Nature Structural & Molecular Biology, researchers from the University of Birmingham have found that transcription start sites (TSS) have a significant role in determining cancer cell behavior.
November 24, 2023 — Source

Health — Cancer — November 22nd, 2023

Breathing new life into old medications: A strategy that targets cancer stem cells
In a review published in the journal Genes & Diseases, researchers from ICMR-National Institute of Nutrition (NIN), advocate for the repurposing of non-cancer drugs to target elusive cancer stem cells (CSCs). By focusing on drugs that are already approved and have established safety records for other conditions, this strategy offers a more immediate and safer avenue to innovate cancer therapy.
November 22, 2023 — Source

Cancer blood tests jumpstart diagnoses and targeted therapy
New research led by a UC Davis Comprehensive Cancer Center clinical scientist shows blood tests used to hunt for cancer DNA may help detect cancers faster and guide the use of targeted therapies. The results of the study were published in npj Precision Oncology.
November 22, 2023 — Source

Chemists use oxygen, copper 'scissors' to make cheaper drug treatments possible
Drugs to treat cancer are often very expensive to produce, resulting in high costs for the patients who need them. Thanks to pathbreaking research by UCLA chemists, led by organic chemistry professor Ohyun Kwon, the price of drug treatments for cancer and other serious illnesses may soon plummet.
November 22, 2023 — Source

Eating more ultra-processed foods may increase risk of upper aerodigestive tract cancers
Eating more ultra-processed foods (UPFs) may be associated with a higher risk of developing cancers of upper aerodigestive tract (including the mouth, throat and oesophagus), according to a new study led by researchers from the University of Bristol and the International Agency for Research on Cancer (IARC). The authors of this international study, which analysed diet and lifestyle data on 450,111 adults who were followed for approximately 14 years, say obesity associated with the consumption of UPFs may not be the only factor to blame.
November 22, 2023 — Source

Genetic predisposition to early breast cancer in Kazakh women
A new research paper titled "Determination of genetic predisposition to early breast cancer in women of Kazakh ethnicity" has been published in Oncotarget.
November 22, 2023 — Source

Lidocaine kills cancer cells by activating bitter taste receptor, preclinical study shows
Their findings, published today in Cell Reports, pave the way for a clinical trial to test the addition of lidocaine to the standard of care therapy for patients with head and neck cancers. The local anesthetic drug has long been suggested to have beneficial effects in cancer patients, but it wasn't known how or why.
November 22, 2023 — Source

New drug shows potential in treatment of cutaneous squamous cell carcinoma
A study conducted at the University of Turku, Finland, shows that plixorafenib, a new drug developed for treating melanoma and lung cancer, may also stop the progression of cutaneous squamous cell carcinoma.
November 22, 2023 — Source

Race/ethnicity, socioeconomics, age contribute to disparities in cancer death
Factors contributing to disparities in cancer death include race/ethnicity, socioeconomic status, geographic location, and age, according to a study published online Nov. 14 in CA: A Cancer Journal for Clinicians.
November 22, 2023 — Source

Telehealth's lasting impact on cancer care delivery
A recent Mayo Clinic retrospective study published in JCO Oncology Practice shows that cancer practices can integrate telehealth without duplicative care, allowing for a more streamlined health care experience for patients and their caregivers.
November 22, 2023 — Source

Health — Cancer — November 21st, 2023

Direct-acting antivirals still underused in hep C-related liver cancer
Direct-acting antiviral agents (DAAs) remain underutilized in patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC), according to a study presented at The Liver Meeting, the annual meeting of the American Association for the Study of Liver Diseases, held from Nov. 10 to 14 in Boston.
November 21, 2023 — Source

New study reveals unexpected consequences of CRISPR-Cas9 gene editing
The study has identified that a cancer cell line derived from leukemia removes a region that encodes a tumor-suppressing gene and genes that control cell growth. The findings are published in the journal Life Science Alliance.
November 21, 2023 — Source

Novel urine-based prognostic model promises to transform bladder cancer treatment
In a study published in the journal Genes & Diseases, researchers from Fudan University, have developed a novel urine-based prognostic model that promises to transform the management and treatment of bladder cancer.
November 21, 2023 — Source

Promising target for CAR T cells helps cancer trick the immune system
The group also discovered a resistance mechanism whereby some tumors trick the cancer-killing immune cells into expressing GRP78, thereby turning off the immune cells or causing them to be killed, too. The research, which has implications for developing immunotherapy for the broad range of difficult-to-treat brain and solid tumors expressing GRP78, was published today in Cell Reports Medicine.
November 21, 2023 — Source

Psychological distress reported for indolent non-Hodgkin lymphomas
Richard A. Newcomb, M.D., from Massachusetts General Hospital in Boston, and colleagues conducted a cross-sectional study of adults newly diagnosed with iNHL in the past three months and assessed the quality of life, psychological symptoms, coping, and perception of prognosis.
November 21, 2023 — Source

Researchers develop new method of precisely targeting cancer lesions while protecting healthy tissues
A team of researchers has developed a new method that suppresses the distribution of drugs to healthy tissues and also rapidly removes the drugs once distributed in the body, which could improve the accuracy of imaging diagnosis of difficult cancers, reduce toxicity to healthy tissues, and further improve the effectiveness of treatment. They report their findings in a recent study published in the Journal of Controlled Release.
November 21, 2023 — Source

Health — Cancer — November 20th, 2023

Amalus Therapeutics develops innovative approach for treating patients with cancer or fibrotic diseases
Ghent University and the booming Ghent biotech landscape welcome a brand new spin-off: Amalus Therapeutics is developing a new class of drugs that selectively target corrupt fibroblast cells. This innovative approach offers the potential to greatly improve the prospects of patients with cancer or fibrotic diseases.
November 20, 2023 — Source

Cervical cancer: NHS pledge to eradicate disease by 2040 can be achieved--here's how
The NHS has pledged to eliminate cervical cancer in England by 2040. This will be achieved by amping up current vaccination and screening programs.
November 20, 2023 — Source

Debunking the top myths about lung cancer screening
Lung cancer is the leading cause of cancer deaths in the U.S., claiming more lives than prostate cancer, breast cancer, and colorectal cancer combined. However, it can be a curable disease if detected early through screening, which can often identify cancer before it spreads or causes symptoms.
November 20, 2023 — Source

Harnessing AI to help pinpoint cancerous tumors
Engineers from the University of Waterloo are harnessing artificial intelligence to help doctors better see and control a non-invasive cancer treatment and, in the process, save lives.
November 20, 2023 — Source

Miniature colons with immune components aid the study of intestinal diseases
A team at the Medical University of South Carolina and Cincinnati Children's has developed a sophisticated model for studying the diseased colon that could lead to the development of personalized treatments for colon-related diseases, such as cancer and inflammatory bowel disease (IBD). The researchers report their findings in Cell Stem Cell.
November 20, 2023 — Source

New AI tool detects up to 13% more breast cancers than human clinicians can
The prospective evidence, published under the title "Prospective implementation of AI-assisted screen reading to improve early detection of breast cancer" in Nature Medicine, found that the tool, called Mia, could significantly increase the early detection of breast cancers in a European health care setting by up to 13%.
November 20, 2023 — Source

New Grant Supports Study of Nanoparticle-Based Cancer Therapies
In the hopes of mitigating chemotherapy's side effects, scientists have explored delivery systems that target tumors more effectively.
November 20, 2023 — Source

New machine learning technique found to be 30% better at predicting cancer cure rates
With the rapid development in computing power over the past few decades, machine-learning (ML) techniques have become popular in medical settings as a way to predict survival rates and life expectancies among patients diagnosed with diseases such as cancer, heart disease, stroke, and more recently, COVID-19. Such statistical modeling helps patients and caregivers balance treatment that offers the highest chance of a cure while minimizing the consequences of potential side effects.
November 20, 2023 — Source

New organoid model could lead to personalized treatments for colon-related diseases
A team at the Medical University of South Carolina and Cincinnati Children's has developed a sophisticated model for studying the diseased colon that could lead to the development of personalized treatments for colon-related diseases, such as cancer and inflammatory bowel disease (IBD). The researchers report their findings in the Nov. 2 issue of Cell Stem Cell.
November 20, 2023 — Source

One ovarian cancer fix: Removing the fallopian tubes
The most effective step to battling ovarian cancer may have little to do with ovaries and more to do with surgical removal of the fallopian tubes.
November 20, 2023 — Source

Personalized cancer medicine: Humans make better treatment decisions than AI, says study
Treating cancer is becoming increasingly complex, but also offers more and more possibilities. After all, the better a tumor's biology and genetic features are understood, the more treatment approaches there are. To be able to offer patients personalized therapies tailored to their disease, laborious and time-consuming analysis and interpretation of various data is required.
November 20, 2023 — Source

Predicting the molecular functions of regulatory genetic variants associated with cancer
A new editorial paper titled "Predicting the molecular functions of regulatory genetic variants associated with cancer" has been published in Oncotarget
November 20, 2023 — Source or Watch Video

Research finds correlation between biomarker HSD3B1 and resistance to combined hormone therapy and radiotherapy
Men with a particular genetic subtype of the steroid biosynthesis enzyme HSD3B1 may exhibit resistance to combined radiation and hormone therapy for prostate cancer, according to new Cleveland Clinic-led research published in Journal of Clinical Investigation.
November 20, 2023 — Source

Robust chromatin map explains heterogeneity of pediatric acute lymphoblastic leukemia
Scientists at St. Jude Children's Research Hospital described the gene regulatory networks contributing to differences between subtypes of the most common childhood cancer, acute lymphoblastic leukemia (ALL). The work examined chromatin, the packaging that compacts DNA, in a cohort of patient samples six times greater than any previous efforts. The results serve as a valuable resource to better understand why patients' outcomes differ and to ultimately improve treatments. The findings were published today in Cell Genomics.
November 20, 2023 — Source

Study finds increased liver cancer risk among Mexican Americans in subsequent generations
In the United States, liver cancer rates have more than tripled since 1980. Some groups, including Latinos, face an even higher risk than the general population-;but researchers do not fully understand why.
November 20, 2023 — Source

Urban environmental exposures drive increased breast cancer incidence, finds study
The findings, appearing in the journal Scientific Reports, serve as a national template for assessing the impact of poor environmental quality across different stages of breast cancer, which is marked by highly diverse origins and mechanisms for spreading. North Carolina serves as a good model; it has a diverse population of 10 million spread over 100 rural and urban counties with varying environmental conditions.
November 20, 2023 — Source

Health — Cancer — November 17th, 2023

Development of a novel bispecific antibody therapy to overcome myeloma heterogeneity
In a new study published in the Blood Journal, researchers have developed a new modality, referred to as Bridging-Bispecific T-cell Engager (B-BiTE). B-BiTE was able to bind to both to the Fc region of human immunoglobulin G monoclonal antibody (mAb) and human CD3 molecule expressed by T cells.
November 17, 2023 — Source

Division of cells in cell cultures and cancer
If cells in cell cultures grow while being treated with division-suppressing agents, their growth becomes excessive and they permanently lose their ability to divide.
November 17, 2023 — Source

Environment and wallet benefit from redispensing cancer pills
Redispensing cancer drugs reduces both environmental impact and medical costs, according to new research. The annual savings could amount to tens of millions.
November 17, 2023 — Source

Exploring the environmental and monetary benefits of redispensing cancer pills
Redispensing cancer drugs reduces both environmental impact and medical costs, according to research from Radboudumc pharmacy published in JAMA Oncology. The annual savings could amount to tens of millions.
November 17, 2023 — Source

Treatment Strategy for Pancreatic Cancer Based on Nanoparticles
One of the deadliest tumors that affect people is pancreatic cancer. In the Western world, it ranks as the fourth most common cause of cancer-related fatalities.
November 17, 2023 — Source

What do you know about pancreatic cancer?
November is Pancreatic Cancer Awareness Month, which makes this a good time to learn more about the risk factors for pancreatic cancer and what you can do to keep yourself safe.
November 17, 2023 — Source

Health — Cancer — November 16th, 2023

AI model predicts patient outcomes across multiple cancer types
Investigators from the UCLA Health Jonsson Comprehensive Cancer Center have developed an artificial intelligence (AI) model based on epigenetic factors that is able to predict patient outcomes successfully across multiple cancer types.
November 16, 2023 — Source

Cancer therapy shows promise against tuberculosis
Scientists at Texas Biomedical Research Institute (Texas Biomed) have found that the therapy dramatically reduces TB growth, even for bacteria that are drug-resistant. The findings, reported in the journal Biomedicine & Pharmacotherapy, were made in novel cellular models featuring TB-infected human cells that can help accelerate screening of potential TB drugs and therapies like this one.
November 16, 2023 — Source

Breakthrough in bladder cancer research
For 40 years, chemotherapy has been the standard treatment for bladder cancer patients who can tolerate this medicine. However, the results were limited, and lasting results were rare. In recent years, two groundbreaking phase-3 clinical studies have focused on a new form of treatment to improve this. They investigated the effects of combining immunotherapy and chemotherapy.
November 16, 2023 — Source

Clinical trials present a new approach using immunotherapy combinations for bladder cancer treatment
After 40 years of treating metastatic bladder cancer with chemotherapy as a primary treatment, scientists now present a new approach using immunotherapy combinations. The results of two studies have been presented at the European Society for Medical Oncology (ESMO) conference in Madrid. The outcomes of these studies could revolutionize the landscape of bladder cancer treatment.
November 16, 2023 — Source

Gene splicing found to reduce effectiveness of CD20-targeting monoclonal antibodies for blood cancers and disorders
Immunotherapies that target the CD20 antigen have revolutionized how patients with a variety of blood cancers and hematologic disorders have been treated. However, many patients develop resistance to these treatments due to a loss of the antigen that's being targeted.
November 16, 2023 — Source

Genomic tug of war could boost cancer therapy
Some patients with myelodysplastic syndromes, like acute myeloid leukemia, benefit from a chemotherapy drug called decitabine that stunts cancer growth. But many others are resistant to decatibine's effects or become resistant over time. Wilmot Cancer Institute researchers have uncovered a "genomic tug of war" in animal studies that could influence how well certain patients--or certain cancers--respond to decitabine.
November 16, 2023 — Source

Novel nanoprobe helps realize in vivo real-time detection of sentinel lymph node metastases in breast cancer
Sentinel lymph node (SLN) is the first lymph node draining from a tumor, and sentinel lymph node biopsy (SLNB) for breast cancer is the standard procedure for clinically node-negative (cN0) early-stage breast cancer. Currently, the commonly used tracers in clinical practice can only trace SLNs without evaluating their metastatic status.
November 16, 2023 — Source

Osimertinib + chemo improves progression-free survival in advanced non-small cell lung cancer: Study
For patients with EGFR-mutated advanced non-small cell lung cancer (NSCLC), osimertinib with chemotherapy leads to significantly longer progression-free survival (PFS) compared with osimertinib alone, according to a study publishedonline Nov. 8 in the New England Journal of Medicine.
November 16, 2023 — Source

Q&A: Enhancing physicians' colonoscopy training for early cancer prevention
A novel colonoscopy training system that integrates automated personalized learning with a manikin--the more realistic version of a mannequin capable of medical simulations--embedded with sensors may help make the routine procedure safer, more accurate and cost-efficient.
November 16, 2023 — Source

Scientists identify T-cell differentiation nodes to improve cancer-killing
Scientists mapped the gene regulatory networks responsible for progressive differentiation states of tumor-infiltrating T cells, using a technology known as single-cell CRISPR screening to knock out or genetically perturb multiple genes potentially involved.
November 16, 2023 — Source

Why it's important to improve communication of unanticipated genomic findings to patients with late-stage cancer
Cancer genomics experts at City of Hope, one of the largest cancer research and treatment organizations in the United States, conducted a qualitative study that underscored the importance of properly preparing patients for unanticipated, inheritable genetic findings prior to receipt of tumor sequencing.
November 16, 2023 — Source

Health — Cancer — November 15th, 2023

A Novel Strategy Developed for Better HCC Treatment
Hepatocellular carcinoma (HCC) is currently the third leading cause of cancer-related mortality across the globe. Transarterial embolization (TAE) therapy is the standard of care for most patients with intermediate-advanced HCC. Its minimum invasiveness stems from its use of embolic agents to limit the tumor blood supply and produce ischemic necrosis. Transarterial chemoembolization (TACE), which mixes chemotherapy drugs with embolic agents, is also widely used in clinical treatment to increase therapeutic benefit.
November 15, 2023 — Source

Artificial intelligence aids fight against acute myeloid leukemia
When Mauricio Ferrato completed his doctorate in computer and information sciences at the University of Delaware a few months ago, he made his mark in more ways than one.
November 15, 2023 — Source

Nanoparticles for optimized cancer therapy
Pancreatic cancer is one of the deadliest types of cancers in humans. It is the fourth leading cause of cancer-related deaths in the western world. The early stages of the disease often progress without symptoms, so diagnosis is usually very late.
November 15, 2023 — Source

Obesity paradox and lung cancer: Metformin-based therapeutic opportunity?
In their recent editorial, researchers Pedro Barrios-Bernal, Norma Hernández-Pedro, Luis Lara-Mejía, and Oscar Arrieta from Instituto Nacional de Cancerología discuss obesity, diabetes and lung cancer. Obesity is a complex multifactorial disease with detrimental effects on health. This disease induces a proinflammatory state, innate and adaptative immune system dysfunction, and immune exhaustion, which in conjunction promote cancer growth.
November 15, 2023 — Source

Patient-centered clinical guideline on partial breast irradiation for early-stage invasive breast cancer and DCIS
The American Society for Radiation Oncology (ASTRO) issued today a clinical guideline on partial breast irradiation for patients with early-stage invasive breast cancer or ductal carcinoma in situ (DCIS). For the guideline, experts in breast cancer compiled evidence--including several recently published large, randomized clinical trials--to provide guidance on which patients can benefit from partial breast radiation, as well as best practices to deliver the treatment effectively.
November 15, 2023 — Source

Researchers develop nanoparticle treatment approach for optimized pancreatic cancer therapy
Pancreatic cancer is one of the deadliest types of cancers in humans. It is the fourth leading cause of cancer-related deaths in the western world. The early stages of the disease often progress without symptoms, so diagnosis is usually very late. Another problem is advanced tumors--and their metastases--can no longer be completely removed.
November 15, 2023 — Source

Stand Up To Cancer unveils new gastroesophageal cancer research teams and awards
Stand Up To Cancer® (SU2C) today announced three Research Teams focused on bringing new therapies to clinical trials for the treatment of gastroesophageal cancer (GEC). The Research Teams, a part of a Dream Team Collective supported by the Torrey Coast Foundation, will unite top researchers from 11 institutions to address critical problems in GEC prevention, diagnosis and treatment.
November 15, 2023 — Source

Study reveals mechanisms restricting oncogene-driven skin cancer formation
To form a cancer, cells need to accumulate oncogenic mutations that confer tumor-initiating properties. However, recent evidence has shown that oncogenic mutations occur at a surprisingly high frequency in normal tissues, suggesting that mutations alone are not sufficient to drive cancer formation and that other mechanisms should promote or restrain oncogene-expressing cells from progressing into invasive tumors.
November 15, 2023 — Source

Women with breast cancer take sexual health into their own hands: Study
A third of users on a popular breast cancer support forum describe using peer-recommended or self-discovered techniques to improve sexual functioning, according to a study published November 15, 2023 in the open-access journal PLOS ONE by Christiana von Hippel from the Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, U.S., and colleagues.
November 15, 2023 — Source

Health — Cancer — November 14th, 2023

Cancer stem cells induce macrophage aging, creating conditions for tumor formation
Cancer stem cells cause the aging of macrophages in mice with healthy immune systems, creating conditions for the formation of tumors.
November 14, 2023 — Source

Disrupting a single gene could improve CAR T cell immunotherapy, new study shows
CAR T cell therapy, a powerful type of immunotherapy, has begun to revolutionize cancer treatment. Pioneered at Memorial Sloan Kettering Cancer Center (MSK), the therapy involves engineering a patient's T cells so they recognize and attack cancer cells. These CAR (chimeric antigen receptor) T cells are then multiplied in a lab and given back to the patient to be a continual fighting force against the cancer.
November 14, 2023 — Source

Nano-CaCO₃ stabilized ferroptosis-inducing Lipiodol based microreactors for TAFE therapy
Hepatocellular carcinoma is the third most common cause of cancer-related deaths worldwide. For most intermediate-advanced HCC patients, transarterial embolization therapy is the mainstream treatment by utilizing embolic agents to block the tumor blood supply to induce ischemic necrosis attributing to its minimal invasiveness.
November 14, 2023 — Source

New results to help fine-tune catalytic properties of bimetallic nanoparticles
Nanoparticles range in size from 1 to 100 nanometers, and compared with usual particles, they are known to have unique features that are increasingly used for diagnosing cancer, developing small electronic devices and solar batteries, as well as in many other spheres.
November 14, 2023 — Source

Pharmaceutical compound sounds the alarm on cancer cells and unleashes T cells
Researchers in Purdue University's College of Pharmacy are leveraging the dual roles played by an enzyme found in both cancer cells and T cells to create a novel cancer immunotherapy compound.
November 14, 2023 — Source

Pharmacy provider Truepill data breach hits 2.3 million customers
Postmeds, doing business as 'Truepill,' is sending notifications of a data breach informing recipients that threat actors accessed their sensitive personal information.
November 14, 2023 — Source

Q&A: How one lab is working to harness the power of the immune system against cancer
Investigator Ming Li, Ph.D., has dedicated his career to understanding the intricate workings of the immune system--both in general and for the critical role it plays in cancer.
November 14, 2023 — Source

Up to 20% of lung cancer patients never smoked
Air pollution has also been linked to the disease.
November 14, 2023 — Source

Health — Cancer — November 13th, 2023

C/EBP&beta cooperates with MYB to maintain the oncogenic program of AML cells
A new editorial perspective titled "C/EBP&beta cooperates with MYB to maintain the oncogenic program of AML cells" has been published in Oncotarget.
November 13, 2023 — Source

Key clues to DNA repair mechanism might lead to new cancer treatments
Researchers from Tokyo Metropolitan University have identified key factors in the mechanism behind DNA repair in our bodies. For the first time, they showed that the "proofreading" portion of the DNA replicating enzyme polymerase epsilon ensured safe termination of replication at damaged portions of the DNA strand, ultimately saving DNA from severe damage.
November 13, 2023 — Source

Research reveals how breast cancer gene mutations may impact cell communication
New Cleveland Clinic research reveals how BRCA1 and BRCA2 gene mutations may impact cell communication in breast tissue, furthering the understanding of how cancer develops.
November 13, 2023 — Source

Researchers develop gel to deliver cancer drugs for solid tumors
Intratumoral therapy--in which cancer drugs are injected directly into tumors--is a promising treatment option for solid cancers but has shown limited success in clinical trials due to an inability to precisely deliver the drug and because most immunotherapies quickly dissipate from the site of injection
November 13, 2023 — Source

Researchers find more than 4,700 gene clusters crucial for prognosis in 32 cancer types
Researchers at the Mount Sinai Center for Transformative Disease Modeling have released a study identifying 4,749 key gene clusters, termed "prognostic modules," that significantly influence the progression of 32 different types of cancer.
November 13, 2023 — Source

Researchers take new AI approach to analyzing tumors
Researchers at Karolinska Institutet and SciLifeLab in Sweden have combined artificial intelligence (AI) techniques used in satellite imaging and community ecology to interpret large amounts of data from tumor tissue. The method, presented in the journal Nature Communications, could contribute to more personalized treatment of cancer patients.
November 13, 2023 — Source

Scientists discover key to a potential natural cancer treatment's potency
Slumbering among thousands of bacterial strains in a collection of natural specimens at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, several fragile vials held something unexpected, and possibly very useful.
November 13, 2023 — Source

Some increase in cancer found after 1986 Chernobyl disaster
The nuclear accident in Chernobyl in 1986 led to the spread of radioactivity across Sweden and Europe. In a long-term study now published in Environmental Epidemiology, researchers have used new, more specific calculation methods to show the connection between radiation dose and certain types of cancer.
November 13, 2023 — Source

Study reveals no neuroinflammation in long COVID patients with neuropsychiatric symptoms
PCC, also known as long COVID, represents a diverse group of symptoms that last for months post-acute COVID-19. Some individuals with PCC have neuropsychiatric symptoms (neuro-PCC), and the underlying mechanisms are poorly understood. CSF provides a means to evaluate neuropathology, given that it circulates the central nervous system (CNS) and serves as a window to the brain.
November 13, 2023 — Source

Health — Cancer — November 10th, 2023

187 new genetic variants linked to prostate cancer found in largest, most diverse study of its kind
A globe-spanning scientific team has compiled the most comprehensive list of genetic variants associated with prostate cancer risk — 451 in all — through a whole-genome analysis that ranks as the largest and most diverse investigation into prostate cancer genetics yet. The research explored the genomes of nearly 950,000 men, including major increases in representation among men from racial and ethnic groups that have often been left out of such research.
November 10, 2023 — Source

Biomimetic nanoparticles offer promise for enhanced detection of circulating tumor cells
Detecting cancer at an early stage is crucial for effective treatment and improving patient outcomes. A key challenge is finding ways to detect minute numbers of circulating tumor cells (CTCs) in blood samples. CTCs have broken away from the original tumor site and entered the bloodstream, acting as an early warning sign that cancer may be spreading or metastasizing to other areas of the body.
November 10, 2023 — Source

New approach to pancreatic cancer treatment expands therapeutic possibilities, shows promise for increased survival
Preclinical research published in the Journal for ImmunoTherapy of Cancer points to a promising new treatment option for people with pancreatic cancer. Researchers from VCU Massey Comprehensive Cancer Center and the VCU Institute of Molecular Medicine (VIMM) suggest that when used in a form that can be delivered directly into the tumor cell, polyinosine--polycytidylic acid (pIC) suppresses tumor growth, induces cancer cell death and enhances survival in animal models with the most common form of pancreatic cancer.
November 10, 2023 — Source

New research offers hope for reduced muscle wastage in cancer patients
Researchers from Trinity, in collaboration with Artelo Biosciences, have made a breakthrough in cancer cachexia. Their work shows that the drug ART27.13 protects against the muscle degeneration associated with colon and lung cancers (cachexia) and believe it may also positively impact life expectancy.
November 10, 2023 — Source

Health — Cancer — November 9th, 2023

Bone scans overstage prostate cancer at initial staging compared with PSMA PET: Study
Bone scans have been found to overstage prostate cancer at initial staging compared to prostate-specific membrane antigen (PSMA) PET, according to new research published in the November issue of the Journal of Nuclear Medicine. The significant false-positive rate of metastases on bone scans means that definitive therapy for local disease may have been withheld from patients inappropriately.
November 9, 2023 — Source

Finding your niche: A synthetic cancer stem cell microenvironment
One of the biggest challenges in biomedical research is finding a way to capture the complexity of the human body in laboratory-based techniques, to enable them to be investigated accurately. Now, researchers from Japan report an approach for precisely imitating a key feature of aggressive cancers in the laboratory.
November 9, 2023 — Source

Jury Still Out on Whether Green Tea Lowers Colon Cancer Risk
Can green tea lower your risk of colorectal cancer? It depends on who — and what research — you believe.
November 9, 2023 — Source

Side-effect avoiding treatment shows early promise against breast cancer in mice
New experimental evidence suggests that substances known as narrow-spectrum Wnt signaling inhibitors--which could have fewer side effects than other related substances--are capable of suppressing the growth of breast cancer tumors in mice.
November 9, 2023 — Source

UN report warns that working in the sun causes skin cancers
New data from two United Nations agencies shows that millions of workers toiling under the sun's glare is fueling skin cancer cases around the world.
November 9, 2023 — Source

Health — Cancer — November 7th, 2023

Active Surveillance for Prostate Cancer a Leap of Faith
When Allan Greenberg was diagnosed with prostate cancer in 2012, he elected to take a then-uncommon approach to treating the disease.
November 7, 2023 — Source

MD Anderson and Jazz Pharmaceuticals collaborate to investigate the potential of zanidatamab in HER2-expressing cancers
The University of Texas MD Anderson Cancer Center and Jazz Pharmaceuticals plc today announced a five-year strategic research collaboration agreement to evaluate zanidatamab, Jazz's investigational HER2-targeted bispecific antibody, in multiple HER2-expressing cancers.
November 7, 2023 — Source

New research suggests a simple, inexpensive option for reducing a major chemotherapy side effect
New research in JNCCN--Journal of the National Comprehensive Cancer Network suggests that patients who have insufficient levels of vitamin D before starting paclitaxel treatment are more likely to experience peripheral neuropathy.
November 7, 2023 — Source

Study estimates global, regional and national lifetime probabilities of developing cancer in 2020
The lifetime risk of cancer is a measure of the cumulative impact of cancer across a defined age span, and has obvious intuitive appeal. There are however few examples in comparative assessments of cancer-specific risk across populations. Therefore, recent research aimed to estimate the lifetime risk of cancer at the global, world region and national level for 36 major cancer types.
November 7, 2023 — Source

Study validates first-in-class AI-driven digital pathology colorectal cancer diagnostic tool
In a peer-reviewed study published today in Nature Communications, a team of scientists from French-American techbio Owkin and pathology labs in France present a blind validation of MSIntuit™ CRC, a first-in-class AI-driven digital pathology diagnostic developed by Owkin, as a pre-screening tool aimed at optimizing the precision of diagnosis and treatment of colorectal cancer.
November 7, 2023 — Source

Health — Cancer — November 6th, 2023

A new gene classification system for gastric cancer
A research team has announced a new genetic classification system for gastric cancer by a multicenter study with the University of Texas MD Anderson Cancer Center. This research could lay the foundation for personalized gastric cancer treatment.
November 6, 2023 — Source

Attacking the roots of pancreatic cancer
Pancreatic cancer is not just one disease, but that's the way it is currently treated. New work from Tannishtha Reya's lab could help pave the way for a change. The research is published in the journal Cancer Cell.
November 6, 2023 — Source

Boosting immune system in chronic myeloid leukemia may lead to discontinuation of blood cancer drugs
In a recent study published in Leukemia, Finnish researchers investigated why some patients with chronic myeloid leukemia (CML) can discontinue their daily medication safely.
November 6, 2023 — Source

Bowel cancer: Aspirin activates protective genes
Researchers have identified a signaling pathway by which aspirin can inhibit colorectal cancer.
November 6, 2023 — Source

Denmark can save lives and costs by reducing nitrate in drinking water, researchers say
Denmark could save lives and more than $300 million a year by reducing the amount of nitrate in its drinking water. This, according to calculations by researchers from the University of Copenhagen, Aarhus University and GEUS. An ever-growing body of research concludes that the amount of nitrate in some Danish boreholes increases the risk of colorectal cancer.
November 6, 2023 — Source

DNA study reveals BRCA1 mutations in three sisters, prompts life-changing decisions
Sisters often share certain genetic traits, such as hair color and facial features. But for three sisters from Minnesota, they discovered a much deeper connection--a shared genetic mutation known to dramatically increase their risk for breast and ovarian cancer.
November 6, 2023 — Source

First in human trial of new drug raises hopes for patients with relapsed blood cancer
A new targeted drug, studied by researchers at The Ohio State University Comprehensive Cancer Center--Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC--James), may offer a new treatment option for patients with blood cancers, including chronic lymphocytic leukemia (CLL) and Non-Hodgkin lymphoma (NHL) whose disease has stopped responding to standard treatments.
November 6, 2023 — Source

Management of recurrent gastrointestinal cancer with ripretinib and surgery
Ripretinib is a tyrosine kinase inhibitor that was approved by the United States FDA in 2020 for treatment of advanced gastrointestinal stromal tumor (GIST) in patients who received prior treatment with three or more tyrosine kinase inhibitors.
November 6, 2023 — Source

Novel urine-based test offers new hope for bladder cancer patients
Bladder cancer, notorious for being one of the most costly malignancies to manage, often results in patient discomfort and frequent invasive and expensive procedures. Traditional treatments, though gradually being replaced by immune checkpoint inhibitors (ICIs), have yielded varied success rates with limited predictors for individual patient responses.
November 6, 2023 — Source

Research finds higher risk of 17 cancers after high BMI in late teens
Men who are overweight or obese at age 18 have a higher risk of 17 different cancers later in life. This has been shown by research from the University of Gothenburg. The research also describes how the youth obesity epidemic is expected to affect the cancer situation over the next 30 years.
November 6, 2023 — Source

Study reveals genetic chain reaction that drives the spread of prostate cancer
New research from scientists at VCU Massey Comprehensive Cancer Center and the VCU Institute of Molecular Medicine (VIMM) determined that a particular gene--MDA-9/Syntenin-1/SDCBP--is the ringleader behind a molecular domino effect driving prostate cancer growth and metastasis. The findings could hold significant clinical implications for the treatment of prostate cancer and other forms of disease.
November 6, 2023 — Source

The uncharted role of HER2 mutant alleles in breast cancer
Somatic HER2 mutations are a novel class of therapeutic targets across different cancer types. Treatment with the tyrosine kinase inhibitor (TKI) neratinib as a single agent continues to be evaluated in HER2-mutant metastatic disease. However, responses are heterogeneous, with frequent early progression.
November 6, 2023 — Source

Health — Cancer — November 3rd, 2023

AI getting better at detecting skin cancer
Artificial intelligence (AI) is increasingly accurate in detecting skin cancer, according to a study presented at the annual meeting of the European Academy of Dermatology and Venereology, held from Oct. 11 to 14 in Berlin.
November 3, 2023 — Source

Four women have two-in-one surgery to reduce their risk of ovarian cancer
Four women have successfully had a combined surgery, in which they gave birth by cesarean section and at the same time had surgery to reduce their risk of ovarian cancer, thanks to a team of researchers and clinicians at UCLH and UCL.
November 3, 2023 — Source

New radiopharmaceutical shows antitumor activity in patients with advanced prostate cancer
Researchers at Weill Cornell Medicine have led a phase 1 trial of a new drug that delivers potent radiation therapy directly and specifically to cancer cells in patients with advanced prostate cancer. The clinical trial showed that the "radiopharmaceutical" was well tolerated and demonstrated promising antitumor activity, according to a new study published on Nov. 2 in the Journal of Clinical Oncology.
November 3, 2023 — Source

Oncology researchers raise ethics concerns posed by patient-facing artificial intelligence
Ready or not, patients with cancer are increasingly likely to find themselves interacting with artificial intelligence technologies to schedule appointments, monitor their health, learn about their disease and its treatment, find support, and more.
November 3, 2023 — Source

Pitch Teardown: The CancerVAX crowdfunding campaign on StartEngine
For this edition of Pitch Deck Teardown, I figured I'd try something new: We're taking a close look at the CancerVAX campaign on the equity crowdfunding platform, StartEngine.
November 3, 2023 — Source

Q&A: Best ways to screen and treat breast cancer
Despite decades of scientific progress, breast cancer remains the most common cancer among women in the United States. Experts are divided on many aspects, such as when and how often to do mammograms, how to rethink interventions for precancer lesions, and how to pinpoint risk and reduce the toxicity of treatments.
November 3, 2023 — Source

Q&A: How cell developmental biology fits into the future of medicine
Ben Stanger, MD, Ph.D. is a practicing Gastroenterologist at Penn Medicine. He is also the Hanna Wise Professor in Cancer Research and professor of Medicine and Cell and Developmental biology at the University of Pennsylvania.
November 3, 2023 — Source

Seeing the unseen: How butterflies can help scientists detect cancer
There are many creatures on our planet with more advanced senses than humans. Turtles can sense Earth's magnetic field. Mantis shrimp can detect polarized light. Elephants can hear much lower frequencies than humans can. Butterflies can perceive a broader range of colors, including ultraviolet (UV) light.
November 3, 2023 — Source or Source

Study shows that smoking 'stops' cancer-fighting proteins, causing cancer and making it harder to treat
Scientists at the Ontario Institute for Cancer Research (OICR) have uncovered one way tobacco smoking causes cancer and makes it harder to treat by undermining the body's anti-cancer safeguards.
November 3, 2023 — Source

Two-drug approach could overcome a common cancer mutation, make treatments more effective
Cancer cells are often a mess of mutations. About 20% to 25% of cancers involve mutations in a complex of molecules called SWI/SNF. Yet drugs designed to block SWI/SNF activity haven't always worked as expected. Researchers at Harvard Medical School have now figured out why.
November 3, 2023 — Source

Health — Cancer — November 2nd, 2023

50-year forecast offers hope for HIV and cancer patients and predicts climate change to increasingly set agenda
The COVID-19 pandemic has changed the way we think about health and revealed significant flaws within our health care systems. It has also raised questions about the role of technology, as well as ethical concerns about the distribution of wealth and its impact on global health. How will this collective awakening that we have experienced influence the coming years and decades?
November 2, 2023 — Source

Colorectal cancer: Aspirin found to activate protective genes
LMU researchers have identified a signaling pathway by which aspirin can inhibit colorectal cancer.
November 2, 2023 — Source

Five counterintuitive ways scientists are approaching cancer research to improve treatment and prevention
How researchers conceptualize a disease informs how they treat it. Cancer is often described as uncontrollable cell growth triggered by genetic damage. But cancer can also be seen from angles that emphasize mathematics, evolutionary game theory and physics, among others.
November 2, 2023 — Source

Nanoparticles deliver treatment directly to tumors of deadly brain cancer
Using nanoparticles administered directly into the cerebrospinal fluid (CSF), a research team has developed a treatment that may overcome significant challenges in treating a particularly deadly brain cancer.
November 2, 2023 — Source or Source

New strategy attacks treatment-resistant lymphomas
A surprising mechanism that makes some cancers treatment-resistant has been discovered by Weill Cornell Medicine and NewYork-Presbyterian investigators. The mechanism, which involves the shuttling of messenger RNAs (mRNAs) from the nucleus to the cytoplasm, ultimately facilitates DNA repair in cancer cells.
November 2, 2023 — Source

Proving the efficacy of local treatment in liver cancer oligometastases
Professor Chai Hong Rim of the Department of Radiation Oncology, Korea University's Ansan Hospital, along with student Jungsue Lee and Sooyeon Kim of the College of Medicine, Korea University, proved the efficacy of active local treatment such as radiotherapy and radiofrequency ablation (RFA) in liver cancer oligometastases (less than 3 to 5 metastatic foci) through a meta-analysis study.
November 2, 2023 — Source

Researchers create machine learning model to calculate chemotherapy success in patients with osteosarcoma
A research team at Johns Hopkins Medicine has created and trained a machine learning model to calculate percent necrosis (PN)--or, what percentage of a tumor is "dead" and no longer active--in patients with osteosarcoma, a type of bone cancer. The model's calculation was 85% correct when compared to the results of a musculoskeletal pathologist. Upon removing one outlier, the accuracy rose to 99%.
November 2, 2023 — Source

Researchers explain how petrochemicals fuel cancer risks
A researcher with Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and collaborators have penned a commentary highlighting how petrochemicals are a major contributor to cancer risks, resulting in a profoundly negative impact on overall health.
November 2, 2023 — Source

Researchers uncover new targets for breast cancers resistant to standard therapies
Researchers at MUSC Hollings Cancer Center believe that some drugs already approved by the FDA or currently in clinical trials could be repurposed for certain breast cancer patients whose cancer has become resistant to standard therapies.
November 2, 2023 — Source

The 15 Best Facial Sunscreens of 2023, Tested and Chosen From 50 Top Brands
From gels to lightweight formulas, here are the best facial sunscreens to protect your skin and reduce your risk of skin cancer.
November 2, 2023 — Source

The role of the epigenome in cancer revealed in new study
For decades, scientists have been sequencing the DNA of many cancer types, identifying errors in the genetic code to help understand the formation of tumors, how they grow and what leads to their spread. But sometimes cancer is driven by subtle changes in the way the genetic code is executed, rather than by mistakes in the code itself. This layer of regulation is called the epigenome.
November 2, 2023 — Source

Health — Cancer — October 31st, 2023

A joint model for predicting circRNA-RBP binding sites based on deep learning
The interaction between circRNAs and RBPs is related to many diseases, especially cancers. Understanding the mechanism of the interaction and predicting their binding sites is critical.
October 31, 2023 — Source

Bacteria Tag Team Tumors with T Cells
A team at Columbia University School of Engineering and Applied Science has developed a technique to enhance chimeric antigen receptor (CAR) T cell therapy in solid tumors. The technique involves engineering E. coli bacteria, that naturally tend to accumulate in the immune privileged core of solid tumors.
October 31, 2023 — Source

Better access to diagnostic tests raises incidence of thyroid cancer in more affluent areas
The incidence of thyroid cancer in São Paulo State, part of Brazil's relatively developed Southeast region, varies considerably according to socioeconomic status (education, poverty, wealth, income, segregation, mobility, and access to resources and services) and access to screening, but is highest in higher-income areas and the state capital.
October 31, 2023 — Source

Customizing Nanoparticles to Target Tumors, Viruses and Toxins
The University of California San Diego's engineers have created modular nanoparticles that are easily customizable to target viruses, cancers, or toxins. As the nanoparticles' surface is designed to accommodate any desired biological molecule, they can be customized for a variety of uses, such as neutralizing biological agents or delivering drugs on a targeted basis.
October 31, 2023 — Source

World's first collection of brain metastasis living samples will help treat each patient with the most effective therapy
At 18 Spanish hospitals, when a patient with brain metastasis undergoes surgery, they can donate a tiny part of their brain to the first repository of brain metastasis living samples in the world, based at CNIO (Spanish National Cancer Research Centre). It is a pioneering collection in the world, created to accelerate the search for therapies against brain metastasis, a disease that affects up to 30% of patients with systemic cancer.
October 31, 2023 — Source

Health — Cancer — October 30th, 2023

Can personalized care prevent excessive screening for colorectal cancer in older adults?
Colorectal cancer screening is widely recommended for adults ages 45 to 75 with an average risk of developing the disease. However, many people don't realize that the benefits of screening for this type of cancer aren't always the same for older adults.
October 30, 2023 — Source

Discovery unlocks potential new arsenal to target leukemia and other cancers
A discovery by a QIMR Berghofer-led team of international scientists has potentially unlocked an entirely new approach to targeting the blood cancer acute myeloid leukemia, bringing hope to patients who are no longer responding to existing treatments.
October 30, 2023 — Source

Examining outcomes in children with Down syndrome and acute lymphoblastic leukemia
Children with Down syndrome have an increased risk of developing acute lymphoblastic leukemia (ALL) and experience higher rates of relapse and treatment toxicity. In recent decades, new therapies have improved outcomes for the general population, but outcomes for children with Down syndrome have lagged and have not been reported for contemporary treatment regimens.
October 30, 2023 — Source

Lymphoid reaction observed in eczema patients receiving dupilumab
Celeste M. Boesjes, M.D., from the University Medical Center Utrecht in the Netherlands, and colleagues conducted a retrospective observational case series involving adult patients with AD treated with dupilumab to examine the clinical and histopathological features of patients clinically suspected for CTCL.
October 30, 2023 — Source

NCCN releases new resources to improve quality of life for people with cancer
The National Comprehensive Cancer Network® (NCCN®) is announcing new resources focused on improving quality of life for people with cancer while making sure care planning reflects individual needs and priorities. Today marks the publication of a new NCCN Guidelines for Patients®: Palliative Care, part of an ongoing expansion of supportive care resources.
October 30, 2023 — Source

Neutrophil PAD4: How does it function in cancer beyond promoting NETosis?
A new editorial paper titled "Neutrophil PAD4: how does it function in cancer beyond promoting NETosis?" has been published in Oncotarget.
October 30, 2023 — Source

New antibody could target breast cancers
An enzyme that may help some breast cancers spread can be stopped with an antibody created in the lab of Cold Spring Harbor Laboratory Professor Nicholas Tonks. With further development, the antibody might offer an effective drug treatment for those same breast cancers.
October 30, 2023 — Source

New radiotherapy with high-performance computing could improve therapy for hard-to-treat cancers
Researchers have used methods from high-performance computing to significantly reduce the time it takes to reconstruct images acquired through four-dimensional magnetic resonance imaging (4D-MRI), a leading-edge, high-quality imaging technique.
October 30, 2023 — Source

Ovarian cancer patients 70% less likely to die with aggressive surgical approach: Study
Patients with ovarian cancer are 70% less likely to die three years after a multidisciplinary surgical approach is deployed, according to new research. The study from the Mater University Hospital on treating advanced ovarian cancer has found that aggressive surgery involving multiple specialists has a significant impact on survival rates.
October 30, 2023 — Source

'Plug and play' nanoparticles could make it easier to tackle various biological targets
Engineers at the University of California San Diego have developed modular nanoparticles that can be easily customized to target different biological entities such as tumors, viruses or toxins. The surface of the nanoparticles is engineered to host any biological molecules of choice, making it possible to tailor the nanoparticles for a wide array of applications, ranging from targeted drug delivery to neutralizing biological agents.
October 30, 2023 — Source or Source

Protein eIF4A emerges as a potential Achilles' heel for triple-negative breast cancer
Improving treatments for triple-negative breast cancer (TNBC), an aggressive tumor with very poor prognosis and limited therapeutic targets, has been challenging. Responding to this need for better treatments, researchers at Baylor College of Medicine and collaborating institutions have investigated potential vulnerabilities in TNBC that could lead to novel therapies and improved outcomes for this devastating condition.
October 30, 2023 — Source

Risk-adapted starting age of CRC screening varies by sex, genetics
Xuechen Chen, Ph.D., from the German Cancer Research Center in Heidelberg, and colleagues illustrated derivation of risk-adjusted starting ages of CRC screening based on the concept of risk advanced period (RAP) using sex and PRS. Participants were from the U.K. Biobank (aged 40 to 69 years) with no family history of CRC and no previous bowel cancer screening.
October 30, 2023 — Source

Soy expansion in Brazil linked to increase in childhood leukemia deaths
Over the past decades, Brazil has become the world's leading soybean producer, as well as the leading consumer of pesticides. Despite concerns about potential public health consequences, little is known about the effects of pesticide exposure in the general population.
October 30, 2023 — Source

Study unveils new approach to more precise, long-lasting, and less toxic cancer treatment
For too long, cancer treatment has been a double-edged sword — the very treatments designed to kill cancer cells often wrought havoc on healthy ones too.
October 30, 2023 — Source

Health — Cancer — October 27th, 2023

An updated look at prostate cancer disparities
Cedars-Sinai Cancer investigators have found that Black men respond as well as white men to systemic therapies for advanced prostate cancer when access to quality health care is equal, regardless of socioeconomic status.
October 27, 2023 — Source

Common chemotherapy drugs don't work like doctors thought, with big implications for drug discovery
A new study from the University of Wisconsin--Madison suggests that chemotherapy may not be reaching its full potential, in part because researchers and doctors have long misunderstood how some of the most common cancer drugs actually ward off tumors.
October 27, 2023 — Source

Digital risk assessment tool can ID risk for cancer susceptibility syndromes, according to study
Implementation of a digital risk assessment tool can identify patients with high-risk cancer susceptibility syndromes, according to a study presented at the annual meeting of the American College of Gastroenterology, held from Oct. 20 to 25 in Vancouver, British Columbia, Canada.
October 27, 2023 — Source

Imaging technique can observe specialized cancer treatment in breast cancer models
For nearly a century, scientific evidence has shown that the use of specific bacteria to target cancer tumors and trigger immune responses in patients can be effective in combating cancer. Such bacterial therapies have proven successful in targeting and treating bladder cancer with minimal damage to healthy tissue, which commonly occurs with traditional radiation and chemotherapy treatments.
October 27, 2023 — Source

Mechanics of breast cancer metastasis discovered, offering target for treatment
The most lethal feature of any cancer is metastasis, the spread of cancer cells throughout the body. New research led by Penn State reveals for the first time the mechanics behind how breast cancer cells may invade healthy tissues. The discovery, showing that a motor protein called dynein powers the movement of cancer cells in soft tissue models, offers new clinical targets against metastasis and has the potential to fundamentally change how cancer is treated.
October 27, 2023 — Source

New antibody shows strong potential as treatment against pancreatic cancer
Scientists have recently concluded a preclinical study that highlights the potential of SIWA318H, an advanced glycation end product (AGE)-targeting antibody, in the fight against pancreatic cancer.
October 27, 2023 — Source

Health — Cancer — October 26th, 2023

Immunologists aim to explore new avenues for immunotherapy of liver metastases
Four distinguished immunologists have been awarded one of the most generously funded research grants from the EU: the ERC Synergy Grant. They aim to explore new avenues for immunotherapy of liver metastases.
October 26, 2023 — Source

Key signaling protein identified as possible target for new therapies in hard-to-treat cancers
The unique signaling protein known as TRPM7 can stimulate and interact with an important cellular signaling hub called the AKT machinery, which is a well-known component of multiple cellular functions that drive growth and proliferation. This interaction causes a significant increase in the gene expression of COX-2, an important pro-inflammatory and pro-tumorigenic gene that is highly expressed in cancer cells and typically coincides with poor prognosis.
October 26, 2023 — Source

Researchers discover resistance to liver cancer treatment
Liver cancer is the fourth deadliest cancer in Hawaiʻi, particularly affecting Native Hawaiian, Filipino and Japanese men. Patients can develop liver failure when tumors metastasize or spread to the healthy portions of the liver which results in a rapid decline of health and even death.
October 26, 2023 — Source

Screening, early cancer detection save lives
When she was 50 years old, Beatrice Karnoscak's first mammogram detected breast cancer. Ten years after finishing treatment, Beatrice was diagnosed with lung cancer. Each time, early screening is what saved her life.
October 26, 2023 — Source

Health — Cancer — October 24th, 2023

AI in histopathology image analysis for cancer precision medicine
In recent years, there have been rapid advancements in the field of computational pathology, which refers to the application of computational methods in pathology workflows. Traditional pathology involves the study of diseases by examining tissues, organs, and bodily fluids. In computational pathology, digital pathology images are analyzed using computer algorithms to extract meaningful information.
October 24, 2023 — Source

AI-assisted smartphone app performs well in skin cancer diagnosis
Artificial intelligence (AI) is already widely used in medical diagnostics. An Austrian-Australian research team led by dermatologist Harald Kittler from MedUni Vienna investigated the extent to which diagnosis and therapy of pigmented skin lesions benefit from it in a realistic clinical scenario. In a study published by The Lancet Digital Health, the team compared the accuracy in diagnosis and therapy recommendation of two different algorithms in smartphone applications with that of doctors.
October 24, 2023 — Source

Better cancer diagnosis thanks to digital 3D images
It all started with an innocuous question at the start of Francesca Catto's doctoral thesis: Wouldn't it be nice if tissue samples could be colored and digitally displayed as a 3D image? For more than 100 years, histology, a branch of pathology that deals with tissue changes, has been using an analog method that involves cutting tissue samples into micrometer-thin slices (about 7 times thinner than a human hair) and examining them for pathological mutations under the microscope.
October 24, 2023 — Source

Certain per- and polyfluoroalkyl 'forever chemicals' identified as potential risk factor for thyroid cancer
Researchers have discovered a link between certain per- and polyfluoroalkyl substances (PFAS) and an increased risk for thyroid cancer.
October 24, 2023 — Source

Collaborative study identifies potential targets to treat the most common childhood liver cancer
Hepatoblastoma is the most frequent liver cancer in childhood. Despite the advances in its combined treatment involving surgery and chemotherapy, this disease presents significant therapeutic challenges, especially for patients with aggressive tumors.
October 24, 2023 — Source

Discovering New Ways to Boost Nanoparticle Delivery to Tumors
Prof. Yucai Wang and Assoc. Prof. Wei Jiang, leading a research team at the University of Science and Technology of China (USTC) within the Chinese Academy of Sciences (CAS), has unveiled the previously unknown mechanism of how tumor vascular basement membranes obstruct nanoparticles (NPs).
October 24, 2023 — Source

Diabetes complications linked to increased risk of colorectal cancer recurrence and death
Complications of diabetes can have numerous negative health effects, from impaired vision and nerve damage to kidney dysfunction and heart disease. In an analysis of information on adults with colorectal cancer, patients who also had diabetes-;particularly those with diabetic complications-;faced a higher risk of dying early.
October 24, 2023 — Source

EPA to ban carcinogenic chemical found in degreasers, cleaners
The U.S. Environmental Protection Agency (EPA) proposes to ban a cancer-causing chemical commonly used as a furniture cleaner and degreaser.
October 24, 2023 — Source

Epigenetically acting drugs could support cancer immunotherapy
Epigenetically active drugs enable the cell to read parts oft he genome that were previously blocked and inaccessible. This leads to the formation of new mRNA transcripts and also new proteins, as scientists from the German Cancer Research Center and the University Hospital Tübingen have now described in research published in Nature Communications.
October 24, 2023 — Source

Finding and targeting dormant tumor cells to prevent breast cancer recurrence
While breast cancer survival continues to improve, thanks to advances in detection and treatment, when breast cancer recurs — or returns after initial treatment — it is incurable. Currently, there is no way to predict who is most likely to experience a breast cancer recurrence, and for the 30 percent of women and men who do relapse, continuous and indefinite treatment is the only option for attempting to slow the cancer growth.
October 24, 2023 — Source

HIF-2α inhibitor belzutifan significantly reduces progression of clear cell renal cell carcinoma
Belzutifan significantly reduced the risk of progression of clear cell renal cell carcinoma (ccRCC), the most common type of kidney cancer, in patients previously treated with immune checkpoint inhibitors and anti-angiogenic therapies compared with everolimus in a phase 3 clinical trial. The trial, led by Toni K. Choueiri, MD, Director of the Lank Center for Genitourinary Cancer at Dana-Farber Cancer Institute, showed the risk of progression was reduced by 25-26%.
October 24, 2023 — Source

Impact of cancer predisposing variants on mortality examined in survivors
Cheng Chen, from the Shanghai Jiao Tong University School of Medicine, and colleagues used data from two retrospective cohort studies--St. Jude Lifetime Cohort (SJLIFE) and the Childhood Cancer Survivor Study (CCSS)--with prospective follow-up of patients alive for at least five years after diagnosis of childhood cancer with corresponding germline whole genome or whole exome sequencing data.
October 24, 2023 — Source

Perioperative durvalumab may change standard-of-care for patients with resectable lung cancer
A regimen of pre-surgical immunotherapy and chemotherapy followed by post-surgical immunotherapy significantly improved event-free survival (EFS) and pathologic complete response (pCR) rates compared to chemotherapy alone for patients with operable non-small cell lung cancer (NSCLC), according to results of a Phase III trial reported by researchers at The University of Texas MD Anderson Cancer Center.
October 24, 2023 — Source

Researchers develop new resource to aid in cancer surveillance at US cancer centers
With the creation of Cancer InFocus, the University of Kentucky Markey Cancer Center's Community Impact Office introduced a new tool monitoring the geographic burden of cancer. This resource--launched in 2022--combines powerful data collection software with an interactive online application to accelerate gaining insight from data in the fight against America's second leading cause of death.
October 24, 2023 — Source

Researchers discover new way to trigger programmed cell death in cancer cells
CD95 receptors, also known as Fas, are called death receptors. These protein receptors reside on cell membranes. When activated, they release a signal that causes the cells to self-destruct.
October 24, 2023 — Source

Sotorasib + panitumumab beneficial for chemorefractory metastatic CRC
For patients with chemorefractory metastatic colorectal cancer, the KRAS G12C inhibitor sotorasib in combination with the epidermal growth factor receptor inhibitor panitumumab results in longer progression-free survival than standard treatment, according to a study published online Oct. 22 in the New England Journal of Medicine. The research was published to coincide with the annual meeting of the European Society for Medical Oncology, held from Oct. 20 to 24 in Madrid.
October 24, 2023 — Source

Study shows thyroid cancer is more common among transgender female veterans
A new study by UC Davis Health endocrinology researchers has shown a high prevalence of thyroid cancer among transgender female veterans. It's the first evidence of such a disparity in the transgender female population in the United States.
October 24, 2023 — Source

The sunscreen paradox: Researchers warn of 'false sense of security'
Sunscreen usage is climbing, but so are melanoma and skin cancer rates: this, researchers say, is the sunscreen paradox.
October 24, 2023 — Source

Health — Cancer — October 23rd, 2023

Clinical trial of adjuvant therapy combination shows improved recurrence-free survival in liver cancer patients
@3
October 23, 2023 — Source

Lung cancer outcomes significantly improved with immunotherapy-based treatment given before and after surgery
A regimen of pre-surgical immunotherapy and chemotherapy followed by post-surgical immunotherapy significantly improved event-free survival (EFS) and pathologic complete response (pCR) rates compared to chemotherapy alone for patients with operable non-small cell lung cancer (NSCLC), according to results of a Phase III trial.
October 23, 2023 — Source

New device rapidly decodes RNA for faster cancer diagnosis
A new device created at the University of Notre Dame employs an innovative method for "listening in" on cells' conversations.
October 23, 2023 — Source

New technology could lead to quick, minimally invasive cancer diagnoses
A new device created at the University of Notre Dame employs an innovative method for "listening in" on cells' conversations.
October 23, 2023 — Source

Quick Genetic Test Offers Hope for Sick, Undiagnosed Kids. But Few Insurers Offer to Pay.
Just 48 hours after her birth in a Seattle-area hospital in 2021, Layla Babayev was undergoing surgery for a bowel obstruction.
October 23, 2023 — Source

Researchers propose new strategy to improve efficiency for nanotherapeutic delivery in tumors
A team led by Prof. Wang Yucai and Associate Prof. Jiang Wei from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) revealed the mechanism of the tumor vascular basement membranes (BM) blocking nanoparticles (NPs) for the first time and developed an immunodriven strategy to increase the NP penetration through the BM barrier.
October 23, 2023 — Source

Study shows skin cancer diagnoses using AI are as reliable as those made by medical experts
Artificial intelligence (AI) is already widely used in medical diagnostics. An Austrian-Australian research team led by dermatologist Harald Kittler from MedUni Vienna has investigated the extent to which diagnosis and therapy of pigmented skin lesions benefit from it in a realistic clinical scenario.
October 23, 2023 — Source

Health — Cancer — October 20th, 2023

A cancer survival calculator is being developed using artificial intelligence
Researchers have developed an artificial intelligence (AI)--based tool for estimating a newly diagnosed cancer patient's chances for surviving long term, according to a study presented at the American College of Surgeons (ACS) Clinical Congress 2023.
October 20, 2023 — Source

Reliable patient education materials on breast cancer are difficult to access, research finds
Women with breast cancer must often make complex decisions about surgery and treatment options during an already stressful time in their lives, and many of these women may turn to the wide variety of materials available online.
October 20, 2023 — Source

Tolerable treatments lacking for higher-risk myelodysplastic syndromes
Shanna Arnold Egloff, Ph.D., from HCA Healthcare in Nashville, Tennessee, and colleagues describe clinical presentation, patient-related factors, prognostic characteristics, treatment patterns, clinical outcomes and resource utilization among 200 patients with HR-MDS within a large U.S. community hospital network.
October 20, 2023 — Source

Health — Cancer — October 19th, 2023

Can golden retrievers live longer? Researchers find gene associated with longevity in the breed
Golden retrievers are one of the most popular breeds of dogs. But research shows they have up to a 65% chance of dying from cancer. In a new study, University of California, Davis, researchers set out to find if certain genetic factors could help their survival rate. But instead of searching for genes associated with a cancer diagnosis in the breed, they instead chose to look for genes associated with longer life.
October 19, 2023 — Source

CAR T-cell therapy for multiple myeloma shows no difference in survival outcomes by race and ethnicity
Patients with multiple myeloma treated with idecabtagene vicleucel, known as "ide-cel," a chimeric antigen receptor (CAR) T-cell therapy, had no difference in overall survival outcomes regardless of race and ethnicity, according to a study published in Blood Advances.
October 19, 2023 — Source

Drug mechanism opens door for new anti-cancer immunotherapies
Researchers have revealed a new mechanism of targeted drug treatment used against chronic lymphocytic leukemia, through the promotion of immune cell function, that could be exploited using new anti-cancer immunotherapies.
October 19, 2023 — Source

Experimental Vaccine Uses Nanoparticles to Target Protein Key to Cancer Spread
Engineers at the University of California San Diego have developed an experimental vaccine that could prevent the spread of metastatic cancers to the lungs. The key ingredients of the vaccine are nanoparticles-fashioned from bacterial viruses-that have been engineered to target a protein known to play a central role in cancer growth and spread. In mice, the vaccine significantly reduced the spread of metastatic breast and skin cancers to the lungs.
October 19, 2023 — Source

GLS2 shapes ferroptosis in hepatocellular carcinoma
In their new editorial, researchers Sawako Suzuki, Divya Venkatesh, Tomoaki Tanaka, and Carol Prives from Columbia University discuss ferroptosis regulation of GLS2 as a potential therapeutic strategy against liver diseases.
October 19, 2023 — Source or Watch Video

mRNA delivered by extracellular vesicles induces immunotherapy response in glioblastoma
A team of researchers at The University of Texas MD Anderson Cancer Center has developed a new method for using extracellular vesicles to enhance responses to immunotherapy in glioblastoma, potentially opening the door for wider use of engineered messenger RNA (mRNA) for cancer therapy.
October 19, 2023 — Source

miRNA Therapy Slows Cancer Growth
Scientists at Purdue University have developed a microRNA therapy designed to slow tumor growth. The technology takes advantage of the tendency of several cancer types to express an excess of surface receptors that bind folate (vitamin B9) and draw it into the cell interior. By attaching the microRNA strand to a folate molecule, the researchers could target it to cancer cells
October 19, 2023 — Source

"Two-for-one" cancer immunotherapy more effective and at least as safe as standard treatments
The findings, which involved hundreds of patients with different types of advanced solid tumors or blood cancers, point to an enticing new path for bispecific therapies that more efficiently unleash the patient's own immune system to eliminate the cancer.
October 19, 2023 — Source

Health — Cancer — October 18th, 2023

Advances in gynecological cancer research could change the treatment landscape
Results from highly anticipated phase 3 clinical trials in gynecological cancers with, among others, new data that cover the entire spectrum of managing patients with cervical cancer, will be presented at the ESMO Congress 2023 in Madrid, Spain. The late-breaking studies will be featured in Presidential and Proffered Paper Sessions, and could change the treatment landscape for women with these cancers.
October 18, 2023 — Source

Experimental drugs could help lung cancer treatment research enter a new era
More people with non-small cell lung cancer (NSCLC) are likely to benefit from new drugs that target molecular alterations in tumor cells, with less need for chemotherapy, following results of multiple clinical trials reported for the first time in late-breaking presentations at the ESMO Congress 2023.
October 18, 2023 — Source

FDA proposes ban on formaldehyde in hair straighteners over health dangers
The U.S. Food and Drug Administration has proposed a ban on the use of formaldehyde in hair relaxers over concerns about its link to respiratory problems and certain cancers.
October 18, 2023 — Source

New study identifies cells that drive pancreatic cancer spread while discovering their weakness
A new study carried out in mice, led by Queen Mary University of London, has identified cells that drive the spread of pancreatic cancer and discovered a weakness in these cells that could be targeted using existing drugs. This offers a promising new approach for treating pancreatic cancer.
October 18, 2023 — Source

People with intellectual disability are often diagnosed with cancer when it is already well advanced
Many people with intellectual disability are diagnosed with cancer when it has already spread (metastasized) and the odds of survival are lower.
October 18, 2023 — Source

Promising new options for treating aggressive prostate cancer
Cedars-Sinai Cancer investigators have identified two promising new treatment options for men with recurrent prostate cancer--both of which helped patients live longer without their disease progressing than the current standard treatment. The results of their international Phase III clinical trial were published today in the New England Journal of Medicine.
October 18, 2023 — Source

Q&A: Hot flashes, vaginal dryness: Is endocrine therapy worth it for breast cancer?
Cancer treatment is riddled with pros and cons, trade-offs. During October, breast cancer awareness month, the spotlight shines on endocrine therapy or "hormonal therapy." The drug, Tamoxifen, and others like it that shut down estrogen, are well-known in this category among breast cancer survivors.
October 18, 2023 — Source

Selenium not linked to recurrence of non-muscle-invasive bladder cancer
Two hundred seventy patients were randomly assigned to selenium plus placebo, vitamin E plus placebo, selenium plus vitamin E, and placebo plus placebo in a double-blind manner (65, 71, 69, and 65 patients, respectively).
October 18, 2023 — Source

Simple MRI scan could predict radiation side effects for prostate cancer
A new Corewell Health study suggests that men who have longer prostatic urethras, the part of the urethra that travels through the prostate, may be at a higher risk of experiencing moderate, often chronic urinary side effects after receiving radiation for prostate cancer.
October 18, 2023 — Source

Study focusing on Black cancer survivors documents how exposure to racial discrimination impacts care
The medical community has understood for some time that experiences with discrimination are bad for the health of people from underserved racial or ethnic groups--populations burdened with worse health outcomes than white patients for conditions including many cancers. The effects of chronic stress on the body have been considered one chief culprit.
October 18, 2023 — Source

The nuclear envelope and breast cancer metastasis
In their new editorial, researchers Emily Hansen and James M. Holaska from Rowan University discuss nuclear morphology--one of the basic visual criteria used by pathologists to diagnose breast cancer. Immunofluorescence staining of the nuclear structural proteins lamin B and emerin was recommended as an effective diagnostic tool for both thyroid and breast cancer, suggesting nuclear structure is intimately tied to malignant transformation.
October 18, 2023 — Source

Unlocking the secrets of cell behaviour on soft substrates: A paradigm shift in mechanobiology
A research group from the University of Turku and Turku Bioscience Centre together with Misvik Biology Ltd in Finland have developed a new method for studying how cancer cells function in softer and stiffer tissue environments. This insight challenges the existing paradigm, opening up new possibilities for research in cancer biology and tissue engineering.
October 18, 2023 — Source

YouTube's new news hub directs you toward reliable sources
The platform is also helping outlets create news-focused Shorts.
October 18, 2023 — Source